DK138854B - Analogifremgangsmåde til fremstilling af s-triazolo(4,3-a)(1,4)benzodiazepinderivater eller 5-oxider eller salte deraf. - Google Patents

Analogifremgangsmåde til fremstilling af s-triazolo(4,3-a)(1,4)benzodiazepinderivater eller 5-oxider eller salte deraf.

Info

Publication number
DK138854B
DK138854B DK560071AA DK560071A DK138854B DK 138854 B DK138854 B DK 138854B DK 560071A A DK560071A A DK 560071AA DK 560071 A DK560071 A DK 560071A DK 138854 B DK138854 B DK 138854B
Authority
DK
Denmark
Prior art keywords
triazolo
oxides
salts
preparation
benzodiazepine derivatives
Prior art date
Application number
DK560071AA
Other languages
Danish (da)
English (en)
Other versions
DK138854C (ja
Inventor
Hans Allgeier
Andre Gagneux
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Priority to FI1368/72A priority Critical patent/FI53821C/fi
Priority to SE7206441A priority patent/SE415101B/xx
Priority to DK248772A priority patent/DK140987B/da
Priority to DK248872AA priority patent/DK140988B/da
Priority to CA164,025A priority patent/CA1008856A/en
Priority to DE19732308280 priority patent/DE2308280A1/de
Priority to NL7302504A priority patent/NL7302504A/xx
Priority to US335268A priority patent/US3870706A/en
Priority to DD16909773A priority patent/DD104529A5/xx
Priority to PL18337273A priority patent/PL92116B1/pl
Priority to PL18337373A priority patent/PL92991B1/pl
Priority to HUCI001345 priority patent/HU165323B/hu
Priority to PL1973160943A priority patent/PL89263B1/pl
Priority to ES412107A priority patent/ES412107A1/es
Priority to AT173773A priority patent/AT329063B/de
Priority to SU1888539A priority patent/SU517257A3/ru
Priority to GB949173A priority patent/GB1439151A/en
Priority to JP2331573A priority patent/JPS5619353B2/ja
Priority to AR24686173A priority patent/AR200859A1/es
Priority to FR7307084A priority patent/FR2248050A1/fr
Priority to AR25257874A priority patent/AR200913A1/es
Priority to AR25257774A priority patent/AR203192A1/es
Priority to SU7402043344A priority patent/SU578877A3/ru
Priority to AT324775A priority patent/AT330787B/de
Priority to AT324475A priority patent/AT330786B/de
Priority to ES439051A priority patent/ES439051A1/es
Priority to ES439052A priority patent/ES439052A1/es
Priority to SU7502043346A priority patent/SU578004A3/ru
Publication of DK138854B publication Critical patent/DK138854B/da
Application granted granted Critical
Publication of DK138854C publication Critical patent/DK138854C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
DK560071AA 1970-11-23 1971-11-15 Analogifremgangsmåde til fremstilling af s-triazolo(4,3-a)(1,4)benzodiazepinderivater eller 5-oxider eller salte deraf. DK138854B (da)

Priority Applications (28)

