DK1383752T3 - Deutererede 3-piperidinopropiophenoner samt lægemidler indeholdende disse forbindelser - Google Patents

Deutererede 3-piperidinopropiophenoner samt lægemidler indeholdende disse forbindelser

Info

Publication number
DK1383752T3
DK1383752T3 DK02727303T DK02727303T DK1383752T3 DK 1383752 T3 DK1383752 T3 DK 1383752T3 DK 02727303 T DK02727303 T DK 02727303T DK 02727303 T DK02727303 T DK 02727303T DK 1383752 T3 DK1383752 T3 DK 1383752T3
Authority
DK
Denmark
Prior art keywords
piperidinopropiophenones
deuterated
well
compounds
illnesses
Prior art date
Application number
DK02727303T
Other languages
English (en)
Inventor
Thomas Stabingis
Rudolf-Giesbert Alken
Original Assignee
Bdd Berolina Drug Dev Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bdd Berolina Drug Dev Gmbh filed Critical Bdd Berolina Drug Dev Gmbh
Application granted granted Critical
Publication of DK1383752T3 publication Critical patent/DK1383752T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
    • C07D295/104—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/108—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
DK02727303T 2001-05-02 2002-04-29 Deutererede 3-piperidinopropiophenoner samt lægemidler indeholdende disse forbindelser DK1383752T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10123129A DE10123129A1 (de) 2001-05-02 2001-05-02 Deuterierte 3-Piperidinopropiophenone sowie diese Verbindungen enthaltende Arzneimittel
EP02727303A EP1383752B1 (de) 2001-05-02 2002-04-29 Deuterierte 3-piperidinopropiophenone sowie diese verbindungen enthaltende arzneimittel

Publications (1)

Publication Number Publication Date
DK1383752T3 true DK1383752T3 (da) 2005-10-17

Family

ID=7684543

Family Applications (1)

Application Number Title Priority Date Filing Date
DK02727303T DK1383752T3 (da) 2001-05-02 2002-04-29 Deutererede 3-piperidinopropiophenoner samt lægemidler indeholdende disse forbindelser

Country Status (22)

