BR0308556A - Tecnologia de otimização do segmento de sistema de serotonina e de catecolaminas - Google Patents
Tecnologia de otimização do segmento de sistema de serotonina e de catecolaminasInfo
- Publication number
- BR0308556A BR0308556A BR0308556-2A BR0308556A BR0308556A BR 0308556 A BR0308556 A BR 0308556A BR 0308556 A BR0308556 A BR 0308556A BR 0308556 A BR0308556 A BR 0308556A
- Authority
- BR
- Brazil
- Prior art keywords
- precursor
- serotonin
- amino acid
- catecholamine
- optimization technology
- Prior art date
Links
- QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 title abstract 7
- 150000003943 catecholamines Chemical class 0.000 title abstract 3
- 229940076279 serotonin Drugs 0.000 title abstract 3
- 238000005457 optimization Methods 0.000 title abstract 2
- 239000002243 precursor Substances 0.000 abstract 5
- 229940024606 amino acid Drugs 0.000 abstract 3
- 235000001014 amino acid Nutrition 0.000 abstract 3
- 150000001413 amino acids Chemical class 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 3
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 abstract 2
- WTDRDQBEARUVNC-LURJTMIESA-N L-DOPA Chemical group OC(=O)[C@@H](N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-LURJTMIESA-N 0.000 abstract 2
- WTDRDQBEARUVNC-UHFFFAOYSA-N L-Dopa Natural products OC(=O)C(N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-UHFFFAOYSA-N 0.000 abstract 2
- LXNHXLLTXMVWPM-UHFFFAOYSA-N pyridoxine Chemical compound CC1=NC=C(CO)C(CO)=C1O LXNHXLLTXMVWPM-UHFFFAOYSA-N 0.000 abstract 2
- 230000001225 therapeutic effect Effects 0.000 abstract 2
- LDCYZAJDBXYCGN-VIFPVBQESA-N 5-hydroxy-L-tryptophan Chemical group C1=C(O)C=C2C(C[C@H](N)C(O)=O)=CNC2=C1 LDCYZAJDBXYCGN-VIFPVBQESA-N 0.000 abstract 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 abstract 1
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 abstract 1
- -1 Foliate Chemical compound 0.000 abstract 1
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 abstract 1
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 abstract 1
- CAHKINHBCWCHCF-JTQLQIEISA-N N-acetyl-L-tyrosine Chemical compound CC(=O)N[C@H](C(O)=O)CC1=CC=C(O)C=C1 CAHKINHBCWCHCF-JTQLQIEISA-N 0.000 abstract 1
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 abstract 1
- 229930003268 Vitamin C Natural products 0.000 abstract 1
- QFGQGUUVPIAIJW-UHFFFAOYSA-N [2-(3,4-dihydroxyphenyl)-2-hydroxyethyl]-trimethylazanium;iodide Chemical compound [I-].C[N+](C)(C)CC(O)C1=CC=C(O)C(O)=C1 QFGQGUUVPIAIJW-UHFFFAOYSA-N 0.000 abstract 1
- 239000011575 calcium Substances 0.000 abstract 1
- 229910052791 calcium Inorganic materials 0.000 abstract 1
- 235000001465 calcium Nutrition 0.000 abstract 1
- 235000018417 cysteine Nutrition 0.000 abstract 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 abstract 1
- 230000004064 dysfunction Effects 0.000 abstract 1
- 229960001682 n-acetyltyrosine Drugs 0.000 abstract 1
- 239000002858 neurotransmitter agent Substances 0.000 abstract 1
- 230000000737 periodic effect Effects 0.000 abstract 1
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Chemical compound OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 abstract 1
- RADKZDMFGJYCBB-UHFFFAOYSA-N pyridoxal hydrochloride Natural products CC1=NC=C(CO)C(C=O)=C1O RADKZDMFGJYCBB-UHFFFAOYSA-N 0.000 abstract 1
- 229960004441 tyrosine Drugs 0.000 abstract 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 abstract 1
- 238000012795 verification Methods 0.000 abstract 1
- 235000019158 vitamin B6 Nutrition 0.000 abstract 1
- 239000011726 vitamin B6 Substances 0.000 abstract 1
- 235000019154 vitamin C Nutrition 0.000 abstract 1
- 239000011718 vitamin C Substances 0.000 abstract 1
- 229940011671 vitamin b6 Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
"TECNOLOGIA DE OTIMIZAçãO DO SEGMENTO DE SISTEMA DE SEROTONINA E DE CATECOLAMINAS". Um processo de tratamento de disfunção de neurotransmissores em um paciente. O processo inclui a etapa de se administrar um aminoácido precursor de uma catecolamina numa faixa terapêutica balanceada e eficaz. O precursor de catecolamina é, de preferência, L-dopa, mas pode ser alternativamente tirosina, D,L-Fenilalanina, ou um isómero ativo seu, e N-acetil-L-tirosina, ou outro precursor aminoácido de L-dopa. é também administrado um aminoácido precursor de serotonina numa faixa terapêutica eficaz. O precursor de serotonina é de preferência 5-HTP, mas pode ser alternativamente triptofano. é administrado, de preferência, pelo menos um co-fator. As opções de co-fatores incluem Vitamina B6, Vitamina C, Cálcio, Foliato e Cisteína. é também descrito um processo de administração e verificação periódica de pacientes.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US36698302P | 2002-03-21 | 2002-03-21 | |
