GB1337737A - Benzodiazepine derivatives - Google Patents

Benzodiazepine derivatives

Info

Publication number
GB1337737A
GB1337737A GB2860172A GB1337737DA GB1337737A GB 1337737 A GB1337737 A GB 1337737A GB 2860172 A GB2860172 A GB 2860172A GB 1337737D A GB1337737D A GB 1337737DA GB 1337737 A GB1337737 A GB 1337737A
Authority
GB
United Kingdom
Prior art keywords
nov
alkyl
prepared
acid ester
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2860172A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Publication of GB1337737A publication Critical patent/GB1337737A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/20—Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

1337737 Semicarbazido substituted benzodiazepine derivatives TAKEDA YAKUHIN KOGYO KK 18 Nov 1970 [18 Nov 1969] 28601/72 Divided out of 1337736 Heading C2C Compounds of the general Formula III wherein rings A and/or B are optionally substituted by one or more halogen, nitro, trifluoromethyl, C 1-6 alkyl, cycloalkyl or C 1-4 alkoxy; R is hydrogen or C 1-6 alkyl; X is oxygen or sulphur; R<SP>1</SP> is a hydrocarbon residue; and the nitrogen at the 4 position is optionally that of an N-oxide group may be prepared by reacting a hydrazino derivative I with an isocyanic acid ester or isothiocyanic acid ester R<SP>1</SP>NCX. The intermediate hydrazino compound I may be prepared by reaction of hydrazine hydrate with an appropriate 2-amino-, 2-methyl mercapto or 2-thione substituted benzodiazepine. Pharmaceutical compositions of the compounds III with the usual excipients show muscle relaxing, anticonvulsant, sedative and sleep inducing activity when administered orally or parenterally.
GB2860172A 1969-11-18 1970-11-18 Benzodiazepine derivatives Expired GB1337737A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP44092366A JPS4910958B1 (en) 1969-11-18 1969-11-18

Publications (1)

Publication Number Publication Date
GB1337737A true GB1337737A (en) 1973-11-21

Family

ID=14052400

Family Applications (2)

Application Number Title Priority Date Filing Date
GB2860172A Expired GB1337737A (en) 1969-11-18 1970-11-18 Benzodiazepine derivatives
GB5479770A Expired GB1337736A (en) 1969-11-18 1970-11-18 Benzodiazepine derivatives

Family Applications After (1)

Application Number Title Priority Date Filing Date
GB5479770A Expired GB1337736A (en) 1969-11-18 1970-11-18 Benzodiazepine derivatives

Country Status (15)

Country Link
JP (2) JPS5010659B1 (en)
AT (2) AT311993B (en)
BE (1) BE759099A (en)
CH (2) CH549588A (en)
DE (2) DE2064926A1 (en)
DK (1) DK141846B (en)
ES (1) ES385641A1 (en)
FI (1) FI51701C (en)
FR (1) FR2073379B1 (en)
GB (2) GB1337737A (en)
NL (1) NL167697C (en)
NO (1) NO126085B (en)
SE (1) SE363111B (en)
YU (1) YU34898B (en)
ZA (1) ZA707644B (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA713364B (en) * 1970-06-18 1972-01-26 Upjohn Co Prganic compounds and process
JPS494470B1 (en) * 1970-08-26 1974-02-01
CH545302A (en) * 1971-04-08 1974-01-13 Ciba Geigy Ag Triazolobenzodiazepine derivs - with anticonvulsant, cns depressant and muscle-relaxant activity
US3751426A (en) * 1971-04-28 1973-08-07 Upjohn Co 1-substituted-6-phenyl-4h-s-triazolo(4,3-a)(1,6)benzodiazepine compounds
GB1377230A (en) * 1971-09-13 1974-12-11 Upjohn Co 4h-s-triazolo -4,3-a- 1,4-benzodiazepines
BE790356A (en) * 1971-10-21 1973-04-20 Takeda Chemical Industries Ltd BENZODIAZEPINE DERIVATIVES
JPS5418280B2 (en) * 1971-10-30 1979-07-06
BE793629A (en) * 1972-01-03 1973-07-03 Upjohn Co NEW BENZODIAZEPINE DERIVATIVES AND THEIR PREPARATION
DE3021107A1 (en) * 1980-06-04 1981-12-17 Hoechst Ag, 6000 Frankfurt CARBAMOYLOXYAMINO-1,4-BENZODIAZEPINE, METHOD FOR IRER PRODUCTION AND MEDICINAL PRODUCTS CONTAINING THE SAME
CA1211437A (en) * 1981-08-12 1986-09-16 Rene Borer Benzazepines
CN111533745A (en) * 2020-05-20 2020-08-14 成都药明康德新药开发有限公司 Process for preparing tert-butyl-3- (aminomethyl) dihydro-5H-triazolodiazepine-8 (9H) -carboxylic acid ester

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH9315A (en) * 1968-11-05 1975-08-22 K Meguro Triazolo(4,3-a)(1,4)benzodiazepine derivatives
US3987052A (en) * 1969-03-17 1976-10-19 The Upjohn Company 6-Phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepines

Also Published As

Publication number Publication date
NL167697B (en) 1981-08-17
YU282770A (en) 1979-10-31
DE2056174A1 (en) 1971-06-24
FR2073379B1 (en) 1974-08-23
ZA707644B (en) 1971-08-25
ES385641A1 (en) 1973-10-01
NL7016848A (en) 1971-05-21
BE759099A (en) 1971-04-30
JPS4910958B1 (en) 1974-03-13
NO126085B (en) 1972-12-18
FI51701B (en) 1976-11-30
NL167697C (en) 1982-01-18
FR2073379A1 (en) 1971-10-01
SE363111B (en) 1974-01-07
AT300816B (en) 1972-08-10
DK141846C (en) 1980-11-24
GB1337736A (en) 1973-11-21
FI51701C (en) 1977-03-10
CH549588A (en) 1974-05-31
DK141846B (en) 1980-06-30
CH551432A (en) 1974-07-15
AT311993B (en) 1973-12-10
DE2064926A1 (en) 1971-07-22
JPS5010659B1 (en) 1975-04-23
YU34898B (en) 1980-04-30

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee