DK132172B - Analogifremgangsmåde til fremstilling af 6,7-benzomorphaner eller salte deraf. - Google Patents
Analogifremgangsmåde til fremstilling af 6,7-benzomorphaner eller salte deraf.Info
- Publication number
- DK132172B DK132172B DK288270AA DK288270A DK132172B DK 132172 B DK132172 B DK 132172B DK 288270A A DK288270A A DK 288270AA DK 288270 A DK288270 A DK 288270A DK 132172 B DK132172 B DK 132172B
- Authority
- DK
- Denmark
- Prior art keywords
- benzomorphans
- salts
- preparation
- analogous process
- analogous
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/20—Spiro-condensed ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/02—Preparation by ring-closure or hydrogenation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/48—Oxygen atoms attached in position 4 having an acyclic carbon atom attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/52—Oxygen atoms attached in position 4 having an aryl radical as the second substituent in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D211/74—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D211/78—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/86—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/22—Bridged ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/22—Bridged ring systems
- C07D221/26—Benzomorphans
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Cartons (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK135572A DK135586B (da) | 1969-06-04 | 1972-03-22 | Substituerede 2-benzyl-4-piperidinoler til anvendelse som mellemprodukter ved fremstilling af benzomorphaner. |
DK135472A DK130831B (da) | 1969-06-04 | 1972-03-22 | Substituerede 2-benzyl-4-piperidoner til anvendelse som mellemprodukter ved fremstilling af benzomorphaner, og fremgangsmåde til deres fremstilling. |
DK135672A DK142619B (da) | 1969-06-04 | 1972-03-22 | Substituerede 2-benzyl-4-piperidoner til anvendelse som mellemprodukter ved fremstilling af benzomorphaner, og fremgangsmåde til deres fremstilling. |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
NL6908529.A NL156047B (nl) | 1969-06-04 | 1969-06-04 | Werkwijze voor de bereiding van farmaceutische preparaten met analgetische en/of morfine-antagonistische werking, gevormde preparaten, alsmede werkwijze voor de bereiding van daartoe geschikte nieuwe 6,7-benzomorfanen. |
NL6908527A NL6908527A (en) | 1969-06-04 | 1969-06-04 | Benzomorphanes as analgesics and morphine- - autogenists |
NL6908528A NL158787B (nl) | 1969-06-04 | 1969-06-04 | Werkwijze ter bereiding van gesubstitueerde 2-benzyl-4-piperidonen en 2-benzyl-4-piperidinolen en zouten van deze verbindingen. |
Publications (2)
Publication Number | Publication Date |
---|---|
DK132172B true DK132172B (da) | 1975-11-03 |
DK132172C DK132172C (da) | 1976-03-29 |
Family
ID=27351494
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK288270A DK132172C (da) | 1969-06-04 | 1970-06-03 | Analogifremgangsmade til fremstilling af 6,7-benzomorphaner eller salte deraf |
Country Status (17)
Country | Link |
---|---|
US (1) | US3764606A (da) |
JP (1) | JPS496907B1 (da) |
CA (1) | CA935430A (da) |
CH (2) | CH546241A (da) |
DE (1) | DE2027077A1 (da) |
DK (1) | DK132172C (da) |
ES (3) | ES380352A1 (da) |
FI (1) | FI53310C (da) |
FR (1) | FR2052930B1 (da) |
GB (1) | GB1299669A (da) |
IE (1) | IE34235B1 (da) |
IT (1) | IT1043829B (da) |
LU (1) | LU61000A1 (da) |
NO (2) | NO133496C (da) |
PH (1) | PH10082A (da) |
PL (1) | PL82622B1 (da) |