PCT/US2003/008843 WO2003079886A2 (en) | 2002-03-21 | 2003-03-21 | Serotonin and catecholamine system segment optimization techonology |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0308556A true BR0308556A (pt) | 2005-05-03 |
Family
ID=28454829
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0308556-2A BR0308556A (pt) | 2002-03-21 | 2003-03-21 | Tecnologia de otimização do segmento de sistema de serotonina e de catecolaminas |
Country Status (7)
Country | Link |
---|---|
US (3) | US20030181509A1 (pt) |
EP (1) | EP1490073A4 (pt) |
AU (1) | AU2003222045A1 (pt) |
BR (1) | BR0308556A (pt) |
CA (1) | CA2479218A1 (pt) |
MX (1) | MXPA04009123A (pt) |
WO (1) | WO2003079886A2 (pt) |
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US6759437B2 (en) * | 1999-10-04 | 2004-07-06 | Martin C. Hinz | Comprehensive pharmacologic therapy for treatment of obesity including cysteine |
US6403657B1 (en) * | 1999-10-04 | 2002-06-11 | Martin C. Hinz | Comprehensive pharmacologic therapy for treatment of obesity |
US20090311795A1 (en) * | 2002-03-21 | 2009-12-17 | Hinz Martin C | Bilateral control of functions traditionally regulated by only serotonin or only dopamine |
CA2479218A1 (en) * | 2002-03-21 | 2003-10-02 | Martin C. Hinz | Serotonin and catecholamine system segment optimization technology |
US20070293571A1 (en) * | 2006-06-08 | 2007-12-20 | Hinz Martin C | Adminstration of dopa precursors with sources of dopa to effectuate optimal catecholamine neurotransmitter outcomes |
AU2003903826A0 (en) * | 2003-07-24 | 2003-08-07 | University Of South Australia | An ofdm receiver structure |
WO2004075724A2 (en) * | 2003-02-21 | 2004-09-10 | Hinz Martin C | Serotonin and catecholamine system segment optimization technology |
US8158149B2 (en) * | 2004-05-12 | 2012-04-17 | Chelsea Therapeutics, Inc. | Threo-DOPS controlled release formulation |
WO2004100929A1 (en) | 2003-05-12 | 2004-11-25 | Synergia Pharma, Inc. | Threo-dops controlled release formulation |
JP4638685B2 (ja) * | 2003-06-10 | 2011-02-23 | ハイデルベルガー ドルツクマシーネン アクチエンゲゼルシヤフト | オフセット印刷機による印刷の際に湿し水を調量する方法 |
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DK1948155T3 (da) * | 2006-06-28 | 2012-07-02 | Chelsea Therapeutics Inc | Farmaceutiske præparater omfattende droxidopa |
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WO2008112773A2 (en) * | 2007-03-12 | 2008-09-18 | Chelsea Therapeutics, Inc. | Droxidopa and pharmaceutical composition thereof for the treatment of neurally mediated hypotension |
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JP2014503592A (ja) * | 2011-01-26 | 2014-02-13 | ニコ ワールドワイド,インコーポレイテッド | 片頭痛の療法 |
JP5880913B2 (ja) | 2011-05-17 | 2016-03-09 | 三郎 佐古田 | パーキンソン病の体幹症状(姿勢反射異常)の治療剤 |
EP2737809A1 (de) * | 2012-12-03 | 2014-06-04 | MüMed | Aminosäurehaltiges Getränk, geeignet zur Verwendung in der Prophylaxe und Behandlung von psychischen Störungen |
US11464756B1 (en) | 2017-05-19 | 2022-10-11 | Jerry Darm | Mecuna pruriens, L-DOPA and 5-HTP based dietary supplements, pharmaceutical formulations and uses thereof |
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US20050233014A1 (en) * | 2004-03-02 | 2005-10-20 | Lee Steve S | Methods for affecting homeostasis and metabolism in a mammalian body |
US20060062859A1 (en) * | 2004-08-05 | 2006-03-23 | Kenneth Blum | Composition and method to optimize and customize nutritional supplement formulations by measuring genetic and metabolomic contributing factors to disease diagnosis, stratification, prognosis, metabolism, and therapeutic outcomes |
-
2003
- 2003-03-21 CA CA002479218A patent/CA2479218A1/en not_active Abandoned
- 2003-03-21 US US10/394,597 patent/US20030181509A1/en not_active Abandoned
- 2003-03-21 AU AU2003222045A patent/AU2003222045A1/en not_active Abandoned
- 2003-03-21 WO PCT/US2003/008843 patent/WO2003079886A2/en not_active Application Discontinuation
- 2003-03-21 EP EP03718029A patent/EP1490073A4/en not_active Withdrawn
- 2003-03-21 BR BR0308556-2A patent/BR0308556A/pt not_active IP Right Cessation
- 2003-03-21 MX MXPA04009123A patent/MXPA04009123A/es unknown
-
2006
- 2006-02-14 US US11/353,644 patent/US20060178423A1/en not_active Abandoned
-
2008
- 2008-03-28 US US12/058,338 patent/US20080241278A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP1490073A2 (en) | 2004-12-29 |
AU2003222045A8 (en) | 2003-10-08 |
MXPA04009123A (es) | 2005-09-08 |
AU2003222045A1 (en) | 2003-10-08 |
US20080241278A1 (en) | 2008-10-02 |
US20060178423A1 (en) | 2006-08-10 |
EP1490073A4 (en) | 2006-02-01 |
WO2003079886A3 (en) | 2004-02-12 |
US20030181509A1 (en) | 2003-09-25 |
WO2003079886A2 (en) | 2003-10-02 |
CA2479218A1 (en) | 2003-10-02 |
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