Application Number Priority Date Filing Date Title
FI1368/72A FI53821C (fi) 1971-11-15 1972-05-15 Foerfarande foer framstaellning av farmakologiskt vaerdefull 6-fenyl-8-klor-4h-s-triazolo(4 3-a)(1 4)bensodiazepin-1-metanol
SE7206441A SE415101B (sv) 1971-11-15 1972-05-17 Analogiforfarande for framstellning av s-triazolo(4,3-a)(1,4)bensodiazepinderivat
DK248772A DK140987B (da) 1971-11-15 1972-05-18 Analogifremgangsmåde til fremstilling af s-triazolo (4,3-a)(1,4) benzodiazepinderivater eller additionssalte deraf med uorganiske eller organiske syrer.
DK248872AA DK140988B (da) 1971-11-15 1972-05-18 Analogifremgangsmåde til fremstilling af et s-triazolo (4,3-a)(1,4) benzodiazepinderivater.
CA164,025A CA1008856A (en) 1971-11-15 1973-02-19 Triazolo-benzodiazepines
DE19732308280 DE2308280A1 (de) 1971-11-15 1973-02-20 Verfahren zur herstellung von neuen diazepinderivaten
NL7302504A NL7302504A (ja) 1971-11-15 1973-02-22
US335268A US3870706A (en) 1971-11-15 1973-02-23 6H-S-TRIAZOLO{8 4,3-a{9 {8 1,4{9 BENZODIAZEPIN-6-ONES
DD16909773A DD104529A5 (ja) 1971-11-15 1973-02-26
SU1888539A SU517257A3 (ru) 1971-11-15 1973-02-27 Способ получени производных бензодиазепина
HUCI001345 HU165323B (ja) 1971-11-15 1973-02-27
PL1973160943A PL89263B1 (ja) 1971-11-15 1973-02-27
ES412107A ES412107A1 (es) 1971-11-15 1973-02-27 Procedimiento para la obtencion de nuevos derivados de dia-zepina.
AT173773A AT329063B (de) 1971-11-15 1973-02-27 Verfahren zur herstellung von neuen diazepinderivaten und ihren salzen
PL18337273A PL92116B1 (ja) 1971-11-15 1973-02-27
PL18337373A PL92991B1 (ja) 1971-11-15 1973-02-27
GB949173A GB1439151A (en) 1971-11-15 1973-02-27 Process for the production of diazepine derivatives
JP2331573A JPS5619353B2 (ja) 1971-11-15 1973-02-28
AR24686173A AR200859A1 (es) 1971-11-15 1973-02-28 Procedimiento para la obtencion de nuevos derivados de diazepina
FR7307084A FR2248050A1 (en) 1971-11-15 1973-02-28 4,5-dihydro-4h-s-triazolo (4,3-a) (1,4) benzodiazepine - cns depressants, anti-convulsants, anti-aggressives and somatic reflex in
AR25257874A AR200913A1 (es) 1971-11-15 1974-03-01 Procedimiento para la elaboracion de nuevos derivados de la diazepina
AR25257774A AR203192A1 (es) 1971-11-15 1974-03-01 Procedimiento para la obtencion de nuevos derivados de diazepina
SU7402043344A SU578877A3 (ru) 1971-11-15 1974-07-15 Способ получени производных диазепина или их солей
AT324475A AT330786B (de) 1971-11-15 1975-04-28 Verfahren zur herstellung von neuen diazepinderivaten
AT324775A AT330787B (de) 1971-11-15 1975-04-28 Verfahren zur herstellung von neuen diazepinderivaten und deren salzen
ES439051A ES439051A1 (es) 1971-11-15 1975-07-01 Procedimiento para la obtencion de nuevos derivados de dia- zepina.
ES439052A ES439052A1 (es) 1971-11-15 1975-07-01 Procedimiento para la obtencion de nuevos derivados de dia- zepina.
SU7502043346A SU578004A3 (ru) 1971-11-15 1975-07-15 Способ получени производных диазепина или их солей

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH1735270 1970-11-23

Publications (2)

Publication Number Publication Date
DK138854B true DK138854B (da) 1978-11-06
DK138854C DK138854C (ja) 1979-04-17

Family

ID=4424771

Family Applications (1)

Application Number Title Priority Date Filing Date
DK560071AA DK138854B (da) 1970-11-23 1971-11-15 Analogifremgangsmåde til fremstilling af s-triazolo(4,3-a)(1,4)benzodiazepinderivater eller 5-oxider eller salte deraf.

