DE60223496D1 - Endgruppenverzweigte polymere verbindungen und diese enthaltende polymere konjugate - Google Patents

Endgruppenverzweigte polymere verbindungen und diese enthaltende polymere konjugate

Info

Publication number
DE60223496D1
DE60223496D1 DE60223496T DE60223496T DE60223496D1 DE 60223496 D1 DE60223496 D1 DE 60223496D1 DE 60223496 T DE60223496 T DE 60223496T DE 60223496 T DE60223496 T DE 60223496T DE 60223496 D1 DE60223496 D1 DE 60223496D1
Authority
DE
Germany
Prior art keywords
end group
polymers containing
polymer compounds
group polymer
disclosed
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60223496T
Other languages
English (en)
Other versions
DE60223496T2 (de
Inventor
Yun Hwang Choe
Richard B Greenwald
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Enzon Pharmaceuticals Inc
Original Assignee
Enzon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Enzon Inc filed Critical Enzon Inc
Application granted granted Critical
Publication of DE60223496D1 publication Critical patent/DE60223496D1/de
Publication of DE60223496T2 publication Critical patent/DE60223496T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Peptides Or Proteins (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Polyethers (AREA)
DE60223496T 2001-02-20 2002-02-19 Endgruppenverzweigte polymere verbindungsgruppen und diese enthaltende polymere konjugate Expired - Lifetime DE60223496T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US27251101P 2001-02-20 2001-02-20
US272511P 2001-02-20
PCT/US2002/004780 WO2002066066A1 (en) 2001-02-20 2002-02-19 Terminally-branched polymeric linkers and polymeric conjugates containing the same

Publications (2)

Publication Number Publication Date
DE60223496D1 true DE60223496D1 (de) 2007-12-27
DE60223496T2 DE60223496T2 (de) 2008-10-02

Family

ID=23040108

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60223496T Expired - Lifetime DE60223496T2 (de) 2001-02-20 2002-02-19 Endgruppenverzweigte polymere verbindungsgruppen und diese enthaltende polymere konjugate

Country Status (9)

Country Link
US (1) US20020161052A1 (de)
EP (1) EP1361895B1 (de)
JP (1) JP2004530736A (de)
AT (1) ATE378071T1 (de)
CA (1) CA2437986A1 (de)
DE (1) DE60223496T2 (de)
DK (1) DK1361895T3 (de)
MX (1) MXPA03007391A (de)
WO (1) WO2002066066A1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6624142B2 (en) * 1997-12-30 2003-09-23 Enzon, Inc. Trimethyl lock based tetrapartate prodrugs
US7332164B2 (en) * 2003-03-21 2008-02-19 Enzon Pharmaceuticals, Inc. Heterobifunctional polymeric bioconjugates
EP1533385A1 (de) * 2003-09-05 2005-05-25 Nuevolution A/S Matrizenabhängigen Verbindungen zur Herstellung von kodierten Molekülen und gesteuerten Verfahren unter Verwendung dieser Verbindungen
PL1792927T3 (pl) 2004-09-22 2013-09-30 Nippon Kayaku Kk Nowy kopolimer blokowy, preparat micelarny i lek przeciwnowotworowy zawierający ten preparat micelarny jako składnik czynny
EP1896082B1 (de) 2005-06-16 2012-12-26 Nektar Therapeutics Konjugate mit abbaubarer verknüpfung und polymer-reagenzien zur herstellung dieser konjugate
US8323669B2 (en) 2006-03-28 2012-12-04 Nippon Kayaku Kabushiki Kaisha Polymer conjugate of taxane
JP5181347B2 (ja) 2006-05-18 2013-04-10 日本化薬株式会社 ポドフィロトキシン類の高分子結合体
CA2658100A1 (en) * 2006-07-19 2008-01-24 Nippon Kayaku Kabushiki Kaisha High-molecular weight conjugate of combretastatins
WO2008056596A1 (en) 2006-11-06 2008-05-15 Nippon Kayaku Kabushiki Kaisha Polymeric derivative of nucleic acid metabolic antagonist
WO2008056654A1 (en) 2006-11-08 2008-05-15 Nippon Kayaku Kabushiki Kaisha Polymeric derivative of nucleic acid metabolic antagonist
WO2009041570A1 (ja) 2007-09-28 2009-04-02 Nippon Kayaku Kabushiki Kaisha ステロイド類の高分子結合体
JP5687899B2 (ja) 2008-03-18 2015-03-25 日本化薬株式会社 生理活性物質の高分子結合体
US9149540B2 (en) 2008-05-08 2015-10-06 Nippon Kayaku Kabushiki Kaisha Polymer conjugate of folic acid or folic acid derivative
WO2010131675A1 (ja) 2009-05-15 2010-11-18 日本化薬株式会社 水酸基を有する生理活性物質の高分子結合体
CN103221054A (zh) 2010-11-17 2013-07-24 日本化药株式会社 新的胞苷类代谢拮抗剂的高分子衍生物
AU2012305405B2 (en) 2011-09-11 2016-01-14 Nippon Kayaku Kabushiki Kaisha Method for manufacturing block copolymer

