DK1327143T3 - Krystalstruktur af BACE og anvendelse deraf - Google Patents
Krystalstruktur af BACE og anvendelse derafInfo
- Publication number
- DK1327143T3 DK1327143T3 DK01973243T DK01973243T DK1327143T3 DK 1327143 T3 DK1327143 T3 DK 1327143T3 DK 01973243 T DK01973243 T DK 01973243T DK 01973243 T DK01973243 T DK 01973243T DK 1327143 T3 DK1327143 T3 DK 1327143T3
- Authority
- DK
- Denmark
- Prior art keywords
- bace
- crystal structure
- agents
- alzheimer
- beta
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Neurology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Crystals, And After-Treatments Of Crystals (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US23457600P | 2000-09-22 | 2000-09-22 | |
PCT/US2001/029387 WO2002025276A1 (en) | 2000-09-22 | 2001-09-19 | Crystal structure of bace and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1327143T3 true DK1327143T3 (da) | 2007-07-02 |
Family
ID=22881945
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK01973243T DK1327143T3 (da) | 2000-09-22 | 2001-09-19 | Krystalstruktur af BACE og anvendelse deraf |
Country Status (8)
Country | Link |
---|---|
US (1) | US7630838B2 (da) |
EP (1) | EP1327143B1 (da) |
AT (1) | ATE355520T1 (da) |
AU (1) | AU2001292843A1 (da) |
DE (1) | DE60126970T2 (da) |
DK (1) | DK1327143T3 (da) |
ES (1) | ES2282292T3 (da) |
WO (1) | WO2002025276A1 (da) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2374346C (en) | 1999-06-28 | 2010-06-22 | Jordan J. N. Tang | Inhibitors of memapsin 2 and use thereof |
US7601528B1 (en) * | 2000-12-23 | 2009-10-13 | Elan Pharmaceuticals, Inc. | Crystallization and structure determination of glycosylated human beta secretase, an enzyme implicated in alzheimer's disease |
US7217556B1 (en) | 2000-12-23 | 2007-05-15 | Pfizer Inc | Crystallization and structure determination of glycosylated human beta secretase, an enzyme implicated in Alzheimer's disease |
US7806980B2 (en) | 2000-12-23 | 2010-10-05 | Elan Pharmaceuticals, Inc. | Method for crystallizing human beta secretase in complex with an inhibitor |
US20040121947A1 (en) * | 2000-12-28 | 2004-06-24 | Oklahoma Medical Research Foundation | Compounds which inhibit beta-secretase activity and methods of use thereof |
US7524668B1 (en) | 2001-05-10 | 2009-04-28 | Elan Pharmaceuticals, Inc. | Crystal of human beta secretase having monoclinic space group symmetry C2 and methods for crystallization thereof |
US7384773B1 (en) * | 2001-05-10 | 2008-06-10 | Pfizer Inc | Crystal of HIV protease-cleaved human beta secretase and method for crystallization thereof |
CA2464736A1 (en) | 2001-10-23 | 2003-05-15 | Oklahoma Medical Research Foundation | Beta-secretase inhibitors and methods of use |
US20060234944A1 (en) * | 2001-10-23 | 2006-10-19 | Oklahoma Medical Reseach Foundation | Beta-secretase inhibitors and methods of use |
CH698246B1 (de) * | 2001-12-20 | 2009-06-30 | Hoffmann La Roche | Test zur Identifizierung von Inhibitoren von Beta-Sekretasen. |
US20040014194A1 (en) * | 2002-03-27 | 2004-01-22 | Schering Corporation | Beta-secretase crystals and methods for preparing and using the same |
US7442537B1 (en) | 2002-05-10 | 2008-10-28 | Elan Pharmaceuticals, Inc. | Crystals of unliganded beta secretase and/or beta secretase-like proteins and the use thereof |
US7166454B1 (en) * | 2002-05-24 | 2007-01-23 | Schering Corporation | Codon-optimized β-secretase and methods of refolding and processing |
WO2004011641A2 (en) * | 2002-07-26 | 2004-02-05 | Astex Technology Limited | Crystal structure of beta-site app-cleaving enzyme (bace) mutants and uses thereof |
AU2003285892A1 (en) * | 2002-10-15 | 2004-05-04 | Bristol-Myers Squibb Company | Bace binding peptides and uses thereof |
MXPA05004033A (es) | 2002-10-16 | 2005-06-08 | Isis Innovation | Hidroxilasas de asparaginil y moduladores de las mismas. |
AU2006208226A1 (en) | 2005-01-24 | 2006-08-03 | Amgen Inc. | Humanized anti-amyloid antibody |
BRPI0608581A2 (pt) * | 2005-03-14 | 2010-01-19 | Transtech Pharma Inc | derivados de benzazol, composiÇÕes e mÉtodos de uso como inibidores de b-secretase |
CA2618508A1 (en) * | 2005-08-10 | 2007-02-22 | Oklahoma Medical Research Foundation | Truncated memapsin 2 for use for treating alzheimer's disease |
TW200815349A (en) | 2006-06-22 | 2008-04-01 | Astrazeneca Ab | New compounds |
EP2261254A3 (en) | 2007-12-21 | 2011-04-13 | Amgen, Inc | Anti-amyloid antibodies and uses thereof |
TW201020244A (en) | 2008-11-14 | 2010-06-01 | Astrazeneca Ab | New compounds |
EP2281824A1 (en) | 2009-08-07 | 2011-02-09 | Noscira, S.A. | Furan-imidazolone derivatives, for the treatment of cognitive, neurodegenerative or neuronal diseases or disorders |
CN103228674B (zh) | 2010-11-10 | 2019-07-05 | 霍夫曼-拉罗奇有限公司 | 用于神经疾病免疫疗法的方法和组合物 |
JP2013542973A (ja) | 2010-11-22 | 2013-11-28 | ノスシラ、ソシエダッド、アノニマ | 神経変性疾患または神経変性状態を治療するためのビピリジンスルホンアミド誘導体 |
US20180107782A1 (en) * | 2014-01-20 | 2018-04-19 | Stevan Hubbard | Atomic model for janus kinase-2 (jak2) and uses thereof |
EP3221361B1 (en) | 2014-11-19 | 2021-04-21 | Genentech, Inc. | Anti-transferrin receptor / anti-bace1 multispecific antibodies and methods of use |
CN107108745B (zh) | 2014-11-19 | 2021-01-12 | 基因泰克公司 | 抗bace1的抗体和其用于神经疾病免疫疗法的用途 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5331573A (en) * | 1990-12-14 | 1994-07-19 | Balaji Vitukudi N | Method of design of compounds that mimic conformational features of selected peptides |
US5942400A (en) * | 1995-06-07 | 1999-08-24 | Elan Pharmaceuticals, Inc. | Assays for detecting β-secretase |
GB9626022D0 (en) * | 1996-12-14 | 1997-01-29 | Smithkline Beecham Plc | Novel compounds |
EP0848062A3 (en) * | 1996-12-14 | 2000-07-05 | Smithkline Beecham Corporation | Aspartic protease ASP1 |
GB9701684D0 (en) * | 1997-01-28 | 1997-03-19 | Smithkline Beecham Plc | Novel compounds |
US6313268B1 (en) * | 1998-10-16 | 2001-11-06 | Vivian Y. H. Hook | Secretases related to Alzheimer's dementia |
CA2374346C (en) * | 1999-06-28 | 2010-06-22 | Jordan J. N. Tang | Inhibitors of memapsin 2 and use thereof |
US20040137518A1 (en) * | 2002-01-31 | 2004-07-15 | Lambert Millard Hurst | CRYSTALLIZED PPARa LIGAND BINDING DOMAIN POLYPEPTIDE AND SCREENING METHODS EMPLOYING SAME |
-
2001
- 2001-09-19 AT AT01973243T patent/ATE355520T1/de not_active IP Right Cessation
- 2001-09-19 DE DE60126970T patent/DE60126970T2/de not_active Expired - Fee Related
- 2001-09-19 EP EP01973243A patent/EP1327143B1/en not_active Expired - Lifetime
- 2001-09-19 AU AU2001292843A patent/AU2001292843A1/en not_active Abandoned
- 2001-09-19 WO PCT/US2001/029387 patent/WO2002025276A1/en active IP Right Grant
- 2001-09-19 US US09/955,737 patent/US7630838B2/en not_active Expired - Fee Related
- 2001-09-19 DK DK01973243T patent/DK1327143T3/da active
- 2001-09-19 ES ES01973243T patent/ES2282292T3/es not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
US7630838B2 (en) | 2009-12-08 |
US20020055459A1 (en) | 2002-05-09 |
ATE355520T1 (de) | 2006-03-15 |
WO2002025276A1 (en) | 2002-03-28 |
EP1327143B1 (en) | 2007-02-28 |
DE60126970D1 (de) | 2007-04-12 |
DE60126970T2 (de) | 2007-11-22 |
EP1327143A1 (en) | 2003-07-16 |
EP1327143A4 (en) | 2005-02-09 |
AU2001292843A1 (en) | 2002-04-02 |
ES2282292T3 (es) | 2007-10-16 |
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