DK1325340T3 - Identifikation af proteinbindingssteder - Google Patents
Identifikation af proteinbindingsstederInfo
- Publication number
- DK1325340T3 DK1325340T3 DK01979110T DK01979110T DK1325340T3 DK 1325340 T3 DK1325340 T3 DK 1325340T3 DK 01979110 T DK01979110 T DK 01979110T DK 01979110 T DK01979110 T DK 01979110T DK 1325340 T3 DK1325340 T3 DK 1325340T3
- Authority
- DK
- Denmark
- Prior art keywords
- segment
- protein
- nucleic acid
- discontinuous
- identification
- Prior art date
Links
- 102000004169 proteins and genes Human genes 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 title 1
- 238000001514 detection method Methods 0.000 abstract 2
- 238000012512 characterization method Methods 0.000 abstract 1
- 230000003993 interaction Effects 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B30/00—Methods of screening libraries
- C40B30/04—Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
- C07K1/047—Simultaneous synthesis of different peptide species; Peptide libraries
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6845—Methods of identifying protein-protein interactions in protein mixtures
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biomedical Technology (AREA)
- Analytical Chemistry (AREA)
- Urology & Nephrology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Hematology (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Cell Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Computational Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Food Science & Technology (AREA)
- Biotechnology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Genetics & Genomics (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Information Retrieval, Db Structures And Fs Structures Therefor (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP00203518A EP1197755A1 (de) | 2000-10-11 | 2000-10-11 | Bestimmung von Protein-Bindungsstellen |
PCT/NL2001/000744 WO2002031510A1 (en) | 2000-10-11 | 2001-10-10 | Identification of protein binding sites |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1325340T3 true DK1325340T3 (da) | 2009-02-16 |
Family
ID=8172123
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK01979110T DK1325340T3 (da) | 2000-10-11 | 2001-10-10 | Identifikation af proteinbindingssteder |
Country Status (14)
Country | Link |
---|---|
US (2) | US7972993B2 (de) |
EP (2) | EP1197755A1 (de) |
JP (2) | JP2004511780A (de) |
AT (1) | ATE411526T1 (de) |
AU (2) | AU2002211099B2 (de) |
CA (1) | CA2424611C (de) |
CY (1) | CY1110101T1 (de) |
DE (1) | DE60136202D1 (de) |
DK (1) | DK1325340T3 (de) |
ES (1) | ES2317941T3 (de) |
IL (2) | IL155277A0 (de) |
NZ (1) | NZ524874A (de) |
PT (1) | PT1325340E (de) |
WO (1) | WO2002031510A1 (de) |
Families Citing this family (58)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5959087A (en) * | 1989-08-07 | 1999-09-28 | Peptide Technology, Ltd. | Tumour necrosis factor binding ligands |
US20030225254A1 (en) * | 1989-08-07 | 2003-12-04 | Rathjen Deborah Ann | Tumour necrosis factor binding ligands |
DE69027121T3 (de) | 1989-08-07 | 2001-08-30 | Peptech Ltd., Dee Why | Bindeligande für tumornekrosisfaktor |
EP1197755A1 (de) | 2000-10-11 | 2002-04-17 | Pepscan Systems B.V. | Bestimmung von Protein-Bindungsstellen |
US7504364B2 (en) | 2002-03-01 | 2009-03-17 | Receptors Llc | Methods of making arrays and artificial receptors |
EP1388544A1 (de) * | 2002-07-31 | 2004-02-11 | D. Collen Research Foundation vzw | Anti-Idiotypische Antikörper gegen Factor VIII-Inhibitor und Verwendungen davon |
US20050136483A1 (en) * | 2003-09-03 | 2005-06-23 | Receptors Llc | Nanodevices employing combinatorial artificial receptors |
