FR2248050A1 - 4,5-dihydro-4h-s-triazolo (4,3-a) (1,4) benzodiazepine - cns depressants, anti-convulsants, anti-aggressives and somatic reflex in - Google Patents

4,5-dihydro-4h-s-triazolo (4,3-a) (1,4) benzodiazepine - cns depressants, anti-convulsants, anti-aggressives and somatic reflex in

Info

Publication number
FR2248050A1
FR2248050A1 FR7307084A FR7307084A FR2248050A1 FR 2248050 A1 FR2248050 A1 FR 2248050A1 FR 7307084 A FR7307084 A FR 7307084A FR 7307084 A FR7307084 A FR 7307084A FR 2248050 A1 FR2248050 A1 FR 2248050A1
Authority
FR
France
Prior art keywords
alkyl
aggressives
convulsants
benzodiazepine
triazolo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7307084A
Other languages
French (fr)
Other versions
FR2248050B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DK560071AA external-priority patent/DK138854B/en
Priority claimed from CH291772A external-priority patent/CH567509A5/en
Priority claimed from CH681972A external-priority patent/CH569737A5/en
Priority claimed from DK248772A external-priority patent/DK140987B/en
Priority claimed from DK248872AA external-priority patent/DK140988B/en
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Publication of FR2248050A1 publication Critical patent/FR2248050A1/en
Application granted granted Critical
Publication of FR2248050B1 publication Critical patent/FR2248050B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
    • C07C243/24—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids
    • C07C243/26—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids with acylating carboxyl groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C243/34—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids with acylating carboxyl groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of a carbon skeleton further substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/20—Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Title cpds are of formula (I): where R' = H or 1-3C alkyl; A = 1-3C alkylene, R2 = OH, 1-6C alkoxy, mono or di-arylmethoxy, N (alkyl)2, N (alkyl)(aralkyl) or N (aralkyl)2, where alkyl = 1-6C and aralkyl = 7-9C, 5-7 membered polymethyleneimino or morpholino both opt. substd. by l.alkyl and with is not >10C or R2A = di (1-4C alkoxy) methyl or 3-6C alkylenedioxymethyl, and rings B and C are opt. subst. by F, Cl, Br, CF3, 1-6C alkyl, or 1-6C alkoxy, and salts and N-oxide of I. I are prepd. e.g. by condensing the corresp. benzodiazepin-6-one with an aryl Mg halide.
FR7307084A 1971-11-15 1973-02-28 4,5-dihydro-4h-s-triazolo (4,3-a) (1,4) benzodiazepine - cns depressants, anti-convulsants, anti-aggressives and somatic reflex in Granted FR2248050A1 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
DK560071AA DK138854B (en) 1970-11-23 1971-11-15 Analogous process for the preparation of s-triazolo (4,3-a) (1,4) benzodiazepine derivatives or 5-oxides or salts thereof.
CH291772A CH567509A5 (en) 1972-02-29 1972-02-29 Diazepin derivs - prepd from triazolobenzodiazepinones and phenylmagnesiumhalide are central depressants, tranquillisers and
CH681872 1972-05-08
CH681972A CH569737A5 (en) 1972-05-08 1972-05-08 4,5-dihydro-4h-s-triazolo (4,3-a) (1,4) benzodiazepine - cns depressants, anti-convulsants, anti-aggressives and somatic reflex in
DK248772A DK140987B (en) 1971-11-15 1972-05-18 Analogous process for the preparation of s-triazolo (4,3-a) (1,4) benzodiazepine derivatives or addition salts thereof with inorganic or organic acids.
DK248872AA DK140988B (en) 1971-11-15 1972-05-18 Analogous process for the preparation of an s-triazolo (4,3-a) (1,4) benzodiazepine derivatives.

Publications (2)

Publication Number Publication Date
FR2248050A1 true FR2248050A1 (en) 1975-05-16
FR2248050B1 FR2248050B1 (en) 1977-01-21

Family

ID=27543704

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7307084A Granted FR2248050A1 (en) 1971-11-15 1973-02-28 4,5-dihydro-4h-s-triazolo (4,3-a) (1,4) benzodiazepine - cns depressants, anti-convulsants, anti-aggressives and somatic reflex in

Country Status (5)

Country Link
AR (1) AR200859A1 (en)
CA (1) CA1008856A (en)
DD (1) DD104529A5 (en)
FR (1) FR2248050A1 (en)
NL (1) NL7302504A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0059386A2 (en) * 1981-02-27 1982-09-08 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Imidazodiazepines, intermediate products and process for their preparation, and medicines containing them
FR2584401A1 (en) * 1985-07-04 1987-01-09 Ile De France NEW BENZAMIDE, PROCESS FOR PREPARING THE SAME AND ITS APPLICATION IN THE THERAPEUTIC FIELD

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0059386A2 (en) * 1981-02-27 1982-09-08 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Imidazodiazepines, intermediate products and process for their preparation, and medicines containing them
EP0059386B1 (en) * 1981-02-27 1985-09-18 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Imidazodiazepines, intermediate products and process for their preparation, and medicines containing them
FR2584401A1 (en) * 1985-07-04 1987-01-09 Ile De France NEW BENZAMIDE, PROCESS FOR PREPARING THE SAME AND ITS APPLICATION IN THE THERAPEUTIC FIELD
EP0210893A1 (en) * 1985-07-04 1987-02-04 Laboratoires DELAGRANGE, Société Anonyme Benzamides, process for their preparation and their therapeutical use

Also Published As

Publication number Publication date
FR2248050B1 (en) 1977-01-21
AR200859A1 (en) 1974-12-27
CA1008856A (en) 1977-04-19
DD104529A5 (en) 1974-03-12
NL7302504A (en) 1973-08-31

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