PT1948155E - Composições farmacêuticas contendo droxidopa - Google Patents
Composições farmacêuticas contendo droxidopa Download PDFInfo
- Publication number
- PT1948155E PT1948155E PT07784556T PT07784556T PT1948155E PT 1948155 E PT1948155 E PT 1948155E PT 07784556 T PT07784556 T PT 07784556T PT 07784556 T PT07784556 T PT 07784556T PT 1948155 E PT1948155 E PT 1948155E
- Authority
- PT
- Portugal
- Prior art keywords
- droxidopa
- compounds
- pharmaceutical compositions
- combinations
- inhibiting compounds
- Prior art date
Links
- QXWYKJLNLSIPIN-SFYZADRCSA-N droxidopa Chemical compound OC(=O)[C@H](N)[C@@H](O)C1=CC=C(O)C(O)=C1 QXWYKJLNLSIPIN-SFYZADRCSA-N 0.000 title abstract 2
- 229960001104 droxidopa Drugs 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 5
- 230000002401 inhibitory effect Effects 0.000 abstract 3
- 102100040999 Catechol O-methyltransferase Human genes 0.000 abstract 1
- 108020002739 Catechol O-methyltransferase Proteins 0.000 abstract 1
- 102000003914 Cholinesterases Human genes 0.000 abstract 1
- 108090000322 Cholinesterases Proteins 0.000 abstract 1
- 102000010909 Monoamine Oxidase Human genes 0.000 abstract 1
- 108010062431 Monoamine oxidase Proteins 0.000 abstract 1
- 208000001089 Multiple system atrophy Diseases 0.000 abstract 1
- 206010031127 Orthostatic hypotension Diseases 0.000 abstract 1
- 229940048961 cholinesterase Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/15—Oximes (>C=N—O—); Hydrazines (>N—N<); Hydrazones (>N—N=) ; Imines (C—N=C)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/275—Nitriles; Isonitriles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/275—Nitriles; Isonitriles
- A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4409—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 4, e.g. isoniazid, iproniazid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Emergency Medicine (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US80603606P | 2006-06-28 | 2006-06-28 |
Publications (1)
Publication Number | Publication Date |
---|---|
PT1948155E true PT1948155E (pt) | 2012-06-15 |
Family
ID=38698773
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT07784556T PT1948155E (pt) | 2006-06-28 | 2007-06-28 | Composições farmacêuticas contendo droxidopa |
Country Status (9)
Country | Link |
---|---|
US (2) | US20080015181A1 (pt) |
EP (3) | EP1948155B1 (pt) |
AT (1) | ATE548034T1 (pt) |
DK (1) | DK1948155T3 (pt) |
ES (2) | ES2383768T3 (pt) |
HR (1) | HRP20120479T1 (pt) |
PL (1) | PL1948155T3 (pt) |
PT (1) | PT1948155E (pt) |
WO (1) | WO2008003028A2 (pt) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8158149B2 (en) | 2004-05-12 | 2012-04-17 | Chelsea Therapeutics, Inc. | Threo-DOPS controlled release formulation |
WO2004100929A1 (en) | 2003-05-12 | 2004-11-25 | Synergia Pharma, Inc. | Threo-dops controlled release formulation |
NZ579368A (en) * | 2007-03-09 | 2012-03-30 | Chelsea Therapeutics Inc | Droxidopa and pharmaceutical composition thereof for the treatment of fibromyalgia |
EP2142185B1 (en) * | 2007-03-12 | 2012-08-15 | Chelsea Therapeutics, Inc. | Droxidopa and pharmaceutical composition thereof for the treatment of neurally mediated hypotension |
ES2431570T3 (es) | 2007-05-07 | 2013-11-27 | Chelsea Therapeutics, Inc. | Droxidopa y composición farmacéutica de la misma para el tratamiento de los trastornos por déficit de atención |
US8388656B2 (en) * | 2010-02-04 | 2013-03-05 | Ebi, Llc | Interspinous spacer with deployable members and related method |
JP5880913B2 (ja) | 2011-05-17 | 2016-03-09 | 三郎 佐古田 | パーキンソン病の体幹症状(姿勢反射異常)の治療剤 |
BR112014018851A2 (pt) | 2012-01-31 | 2017-07-04 | Lundbeck Na Ltd | melhoramento da estabilidade postural administrando droxidopa |
US20130253061A1 (en) | 2012-03-20 | 2013-09-26 | Chelsea Therapeutics, Inc. | Method of droxidopa synthesis |