US20050037381A1 (en) * | 2002-09-16 | 2005-02-17 | Receptors Llc | Artificial receptors, building blocks, and methods |
US20060057625A1 (en) * | 2002-09-16 | 2006-03-16 | Carlson Robert E | Scaffold-based artificial receptors and methods |
US20060051802A1 (en) * | 2002-09-16 | 2006-03-09 | Receptors Llc | Artificial receptors, building blocks, and methods |
US20050170385A1 (en) * | 2002-09-16 | 2005-08-04 | Receptors Llc | Artificial receptors including gradients |
US20040137481A1 (en) * | 2002-09-16 | 2004-07-15 | Receptors Llc | Artificial receptor building blocks, components, and kits |
US7469076B2 (en) * | 2003-09-03 | 2008-12-23 | Receptors Llc | Sensors employing combinatorial artificial receptors |
US7736909B2 (en) | 2003-01-09 | 2010-06-15 | Board Of Regents, The University Of Texas System | Methods and compositions comprising capture agents |
EP1452868A2 (de) | 2003-02-27 | 2004-09-01 | Pepscan Systems B.V. | Verfahren zur Selektion eines potenziellen Arzneimittels |
EP1613737A4 (de) * | 2003-03-28 | 2008-12-03 | Receptors Llc | Reversibel immobilisierte bausteine beinhaltend künstliche rezeptoren und verfahren |
US7365154B2 (en) | 2003-06-23 | 2008-04-29 | Centocor, Inc. | Peptides antagonistic to an anti-angiogenic antibody and uses therefor |
EP1789797A1 (de) * | 2004-09-03 | 2007-05-30 | Receptors LLC | Kombinatorische künstliche rezeptoren mit anbindungsbausteinen |
US7985715B2 (en) * | 2004-09-11 | 2011-07-26 | Receptors Llc | Combinatorial artificial receptors including peptide building blocks |
US20100004134A1 (en) * | 2007-01-12 | 2010-01-07 | Lawrence Horowitz | Combinatorial libraries of conformationally constrained polypeptide sequences |
EP2393832B1 (de) | 2009-02-06 | 2015-07-08 | Pepscan Systems BV | Verkürzte cystin-knoten-proteine |
KR20120122869A (ko) | 2009-06-02 | 2012-11-07 | 보드 오브 리전츠, 더 유니버시티 오브 텍사스 시스템 | 신경변성 질환을 갖는 대상에서 항체에 의해 인식되는 소분자의 확인법 |
WO2011047257A1 (en) | 2009-10-16 | 2011-04-21 | The Board Of Regents Of The University Of Texas System | Compositions and methods for producing cyclic peptoid libraries |
BR112012028764A2 (pt) * | 2010-05-11 | 2017-03-14 | Aveo Pharmaceuticals Inc | anticor-pos antifgfr2 |
WO2012139137A2 (en) | 2011-04-08 | 2012-10-11 | Tufts Medical Center, Inc. | Pepducin design and use |
BR112014012590A8 (pt) | 2011-11-23 | 2017-12-19 | Igenica Inc | Anticorpos anti-cd98 e métodos de uso dos mesmos |
JP6012767B2 (ja) | 2012-02-07 | 2016-10-25 | ヴィブラント ホールディングス リミテッド ライアビリティ カンパニー | 基板、ペプチドアレイ、および方法 |
US10006909B2 (en) | 2012-09-28 | 2018-06-26 | Vibrant Holdings, Llc | Methods, systems, and arrays for biomolecular analysis |
CA2887129A1 (en) | 2012-10-09 | 2014-04-17 | Igenica, Inc. | Anti-c16orf54 antibodies and methods of use thereof |
US10286376B2 (en) | 2012-11-14 | 2019-05-14 | Vibrant Holdings, Llc | Substrates, systems, and methods for array synthesis and biomolecular analysis |
JP5981667B2 (ja) | 2013-02-15 | 2016-08-31 | ヴィブラント ホールディングス リミテッド ライアビリティ カンパニー | 増幅された電気化学発光検出のための方法および組成物 |
EP2767549A1 (de) | 2013-02-19 | 2014-08-20 | Adienne S.A. | Anti-CD26-Antikörper und Verwendungen davon |
DK3087083T3 (da) | 2013-12-27 | 2019-12-16 | Hoffmann La Roche | Systemisk opdagelse, modning og forlængelse af peptidbindere til proteiner |
HUE050279T2 (hu) | 2014-01-24 | 2020-11-30 | Ngm Biopharmaceuticals Inc | Béta-klotho 2-es doménjéhez kötõdõ antitestek és azok alkalmazási módszerei |
WO2015166036A1 (en) | 2014-05-02 | 2015-11-05 | Morphosys Ag | Peptide libraries |
AU2015314934A1 (en) * | 2014-09-10 | 2017-04-20 | Vibrant Holdings, Llc | Peptide microarrays and novel biomarkers for celiac disease |