SE (2) | SE374368B (da) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK155999B (da) * | 1974-04-18 | 1989-06-12 | Bristol Myers Co | Analogifremgangsmaade til fremstilling af benzomorphanderivater |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4010164A (en) * | 1973-03-28 | 1977-03-01 | Boehringer Ingelheim Gmbh | N-(furyl-methyl)-2-hydroxy-5,9,9-trimethyl-benzomorphans and salts thereof |
US3853889A (en) * | 1973-07-18 | 1974-12-10 | Bristol Myers Co | 3,14-substituted-8-oxamorphinans |
US3959290A (en) * | 1973-07-18 | 1976-05-25 | Bristol-Myers Company | 3,14-Substituted-8-oxamorphinans |
US3892757A (en) * | 1973-08-29 | 1975-07-01 | Purdue Research Foundation | Trialkylmethanobenzazocinols |
US3891658A (en) * | 1973-08-29 | 1975-06-24 | Purdue Research Foundation | N-Phenethyl trialkylmethanobenz-azolines |
GB1513961A (en) * | 1975-02-25 | 1978-06-14 | Acf Chemiefarma Nv | 6,7-benzomorphans method for their preparation and intermediates |
US4127577A (en) * | 1975-11-24 | 1978-11-28 | Sterling Drug Inc. | Aminomethanobenzazocine process |
US4205171A (en) * | 1976-01-12 | 1980-05-27 | Sterling Drug Inc. | Aminomethanobenzazocines and nitromethanobenzazocines |
NL7804509A (nl) * | 1978-04-26 | 1979-10-30 | Acf Chemiefarma Nv | Nieuwe 6,7-benzomorfanderivaten en zuuradditiezouten daarvan. |
US4208523A (en) * | 1978-11-30 | 1980-06-17 | Sterling Drug Inc. | 11-Lower-alkyl-, 11-phenyl-lower-alkyl- and 11-cyclo-lower-alkyl-lower-alkyl-hexahydro-2,6-methano-3-benzazocines |
US5010083A (en) * | 1988-03-28 | 1991-04-23 | Hoechst-Roussel Pharmaceuticals, Inc. | 2,6-methano-1,3-benzodiazocine compounds which have useful pharmaceutical utility |
US5264575A (en) * | 1988-03-28 | 1993-11-23 | Hoechst-Roussel Pharmaceuticals Inc. | Process of preparing 2,6-methano-1,3-benzodiazocine compounds |
US5097033A (en) * | 1988-03-28 | 1992-03-17 | Hoechst-Roussel Pharmaceuticals Inc. | 2,6-methano-1,3-benzodiazocine compounds |
DE19528472A1 (de) * | 1995-08-03 | 1997-02-06 | Boehringer Ingelheim Kg | Neues Verfahren zur Herstellung von Norbenzomorphan einer Zwischenstufe bei Herstellung von pharmazeutisch wertvollen Benzomorphanderivaten, insbesondere von (-)-(1R,5S,S"R)-3'-Hydroxy-2-(2-methoxypropyl-)-5,9,9-trimethyl-6,7 benzomorphan |
US6136980A (en) * | 1998-05-01 | 2000-10-24 | Boehringer Ingelheim Kg | Method of preparing norbenzomorphane as an intermediate in the preparation of pharmaceutically useful benzomorphane derivatives, in particular (-)-(1R,5S,2"R)-3'-hydroxy-2-(2-methoxypropyl)-5,9,9-trimethyl-6,7-benzo morphane |
DE19822822A1 (de) * | 1998-05-20 | 1999-11-25 | Boehringer Ingelheim Pharma | Verbessertes Verfahren zur Herstellung von pharmazeutisch wertvollen Norbenzomorphanderivaten |
US7923454B2 (en) * | 2002-05-17 | 2011-04-12 | Jenken Biosciences, Inc. | Opioid and opioid-like compounds and uses thereof |
EP2987788A1 (en) | 2002-05-17 | 2016-02-24 | Taiwanj Pharmaceuticals Co., Ltd. | Opioid and opioid-like compounds and uses thereof |
US7501433B2 (en) * | 2002-05-17 | 2009-03-10 | Jenken Biosciences, Inc. | Opioid and opioid-like compounds and uses thereof |
US8017622B2 (en) | 2003-05-16 | 2011-09-13 | Jenken Biosciences, Inc. | Opioid and opioid-like compounds and uses thereof |
CA2900023A1 (en) * | 2013-01-31 | 2014-08-07 | Purdue Pharma L.P. | Benzomorphan analogs and the use thereof |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB997637A (en) * | 1962-01-31 | 1965-07-07 | Smith Kline French Lab | Substituted 2-cyclopropylmethyl-6,7-benzmorphans |