Country Link
US (1) US7307091B2 (da)
EP (1) EP1383752B1 (da)
JP (1) JP4373097B2 (da)
KR (1) KR100894846B1 (da)
CN (2) CN101002770A (da)
AT (1) ATE298324T1 (da)
AU (1) AU2002257562B2 (da)
CA (1) CA2446890C (da)
CZ (1) CZ20033060A3 (da)
DE (2) DE10123129A1 (da)
DK (1) DK1383752T3 (da)
ES (1) ES2244768T3 (da)
HU (1) HUP0400077A2 (da)
IL (1) IL158668A0 (da)
IS (1) IS7006A (da)
NO (1) NO20034863L (da)
NZ (1) NZ529586A (da)
PL (1) PL363313A1 (da)
PT (1) PT1383752E (da)
RU (1) RU2296755C2 (da)
SI (1) SI1383752T1 (da)
WO (1) WO2002088100A2 (da)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10261807A1 (de) 2002-12-19 2004-07-01 Turicum Drug Development Ag Deuterierte Catecholaminderivate sowie diese Verbindungen enthaltende Arzneimittel
HUP0300929A3 (en) * 2003-04-09 2005-06-28 Richter Gedeon Vegyeszet Analgetic and/or muscle relaxant pharmaceutical composition
DE102005014080B4 (de) * 2005-03-21 2007-11-22 Birds Pharma Gmbh Berolina Innovative Research & Development Services Additionssalze des Tolperison, Verfahren zu deren Herstellung, Verwendung derselben und diese enthaltende Arzneimittel
CN101268050B (zh) * 2005-07-26 2012-11-28 奈科明有限责任公司 同位素取代的泮托拉唑
US7601737B2 (en) * 2005-07-26 2009-10-13 Nycomed Gmbh Isotopically substituted proton pump inhibitors
CN101268051B (zh) * 2005-07-26 2011-08-31 奈科明有限责任公司 同位素取代的质子泵抑制剂
EP1934201A1 (en) * 2005-10-06 2008-06-25 Auspex Pharmaceuticals Inc. Deuterated inhibitors of gastric h+, k+-atpase with enhanced therapeutic properties
CA2651732C (en) 2006-05-18 2014-10-14 Mannkind Corporation Intracellular kinase inhibitors
AU2007286186A1 (en) * 2006-08-08 2008-02-21 Auspex Pharmaceuticals, Inc. Preparation and utility of substituted quinazoline compounds with alpha-adrenergic blocking effects
US20130197031A1 (en) * 2010-09-03 2013-08-01 IVAX International GmbH Deuterated analogs of pridopidine useful as dopaminergic stabilizers
KR20230023817A (ko) 2013-12-03 2023-02-17 인트라-셀룰라 써래피스, 인코퍼레이티드. 신규한 방법
CN106535898A (zh) * 2014-04-04 2017-03-22 细胞内治疗公司 有机化合物
WO2017105881A1 (en) * 2015-12-15 2017-06-22 NeuForm Pharmaceuticals, Inc. Deuterated compounds for treating pain
EP3407889B1 (en) 2016-03-25 2021-05-19 Intra-Cellular Therapies, Inc. Organic compounds and their use in treating or preventing central nervous system disorders
JP7013454B2 (ja) 2016-10-12 2022-02-15 イントラ－セルラー・セラピーズ・インコーポレイテッド アモルファス固体分散体
CN106588817A (zh) * 2016-12-13 2017-04-26 湖南亚大制药有限公司 一种盐酸乙哌立松的合成方法
CN116327770A (zh) 2017-03-24 2023-06-27 细胞内治疗公司 新组合物和方法
KR20210052471A (ko) 2018-08-31 2021-05-10 인트라-셀룰라 써래피스, 인코퍼레이티드. 신규한 방법
JP7457000B2 (ja) 2018-08-31 2024-03-27 イントラ－セルラー・セラピーズ・インコーポレイテッド 新規方法
CN110845443B (zh) * 2019-12-11 2023-09-05 嘉实（湖南）医药科技有限公司 一种制备高纯度盐酸托哌酮的方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5527914B2 (da) * 1973-12-14 1980-07-24
US3995047A (en) * 1973-12-14 1976-11-30 Eisai Co., Ltd. Propiophenone derivatives in the treatment of pathological muscular conditions
HU33131A (da) * 1984-01-26 1984-10-29

Also Published As

Publication number Publication date
RU2003133924A (ru) 2005-05-10
AU2002257562B2 (en) 2007-01-11
DE50203456D1 (de) 2005-07-28
DE10123129A1 (de) 2002-11-14
SI1383752T1 (sl) 2005-12-31
CZ20033060A3 (cs) 2004-09-15
KR20040015240A (ko) 2004-02-18
US7307091B2 (en) 2007-12-11
CN1527823A (zh) 2004-09-08
WO2002088100A2 (de) 2002-11-07
NZ529586A (en) 2005-07-29
US20040186136A1 (en) 2004-09-23
PL363313A1 (en) 2004-11-15
ATE298324T1 (de) 2005-07-15
CN1293064C (zh) 2007-01-03
JP4373097B2 (ja) 2009-11-25
PT1383752E (pt) 2005-11-30
KR100894846B1 (ko) 2009-04-24
CA2446890A1 (en) 2002-11-07
RU2296755C2 (ru) 2007-04-10
WO2002088100A3 (de) 2003-05-30
CA2446890C (en) 2010-02-23
JP2004527558A (ja) 2004-09-09
EP1383752B1 (de) 2005-06-22
IS7006A (is) 2003-10-30
NO20034863D0 (no) 2003-10-31
CN101002770A (zh) 2007-07-25
IL158668A0 (en) 2004-05-12
EP1383752A2 (de) 2004-01-28
NO20034863L (no) 2003-12-30
HUP0400077A2 (hu) 2004-04-28
ES2244768T3 (es) 2005-12-16

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