Country Status (25)

Country Link
US (1) US4427590A (ja)
JP (2) JPS5619352B1 (ja)
AT (1) AT313282B (ja)
AU (1) AU465108B2 (ja)
BE (1) BE775558A (ja)
CA (1) CA983027A (ja)
CS (1) CS178091B2 (ja)
DE (1) DE2156472A1 (ja)
DK (1) DK138854B (ja)
FI (1) FI52864C (ja)
FR (1) FR2115265B1 (ja)
GB (1) GB1377650A (ja)
GT (1) GT197853300A (ja)
HK (1) HK16078A (ja)
HU (1) HU165317B (ja)
IE (1) IE35811B1 (ja)
IL (1) IL38151A (ja)
KE (1) KE2827A (ja)
MY (1) MY7800232A (ja)
NL (1) NL174252C (ja)
PL (1) PL72358B1 (ja)
SE (1) SE389499B (ja)
SU (2) SU523639A3 (ja)
YU (1) YU293871A (ja)
ZA (1) ZA717721B (ja)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4932874B1 (ja) 1970-12-11 1974-09-03
US4902794A (en) * 1971-04-28 1990-02-20 The Upjohn Company Triazolo-benzodiazepines
GB1377230A (en) * 1971-09-13 1974-12-11 Upjohn Co 4h-s-triazolo -4,3-a- 1,4-benzodiazepines
US3767660A (en) * 1971-09-13 1973-10-23 Upjohn Co 4h-s-triazolo(4,3-a)(1,4)benzodiazepines
GB1381158A (en) * 1971-09-13 1975-01-22 Upjohn Co Benzodiazepines and the manufacture thereof
US4009175A (en) * 1976-03-15 1977-02-22 The Upjohn Company 1-[(Aminooxy)-methyl]-6-substituted-4H-s-triazolo[4,3-a][1,4] benzodiazepines
DE3332830A1 (de) * 1982-09-16 1984-03-22 The Upjohn Co., 49001 Kalamazoo, Mich. Verwendung von benzodiazepinen zur bekaempfung oder bei der behandlung von panikzustaenden
DE3328255A1 (de) * 1983-08-04 1985-02-21 Siemens AG, 1000 Berlin und 8000 München Klebestation fuer einen schnelldrucker
GB9911152D0 (en) * 1999-05-14 1999-07-14 Glaxo Group Ltd Short-acting benzodiazepines
US7160880B1 (en) 1999-05-14 2007-01-09 Cenes Limited Short-acting benzodiazepines
KR20150081370A (ko) 2006-07-10 2015-07-13 파이온 유케이 리미티드 속효형 벤조디아제핀 염 및 이의 중합체 형태
EP2450039A1 (en) 2010-11-08 2012-05-09 PAION UK Ltd. Dosing regimen for sedation with CNS 7056 (Remimazolam)
AR094963A1 (es) 2013-03-04 2015-09-09 Ono Pharmaceutical Co Reacción de oxidación excelente en el índice de conversión
TW201945346A (zh) 2018-04-10 2019-12-01 德商拜耳廠股份有限公司 2,4,5-三取代的1,2,4-三唑酮之製備方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3987052A (en) * 1969-03-17 1976-10-19 The Upjohn Company 6-Phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepines
FR2022598A1 (en) * 1969-11-04 1970-07-31 Pakeda Chemical Ind Sedative chloro-phenyl-triazolobenzodiazepines

Also Published As

Publication number Publication date
HK16078A (en) 1978-03-31
NL7115785A (ja) 1972-05-25
GT197853300A (es) 1980-01-10
NL174252B (nl) 1983-12-16
BE775558A (fr) 1972-05-19
IE35811L (en) 1972-05-23
FI52864C (fi) 1977-12-12
AT313282B (de) 1974-02-11
CA983027A (en) 1976-02-03
HU165317B (ja) 1974-08-28
AU3596671A (en) 1973-05-31
JPS5919956B2 (ja) 1984-05-09
KE2827A (en) 1978-04-07
SE389499B (sv) 1976-11-08
IL38151A (en) 1975-10-15
AU465108B2 (en) 1975-09-18
FR2115265B1 (ja) 1974-11-15
FR2115265A1 (ja) 1972-07-07
ZA717721B (en) 1972-08-30
MY7800232A (en) 1978-12-31
IE35811B1 (en) 1976-05-26
CS178091B2 (ja) 1977-08-31
SU523639A3 (ru) 1976-07-30
FI52864B (ja) 1977-08-31
GB1377650A (en) 1974-12-18
DK138854C (ja) 1979-04-17
JPS568387A (en) 1981-01-28
IL38151A0 (en) 1972-01-27
YU293871A (en) 1982-06-30
JPS5619352B1 (ja) 1981-05-07
DE2156472A1 (de) 1972-05-31
PL72358B1 (ja) 1974-06-29
US4427590A (en) 1984-01-24
SU568366A3 (ru) 1977-08-05
NL174252C (nl) 1984-05-16

