DK141846B - Analogifremgangsmåde til fremstilling af 1-oxo- eller 1-thioxo-s-triazolo(4,3-a)(1,4)benzodiazepinderivater. - Google Patents
Analogifremgangsmåde til fremstilling af 1-oxo- eller 1-thioxo-s-triazolo(4,3-a)(1,4)benzodiazepinderivater. Download PDFInfo
- Publication number
- DK141846B DK141846B DK582970AA DK582970A DK141846B DK 141846 B DK141846 B DK 141846B DK 582970A A DK582970A A DK 582970AA DK 582970 A DK582970 A DK 582970A DK 141846 B DK141846 B DK 141846B
- Authority
- DK
- Denmark
- Prior art keywords
- benzodiazepine
- phenyl
- chloro
- parts
- compound
- Prior art date
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- ISZFECZEQLODQT-UHFFFAOYSA-N [1,2,4]triazolo[4,3-a][1,4]benzodiazepine-1-thione Chemical class S=C1N=NC=2N1C1=C(C=NC2)C=CC=C1 ISZFECZEQLODQT-UHFFFAOYSA-N 0.000 title claims description 3
- 238000004519 manufacturing process Methods 0.000 title description 2
- -1 4-substituted semicarbazido Chemical group 0.000 claims description 15
- 125000004432 carbon atom Chemical group C* 0.000 claims description 9
- 125000000217 alkyl group Chemical group 0.000 claims description 8
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 8
- 229910052760 oxygen Inorganic materials 0.000 claims description 8
- 239000001301 oxygen Substances 0.000 claims description 8
- 229910052757 nitrogen Inorganic materials 0.000 claims description 5
- 125000004433 nitrogen atom Chemical group N* 0.000 claims description 5
- 238000002360 preparation method Methods 0.000 claims description 5
- 125000003545 alkoxy group Chemical group 0.000 claims description 3
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 3
- 150000003839 salts Chemical class 0.000 claims description 3
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 3
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 2
- 125000005843 halogen group Chemical group 0.000 claims description 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 2
- 229910052717 sulfur Chemical group 0.000 claims description 2
- 239000011593 sulfur Chemical group 0.000 claims description 2
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 45
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- 150000001875 compounds Chemical class 0.000 description 26
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- TZZMFMFEBJSMSP-UHFFFAOYSA-N 1-[[7-chloro-5-(4-methoxyphenyl)-3H-1,4-benzodiazepin-2-yl]amino]-3-methylurea Chemical compound ClC=1C=CC2=C(C(=NCC(=N2)NNC(=O)NC)C2=CC=C(C=C2)OC)C=1 TZZMFMFEBJSMSP-UHFFFAOYSA-N 0.000 description 2
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- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 2
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- 239000003826 tablet Substances 0.000 description 1
- 229940095064 tartrate Drugs 0.000 description 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 description 1
- 230000007306 turnover Effects 0.000 description 1
- 239000008096 xylene Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
- C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
- C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
- C07D243/20—Nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP44092366A JPS4910958B1 (en, 2012) | 1969-11-18 | 1969-11-18 | |
| JP9236669 | 1969-11-18 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DK141846B true DK141846B (da) | 1980-06-30 |
| DK141846C DK141846C (en, 2012) | 1980-11-24 |
Family
ID=14052400
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK582970AA DK141846B (da) | 1969-11-18 | 1970-11-17 | Analogifremgangsmåde til fremstilling af 1-oxo- eller 1-thioxo-s-triazolo(4,3-a)(1,4)benzodiazepinderivater. |
Country Status (15)
| Country | Link |
|---|---|
| JP (2) | JPS5010659B1 (en, 2012) |
| AT (2) | AT311993B (en, 2012) |
| BE (1) | BE759099A (en, 2012) |
| CH (2) | CH551432A (en, 2012) |
| DE (2) | DE2056174A1 (en, 2012) |
| DK (1) | DK141846B (en, 2012) |
| ES (1) | ES385641A1 (en, 2012) |
| FI (1) | FI51701C (en, 2012) |
| FR (1) | FR2073379B1 (en, 2012) |
| GB (2) | GB1337736A (en, 2012) |
