ATE355520T1 - Kristallstruktur von bace und verwendungen dafür - Google Patents
Kristallstruktur von bace und verwendungen dafürInfo
- Publication number
- ATE355520T1 ATE355520T1 AT01973243T AT01973243T ATE355520T1 AT E355520 T1 ATE355520 T1 AT E355520T1 AT 01973243 T AT01973243 T AT 01973243T AT 01973243 T AT01973243 T AT 01973243T AT E355520 T1 ATE355520 T1 AT E355520T1
- Authority
- AT
- Austria
- Prior art keywords
- bace
- crystal structure
- agents
- alzheimer
- beta
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US23457600P | 2000-09-22 | 2000-09-22 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE355520T1 true ATE355520T1 (de) | 2006-03-15 |
Family
ID=22881945
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT01973243T ATE355520T1 (de) | 2000-09-22 | 2001-09-19 | Kristallstruktur von bace und verwendungen dafür |
Country Status (8)
Country | Link |
---|---|
US (1) | US7630838B2 (de) |
EP (1) | EP1327143B1 (de) |
AT (1) | ATE355520T1 (de) |
AU (1) | AU2001292843A1 (de) |
DE (1) | DE60126970T2 (de) |
DK (1) | DK1327143T3 (de) |
ES (1) | ES2282292T3 (de) |
WO (1) | WO2002025276A1 (de) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2374610A1 (en) | 1999-06-28 | 2001-01-04 | Jordan J. N. Tang | Catalytically active recombinant memapsin and methods of use thereof |
US7806980B2 (en) | 2000-12-23 | 2010-10-05 | Elan Pharmaceuticals, Inc. | Method for crystallizing human beta secretase in complex with an inhibitor |
US7217556B1 (en) | 2000-12-23 | 2007-05-15 | Pfizer Inc | Crystallization and structure determination of glycosylated human beta secretase, an enzyme implicated in Alzheimer's disease |
US7601528B1 (en) * | 2000-12-23 | 2009-10-13 | Elan Pharmaceuticals, Inc. | Crystallization and structure determination of glycosylated human beta secretase, an enzyme implicated in alzheimer's disease |
US20040121947A1 (en) * | 2000-12-28 | 2004-06-24 | Oklahoma Medical Research Foundation | Compounds which inhibit beta-secretase activity and methods of use thereof |
US7384773B1 (en) * | 2001-05-10 | 2008-06-10 | Pfizer Inc | Crystal of HIV protease-cleaved human beta secretase and method for crystallization thereof |
US7524668B1 (en) | 2001-05-10 | 2009-04-28 | Elan Pharmaceuticals, Inc. | Crystal of human beta secretase having monoclinic space group symmetry C2 and methods for crystallization thereof |
US20060234944A1 (en) * | 2001-10-23 | 2006-10-19 | Oklahoma Medical Reseach Foundation | Beta-secretase inhibitors and methods of use |
EP1448218A4 (de) | 2001-10-23 | 2009-01-14 | Oklahoma Med Res Found | Beta-secretase-hemmer und anwendungsverfahren |
CH698246B1 (de) * | 2001-12-20 | 2009-06-30 | Hoffmann La Roche | Test zur Identifizierung von Inhibitoren von Beta-Sekretasen. |
US20040014194A1 (en) * | 2002-03-27 | 2004-01-22 | Schering Corporation | Beta-secretase crystals and methods for preparing and using the same |
US7442537B1 (en) | 2002-05-10 | 2008-10-28 | Elan Pharmaceuticals, Inc. | Crystals of unliganded beta secretase and/or beta secretase-like proteins and the use thereof |
US7166454B1 (en) | 2002-05-24 | 2007-01-23 | Schering Corporation | Codon-optimized β-secretase and methods of refolding and processing |
US20040096950A1 (en) * | 2002-07-26 | 2004-05-20 | Vuillard Laurent Michel Marie | Crystal structure of beta site APP cleaving enzyme (BACE) and methods of use thereof |
AU2003285892A1 (en) * | 2002-10-15 | 2004-05-04 | Bristol-Myers Squibb Company | Bace binding peptides and uses thereof |
EP1554394B1 (de) | 2002-10-16 | 2009-12-16 | Isis Innovation Limited | Screening-Methoden unter Verwendung eines Strukturmodells von FIH |