GB2571696B (en) | 2017-10-09 | 2020-05-27 | Compass Pathways Ltd | Large scale method for the preparation of Psilocybin and formulations of Psilocybin so produced |
WO2020212948A1 (en) | 2019-04-17 | 2020-10-22 | Compass Pathfinder Limited | Methods of treating neurocognitive disorders, chronic pain and reducing inflammation |
US20230219889A1 (en) | 2020-05-19 | 2023-07-13 | Cybin Irl Limited | Deuterated tryptamine derivatives and methods of use |
GB202008961D0 (en) * | 2020-06-12 | 2020-07-29 | Beckley Psytech Ltd | Pharmaceutical composition |
KR20230024378A (ko) | 2020-06-12 | 2023-02-20 | 벡클리 싸이테크 리미티드 | 5-메톡시-n, n-디메틸트립타민의 벤조에이트 염을 포함하는 조성물 |
GB202212116D0 (en) | 2022-08-19 | 2022-10-05 | Beckley Psytech Ltd | Pharmaceutically acceptable salts and Compositions thereof |
Family Cites Families (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3920728A (en) | 1973-08-22 | 1975-11-18 | Hoffmann La Roche | Separation and resolution of isomeric forms of 3-(3,4-dihydroxy-phenyl)-serine |
JPS5419931A (en) * | 1977-07-11 | 1979-02-15 | Sumitomo Chem Co Ltd | Separation of threo, erythro-3-(3,4-dibenzyloxyphenyl)serines |
US4319046A (en) * | 1977-07-22 | 1982-03-09 | The Sherwin-Williams Company | Preparation of 1,2 diaminobenzene by high pressure acid hydrolysis of benzemidazolone |
JPS5629551A (en) | 1979-08-20 | 1981-03-24 | Sumitomo Chem Co Ltd | Preparation of optically active threo-3- 3,4- dihydroxyphenyl serine |
JPS56104815A (en) | 1980-01-23 | 1981-08-20 | Sumitomo Chem Co Ltd | Remedy for peripheral orthostatic hypotension |
US4421767A (en) * | 1981-06-01 | 1983-12-20 | Merrell Toraude Et Compagnie | Compounds and methods for treating depression |
JPS5852219A (ja) * | 1981-09-22 | 1983-03-28 | Sumitomo Chem Co Ltd | パ−キンソン病治療剤 |
US4480109A (en) * | 1982-01-14 | 1984-10-30 | Sumitomo Chemical Company, Limited | Process for producing threo-3-(3,4-dihydroxyphenyl)serine |
CA1223602A (en) | 1983-05-25 | 1987-06-30 | Naohito Ohashi | Process for producing 3-(3,4-dihydroxyphenyl) serine |
JPS6067420A (ja) * | 1983-09-22 | 1985-04-17 | Sumitomo Chem Co Ltd | 精神運動興奮抑制剤 |
JPS6098995A (ja) | 1983-11-04 | 1985-06-01 | Microbial Chem Res Found | 光学活性3−(3,4−ジヒドロキシフエニル)セリン,およびその誘導体の製造法 |
JPS6185318A (ja) * | 1984-10-04 | 1986-04-30 | Sumitomo Seiyaku Kk | 利尿薬 |
JPS62106015A (ja) * | 1985-10-31 | 1987-05-16 | Sumitomo Pharmaceut Co Ltd | 抗痴呆薬 |
DK175069B1 (da) | 1986-03-11 | 2004-05-24 | Hoffmann La Roche | Pyrocatecholderivater |
YU213587A (en) | 1986-11-28 | 1989-06-30 | Orion Yhtymae Oy | Process for obtaining new pharmacologic active cateholic derivatives |
GB8720600D0 (en) * | 1987-09-02 | 1987-10-07 | Saad Al Damluji | Pharmaceutical compositions |
US5240930A (en) * | 1987-09-02 | 1993-08-31 | National Research Development Corporation | Pharmaceutical compositions for treatment of depression and low blood pressure |
US5015564A (en) * | 1988-12-23 | 1991-05-14 | Eastman Kodak Company | Stabilizatin of precipitated dispersions of hydrophobic couplers, surfactants and polymers |
JP2603566B2 (ja) * | 1991-03-27 | 1997-04-23 | 住友製薬株式会社 | 尿失禁治療剤 |
JP3559572B2 (ja) * | 1993-01-29 | 2004-09-02 | 住友製薬株式会社 | 急性痛および慢性痛用鎮痛剤 |
JP3764179B2 (ja) * | 1994-07-05 | 2006-04-05 | 克寛 西野 | 運動・意識または言語障害の機能改善剤 |
DE19619510A1 (de) * | 1995-05-18 | 1996-11-21 | Sumitomo Chemical Co | Verfahren zur Herstellung von Threo-3-(3,4-dihydroxyphenyl)serin |
GB9510481D0 (en) * | 1995-05-24 | 1995-07-19 | Orion Yhtymae Oy | New catechol derivatives |
US6929801B2 (en) * | 1996-02-19 | 2005-08-16 | Acrux Dds Pty Ltd | Transdermal delivery of antiparkinson agents |
US6746688B1 (en) * | 1996-10-13 | 2004-06-08 | Neuroderm Ltd. | Apparatus for the transdermal treatment of Parkinson's disease |
