DK1394178T3 - Fremgangsmåde til fastlæggelse af den terapeutiske aktivitet af et MBP-fragment - Google Patents
Fremgangsmåde til fastlæggelse af den terapeutiske aktivitet af et MBP-fragmentInfo
- Publication number
- DK1394178T3 DK1394178T3 DK03022727T DK03022727T DK1394178T3 DK 1394178 T3 DK1394178 T3 DK 1394178T3 DK 03022727 T DK03022727 T DK 03022727T DK 03022727 T DK03022727 T DK 03022727T DK 1394178 T3 DK1394178 T3 DK 1394178T3
- Authority
- DK
- Denmark
- Prior art keywords
- mbp
- residues
- levels
- amino acid
- synthetic peptides
- Prior art date
Links
- 239000012634 fragment Substances 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 6
- 101001018318 Homo sapiens Myelin basic protein Proteins 0.000 abstract 5
- 102000054064 human MBP Human genes 0.000 abstract 5
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 4
- 125000000539 amino acid group Chemical group 0.000 abstract 3
- 230000002411 adverse Effects 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 230000007423 decrease Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 238000007913 intrathecal administration Methods 0.000 abstract 1
- 238000001990 intravenous administration Methods 0.000 abstract 1
- 230000000926 neurological effect Effects 0.000 abstract 1
- 238000006386 neutralization reaction Methods 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 230000009885 systemic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4713—Autoimmune diseases, e.g. Insulin-dependent diabetes mellitus, multiple sclerosis, rheumathoid arthritis, systemic lupus erythematosus; Autoantigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Gastroenterology & Hepatology (AREA)
- Hospice & Palliative Care (AREA)
- Physical Education & Sports Medicine (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Rehabilitation Therapy (AREA)
- Rheumatology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Psychiatry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA2201841A CA2201841C (en) | 1997-04-04 | 1997-04-04 | Peptide specificity of anti-myelin basic protein and the administration of myelin basic protein peptides to multiple sclerosis patients |
| PCT/CA1998/000290 WO1998045327A1 (en) | 1997-04-04 | 1998-04-03 | Peptide fragments of myelin basic protein, their pharmaceutical compositions and their use in treating multiple sclerosis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1394178T3 true DK1394178T3 (da) | 2008-05-26 |
Family
ID=4160340
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK03022727T DK1394178T3 (da) | 1997-04-04 | 1998-04-03 | Fremgangsmåde til fastlæggelse af den terapeutiske aktivitet af et MBP-fragment |
| DK98914725T DK0970121T3 (da) | 1997-04-04 | 1998-04-03 | Peptidfragmenter af myelin-basisk-protein, deres farmaceutiske sammensætninger og deres anvendelse i behandling af multipel sklerose |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK98914725T DK0970121T3 (da) | 1997-04-04 | 1998-04-03 | Peptidfragmenter af myelin-basisk-protein, deres farmaceutiske sammensætninger og deres anvendelse i behandling af multipel sklerose |
Country Status (20)
| Country | Link |
|---|---|
| EP (2) | EP0970121B1 (cs) |
| JP (1) | JP4173557B2 (cs) |
| AT (2) | ATE386941T1 (cs) |
| AU (1) | AU751303B2 (cs) |
| CA (2) | CA2494338C (cs) |
| CY (2) | CY1107445T1 (cs) |
| CZ (1) | CZ299535B6 (cs) |
| DE (2) | DE69839163T2 (cs) |
| DK (2) | DK1394178T3 (cs) |
| ES (2) | ES2299657T3 (cs) |
| HU (1) | HU226768B1 (cs) |
| NO (1) | NO325018B1 (cs) |
| NZ (1) | NZ338091A (cs) |
| PL (1) | PL191965B1 (cs) |
| PT (2) | PT1394178E (cs) |
| RO (1) | RO119303B1 (cs) |
| RU (1) | RU2198893C2 (cs) |
| SK (1) | SK285815B6 (cs) |
| UA (1) | UA60331C2 (cs) |
| WO (1) | WO1998045327A1 (cs) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1401484A1 (en) | 2001-06-11 | 2004-03-31 | Transition Therapeutics Inc. | Combination therapies using vitamin b12 and interferon for treatment of viral, proliferative and inflammatory diseases |