CA2589860A1 (en) | 2005-01-24 | 2006-08-03 | Amgen Inc. | Humanized anti-amyloid antibody |
MX2007011234A (es) * | 2005-03-14 | 2007-11-12 | Transtech Pharma Inc | Derivados de benzazol, composiciones y metodos de uso en la forma de inhibidores de b-secretasa. |
US20070092517A1 (en) * | 2005-08-10 | 2007-04-26 | Oklahoma Medical Research Foundation | Truncated memapsin 2 compositions and treatments |
TW200815349A (en) | 2006-06-22 | 2008-04-01 | Astrazeneca Ab | New compounds |
EP2261254A3 (de) | 2007-12-21 | 2011-04-13 | Amgen, Inc | Antiamyloide Antikörper und deren Verwendungen |
TW201020244A (en) | 2008-11-14 | 2010-06-01 | Astrazeneca Ab | New compounds |
EP2281824A1 (de) | 2009-08-07 | 2011-02-09 | Noscira, S.A. | Furan-Imidazolon-Derivate zur Behandlung von kognitiven, neurodegenerativen oder neuronalen Erkrankungen oder Funktionsstörungen |
EA201390669A1 (ru) * | 2010-11-10 | 2013-11-29 | Дженентек, Инк. | Способы и композиции для иммунотерапии заболеваний нервной системы |
US9284296B2 (en) | 2010-11-22 | 2016-03-15 | Aubergine Pharmaceuticals Llc | Bipyridine sulfonamide derivatives for the treatment of neurodegenerative diseases or conditions |
WO2015109275A1 (en) * | 2014-01-20 | 2015-07-23 | New York University | Atomic model for janus kinase-2 (jak2) and uses thereof |
JP6859259B2 (ja) | 2014-11-19 | 2021-04-14 | ジェネンテック, インコーポレイテッド | BACElに対する抗体及び神経疾患免疫療法のためのその使用 |
US11008403B2 (en) | 2014-11-19 | 2021-05-18 | Genentech, Inc. | Anti-transferrin receptor / anti-BACE1 multispecific antibodies and methods of use |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5331573A (en) * | 1990-12-14 | 1994-07-19 | Balaji Vitukudi N | Method of design of compounds that mimic conformational features of selected peptides |
JPH11507538A (ja) * | 1995-06-07 | 1999-07-06 | アテナ ニューロサイエンシズ インコーポレイティド | β−セクレターゼ、β−セクレターゼに対する抗体、及びβ−セクレターゼ阻害を検出するためのアッセイ |
EP0848062A3 (de) | 1996-12-14 | 2000-07-05 | Smithkline Beecham Corporation | Aspartylprotease ASP1 |
GB9626022D0 (en) | 1996-12-14 | 1997-01-29 | Smithkline Beecham Plc | Novel compounds |
GB9701684D0 (en) | 1997-01-28 | 1997-03-19 | Smithkline Beecham Plc | Novel compounds |
US6313268B1 (en) | 1998-10-16 | 2001-11-06 | Vivian Y. H. Hook | Secretases related to Alzheimer's dementia |
CA2374610A1 (en) | 1999-06-28 | 2001-01-04 | Jordan J. N. Tang | Catalytically active recombinant memapsin and methods of use thereof |
US20040137518A1 (en) * | 2002-01-31 | 2004-07-15 | Lambert Millard Hurst | CRYSTALLIZED PPARa LIGAND BINDING DOMAIN POLYPEPTIDE AND SCREENING METHODS EMPLOYING SAME |
-
2001
- 2001-09-19 AU AU2001292843A patent/AU2001292843A1/en not_active Abandoned
- 2001-09-19 DE DE60126970T patent/DE60126970T2/de not_active Expired - Fee Related
- 2001-09-19 ES ES01973243T patent/ES2282292T3/es not_active Expired - Lifetime
- 2001-09-19 WO PCT/US2001/029387 patent/WO2002025276A1/en active IP Right Grant
- 2001-09-19 AT AT01973243T patent/ATE355520T1/de not_active IP Right Cessation
- 2001-09-19 EP EP01973243A patent/EP1327143B1/de not_active Expired - Lifetime
- 2001-09-19 US US09/955,737 patent/US7630838B2/en not_active Expired - Fee Related
- 2001-09-19 DK DK01973243T patent/DK1327143T3/da active
Also Published As
Publication number | Publication date |
---|---|
AU2001292843A1 (en) | 2002-04-02 |
EP1327143B1 (de) | 2007-02-28 |
EP1327143A1 (de) | 2003-07-16 |
DE60126970D1 (de) | 2007-04-12 |
US20020055459A1 (en) | 2002-05-09 |
DK1327143T3 (da) | 2007-07-02 |
ES2282292T3 (es) | 2007-10-16 |
DE60126970T2 (de) | 2007-11-22 |
EP1327143A4 (de) | 2005-02-09 |
US7630838B2 (en) | 2009-12-08 |
WO2002025276A1 (en) | 2002-03-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |