DK1361895T3 - Endegruppeforgrenede polymere linkere og polymere konjugater indeholdende disse - Google Patents
Endegruppeforgrenede polymere linkere og polymere konjugater indeholdende disseInfo
- Publication number
- DK1361895T3 DK1361895T3 DK02709573T DK02709573T DK1361895T3 DK 1361895 T3 DK1361895 T3 DK 1361895T3 DK 02709573 T DK02709573 T DK 02709573T DK 02709573 T DK02709573 T DK 02709573T DK 1361895 T3 DK1361895 T3 DK 1361895T3
- Authority
- DK
- Denmark
- Prior art keywords
- polymeric
- end group
- linkers
- conjugates containing
- group branched
- Prior art date
Links
- 229940002612 prodrug Drugs 0.000 abstract 3
- 239000000651 prodrug Substances 0.000 abstract 3
- 241000124008 Mammalia Species 0.000 abstract 1
- 239000013543 active substance Substances 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000003379 elimination reaction Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
- Peptides Or Proteins (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Polyethers (AREA)
- Materials For Medical Uses (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US27251101P | 2001-02-20 | 2001-02-20 | |
| PCT/US2002/004780 WO2002066066A1 (en) | 2001-02-20 | 2002-02-19 | Terminally-branched polymeric linkers and polymeric conjugates containing the same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1361895T3 true DK1361895T3 (da) | 2008-02-18 |
Family
ID=23040108
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK02709573T DK1361895T3 (da) | 2001-02-20 | 2002-02-19 | Endegruppeforgrenede polymere linkere og polymere konjugater indeholdende disse |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20020161052A1 (https=) |
| EP (1) | EP1361895B1 (https=) |
| JP (1) | JP2004530736A (https=) |
| AT (1) | ATE378071T1 (https=) |
| CA (1) | CA2437986A1 (https=) |
| DE (1) | DE60223496T2 (https=) |
| DK (1) | DK1361895T3 (https=) |
| MX (1) | MXPA03007391A (https=) |
| WO (1) | WO2002066066A1 (https=) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6624142B2 (en) * | 1997-12-30 | 2003-09-23 | Enzon, Inc. | Trimethyl lock based tetrapartate prodrugs |
| US7332164B2 (en) * | 2003-03-21 | 2008-02-19 | Enzon Pharmaceuticals, Inc. | Heterobifunctional polymeric bioconjugates |
| EP1533385A1 (en) * | 2003-09-05 | 2005-05-25 | Nuevolution A/S | Templated compounds for generation of encoded molecules and directional methods using such compounds |
| JP4820758B2 (ja) | 2004-09-22 | 2011-11-24 | 日本化薬株式会社 | 新規ブロック共重合体、ミセル調製物及びそれを有効成分とする抗癌剤 |
| BRPI0611872B8 (pt) | 2005-06-16 | 2021-05-25 | Nektar Therapeutics | reagente polimérico, conjugado, método para preparação de um conjugado e composição farmacêutica |
| JP5249016B2 (ja) | 2006-03-28 | 2013-07-31 | 日本化薬株式会社 | タキサン類の高分子結合体 |
| KR20090009241A (ko) | 2006-05-18 | 2009-01-22 | 니폰 가야꾸 가부시끼가이샤 | 포도필로톡신류의 고분자 결합체 |
| KR20090031597A (ko) * | 2006-07-19 | 2009-03-26 | 니폰 가야꾸 가부시끼가이샤 | 콤브레타스타틴류의 고분자 결합체 |
| WO2008056596A1 (fr) | 2006-11-06 | 2008-05-15 | Nippon Kayaku Kabushiki Kaisha | Dérivé polymère d'un antagoniste métabolique d'acide nucléique |
| JP5548365B2 (ja) | 2006-11-08 | 2014-07-16 | 日本化薬株式会社 | 核酸系代謝拮抗剤の高分子誘導体 |
| US8703878B2 (en) | 2007-09-28 | 2014-04-22 | Nippon Kayaku Kabushiki Kaisha | High-molecular weight conjugate of steroids |
| WO2009116509A1 (ja) | 2008-03-18 | 2009-09-24 | 日本化薬株式会社 | 生理活性物質の高分子結合体 |
| WO2009136572A1 (ja) | 2008-05-08 | 2009-11-12 | 日本化薬株式会社 | 葉酸若しくは葉酸誘導体の高分子結合体 |
| EP2431403B1 (en) | 2009-05-15 | 2016-09-28 | Nipponkayaku Kabushikikaisha | Polymer conjugate of bioactive substance having hydroxy group |
| EP2641605B1 (en) | 2010-11-17 | 2018-03-07 | Nippon Kayaku Kabushiki Kaisha | Polymer derivative of cytidine metabolism antagonist |
| KR101849142B1 (ko) | 2011-09-11 | 2018-04-16 | 니폰 가야꾸 가부시끼가이샤 | 블록 공중합체의 제조방법 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5552391A (en) * | 1990-01-16 | 1996-09-03 | La Jolla Pharmaceutical Company | Chemically-defined non-polymeric valency platform molecules and conjugates thereof |
| WO1993024476A1 (en) * | 1992-06-04 | 1993-12-09 | Clover Consolidated, Limited | Water-soluble polymeric carriers for drug delivery |
| US5880131A (en) * | 1993-10-20 | 1999-03-09 | Enzon, Inc. | High molecular weight polymer-based prodrugs |
