GB1325876A - Piperazine derivatives their preparation and pharmaceutical compositions containing them - Google Patents

Piperazine derivatives their preparation and pharmaceutical compositions containing them

Info

Publication number
GB1325876A
GB1325876A GB1325876DA GB1325876A GB 1325876 A GB1325876 A GB 1325876A GB 1325876D A GB1325876D A GB 1325876DA GB 1325876 A GB1325876 A GB 1325876A
Authority
GB
United Kingdom
Prior art keywords
compounds
esters
alkyl
reacting
piperazine derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Ltd
Original Assignee
Pfizer Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Ltd filed Critical Pfizer Ltd
Publication of GB1325876A publication Critical patent/GB1325876A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1325876 Piperazine derivatives PFIZER Ltd 13 Aug 1970 [15 Aug 1969] 40829/69 Heading C2C Novel piperazine derivatives of the formula in which R is ureido, sulphamoylamino, carbamoyl sulphemayl, C 2-7 alkoxycarbonyl or NO 2 ; R<SP>1</SP> is H, halogen or C 1-6 alkyl; R<SP>2</SP> is H or C 1-6 alkyl; R 3 is H, halogen, C 1-6 alkyl or C 1-6 alkoxy; n is 1 or 2; and X is O or S, the esters of compounds in which R<SP>2</SP> is H, and the N-oxides and pharmaceutically acceptable acid addition salts thereof are prepared by reacting the appropriate N-phenylpiperazines with epoxides or chlorohydrins of the formulae or by reacting phenoxy- or phenylthio-propanolamines of the formula with corresponding N,N-bis(2-chloroethyl) anilines. The esters and ethers of the above compounds may be obtained by esterification or etherification of the corresponding compounds in which R<SP>2</SP> is H. 1 - (4 - Acetamidophenoxy) - 3 - [4 - (2 - methoxyphenyl)-piperazin-1-yl] propon-2-ol is obtained by reacting 1-(4-acetamidophenoxy)2,3- epoxypropane with 1(2-methoxyphenyl)piperazine. Pharmaceutical compositions suitable for oral or parenteral administration, contain the above novel compounds or esters, N-oxides or acid addition salts thereof and pharmaceutically acceptable carriers. The compounds possess hypersensitive activity.
GB1325876D 1969-08-15 1969-08-15 Piperazine derivatives their preparation and pharmaceutical compositions containing them Expired GB1325876A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB4082969 1969-08-15

Publications (1)

Publication Number Publication Date
GB1325876A true GB1325876A (en) 1973-08-08

Family

ID=10416843

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1325876D Expired GB1325876A (en) 1969-08-15 1969-08-15 Piperazine derivatives their preparation and pharmaceutical compositions containing them

Country Status (7)

Country Link
BR (1) BR6915239D0 (en)
CH (1) CH528517A (en)
DE (1) DE2040438A1 (en)
FR (1) FR2068501B1 (en)
GB (1) GB1325876A (en)
NL (1) NL7011951A (en)
SE (1) SE377935B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010532382A (en) * 2007-06-29 2010-10-07 エモリー・ユニバーシテイ NMDA receptor antagonist for neuroprotection

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5550950B1 (en) * 1971-07-02 1980-12-20
CA1012540A (en) * 1972-06-17 1977-06-21 Sumitomo Chemical Company 2-propanol derivatives and preparation thereof
US7985763B2 (en) 2007-04-10 2011-07-26 National Health Research Institutes Hepatitis C virus inhibitors
US7897764B2 (en) * 2007-06-08 2011-03-01 National Health Research Institutes Thiourea derivatives
US8198284B2 (en) 2008-04-30 2012-06-12 National Health Research Institutes Treatment of neurodegenerative disorders with thiourea compounds

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1382420A (en) * 1963-01-14 1964-12-18 Ciba Geigy Process for the preparation of diaza-cyclo-alkanes, inter alia 1- (2-hydroxy-3-phenoxy-propyl) -4- (2-methyl-phenyl) -piperazine
CA967965A (en) * 1968-12-24 1975-05-20 Hoffmann-La Roche Limited Aromatic ethers and process for the manufacture thereof

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010532382A (en) * 2007-06-29 2010-10-07 エモリー・ユニバーシテイ NMDA receptor antagonist for neuroprotection
US9079852B2 (en) 2007-06-29 2015-07-14 Emory University NMDA receptor antagonists for neuroprotection

Also Published As

Publication number Publication date
SE377935B (en) 1975-08-04
NL7011951A (en) 1971-02-17
CH528517A (en) 1972-09-30
FR2068501B1 (en) 1974-08-30
BR6915239D0 (en) 1973-02-13
FR2068501A1 (en) 1971-08-27
DE2040438A1 (en) 1971-03-04

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee