DK1349846T3 - Arylerede furan- og thiohencarboxylsyreamider med kaliumkanalblokerende virkning - Google Patents

Arylerede furan- og thiohencarboxylsyreamider med kaliumkanalblokerende virkning

Info

Publication number
DK1349846T3
DK1349846T3 DK01985832T DK01985832T DK1349846T3 DK 1349846 T3 DK1349846 T3 DK 1349846T3 DK 01985832 T DK01985832 T DK 01985832T DK 01985832 T DK01985832 T DK 01985832T DK 1349846 T3 DK1349846 T3 DK 1349846T3
Authority
DK
Denmark
Prior art keywords
thiohene
carboxylic acid
acid amides
potassium channel
blocking effect
Prior art date
Application number
DK01985832T
Other languages
Danish (da)
English (en)
Inventor
Stefan Peukert
Joachim Brendel
Horst Hemmerle
Heinz-Werner Kleemann
Original Assignee
Aventis Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Gmbh filed Critical Aventis Pharma Gmbh
Application granted granted Critical
Publication of DK1349846T3 publication Critical patent/DK1349846T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK01985832T 2000-12-12 2001-11-29 Arylerede furan- og thiohencarboxylsyreamider med kaliumkanalblokerende virkning DK1349846T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10061876A DE10061876A1 (de) 2000-12-12 2000-12-12 Arylierte Furan- und Thiophencarbonsäureamide, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament sowie sie enthaltende pharmazeutische Zubereitungen
PCT/EP2001/013958 WO2002048131A1 (de) 2000-12-12 2001-11-29 Arylierte furan- und thiophencarbonsäureamide mit kalium kanal blockierender wirkung

Publications (1)

Publication Number Publication Date
DK1349846T3 true DK1349846T3 (da) 2005-05-30

Family

ID=7666837

Family Applications (1)

Application Number Title Priority Date Filing Date
DK01985832T DK1349846T3 (da) 2000-12-12 2001-11-29 Arylerede furan- og thiohencarboxylsyreamider med kaliumkanalblokerende virkning

Country Status (30)

Country Link
US (1) US6982279B2 (et)
EP (1) EP1349846B1 (et)
JP (1) JP4252798B2 (et)
KR (1) KR20030061846A (et)
CN (1) CN1225463C (et)
AR (1) AR032781A1 (et)
AT (1) ATE288906T1 (et)
AU (2) AU2002235743B2 (et)
BR (1) BR0116084A (et)
CA (1) CA2431095A1 (et)
CZ (1) CZ20031633A3 (et)
DE (2) DE10061876A1 (et)
DK (1) DK1349846T3 (et)
EE (1) EE05306B1 (et)
ES (1) ES2236335T3 (et)
HK (1) HK1061850A1 (et)
HR (1) HRP20030469A2 (et)
HU (1) HUP0303665A3 (et)
IL (2) IL156314A0 (et)
MX (1) MXPA03004770A (et)
NO (1) NO329163B1 (et)
NZ (1) NZ526383A (et)
PL (1) PL362410A1 (et)
PT (1) PT1349846E (et)
RS (1) RS50336B (et)
RU (1) RU2275366C2 (et)
SK (1) SK287464B6 (et)
TW (1) TWI288134B (et)
WO (1) WO2002048131A1 (et)
ZA (1) ZA200304091B (et)

