DK136528B - Analogifremgangsmåde til fremstilling af aromatiske ethere eller disse forbindelsers syreadditionssalte eller de tilsvarende optisk aktive antipoder. - Google Patents

Analogifremgangsmåde til fremstilling af aromatiske ethere eller disse forbindelsers syreadditionssalte eller de tilsvarende optisk aktive antipoder.

Info

Publication number
DK136528B
DK136528B DK680869AA DK680869A DK136528B DK 136528 B DK136528 B DK 136528B DK 680869A A DK680869A A DK 680869AA DK 680869 A DK680869 A DK 680869A DK 136528 B DK136528 B DK 136528B
Authority
DK
Denmark
Prior art keywords
compounds
preparation
acid addition
addition salts
optically active
Prior art date
Application number
DK680869AA
Other languages
English (en)
Other versions
DK136528C (da
Inventor
Albrecht Edenhofer
Hans Spiegelberg
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of DK136528B publication Critical patent/DK136528B/da
Application granted granted Critical
Publication of DK136528C publication Critical patent/DK136528C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D203/00—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D203/04—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D203/06—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D203/08—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring nitrogen atom
    • C07D203/10—Radicals substituted by singly bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
    • C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
    • C07D295/104—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/108—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
    • C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
    • C07D303/22—Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/34—Compounds containing oxirane rings with hydrocarbon radicals, substituted by sulphur, selenium or tellurium atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK680869AA 1968-12-24 1969-12-22 Analogifremgangsmåde til fremstilling af aromatiske ethere eller disse forbindelsers syreadditionssalte eller de tilsvarende optisk aktive antipoder. DK136528B (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH1926968A CH528516A (de) 1968-12-24 1968-12-24 Verfahren zur Herstellung von aromatischen Äthern

Publications (2)

Publication Number Publication Date
DK136528B true DK136528B (da) 1977-10-24
DK136528C DK136528C (da) 1978-03-28

Family

ID=4438418

Family Applications (1)

Application Number Title Priority Date Filing Date
DK680869AA DK136528B (da) 1968-12-24 1969-12-22 Analogifremgangsmåde til fremstilling af aromatiske ethere eller disse forbindelsers syreadditionssalte eller de tilsvarende optisk aktive antipoder.

Country Status (18)

Country Link
US (1) US3701777A (da)
JP (3) JPS495350B1 (da)
AT (4) AT296314B (da)
BE (1) BE743494A (da)
CA (1) CA967965A (da)
CH (7) CH521355A (da)
CS (2) CS159259B2 (da)
DE (1) DE1964423A1 (da)
DK (1) DK136528B (da)
ES (1) ES374836A1 (da)
FI (1) FI53126C (da)
FR (1) FR2027036B1 (da)
GB (1) GB1290490A (da)
IL (1) IL33508A (da)
MY (1) MY7300260A (da)
NL (1) NL6919400A (da)
NO (1) NO126734B (da)
SE (1) SE361666B (da)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1325876A (en) * 1969-08-15 1973-08-08 Pfizer Ltd Piperazine derivatives their preparation and pharmaceutical compositions containing them
GB1317479A (en) * 1970-11-10 1973-05-16 Pfizer Ltd 1-2-hydroxy-3-phenoxy or phenylthiopropyl-4-phenyl-piperazine derivatives
US3951983A (en) * 1970-11-10 1976-04-20 Pfizer Inc. Phenoxypropanolpiperazines
US3930004A (en) * 1970-11-10 1975-12-30 Pfizer Method of using phenoxypropanolpiperazine compounds to lower blood pressure
FR2154493B1 (da) * 1971-09-13 1975-10-31 Kali Chemie Ag
BE792187A (fr) * 1971-12-03 1973-03-30 Sumitomo Chemical Co Nouveaux derives d'alkylamines
NL175059C (nl) * 1974-02-23 Boehringer Mannheim Gmbh Bereiding van bloeddrukverlagende stoffen en van preparaten die ze bevatten.
GB1583372A (en) * 1977-04-04 1981-01-28 Degussa 1-(3-(3,4,5-trimethoxyphenoxy)-2-hydroxypropyl)-4-aryl piperazine derivatives
US4336382A (en) * 1979-09-06 1982-06-22 Hoffmann-La Roche Inc. 1,4-Disubstituted piperazine compounds
JPS58164583A (ja) * 1982-03-18 1983-09-29 Nippon Shinyaku Co Ltd フエノキシプロパノ−ルアミン誘導体
US4616017A (en) * 1984-06-04 1986-10-07 Merck & Co., Inc. Aminohydroxypropoxy substituted aryl compounds
FR2568878B1 (fr) * 1984-08-07 1986-11-21 Cortial Nouveaux derives de (phenylpiperazinylethylamine ethoxy)-4 phenol, leur methode de preparation et leur application therapeutique
EP0179009A1 (fr) * 1984-09-19 1986-04-23 Cortial S.A. Nouvelles n1-(aminoalcoxy)-4 isopropyl-5 phénoxy)-2 éthyl n4-phényl pipérazines, leur méthode de préparation et leur application thérapeutique
GB8619472D0 (en) * 1986-08-09 1986-09-17 Pfizer Ltd Anti-arrhythmia agents
US4906634A (en) * 1988-03-08 1990-03-06 Schering A.G. Novel N-[4-(aminosubstituted)phenyl]methanesulfonamides and their use as cardiovascular agents
FR2632641B1 (fr) * 1988-06-13 1990-10-12 Irceba ((aryl-4-piperazinyl-1)-2 ethoxy)-3 p-cymene, les derives ortho, meta, para monosubstitues ou disubstitues sur le noyau phenyle dudit produit, le procede de preparation desdits derives, et les medicaments contenant lesdits composes comme principe actif
US5051423A (en) * 1988-07-13 1991-09-24 Schering Ag Derivatized alkanolamines as cardiovascular agents
US5614526A (en) * 1995-06-09 1997-03-25 Hoffmann-La Roche Inc. Use of phenoxy-piperzine derivatives
DK0958280T3 (da) * 1997-10-31 2005-08-29 Daiichi Suntory Pharma Co Ltd Arylpiperidinopropanol- og arylpiperazinopropanolderivater og farmaceutiske midler der indeholder disse
US9951088B2 (en) * 2012-05-09 2018-04-24 Sunovion Pharmaceuticals Inc. D2 receptor modulators and methods of use thereof in the treatment of diseases and disorders

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1382420A (fr) * 1963-01-14 1964-12-18 Ciba Geigy Procédé pour la préparation de diaza-cyclo-alcanes, entre autres de la 1-(2-hydroxy-3-phénoxy-propyl)-4-(2-méthyl-phényl)-pipérazine

Also Published As

Publication number Publication date
JPS495349B1 (da) 1974-02-06
JPS495350B1 (da) 1974-02-06
FI53126B (da) 1977-10-31
CA967965A (en) 1975-05-20
ES374836A1 (es) 1972-01-16
FR2027036A1 (da) 1970-09-25
CH506534A (de) 1971-04-30
CS159258B2 (da) 1974-12-27
FR2027036B1 (da) 1973-01-12
MY7300260A (en) 1973-12-31
CH521354A (de) 1972-04-15
CH506535A (de) 1971-04-30
JPS495348B1 (da) 1974-02-06
DK136528C (da) 1978-03-28
FI53126C (da) 1978-02-10
AT296314B (de) 1972-02-10
CS159259B2 (da) 1974-12-27
GB1290490A (da) 1972-09-27
NO126734B (da) 1973-03-19
BE743494A (da) 1970-06-22
IL33508A0 (en) 1970-02-19
SE361666B (da) 1973-11-12
AT296318B (de) 1972-02-10
IL33508A (en) 1974-05-16
CH521356A (de) 1972-04-15
CH506536A (de) 1971-04-30
US3701777A (en) 1972-10-31
CH528516A (de) 1972-09-30
DE1964423A1 (de) 1970-07-30
NL6919400A (da) 1970-06-26
AT296319B (de) 1972-01-15
CH521355A (de) 1972-04-15
AT296317B (de) 1972-02-10