| US5965566A (en) * | 1993-10-20 | 1999-10-12 | Enzon, Inc. | High molecular weight polymer-based prodrugs |
| US5840900A (en) * | 1993-10-20 | 1998-11-24 | Enzon, Inc. | High molecular weight polymer-based prodrugs |
| US6011042A (en) * | 1997-10-10 | 2000-01-04 | Enzon, Inc. | Acyl polymeric derivatives of aromatic hydroxyl-containing compounds |
| US6180095B1 (en) * | 1997-12-17 | 2001-01-30 | Enzon, Inc. | Polymeric prodrugs of amino- and hydroxyl-containing bioactive agents |
| US5965119A (en) * | 1997-12-30 | 1999-10-12 | Enzon, Inc. | Trialkyl-lock-facilitated polymeric prodrugs of amino-containing bioactive agents |
| US6153655A (en) * | 1998-04-17 | 2000-11-28 | Enzon, Inc. | Terminally-branched polymeric linkers and polymeric conjugates containing the same |
-
2002
- 2002-02-19 EP EP02709573A patent/EP1361895B1/en not_active Expired - Lifetime
- 2002-02-19 WO PCT/US2002/004780 patent/WO2002066066A1/en not_active Ceased
- 2002-02-19 DE DE60223496T patent/DE60223496T2/de not_active Expired - Lifetime
- 2002-02-19 AT AT02709573T patent/ATE378071T1/de not_active IP Right Cessation
- 2002-02-19 CA CA002437986A patent/CA2437986A1/en not_active Abandoned
- 2002-02-19 US US10/078,649 patent/US20020161052A1/en not_active Abandoned
- 2002-02-19 MX MXPA03007391A patent/MXPA03007391A/es active IP Right Grant
- 2002-02-19 JP JP2002565624A patent/JP2004530736A/ja active Pending
- 2002-02-19 DK DK02709573T patent/DK1361895T3/da active
Also Published As
| Publication number | Publication date |
|---|---|
| ATE378071T1 (de) | 2007-11-15 |
| WO2002066066A1 (en) | 2002-08-29 |
| CA2437986A1 (en) | 2002-08-29 |
| WO2002066066A9 (en) | 2003-10-16 |
| EP1361895A1 (en) | 2003-11-19 |
| DE60223496T2 (de) | 2008-10-02 |
| DE60223496D1 (de) | 2007-12-27 |
| EP1361895B1 (en) | 2007-11-14 |
| JP2004530736A (ja) | 2004-10-07 |
| MXPA03007391A (es) | 2003-12-04 |
| EP1361895A4 (en) | 2005-01-19 |
| US20020161052A1 (en) | 2002-10-31 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK1362053T3 (da) | Terminalt forgrenede polymere linkere og polymere konjugater indeholdende disse | |
| DK1361895T3 (da) | Endegruppeforgrenede polymere linkere og polymere konjugater indeholdende disse | |
| NO20013451L (no) | 1-Heterocyklus-substituerte diarylaminer | |
| ES2154661T3 (es) | Preparados liquidos que contienen cyclosporin y procedimiento para su obtencion. | |
| CY1121983T1 (el) | Παραγωγο ραπαμυκινης για τη θεραπευτικη αντιμετωπιση καρκινου του παγκρεατος | |
| DK1093819T3 (da) | Forbindelse og præparat til tilförsel af aktive midler | |
| DK1455839T3 (da) | Heterobifunktioneller poly(ethylenglycol)-derivater og fremgangsmåder til fremstilling heraf | |
| DE60039550D1 (de) | Tonabhängige Fehlerdiffusion | |
| TR200101103T2 (tr) | CGMP PDE-İnhibitörü içeren kontrollu serbest bırakılan farmasötik formülasyonlar | |
| NO20001972D0 (no) | Polymert drivstoffadditiv og fremgangsmõte for õ fremstille dette, og drivstoff som inneholder additivet | |
| AP2002002458A0 (en) | Compounds for the treatment of ischemia. | |
| EP1542658A4 (en) | PHARMACEUTICAL COMPOSITIONS | |
| ZA200107096B (en) | Woodworking jig. | |
| TR200100054T2 (tr) | Paroksetin metansülfonat | |
| AR024138A1 (es) | Inhibidores de la proliferacion celular | |
| DE10084671T1 (de) | Pharmazeutische Zusammensetzungen | |
| NO20023161D0 (no) | Substituerte piperidiner, legemidler inneholdende disse forbindelser og fremgangsmåter for fremstilling av dem | |
| BR0209695A (pt) | Conjugados de lipìdeo-polìmero | |
| ATE297904T1 (de) | Halo-alkoxycarbonylverbindungen | |
| ATE240303T1 (de) | 1,2,4-triazol-3-thion verbindungen | |
| NO20030579D0 (no) | Vaskul¶re grafter og fremgangsmåter til implantering derav | |
| HUP0100350A2 (hu) | A prosztatarák kezelésére alkalmazható konjugátumok, azokat hatóanyagként tartalmazó gyógyászati készítmények, elárás ezek előállítására, valamint alkalmazásuk | |
| DK1666924T3 (da) | Kovalent bundne, hydrofile belægningssammensætninger til implantater | |
| NO20014803D0 (no) | Pyrido-tieno-diazepiner, fremgangsmåte for fremstilling derav og farmasöytiske blandinger inneholdende dem | |
| WO2001032216A3 (fr) | Produit comprenant au moins une substance inhibitrice des no synthases en association avec au moins une substance inhibitrice des phospholipases a2 |