| RU2261713C1 (ru) * | 2004-04-27 | 2005-10-10 | Государственное учреждение "Межотраслевой научно-технический комплекс "Микрохирургия глаза" им. акад. С.Н. Федорова Министерства здравоохранения Российской Федерации" | Способ лечения тяжелой формы острого оптического неврита у пациентов с рассеянным склерозом |
| EP2488196B1 (en) | 2009-10-12 | 2015-12-16 | LIFEBio Laboratories LLC | Composition for treatment of multiple sclerosis |
| RU2646817C1 (ru) * | 2016-12-27 | 2018-03-07 | Федеральное государственное бюджетное учреждение науки институт биоорганической химии им. академиков М.М. Шемякина и Ю.А. Овчинникова Российской академии наук (ИБХ РАН) | Пептид из состава тяжелой цепи иммуноглобулина человека, пригодный для лечения рассеянного склероза |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2021611C1 (ru) * | 1991-04-19 | 1994-10-15 | Михайленко Анатолий Андреевич | Способ диагностики рассеянного склероза |
| CA2053799C (en) * | 1991-10-22 | 2002-03-12 | Kenneth G. Warren | Synthetic peptide specificity of anti-myelin basic protein from multiple sclerosis cerebrospinal fluid |
| US5817629A (en) * | 1991-10-22 | 1998-10-06 | The Governors Of The University Of Alberta | Peptide specificity of anti-myelin basic protein and the administration of myelin basic protein peptides to multiple sclerosis patients |
| WO1993021222A1 (en) * | 1992-04-09 | 1993-10-28 | Autoimmune, Inc. | Suppression of t-cell proliferation using peptide fragments of myelin basic protein |
| US5824315A (en) * | 1993-10-25 | 1998-10-20 | Anergen, Inc. | Binding affinity of antigenic peptides for MHC molecules |
| WO1996012737A2 (en) * | 1994-10-25 | 1996-05-02 | Immulogic Pharmaceutical Corporation | Compositions and treatment for multiple sclerosis |
| US6329499B1 (en) * | 1994-11-18 | 2001-12-11 | Neurocrine Biosciences, Inc. | Methods for treatment of multiple sclerosis using peptide analogues of human myelin basic protein |
-
1997
- 1997-04-04 CA CA002494338A patent/CA2494338C/en not_active Expired - Fee Related
- 1997-04-04 CA CA2201841A patent/CA2201841C/en not_active Expired - Fee Related
-
1998
- 1998-03-04 UA UA99116049A patent/UA60331C2/uk unknown
- 1998-04-03 AT AT03022727T patent/ATE386941T1/de not_active IP Right Cessation
- 1998-04-03 ES ES03022727T patent/ES2299657T3/es not_active Expired - Lifetime
- 1998-04-03 PT PT03022727T patent/PT1394178E/pt unknown
- 1998-04-03 AU AU69130/98A patent/AU751303B2/en not_active Ceased
- 1998-04-03 DK DK03022727T patent/DK1394178T3/da active
- 1998-04-03 DE DE69839163T patent/DE69839163T2/de not_active Expired - Lifetime
- 1998-04-03 NZ NZ338091A patent/NZ338091A/en unknown
- 1998-04-03 JP JP54217098A patent/JP4173557B2/ja not_active Expired - Fee Related
- 1998-04-03 EP EP98914725A patent/EP0970121B1/en not_active Expired - Lifetime
- 1998-04-03 AT AT98914725T patent/ATE400582T1/de not_active IP Right Cessation
- 1998-04-03 DK DK98914725T patent/DK0970121T3/da active
- 1998-04-03 PT PT98914725T patent/PT970121E/pt unknown
- 1998-04-03 ES ES98914725T patent/ES2307317T3/es not_active Expired - Lifetime
- 1998-04-03 PL PL336085A patent/PL191965B1/pl not_active IP Right Cessation
- 1998-04-03 RO RO99-01064A patent/RO119303B1/ro unknown
- 1998-04-03 DE DE69839694T patent/DE69839694D1/de not_active Expired - Lifetime
- 1998-04-03 RU RU99122954/04A patent/RU2198893C2/ru not_active IP Right Cessation
- 1998-04-03 SK SK1329-99A patent/SK285815B6/sk not_active IP Right Cessation
- 1998-04-03 CZ CZ0346499A patent/CZ299535B6/cs not_active IP Right Cessation
- 1998-04-03 EP EP03022727A patent/EP1394178B1/en not_active Expired - Lifetime
- 1998-04-03 WO PCT/CA1998/000290 patent/WO1998045327A1/en active IP Right Grant
- 1998-04-03 HU HU0000812A patent/HU226768B1/hu not_active IP Right Cessation
-
1999
- 1999-10-01 NO NO19994806A patent/NO325018B1/no not_active IP Right Cessation
-
2008
- 2008-04-24 CY CY20081100462T patent/CY1107445T1/el unknown
- 2008-08-05 CY CY20081100818T patent/CY1108239T1/el unknown
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