DK124031B - Analogifremgangsmåde til fremstilling af fenylsubstituerede piperazinylalkylaminouraciler, -uracilætere eller -uraciltioætere eller salte deraf. - Google Patents

Analogifremgangsmåde til fremstilling af fenylsubstituerede piperazinylalkylaminouraciler, -uracilætere eller -uraciltioætere eller salte deraf.

Info

Publication number
DK124031B
DK124031B DK424770AA DK424770A DK124031B DK 124031 B DK124031 B DK 124031B DK 424770A A DK424770A A DK 424770AA DK 424770 A DK424770 A DK 424770A DK 124031 B DK124031 B DK 124031B
Authority
DK
Denmark
Prior art keywords
uracilthioethers
uraciletes
piperazinylalkylaminouracils
phenyl
salts
Prior art date
Application number
DK424770AA
Other languages
English (en)
Inventor
W Schoetensack
W Pruesse
K Klemm
Original Assignee
Byk Gulden Lomberg Chem Fab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Byk Gulden Lomberg Chem Fab filed Critical Byk Gulden Lomberg Chem Fab
Publication of DK124031B publication Critical patent/DK124031B/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/553—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms with halogen atoms or nitro radicals directly attached to ring carbon atoms, e.g. fluorouracil
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/557—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. orotic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/60—Three or more oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Communication Cables (AREA)
DK424770AA 1969-08-20 1970-08-19 Analogifremgangsmåde til fremstilling af fenylsubstituerede piperazinylalkylaminouraciler, -uracilætere eller -uraciltioætere eller salte deraf. DK124031B (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE1942405A DE1942405C3 (de) 1969-08-20 1969-08-20 Arylsubstituierte Piperazinylpropylenaminouracile

Publications (1)

Publication Number Publication Date
DK124031B true DK124031B (da) 1972-09-04

Family

ID=5743321

Family Applications (1)

Application Number Title Priority Date Filing Date
DK424770AA DK124031B (da) 1969-08-20 1970-08-19 Analogifremgangsmåde til fremstilling af fenylsubstituerede piperazinylalkylaminouraciler, -uracilætere eller -uraciltioætere eller salte deraf.

Country Status (24)