AU2016251501A1 (en) | 2015-04-20 | 2017-10-19 | F. Hoffmann-La Roche Ag | Specific peptide binders to proteins identified via systemic discovery, maturation and extension process |
MX2018000305A (es) * | 2015-06-24 | 2018-03-14 | Japan Chem Res | Anticuerpo anti-receptor de transferrina humana que penetra la barrera hematoencefalica. |
JP6914193B2 (ja) | 2015-06-24 | 2021-08-04 | Jcrファーマ株式会社 | Bdnfを含む融合蛋白質 |
PE20181322A1 (es) | 2015-09-01 | 2018-08-14 | Agenus Inc | Anticuerpo anti-pd1 y sus metodos de uso |
CA3005029A1 (en) | 2015-11-13 | 2017-05-18 | Oasis Pharmaceuticals, LLC | Protease-activated receptor-2 modulators |
NZ749355A (en) | 2016-05-27 | 2023-04-28 | Agenus Inc | Anti-tim-3 antibodies and methods of use thereof |
CA3037380A1 (en) | 2016-10-11 | 2018-04-19 | Agenus Inc. | Anti-lag-3 antibodies and methods of use thereof |
SI3551660T1 (sl) | 2016-12-07 | 2024-02-29 | Agenus Inc. | Protitelesa proti antictla-4 in načini njihove uporabe |
EP3560958A4 (de) | 2016-12-26 | 2020-08-12 | JCR Pharmaceuticals Co., Ltd. | Zur penetration einer blut-hirn-schranke fähiger, neuartiger anti-human-transferrin-rezeptor-antikörper |
KR102629972B1 (ko) | 2017-04-13 | 2024-01-29 | 아게누스 인코포레이티드 | 항-cd137 항체 및 이의 사용 방법 |
US11021537B2 (en) | 2017-05-01 | 2021-06-01 | Agenus Inc. | Anti-TIGIT antibodies and methods of use thereof |
US10538808B2 (en) | 2017-05-26 | 2020-01-21 | Vibrant Holdings, Llc | Photoactive compounds and methods for biomolecule detection and sequencing |
CN111278858B (zh) | 2017-07-11 | 2024-07-23 | 指南针制药有限责任公司 | 结合人cd137的激动剂抗体及其用途 |
US11718679B2 (en) | 2017-10-31 | 2023-08-08 | Compass Therapeutics Llc | CD137 antibodies and PD-1 antagonists and uses thereof |
US11851497B2 (en) | 2017-11-20 | 2023-12-26 | Compass Therapeutics Llc | CD137 antibodies and tumor antigen-targeting antibodies and uses thereof |
WO2020033925A2 (en) | 2018-08-09 | 2020-02-13 | Compass Therapeutics Llc | Antibodies that bind cd277 and uses thereof |
BR112021008795A2 (pt) | 2018-11-13 | 2021-08-31 | Compass Therapeutics Llc | Construtos de ligação multiespecíficos contra moléculas de ponto de verificação e seus usos |
CN113474371A (zh) | 2019-01-16 | 2021-10-01 | 指南针制药有限责任公司 | 与人cd137结合的抗体的制剂及其用途 |
WO2021042019A1 (en) | 2019-08-30 | 2021-03-04 | Agenus Inc. | Anti-cd96 antibodies and methods of use thereof |
US11459389B2 (en) | 2019-10-24 | 2022-10-04 | Massachusetts Institute Of Technology | Monoclonal antibodies that bind human CD161 |
RU2743316C1 (ru) * | 2020-08-14 | 2021-02-17 | Автономная некоммерческая образовательная организация высшего образования Сколковский институт науки и технологий | Способ идентификации участков связывания белковых комплексов |
JP2024534265A (ja) | 2021-08-23 | 2024-09-18 | イミュニタス セラピューティクス,インコーポレーテッド | 抗cd161抗体及びその使用 |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ207394A (en) * | 1983-03-08 | 1987-03-06 | Commw Serum Lab Commission | Detecting or determining sequence of amino acids |
US5368712A (en) | 1989-11-02 | 1994-11-29 | Synporin Technologies, Inc. | Biologically mimetic synthetic ion channel transducers |
US6040423A (en) * | 1990-08-31 | 2000-03-21 | Gsellschaft Fur Biotechnologische Forschung Mbh (Gbf) | Process for synthesis of peptides |
IE68675B1 (en) * | 1990-11-01 | 1996-07-10 | Takeda Chemical Industries Ltd | Aminocoumaran derivatives their production and use |
WO1992008808A1 (en) * | 1990-11-14 | 1992-05-29 | Siska Diagnostics, Inc. | Non-isotopic detection of nucleic acids using a polystyrene support-based sandwich hybridization assay and compositions useful therefor |
JPH04204379A (ja) | 1990-11-30 | 1992-07-24 | Hitachi Ltd | 生体成分分析法 |