Similar Documents

Publication Publication Date Title
DK138691B (da) Analogifremgangsmåde til fremstilling af imidazo(5,1-f)triazinoner eller salte deraf.
DK131725B (da) Analogifremgangsmåde til fremstilling af 2,4-diaminoquinazoliner eller salte deraf.
DK132172B (da) Analogifremgangsmåde til fremstilling af 6,7-benzomorphaner eller salte deraf.
DK138692B (da) Analogifremgangsmåde til fremstilling af s-triazolo(4,3-b)pyridaziner eller salte deraf.
DK138854B (da) Analogifremgangsmåde til fremstilling af s-triazolo(4,3-a)(1,4)benzodiazepinderivater eller 5-oxider eller salte deraf.
DK138424B (da) Analogifremgangsmåde til fremstilling af 5-oxopyrido(2,3-d)pyrimidin-6-carboxylsyre-derivater.
DK143277C (da) Analogifremgangsmaade til fremstilling af s-triazolo(1,5-a)(1,4)benzodiazepinderivater eller 5-oxider eller syreadditionssalte deraf
DK140761B (da) Fremgangsmåde til fremstilling af indolo (2,3-a)-kinoliziner eller salte deraf.
DK140638B (da) Analogifremgangsmåde til fremstilling af s-triazolo(1,5-a)(1,4)benzodiazepinderivater.
DK135534B (da) Fremgangsmåde til fremstilling af pyrasol-(3,4-d)-pyrimidiner eller salte heraf.
DK138797B (da) Analogifremgangsmåde til fremstilling af 1,4-benzodiazepin-derivater eller N-oxider eller salte deraf.
DK126946B (da) Analogifremgangsmåde til fremstilling af 6-morpholino-4-oxo-4,5-dihydro-isothiazolo[5,4-d] pyrimidinderivater eller salte deraf.
DK131374B (da) Fremgangsmåde til fremstilling af 1,4-benzodiazepinderivater eller salte deraf.
DK139973B (da) Analogifremgangsmåde til fremstilling af s-triazolo-(4,3-a)(1,4)-benzodiazepinderivater eller syreadditionssalte deraf.
DK139872B (da) Analogifremgangsmåde til fremstilling af pyrimido(1,2-a)(1,4)benzodiazepin-3-on-derivater.
DK137754B (da) Fremgangsmåde til fremstilling af 1,4-benzodiazepinderivater.
DK126201B (da) Analogifremgangsmåde til fremstilling af 1,4-benzodiazepinderivater eller salte deraf.
DK137332B (da) Analogifremgangsmåde til fremstilling af benzodiazepinderivater eller farmaceutisk acceptable salte deraf.
DK137237B (da) Analogifremgangsmåde til fremstilling af 1,4-benzodiazepinforbindelser eller 4-N-oxider eller salte heraf.
DK130833B (da) Analogifremgangsmåde til fremstilling af N(6)-disubstituerede adenosinderivater.
FI52728C (fi) Menetelmä s-triatsolo(4,3-a)(1,4)bentsosiatsepiinijohdannaisten valmis tamiseksi.
DK140988B (da) Analogifremgangsmåde til fremstilling af et s-triazolo (4,3-a)(1,4) benzodiazepinderivater.
DK124885B (da) Analogifremgangsmåde til fremstilling af 4-alkenyl-substituerede 1,2-difenyl-3,5-dioxopyrazolidiner eller salte heraf.
DK136476B (da) Analogifremgangsmåde til fremstilling af pyrazolo(3,4-e)(1,4)diazepin-7(1H)-onforbindelser eller salte deraf.
DK127115B (da) Fremgangsmåde til fremstilling af 1,4-benzodiazepinderivater.

Legal Events

Date Code Title Description
PBP Patent lapsed