| NL (1) | NL167697C (en, 2012) |
| NO (1) | NO126085B (en, 2012) |
| SE (1) | SE363111B (en, 2012) |
| YU (1) | YU34898B (en, 2012) |
| ZA (1) | ZA707644B (en, 2012) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA713364B (en) * | 1970-06-18 | 1972-01-26 | Upjohn Co | Prganic compounds and process |
| JPS494470B1 (en, 2012) * | 1970-08-26 | 1974-02-01 | ||
| CH545302A (de) * | 1971-04-08 | 1974-01-13 | Ciba Geigy Ag | Verfahren zur Herstellung von neuen Triazolo-benzodiazepinderivaten |
| US3751426A (en) * | 1971-04-28 | 1973-08-07 | Upjohn Co | 1-substituted-6-phenyl-4h-s-triazolo(4,3-a)(1,6)benzodiazepine compounds |
| GB1377230A (en) * | 1971-09-13 | 1974-12-11 | Upjohn Co | 4h-s-triazolo -4,3-a- 1,4-benzodiazepines |
| BE790356A (fr) * | 1971-10-21 | 1973-04-20 | Takeda Chemical Industries Ltd | Derives de benzodiazepine |
| JPS5418280B2 (en, 2012) * | 1971-10-30 | 1979-07-06 | ||
| BE793629A (fr) * | 1972-01-03 | 1973-07-03 | Upjohn Co | Nouveaux derives de benzodiazepines et leur preparation |
| DE3021107A1 (de) * | 1980-06-04 | 1981-12-17 | Hoechst Ag, 6000 Frankfurt | Carbamoyloxyamino-1,4-benzodiazepine, verfahren zu irer herstellung und diese enthaltende arzneimittel |
| CA1211437A (en) * | 1981-08-12 | 1986-09-16 | Rene Borer | Benzazepines |
| CN111533745A (zh) * | 2020-05-20 | 2020-08-14 | 成都药明康德新药开发有限公司 | 叔丁基-3-(氨基甲基)二氢-5h-三唑并二氮杂卓-8(9h)-甲酸基酯制法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI50981C (fi) * | 1968-11-05 | 1976-09-10 | Takeda Chemical Industries Ltd | Menetelmä unilääkkeinä ja rauhoittavina lääkkeinä vaikuttavien s-triat solo-(4,3-a)(1,4)-bentsodiatsepiinien valmistamiseksi. |
| US3987052A (en) * | 1969-03-17 | 1976-10-19 | The Upjohn Company | 6-Phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepines |
-
0
- BE BE759099D patent/BE759099A/xx not_active IP Right Cessation
-
1969
- 1969-11-17 JP JP44092336A patent/JPS5010659B1/ja active Pending
- 1969-11-18 JP JP44092366A patent/JPS4910958B1/ja active Pending
-
1970
- 1970-11-11 ZA ZA707644A patent/ZA707644B/xx unknown
- 1970-11-13 NO NO4341/70A patent/NO126085B/no unknown
- 1970-11-14 DE DE19702056174 patent/DE2056174A1/de active Pending
- 1970-11-14 DE DE19702064926 patent/DE2064926A1/de active Pending
- 1970-11-17 FR FR7041215A patent/FR2073379B1/fr not_active Expired
- 1970-11-17 DK DK582970AA patent/DK141846B/da unknown
- 1970-11-17 NL NL7016848A patent/NL167697C/xx not_active IP Right Cessation
- 1970-11-17 ES ES385641A patent/ES385641A1/es not_active Expired
- 1970-11-18 AT AT995571A patent/AT311993B/de not_active IP Right Cessation
- 1970-11-18 CH CH1708170A patent/CH551432A/xx not_active IP Right Cessation
- 1970-11-18 YU YU2827/70A patent/YU34898B/xx unknown
- 1970-11-18 AT AT1038070A patent/AT300816B/de not_active IP Right Cessation
- 1970-11-18 CH CH1060273A patent/CH549588A/xx not_active IP Right Cessation
- 1970-11-18 FI FI703096A patent/FI51701C/fi active
- 1970-11-18 SE SE15638/70A patent/SE363111B/xx unknown
- 1970-11-18 GB GB5479770A patent/GB1337736A/en not_active Expired
- 1970-11-18 GB GB2860172A patent/GB1337737A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| ZA707644B (en) | 1971-08-25 |
| DE2056174A1 (de) | 1971-06-24 |
| NL167697C (nl) | 1982-01-18 |
| NO126085B (en, 2012) | 1972-12-18 |
| DK141846C (en, 2012) | 1980-11-24 |
| CH549588A (de) | 1974-05-31 |
| FR2073379A1 (en, 2012) | 1971-10-01 |
| BE759099A (fr) | 1971-04-30 |
| FR2073379B1 (en, 2012) | 1974-08-23 |
| AT300816B (de) | 1972-08-10 |
| YU34898B (en) | 1980-04-30 |
| NL7016848A (en, 2012) | 1971-05-21 |
| FI51701C (fi) | 1977-03-10 |
| AT311993B (de) | 1973-12-10 |
| SE363111B (en, 2012) | 1974-01-07 |
| ES385641A1 (es) | 1973-10-01 |
| FI51701B (en, 2012) | 1976-11-30 |
| GB1337736A (en) | 1973-11-21 |
| DE2064926A1 (de) | 1971-07-22 |
| JPS5010659B1 (en, 2012) | 1975-04-23 |
| GB1337737A (en) | 1973-11-21 |
| NL167697B (nl) | 1981-08-17 |
| CH551432A (de) | 1974-07-15 |
| YU282770A (en) | 1979-10-31 |
| JPS4910958B1 (en, 2012) | 1974-03-13 |
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