CY1110101T1 - Ταυτοποιηση θεσεων προσδεσης πρωτεϊνων - Google Patents

Ταυτοποιηση θεσεων προσδεσης πρωτεϊνων

Info

Publication number
CY1110101T1
CY1110101T1 CY20091100021T CY091100021T CY1110101T1 CY 1110101 T1 CY1110101 T1 CY 1110101T1 CY 20091100021 T CY20091100021 T CY 20091100021T CY 091100021 T CY091100021 T CY 091100021T CY 1110101 T1 CY1110101 T1 CY 1110101T1
Authority
CY
Cyprus
Prior art keywords
nucleic acid
protein
discontinuous
identification
library
Prior art date
Application number
CY20091100021T
Other languages
English (en)
Inventor
Jelle Wouter Slootstra
Wouter Cornelis Puijk
Robert Hans Meloen
Dijk Evert Van
Dijken Pieter Van
Original Assignee
Pepscan Systems B.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pepscan Systems B.V. filed Critical Pepscan Systems B.V.
Publication of CY1110101T1 publication Critical patent/CY1110101T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B30/00—Methods of screening libraries
    • C40B30/04—Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/047—Simultaneous synthesis of different peptide species; Peptide libraries
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6845—Methods of identifying protein-protein interactions in protein mixtures

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Analytical Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Genetics & Genomics (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Information Retrieval, Db Structures And Fs Structures Therefor (AREA)

Abstract

Η εφεύρεση αφορά στον τομέα της μοριακής αναγνώρισης ή ανίχνευσης ασυνεχών ή χωροδιατακτικών θέσεων πρόσδεσης ή επίτοπων που αντιστοιχούν σε ένα προσδένον μόριο, ιδίως σε σχέση με αλληλεπιδράσεις πρωτεΐνης-πρωτεΐνης, πρωτεΐνης-νουκλεϊνικού οξέος, νουκλεϊνικού οξέος-νουκλεϊνικού οξέος ή βιομορίων-προσδέματος. Η εφεύρεση παρέχει μια συνθετική μοριακή βιβλιοθήκη η οποία επιτρέπει τη δοκιμασία για ταυτοποίηση, χαρακτηρισμό ή ανίχνευση μιας ασυνεχούς θέσεως πρόσδεσης η οποία είναι ικανή να αλληλεπιδρά με ένα προσδένον μόριο, όπου η εν λόγω βιβλιοθήκη έχει εφοδιαστεί με μια πολλαπλότητα δοκιμαστικών οντοτήτων, όπου έκαστη δοκιμαστική οντότητα περιλαμβάνει τουλάχιστον ένα πρώτο τμήμα κηλιδωμένο δίπλα σε ένα δεύτερο τμήμα, όπου έκαστο τμήμα έχει την ικανότητα να είναι ένα δυνητικό μονό μέρος μιας ασυνεχούς θέσεως πρόσδεσης.
CY20091100021T 2000-10-11 2009-01-13 Ταυτοποιηση θεσεων προσδεσης πρωτεϊνων CY1110101T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP00203518A EP1197755A1 (en) 2000-10-11 2000-10-11 Identification of protein binding sites
EP01979110A EP1325340B1 (en) 2000-10-11 2001-10-10 Identification of protein binding sites

Publications (1)

Publication Number Publication Date
CY1110101T1 true CY1110101T1 (el) 2015-01-14

Family

ID=8172123

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20091100021T CY1110101T1 (el) 2000-10-11 2009-01-13 Ταυτοποιηση θεσεων προσδεσης πρωτεϊνων

Country Status (14)

Country Link
US (2) US7972993B2 (el)
EP (2) EP1197755A1 (el)
JP (2) JP2004511780A (el)
AT (1) ATE411526T1 (el)
AU (2) AU1109902A (el)
CA (1) CA2424611C (el)
CY (1) CY1110101T1 (el)
DE (1) DE60136202D1 (el)
DK (1) DK1325340T3 (el)
ES (1) ES2317941T3 (el)
IL (2) IL155277A0 (el)
NZ (1) NZ524874A (el)
PT (1) PT1325340E (el)
WO (1) WO2002031510A1 (el)

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Also Published As

Publication number Publication date
EP1197755A1 (en) 2002-04-17
PT1325340E (pt) 2009-01-07
US20120190564A1 (en) 2012-07-26
JP2004511780A (ja) 2004-04-15
AU2002211099B2 (en) 2007-01-11
EP1325340A1 (en) 2003-07-09
WO2002031510A1 (en) 2002-04-18
US20030228605A1 (en) 2003-12-11
ES2317941T3 (es) 2009-05-01
JP2009058517A (ja) 2009-03-19
EP1325340B1 (en) 2008-10-15
CA2424611A1 (en) 2002-04-18
AU1109902A (en) 2002-04-22
JP4808756B2 (ja) 2011-11-02
US7972993B2 (en) 2011-07-05
CA2424611C (en) 2011-01-25
DE60136202D1 (de) 2008-11-27
DK1325340T3 (da) 2009-02-16
NZ524874A (en) 2004-09-24
IL155277A (en) 2011-07-31
IL155277A0 (en) 2003-11-23
ATE411526T1 (de) 2008-10-15

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