JPH115738A (ja) * | 1997-06-15 | 1999-01-12 | Katsuhiro Nishino | 脳虚血に伴う神経脱落症状の予防剤および超急性期治療剤 |
US6033993A (en) * | 1997-09-23 | 2000-03-07 | Olin Microelectronic Chemicals, Inc. | Process for removing residues from a semiconductor substrate |
US6001607A (en) * | 1998-04-13 | 1999-12-14 | Incyte Pharmaceuticals, Inc. | Human growth-associated methyltransfeases |
FR2777781B1 (fr) * | 1998-04-24 | 2004-04-09 | Rhone Poulenc Rorer Sa | Associations riluzole et l-dopa pour le traitement de la maladie de parkinson |
US20020177593A1 (en) * | 1998-09-30 | 2002-11-28 | Yuji Ishihara | Agents and crystals for improving excretory potency of urinary bladder |
NZ512027A (en) * | 1998-11-10 | 2004-04-30 | Teva Pharma | Dispersible compositions containing L-dopa ethyl ester |
GB2344819A (en) | 1998-12-18 | 2000-06-21 | Portela & Ca Sa | 2-Phenyl-1-(3,4-dihydroxy-5-nitrophenyl)-1-ethanones |
US6610324B2 (en) * | 1999-04-07 | 2003-08-26 | The Mclean Hospital Corporation | Flupirtine in the treatment of fibromyalgia and related conditions |
ATE305307T1 (de) * | 1999-07-01 | 2005-10-15 | Pharmacia & Upjohn Co Llc | Reboxetin zur behandlung von migränekopfschmerzen |
US20010047032A1 (en) * | 1999-12-30 | 2001-11-29 | Castillo Gerardo M. | Polyhydroxylated aromatic compounds for the treatment of amyloidosis and alpha-synuclein fibril diseases |
AU2002246490A1 (en) * | 2000-10-12 | 2002-07-30 | Pharmacia And Upjohn Company | Method of treating parkinson's disease |
CA2463624A1 (en) * | 2001-10-15 | 2003-04-24 | National Research Council Of Canada | Anti-glycation agents for preventing age-, diabetes-, and smoking-related complications |
US6602911B2 (en) * | 2001-11-05 | 2003-08-05 | Cypress Bioscience, Inc. | Methods of treating fibromyalgia |
BR0308556A (pt) * | 2002-03-21 | 2005-05-03 | Martin C Hinnz | Tecnologia de otimização do segmento de sistema de serotonina e de catecolaminas |
US7897639B2 (en) * | 2003-10-21 | 2011-03-01 | Colucid Pharmaceuticals, Inc. | Carbamoyl esters that inhibit cholinesterase and release pharmacologically active agents |
EP1737473A4 (en) * | 2004-04-19 | 2009-08-26 | Noven Therapeutics Llc | COMBINATIONS OF LITHIUM AND USES THEREOF |
US20070004639A1 (en) * | 2005-07-01 | 2007-01-04 | Bodybio, Inc. | Methods and compositions for treating Parkinson's disease |
-
2007
- 2007-06-28 EP EP07784556A patent/EP1948155B1/en active Active
- 2007-06-28 DK DK07784556.8T patent/DK1948155T3/da active
- 2007-06-28 US US11/770,191 patent/US20080015181A1/en not_active Abandoned
- 2007-06-28 EP EP11165690A patent/EP2363123A1/en not_active Withdrawn
- 2007-06-28 WO PCT/US2007/072334 patent/WO2008003028A2/en active Application Filing
- 2007-06-28 PL PL07784556T patent/PL1948155T3/pl unknown
- 2007-06-28 ES ES07784556T patent/ES2383768T3/es active Active
- 2007-06-28 AT AT07784556T patent/ATE548034T1/de active
- 2007-06-28 PT PT07784556T patent/PT1948155E/pt unknown
- 2007-06-28 ES ES11165693T patent/ES2571730T3/es active Active
- 2007-06-28 EP EP11165693.0A patent/EP2363124B1/en active Active
-
2012
- 2012-06-06 HR HRP20120479TT patent/HRP20120479T1/hr unknown
-
2015
- 2015-10-16 US US14/885,158 patent/US20160106694A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
ES2383768T3 (es) | 2012-06-26 |
US20080015181A1 (en) | 2008-01-17 |
EP2363123A1 (en) | 2011-09-07 |
US20160106694A1 (en) | 2016-04-21 |
PL1948155T3 (pl) | 2012-10-31 |
DK1948155T3 (da) | 2012-07-02 |
EP1948155A2 (en) | 2008-07-30 |
EP2363124A1 (en) | 2011-09-07 |
EP1948155B1 (en) | 2012-03-07 |
HRP20120479T1 (hr) | 2012-07-31 |
EP2363124B1 (en) | 2016-02-17 |
WO2008003028A3 (en) | 2008-03-20 |
WO2008003028A2 (en) | 2008-01-03 |
ES2571730T3 (es) | 2016-05-26 |
ATE548034T1 (de) | 2012-03-15 |
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