US3250678A (en) * | 1963-01-16 | 1966-05-10 | Sterling Drug Inc | Analgesia producing benzazocines |
GB1050227A (da) * | 1963-11-07 | |||
US3345373A (en) * | 1964-05-25 | 1967-10-03 | Smith Kline French Lab | 2-polymethylallyl-5, 9-dimethyl-6, 7-benzmorphans and derivatives |
US3322778A (en) * | 1964-05-26 | 1967-05-30 | Smith Kline French Lab | Novel ether derivatives of benzmorphans |
DE1545792B2 (de) * | 1965-02-27 | 1975-08-07 | Bayer Ag, 5090 Leverkusen | Verfahren zur Herstellung von 4-Hydroxyplperidinen |
DE1545827C3 (de) * | 1965-06-25 | 1975-09-11 | Bayer Ag, 5090 Leverkusen | Verfahren zur Herstellung von 6,7-Benzomorphanen |
NL132138C (da) * | 1966-05-20 | |||
NL132139C (da) * | 1966-05-20 | |||
US3553223A (en) * | 1968-01-05 | 1971-01-05 | Hoffmann La Roche | Acid catalyzed cyclization of tetrahydropyridines containing an electron withdrawing group on the nitrogen |
-
1970
- 1970-05-26 IE IE679/70A patent/IE34235B1/xx unknown
- 1970-05-27 LU LU61000D patent/LU61000A1/xx unknown
- 1970-05-27 US US00041079A patent/US3764606A/en not_active Expired - Lifetime
- 1970-06-01 GB GB26345/70A patent/GB1299669A/en not_active Expired
- 1970-06-02 DE DE19702027077 patent/DE2027077A1/de not_active Ceased
- 1970-06-03 CH CH726873A patent/CH546241A/xx not_active IP Right Cessation
- 1970-06-03 CH CH829770A patent/CH566989A5/xx not_active IP Right Cessation
- 1970-06-03 DK DK288270A patent/DK132172C/da active
- 1970-06-03 PL PL1970141075A patent/PL82622B1/pl unknown
- 1970-06-03 ES ES380352A patent/ES380352A1/es not_active Expired
- 1970-06-03 IT IT68879/70A patent/IT1043829B/it active
- 1970-06-03 NO NO2165/70A patent/NO133496C/no unknown
- 1970-06-03 FR FR7020440A patent/FR2052930B1/fr not_active Expired
- 1970-06-04 CA CA084689A patent/CA935430A/en not_active Expired
- 1970-06-04 JP JP45047674A patent/JPS496907B1/ja active Pending
- 1970-06-04 PH PH11504A patent/PH10082A/en unknown
- 1970-06-04 SE SE7007767A patent/SE374368B/xx unknown
- 1970-06-04 FI FI1599/70A patent/FI53310C/fi active
-
1972
- 1972-09-30 ES ES407194A patent/ES407194A1/es not_active Expired
- 1972-09-30 ES ES407195A patent/ES407195A1/es not_active Expired
-
1973
- 1973-08-30 SE SE7311827A patent/SE400277B/xx unknown
-
1975
- 1975-04-18 NO NO751399A patent/NO137091C/no unknown
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK155999B (da) * | 1974-04-18 | 1989-06-12 | Bristol Myers Co | Analogifremgangsmaade til fremstilling af benzomorphanderivater |
Also Published As
Publication number | Publication date |
---|---|
IE34235B1 (en) | 1975-03-19 |
ES380352A1 (es) | 1973-04-16 |
NO133496B (da) | 1976-02-02 |
PL82622B1 (da) | 1975-10-31 |
GB1299669A (en) | 1972-12-13 |
SE374368B (da) | 1975-03-03 |
NO137091C (no) | 1977-12-28 |
SE400277B (sv) | 1978-03-20 |
CA935430A (en) | 1973-10-16 |
DE2027077A1 (de) | 1970-12-17 |
NO751399L (da) | 1970-12-05 |
FI53310B (da) | 1977-12-30 |
CH566989A5 (da) | 1975-09-30 |
FR2052930B1 (da) | 1974-10-11 |
US3764606A (en) | 1973-10-09 |
NO133496C (da) | 1976-05-12 |
IT1043829B (it) | 1980-02-29 |
ES407195A1 (es) | 1976-02-01 |
JPS496907B1 (da) | 1974-02-16 |
DK132172C (da) | 1976-03-29 |
LU61000A1 (da) | 1970-07-28 |
IE34235L (en) | 1970-12-04 |
FI53310C (fi) | 1978-04-10 |
FR2052930A1 (da) | 1971-04-16 |
CH546241A (de) | 1974-02-28 |
PH10082A (en) | 1976-08-12 |
NO137091B (no) | 1977-09-19 |
ES407194A1 (es) | 1976-02-01 |
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