Similar Documents

Publication Publication Date Title
DK136528B (da) Analogifremgangsmåde til fremstilling af aromatiske ethere eller disse forbindelsers syreadditionssalte eller de tilsvarende optisk aktive antipoder.
DK124884B (da) Analogifremgangsmåde til fremstilling af 2-brom-α-ergokryptin eller syreadditionssalte deraf.
DK135769B (da) Analogifremgangsmåde til fremstilling af racemiske eller optisk aktive 1-(beta-aryl)ethylimidazolethere eller syreadditionssalte deraf.
DK107490C (da) Fremgangsmåde til fremstilling af bis-phenylalkylaminer eller salte eller kvaternære forbindelser deraf eller de tilsvarende optisk aktive fobindelser.
DK133976B (da) Analogifremgangsmåde til fremstilling af tricykliske forbindelser eller disse forbindelsers additionssalte.
DK129581B (da) Analogifremgangsmåde til fremstilling af substituerede N-allyl-2-arylamino-imidazolin-(2)-forbindelser eller syreadditionssalte deraf.
DK125021B (da) Analogifremgangsmåde til fremstilling af 1,2,3,4-tetrahydro-4-phenyl-isoquinolinderivater eller syreadditionssalte deraf eller de tilsvarende optisk aktive forbindelser.
DK133335B (da) Analogifremgangsmåde til fremstilling af aromatiske ethere eller syreadditionssalte deraf.
DK136527B (da) Analogifremgangsmåde til fremstilling af racemiske eller optisk aktive p-alkoxyfenoxypropanolaminer eller syreadditionssalte deraf.
DK140281B (da) Analogifremgangsmåde til fremstilling af racemiske eller optisk aktive 1-phenoxy-2-hydroxy-3-cycloalkylaminopropaner eller syreadditionssalte heraf.
DK122133B (da) Analogifremgangsmåde til fremstilling af racemiske eller optisk aktive substituerede 3-alkoxythianaphthen-2-carboxamider eller syreadditionssalte eller kvaternære ammoniumsalte deraf.
DK124682B (da) Analogifremgangsmåde til fremstilling af N-oxider af 2,4-diamino-5-benzylpyrimidiner eller syreadditionssalte af disse forbindelser.
DK139575B (da) Analogifremgangsmåde til fremstilling af 2-aminomethylen-1-indanon-forbindelser eller syreadditionssalte deraf.
DK131721B (da) Analogifremgangsmåde til fremstilling af adamantanylaminer eller 3,5,7-trimethylhomologe eller syreadditionssalte deraf.
DK120709B (da) Analogifremgangsmåde til fremstilling af substituerede hydroxyfenyl-alkylaminer eller optisk aktive antipoder eller salte deraf.
DK127644B (da) Analogifremgangsmåde til fremstilling af ergopeptiner eller syreadditionssalte deraf.
DK119883B (da) Fremgangsmåde til fremstilling af basiske ætere eller disse forbindelsers syreadditionssalte eller kvartære forbindelser.
DK130582B (da) Analogifremgangsmåde til fremstilling af racemiske blandinger eller optisk aktive isomere af 5-cyclohexyl-1-indancarboxylsyreforbindelser.
DK139582B (da) Analogifremgangsmåde til fremstilling af racemiske eller optisk aktive benzocycloheptaisoquinolin-forbindelser eller syreadditionssalte deraf.
DK120155B (da) Analogifremgangsmåde til fremstilling af aminopropiofenoner eller syreadditionssalte deraf.
DK135285B (da) Analogifremgangsmåde til fremstilling af 5-substituerede 5,10-dihydro-11H-dibenzo(b,e)(1,4)diazepin-11-oner eller 11-substituerede 5, 11-dihydro-6H-pyrido(2,3-b)(1,4)benzodiazepin-6-oner eller syreadditionssalte deraf.
DK138650B (da) Analogifremgangsmåde til fremstilling af racemiske eller optisk aktive penicilliner.
DK127059B (da) Analogifremgangsmåde til fremstilling af substituerede 1-phenoxy-2-hydroxy-3-tert.butylaminopropaner eller salte heraf eller de tilsvarende optisk aktive antipoder.
DK129718B (da) Analogifremgangsmåde til fremstilling af tiazolino-pyrimidin-5-oner eller deres syreadditionssalte eller de tilsvarende optisk aktive forbindelser.
DK123716B (da) Analogifremgangsmåde til fremstilling af 1-cyloalkylmethyl-3-alkyl-3-(m-oxyphenyl)-pyrrolidinforbindelser eller salte deraf.