DK130582B - Analogifremgangsmåde til fremstilling af racemiske blandinger eller optisk aktive isomere af 5-cyclohexyl-1-indancarboxylsyreforbindelser. - Google Patents

Analogifremgangsmåde til fremstilling af racemiske blandinger eller optisk aktive isomere af 5-cyclohexyl-1-indancarboxylsyreforbindelser.

Info

Publication number
DK130582B
DK130582B DK42170AA DK42170A DK130582B DK 130582 B DK130582 B DK 130582B DK 42170A A DK42170A A DK 42170AA DK 42170 A DK42170 A DK 42170A DK 130582 B DK130582 B DK 130582B
Authority
DK
Denmark
Prior art keywords
cyclohexyl
preparation
optically active
acid compounds
racemic mixtures
Prior art date
Application number
DK42170AA
Other languages
English (en)
Other versions
DK130582C (da
Inventor
P F Juby
R A Partyka
T W Hudyma
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of DK130582B publication Critical patent/DK130582B/da
Application granted granted Critical
Publication of DK130582C publication Critical patent/DK130582C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
    • C07C205/55—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/51—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition
    • C07C45/511—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of singly bound oxygen functional groups to >C = O groups
    • C07C45/513—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of singly bound oxygen functional groups to >C = O groups the singly bound functional group being an etherified hydroxyl group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pain & Pain Management (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK42170AA 1969-01-31 1970-01-29 Analogifremgangsmåde til fremstilling af racemiske blandinger eller optisk aktive isomere af 5-cyclohexyl-1-indancarboxylsyreforbindelser. DK130582B (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US79572669A 1969-01-31 1969-01-31

Publications (2)

Publication Number Publication Date
DK130582B true DK130582B (da) 1975-03-10
DK130582C DK130582C (da) 1975-08-18

Family

ID=25166286

Family Applications (1)

Application Number Title Priority Date Filing Date
DK42170AA DK130582B (da) 1969-01-31 1970-01-29 Analogifremgangsmåde til fremstilling af racemiske blandinger eller optisk aktive isomere af 5-cyclohexyl-1-indancarboxylsyreforbindelser.

Country Status (11)

Country Link
JP (2) JPS4925662B1 (da)
BE (1) BE745177A (da)
CH (2) CH565132A5 (da)
DE (1) DE2004038C3 (da)
DK (1) DK130582B (da)
ES (1) ES376067A1 (da)
FR (1) FR2034514B1 (da)
GB (1) GB1291644A (da)
NL (1) NL165930C (da)
SE (1) SE345995B (da)
YU (1) YU34270B (da)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5530487U (da) * 1978-08-18 1980-02-27
JPS57156434A (en) * 1981-03-19 1982-09-27 Takeda Chem Ind Ltd Zinc indanecarboxylate
JPS63143813U (da) * 1987-03-13 1988-09-21
EP2277848B1 (en) * 2003-04-15 2016-09-14 Aquinox Pharmaceuticals (Canada) Inc. Indene derivatives as pharmaceutical agents
CA2902764A1 (en) 2013-03-14 2014-09-18 Aquinox Pharmaceuticals (Canada) Inc. Ship1 modulators and methods related thereto
KR20220110337A (ko) 2013-03-14 2022-08-05 에퀴녹스 파머수티칼스 (캐나다) 인코포레이티드 Ship1 조절제 및 그와 관련된 방법
AU2016281658A1 (en) 2015-06-26 2017-12-07 Aquinox Pharmaceuticals (Canada) Inc. Crystalline solid forms of the acetate salt of (1s,3s,4r)-4-((3as,4r,5s,7as)-4-(aminomethyl)-7a-methyl-1-methyleneoctahydro-1h-inden-5-yl)-3-(hydroxymethyl)-4-methylcyclohexanol
US10053415B2 (en) 2016-01-20 2018-08-21 Aquinox Pharmaceuticals (Canada) Inc. Synthesis of a substituted indene derivative

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2886589A (en) * 1957-08-05 1959-05-12 Merck & Co Inc 8-methyl-5-oxyphenyl hexahydroindan compounds
JPS5121981B1 (da) * 1967-09-11 1976-07-06

Also Published As

Publication number Publication date
ES376067A1 (es) 1972-05-16
DK130582C (da) 1975-08-18
DE2004038B2 (de) 1981-07-23
NL165930B (nl) 1981-01-15
NL165930C (nl) 1981-06-15
JPS4925662B1 (da) 1974-07-02
YU34270B (en) 1979-04-30
DE2004038C3 (de) 1982-03-25
BE745177A (fr) 1970-07-29
JPS5136271B1 (da) 1976-10-07
SE345995B (da) 1972-06-19
GB1291644A (en) 1972-10-04
CH544055A (de) 1973-11-15
YU21170A (en) 1978-10-31
DE2004038A1 (de) 1970-08-06
NL7001380A (da) 1970-08-04
FR2034514B1 (da) 1973-07-13
CH565132A5 (da) 1975-08-15
FR2034514A1 (da) 1970-12-11

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