NL9101953A (nl) | 1991-11-21 | 1993-06-16 | Seed Capital Investments | Testinrichting omvattende een plaat met een veelvoud van putjes met een bijbehorende doseerinrichting, alsmede een kit die deze inrichtingen omvat en toepassing van de inrichtingen. |
US5824483A (en) * | 1994-05-18 | 1998-10-20 | Pence Inc. | Conformationally-restricted combinatiorial library composition and method |
DE69526665T2 (de) * | 1994-09-21 | 2002-11-21 | Cytogen Corp., Princeton | Antigen bindende peptide (abtides) aus peptidbibliotheken |
US5885577A (en) | 1994-09-21 | 1999-03-23 | Cytogen Corporation | Antigen binding peptides (abtides) from peptide libraries |
US5940447A (en) | 1996-08-30 | 1999-08-17 | Motorola, Inc. | Wireless powered communication device using power signal sampling and method |
US6306643B1 (en) | 1998-08-24 | 2001-10-23 | Affymetrix, Inc. | Methods of using an array of pooled probes in genetic analysis |
US6461812B2 (en) * | 1998-09-09 | 2002-10-08 | Agilent Technologies, Inc. | Method and multiple reservoir apparatus for fabrication of biomolecular arrays |
JP4024442B2 (ja) | 1998-12-15 | 2007-12-19 | 富士フイルム株式会社 | 試験片と生体由来物質の定量方法及び装置 |
US6642353B1 (en) | 1999-03-17 | 2003-11-04 | Chugai Seiyaku Kabushiki Kaisha | Peptide ligands for the erythropoietin receptor |
EP1197755A1 (de) | 2000-10-11 | 2002-04-17 | Pepscan Systems B.V. | Bestimmung von Protein-Bindungsstellen |
-
2000
- 2000-10-11 EP EP00203518A patent/EP1197755A1/de not_active Withdrawn
-
2001
- 2001-10-10 PT PT01979110T patent/PT1325340E/pt unknown
- 2001-10-10 DE DE60136202T patent/DE60136202D1/de not_active Expired - Lifetime
- 2001-10-10 ES ES01979110T patent/ES2317941T3/es not_active Expired - Lifetime
- 2001-10-10 DK DK01979110T patent/DK1325340T3/da active
- 2001-10-10 AU AU2002211099A patent/AU2002211099B2/en not_active Ceased
- 2001-10-10 NZ NZ524874A patent/NZ524874A/en not_active IP Right Cessation
- 2001-10-10 AU AU1109902A patent/AU1109902A/xx active Pending
- 2001-10-10 CA CA2424611A patent/CA2424611C/en not_active Expired - Fee Related
- 2001-10-10 EP EP01979110A patent/EP1325340B1/de not_active Expired - Lifetime
- 2001-10-10 WO PCT/NL2001/000744 patent/WO2002031510A1/en active IP Right Grant
- 2001-10-10 JP JP2002534844A patent/JP2004511780A/ja active Pending
- 2001-10-10 AT AT01979110T patent/ATE411526T1/de active
- 2001-10-10 IL IL15527701A patent/IL155277A0/xx unknown
-
2003
- 2003-04-07 IL IL155277A patent/IL155277A/en not_active IP Right Cessation
- 2003-04-10 US US10/411,869 patent/US7972993B2/en not_active Expired - Fee Related
-
2008
- 2008-09-24 JP JP2008244881A patent/JP4808756B2/ja not_active Expired - Fee Related
-
2009
- 2009-01-13 CY CY20091100021T patent/CY1110101T1/el unknown
-
2011
- 2011-05-05 US US13/101,894 patent/US20120190564A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
DE60136202D1 (de) | 2008-11-27 |
CA2424611A1 (en) | 2002-04-18 |
PT1325340E (pt) | 2009-01-07 |
CA2424611C (en) | 2011-01-25 |
JP4808756B2 (ja) | 2011-11-02 |
NZ524874A (en) | 2004-09-24 |
EP1325340A1 (de) | 2003-07-09 |
EP1197755A1 (de) | 2002-04-17 |
JP2004511780A (ja) | 2004-04-15 |
JP2009058517A (ja) | 2009-03-19 |
WO2002031510A1 (en) | 2002-04-18 |
AU1109902A (en) | 2002-04-22 |
CY1110101T1 (el) | 2015-01-14 |
IL155277A0 (en) | 2003-11-23 |
US7972993B2 (en) | 2011-07-05 |
US20120190564A1 (en) | 2012-07-26 |
IL155277A (en) | 2011-07-31 |
AU2002211099B2 (en) | 2007-01-11 |
US20030228605A1 (en) | 2003-12-11 |
ATE411526T1 (de) | 2008-10-15 |
ES2317941T3 (es) | 2009-05-01 |
EP1325340B1 (de) | 2008-10-15 |
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