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JP5030947B2 (ja) 2005-05-13 2012-09-19 ヴァイロケム・ファーマ・インコーポレーテッド フラビウイルス感染の治療及び予防のための化合物及び方法
WO2007015775A2 (en) * 2005-07-22 2007-02-08 Merck & Co., Inc. Potassium channel inhibitors
GB0525164D0 (en) 2005-12-09 2006-01-18 Xention Discovery Ltd Compounds
WO2007124849A2 (en) * 2006-04-27 2007-11-08 Sanofi-Aventis Deutschland Gmbh Inhibitors of the task-1 and task-3 ion channel
KR20090086081A (ko) * 2006-11-15 2009-08-10 바이로켐 파마 인코포레이티드 플라비바이러스 감염의 치료 또는 예방용 티오펜 유사체
US8263641B2 (en) 2007-09-10 2012-09-11 Calcimedica, Inc. Compounds that modulate intracellular calcium
ITMI20071971A1 (it) * 2007-10-10 2009-04-11 Altergon Sa Composizione farmaceutica per la somministrazione sublinguale di progesterone, e metodo per la sua preparazione
WO2009076454A2 (en) 2007-12-12 2009-06-18 Calcimedica, Inc. Compounds that modulate intracellular calcium
TWI392673B (zh) 2008-08-27 2013-04-11 Calcimedica Inc 調控細胞內鈣離子濃度之化合物
GB0815781D0 (en) 2008-08-29 2008-10-08 Xention Ltd Novel potassium channel blockers
GB0815784D0 (en) 2008-08-29 2008-10-08 Xention Ltd Novel potassium channel blockers
GB0815782D0 (en) 2008-08-29 2008-10-08 Xention Ltd Novel potassium channel blockers
US8524763B2 (en) 2008-09-22 2013-09-03 Calcimedica, Inc. Inhibitors of store operated calcium release
US8143269B2 (en) 2008-10-03 2012-03-27 Calcimedica, Inc. Inhibitors of store operated calcium release
MY161598A (en) * 2009-01-30 2017-04-28 Glaxosmithkline Llc Crystalline n-{ (1s)-2-amino-1-[(3-fluorophenyl)methyl]ethyl} -5-chloro-4-(4-chloro-1-methyl-1h-pyrazol-5-yl)-2-thiophenecarboxamide hydrochloride
US8618307B2 (en) 2009-09-16 2013-12-31 Calcimedica, Inc. Compounds that modulate intracellular calcium
US8722731B2 (en) 2010-06-07 2014-05-13 Novomedix, Llc Furanyl compounds and the use thereof
JP5916149B2 (ja) 2010-08-27 2016-05-11 カルシメディカ，インク． 細胞内カルシウムを調節する化合物
GB201105659D0 (en) 2011-04-01 2011-05-18 Xention Ltd Compounds
NO3175985T3 (et) 2011-07-01 2018-04-28
WO2013112932A1 (en) 2012-01-27 2013-08-01 Gilead Sciences, Inc. Combination therapies using late sodium ion channel blockers and potassium ion channel blockers
WO2014059333A1 (en) 2012-10-12 2014-04-17 Calcimedica, Inc. Compounds that modulate intracellular calcium
CN103012381B (zh) * 2013-01-10 2015-01-07 山东大学 苯基呋喃类化合物、其制备方法及在制备抗心律失常药物中的应用
KR101721490B1 (ko) * 2014-07-30 2017-03-30 한국생명공학연구원 페닐 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 세포증식성 질병의 예방 또는 치료용 약학적 조성물
EP3366683A1 (en) 2017-02-28 2018-08-29 Acousia Therapeutics GmbH Cyclic amides, acteamides and ureas useful as potassium channel openers

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Also Published As

Publication number Publication date
ATE288906T1 (de) 2005-02-15
NO329163B1 (no) 2010-08-30
HUP0303665A2 (hu) 2004-03-01
HRP20030469A2 (en) 2005-04-30
DE10061876A1 (de) 2002-06-20
AR032781A1 (es) 2003-11-26
ZA200304091B (en) 2004-04-23
IL156314A (en) 2008-12-29
NO20032535L (no) 2003-07-29
EE200300240A (et) 2003-08-15
BR0116084A (pt) 2003-10-14
SK7252003A3 (en) 2003-12-02
RU2275366C2 (ru) 2006-04-27
NZ526383A (en) 2004-11-26
PL362410A1 (en) 2004-11-02
US20040068120A1 (en) 2004-04-08
EP1349846A1 (de) 2003-10-08
TWI288134B (en) 2007-10-11
US6982279B2 (en) 2006-01-03
AU3574302A (en) 2002-06-24
CN1479734A (zh) 2004-03-03
HK1061850A1 (en) 2004-10-08
SK287464B6 (sk) 2010-10-07
HUP0303665A3 (en) 2005-02-28
CZ20031633A3 (cs) 2003-08-13
YU42503A (sh) 2006-05-25
MXPA03004770A (es) 2003-09-10
AU2002235743B2 (en) 2006-07-20
JP2004526680A (ja) 2004-09-02
DE50105337D1 (de) 2005-03-17
JP4252798B2 (ja) 2009-04-08
EE05306B1 (et) 2010-06-15
IL156314A0 (en) 2004-01-04
CN1225463C (zh) 2005-11-02
WO2002048131A1 (de) 2002-06-20
NO20032535D0 (no) 2003-06-04
ES2236335T3 (es) 2005-07-16
EP1349846B1 (de) 2005-02-09
RS50336B (sr) 2009-11-10
CA2431095A1 (en) 2002-06-20
PT1349846E (pt) 2005-05-31
KR20030061846A (ko) 2003-07-22

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