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5552391A (en) * 1990-01-16 1996-09-03 La Jolla Pharmaceutical Company Chemically-defined non-polymeric valency platform molecules and conjugates thereof
WO1993024476A1 (en) * 1992-06-04 1993-12-09 Clover Consolidated, Limited Water-soluble polymeric carriers for drug delivery
US5880131A (en) * 1993-10-20 1999-03-09 Enzon, Inc. High molecular weight polymer-based prodrugs
US5840900A (en) * 1993-10-20 1998-11-24 Enzon, Inc. High molecular weight polymer-based prodrugs
US5965566A (en) * 1993-10-20 1999-10-12 Enzon, Inc. High molecular weight polymer-based prodrugs
US6011042A (en) * 1997-10-10 2000-01-04 Enzon, Inc. Acyl polymeric derivatives of aromatic hydroxyl-containing compounds
US6180095B1 (en) * 1997-12-17 2001-01-30 Enzon, Inc. Polymeric prodrugs of amino- and hydroxyl-containing bioactive agents
US5965119A (en) * 1997-12-30 1999-10-12 Enzon, Inc. Trialkyl-lock-facilitated polymeric prodrugs of amino-containing bioactive agents
US6153655A (en) * 1998-04-17 2000-11-28 Enzon, Inc. Terminally-branched polymeric linkers and polymeric conjugates containing the same

Also Published As

Publication number Publication date
WO2002066066A9 (en) 2003-10-16
WO2002066066A1 (en) 2002-08-29
DE60223496T2 (de) 2008-10-02
JP2004530736A (ja) 2004-10-07
DK1361895T3 (da) 2008-02-18
EP1361895A4 (de) 2005-01-19
US20020161052A1 (en) 2002-10-31
EP1361895B1 (de) 2007-11-14
CA2437986A1 (en) 2002-08-29
MXPA03007391A (es) 2003-12-04
ATE378071T1 (de) 2007-11-15
EP1361895A1 (de) 2003-11-19

Similar Documents

Publication Publication Date Title
DE60223499D1 (de) Terminal verzweigte, polymere linker und diese enthaltende polymere konjugate
DE60223496D1 (de) Endgruppenverzweigte polymere verbindungen und diese enthaltende polymere konjugate
CY1121983T1 (el) Παραγωγο ραπαμυκινης για τη θεραπευτικη αντιμετωπιση καρκινου του παγκρεατος
EP1181323A4 (de) Biomaterialien die durch nukleophile reaktion auf konjugierten ungesättigten gruppen addiert sind
NO20021862D0 (no) Katalysatorsammensetninger, fremgangsmåter for polymerisasjon og polymerer derfra
CY2603B2 (en) Pharmaceutical compositions
ATE432955T1 (de) Polyglutamat-aminosäure-konjugate und verfahren
DE60022866D1 (de) Bizyklische heterozyklen, diese verbindungen enthaltende zusammenstellungen und verfahren zu deren herstellung
WO2009014829A3 (en) Methods for introducing reactive secondary amines pendant to polymer backbones that are useful for diazeniumdiolation
DE502004003225D1 (de) (meth)acryls ureester monoalkoxilierter polyole und deren he rstellung
TW200806333A (en) Single phase whitening dentifrice
NO20013451L (no) 1-Heterocyklus-substituerte diarylaminer
ATE541587T1 (de) Konjugat-additionsreaktionen zur kontrollierten abgabe von pharmazeutisch wirksamen substanzen
CY1111389T1 (el) Φαρμακευτικες ενωσεις που περιεχουν ιματινιμπη και ενα επιβραδυντικο εκλυσης
BR0210335A (pt) Copolìmero de blocos, e, composição
BR9908078A (pt) Processo para a reticulação superficial de partìculas de polìmeros superabsorventes, polìmero superabsorvente reticulado na superfìcie, e, uso do mesmo
DE60321965D1 (de) Amidfunktionelle polymere, zusammensetzungen und verfahren
DE602006003617D1 (de) Zusammensetzungen enthaltend Levetiracetam und Verfahren zu deren Herstellung.
TW200712121A (en) Polymeric composition comprising polyolefins and amphiphilic block copolymers and optionally other polymers and/or fillers and dyeing or printing such compositions
PT1948155E (pt) Composições farmacêuticas contendo droxidopa
PT1656410E (pt) Processo para preparação de polímeros funcionalizados a partir de álcoois poliméricos
ATE240303T1 (de) 1,2,4-triazol-3-thion verbindungen
AU2002361298A1 (en) Photoactivatable composition and the use of same
TWI266775B (en) Polyacrylic acid hydrazide and crosslinking or hardening agent for resin
ATE271032T1 (de) Amphiphile polyamin verbindungen

Legal Events

Date Code Title Description
8364 No opposition during term of opposition