Country Link
US (2) US3957786A (da)
AT (2) AT318651B (da)
BE (1) BE755015A (da)
BG (3) BG17796A3 (da)
BR (1) BR6915466D0 (da)
CA (1) CA956944A (da)
CH (2) CH582173A5 (da)
DE (1) DE1942405C3 (da)
DK (1) DK124031B (da)
ES (1) ES382842A1 (da)
FI (1) FI54479C (da)
FR (1) FR2073300B1 (da)
GB (1) GB1309324A (da)
HK (1) HK23678A (da)
HU (1) HU163664B (da)
IE (1) IE35177B1 (da)
IL (1) IL35121A (da)
LU (1) LU61527A1 (da)
NL (1) NL155014B (da)
NO (1) NO129148B (da)
SE (1) SE386448B (da)
SU (1) SU399130A3 (da)
YU (2) YU36509B (da)
ZA (1) ZA705729B (da)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2329399A1 (de) * 1973-06-08 1975-01-02 Wuelfing J A Fa 4-alkyl-aminouracile, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
LU74319A1 (da) * 1976-02-09 1977-08-19
DE3326118A1 (de) 1982-08-02 1984-02-09 Byk Gulden Lomberg Chemische Fabrik Gmbh, 7750 Konstanz Pyridopyrimidintrione, verfahren zu ihrer herstellung, ihre verwendung und sie enthaltende arzneimittel
IE62890B1 (en) * 1988-12-06 1995-03-08 Hafslund Nycomed Pharma New piperazinylalkyl-3(2h)-pyridazinones process for the preparation thereof and the use thereof as agents lowering blood pressure
CA2024428A1 (en) * 1989-09-06 1991-03-07 Masayuki Ishikawa Agent for treating urinary obstruction
AU7078691A (en) * 1990-02-01 1991-08-21 Byk Gulden Lomberg Chemische Fabrik Gmbh Use of urapidile and derivatives for treating arteriosclerotic diseases
DE4425143A1 (de) * 1994-07-15 1996-01-18 Basf Ag Substituierte Pyrimidinverbindungen und deren Verwendung
EP0796251B1 (de) * 1994-12-07 2001-10-17 Byk Gulden Lomberg Chemische Fabrik GmbH Uracilderivate
HUP0104493A3 (en) 1998-09-30 2002-12-28 Takeda Pharmaceutical Drugs for improving vesical excretory strength
EP1341777B1 (en) * 2000-11-29 2007-09-26 Eli Lilly And Company 1-(2-m-methanesulfonamidophenylethyl)-4-(m-trifluoromethylphenyl)piperazine and pharmaceutically acceptable salts and solvates thereof and their use in the treatement of incontinence
WO2003000664A1 (de) * 2001-06-22 2003-01-03 Bayer Aktiengesellschaft Uracilderivative und ihre verwendung bei der behandlung bakterieller erkrankungen
US20050059744A1 (en) * 2003-09-12 2005-03-17 Allergan, Inc. Methods and compositions for the treatment of pain and other alpha 2 adrenergic-mediated conditions
JP5165242B2 (ja) 2003-09-12 2013-03-21 アラーガン、インコーポレイテッド 疼痛およびα２アドレナリン受容体が関与する他の状態の処置のための方法および組成物
US20050058696A1 (en) * 2003-09-12 2005-03-17 Allergan, Inc. Methods and compositions for the treatment of pain and other alpha 2 adrenergic-mediated conditions
US20060264442A1 (en) * 2005-05-18 2006-11-23 Allergan, Inc. Methods for the treatment of ocular and neurodegenerative conditions in a mammal
CN101200451B (zh) * 2006-12-15 2010-12-15 重庆药友制药有限责任公司 一种盐酸乌拉地尔的制备方法
CN102295607B (zh) * 2011-06-16 2013-04-17 郑州大学 乌拉地尔的逆相转移催化制备方法
KR102638538B1 (ko) 2021-12-28 2024-02-20 주식회사 한서켐 우라피딜 제조 중간체의 제조방법
CN115477616A (zh) * 2022-09-27 2022-12-16 河北广祥制药有限公司 一种乌拉地尔杂质的制备方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2567651A (en) * 1951-09-11 J-dialkyl-g-amino-l

Also Published As

Publication number Publication date
GB1309324A (en) 1973-03-07
BR6915466D0 (pt) 1973-05-15
AT302359B (de) 1972-10-10
US4067982A (en) 1978-01-10
IE35177L (en) 1971-02-20
DE1942405A1 (de) 1971-09-16
SU399130A3 (da) 1973-09-27
BE755015A (fr) 1971-02-01
IE35177B1 (en) 1975-12-10
NO129148B (da) 1974-03-04
NL7012364A (da) 1971-02-23
IL35121A0 (en) 1970-10-30
ZA705729B (en) 1972-03-29
SE386448B (sv) 1976-08-09
CH551990A (de) 1974-07-31
SU363248A3 (da) 1972-12-30
YU207670A (en) 1982-02-25
BG17796A3 (da) 1973-12-25
YU203979A (en) 1982-02-25
FR2073300A1 (da) 1971-10-01
BG17585A3 (da) 1973-11-10
CA956944A (en) 1974-10-29
CH582173A5 (da) 1976-11-30
HK23678A (en) 1978-05-12
YU36509B (en) 1984-02-29
DE1942405C3 (de) 1974-05-30
DE1942405B2 (de) 1973-10-31
HU163664B (da) 1973-10-27
LU61527A1 (da) 1971-06-22
FI54479C (fi) 1978-12-11
YU36518B (en) 1984-02-29
US3957786A (en) 1976-05-18
FI54479B (fi) 1978-08-31
FR2073300B1 (da) 1974-02-01
ES382842A1 (es) 1973-02-16
BG17795A3 (da) 1973-12-25
AT318651B (de) 1974-11-11
NL155014B (nl) 1977-11-15
IL35121A (en) 1974-03-14

Similar Documents

Publication Publication Date Title
DK138795B (da) Analogifremgangsmåde til fremstilling af N-benzylimidazolderivater eller salte deraf.
DK139869B (da) Analogifremgangsmåde til fremstilling af phenyl-imidazolyl-alkansyrederivater eller salte deraf.
DK134113B (da) Analogifremgangsmåde til fremstilling af 1,2,3,4-tetrahydro-7-halogen-eller 7-trifluormethyl-6-sulfamyl-4-quinazolinoner eller salte heraf.
DK132172B (da) Analogifremgangsmåde til fremstilling af 6,7-benzomorphaner eller salte deraf.
DK131725B (da) Analogifremgangsmåde til fremstilling af 2,4-diaminoquinazoliner eller salte deraf.
DK124031B (da) Analogifremgangsmåde til fremstilling af fenylsubstituerede piperazinylalkylaminouraciler, -uracilætere eller -uraciltioætere eller salte deraf.
DK128005B (da) Analogifremgangsmåde til fremstilling af bis-chromoner eller salte, amider eller estere deraf.
DK126788B (da) Analogifremgangsmåde til fremstilling af γ-morpholino-p-amino-butyrophenoner eller salte deraf.
DK129650B (da) Analogifremgangsmåde til fremstilling af 1-phenoxy-2-hydroxy-3-amino-propaner eller salte deraf.
DK128078B (da) Analogifremgangsmåde til fremstilling af 1,2,3,4-tetrahydroisoquinolinderivater eller salte deraf.
DK140697B (da) Fremgangsmåde til fremstilling af 2-amino-4-hydroxy-6-hydroxymethyl-7,7-dimethyl-7,8-dihydropteridin.
DK123708B (da) Fremgangsmåde til fremstilling af polyencarboxylsyrer eller salte deraf.
DK137758B (da) Analogifremgangsmåde til fremstilling af 2-(5-nitro-2-imidazolyl)-benzimidazoler eller salte deraf.
DK123032B (da) Analogifremgangsmåde til fremstilling af 1-phenoxymethyl-3,4-dihydro- og -1,2,3,4-tetrahydro-isoquinolin-forbindelser eller salte deraf.
DK120159B (da) Analogifremgangsmåde til fremstilling af p-alkyloxy-, p-alkenyloxy-, p-alkynyloxy- eller p-cycloalkenyloxyfenyleddikesyrer eller salte deraf.
DK133979B (da) Analogifremgangsmåde til fremstilling af 5-methyl-10-(beta-alkylaminethyl)-dibenzo(b,f)-azepiner eller salte deraf.
DK125474B (da) Analogifremgangsmåde til fremstilling af 1H-3,4-dihydro-2,3-benzoxaziner eller salte deraf.
DK133694B (da) Analogifremgangsmåde til fremstilling af 4-imino-1,4-dihydropyridin-forbindelser eller salte deraf.
DK123242B (da) Analogifremgangsmåde til fremstilling af 3-(5-nitro-2-imidazolylmetylenamino)-2-oksazolidinoner eller salte deraf.
DK133778B (da) Analogifremgangsmåde til fremstilling af substituerede isoquinoliner eller salte heraf.
DK124035B (da) Fremgangsmåde til fremstilling af α-carboxybenzylpencillin eller salte deraf.
DK127432B (da) Analogifremgangsmåde til fremstilling af acylaminopenicillansyrer eller salte deraf.
DK134557B (da) Analogifremgangsmåde til fremstilling af estere af alfa-amino-aryl-eller thienylmetylpenicilliner eller salte heraf.
DK124885B (da) Analogifremgangsmåde til fremstilling af 4-alkenyl-substituerede 1,2-difenyl-3,5-dioxopyrazolidiner eller salte heraf.
DK124545B (da) Analogifremgangsmåde til fremstilling af bisimidazolyl-bisphenylmethaner eller salte deraf.

Legal Events

Date Code Title Description
PUP Patent expired