DK1303269T3 - 3-substituerede oxindolderivater og deres anvendelse som KCNQ-kaliumkanalmodulatorer - Google Patents
3-substituerede oxindolderivater og deres anvendelse som KCNQ-kaliumkanalmodulatorerInfo
- Publication number
- DK1303269T3 DK1303269T3 DK01940246T DK01940246T DK1303269T3 DK 1303269 T3 DK1303269 T3 DK 1303269T3 DK 01940246 T DK01940246 T DK 01940246T DK 01940246 T DK01940246 T DK 01940246T DK 1303269 T3 DK1303269 T3 DK 1303269T3
- Authority
- DK
- Denmark
- Prior art keywords
- potassium channel
- channel modulators
- oxindole derivatives
- kcnq potassium
- substituted oxindole
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P31/12—Antivirals
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- A61P31/18—Antivirals for RNA viruses for HIV
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DKPA200001022 | 2000-06-29 | ||
DKPA200100394 | 2001-03-08 | ||
PCT/DK2001/000412 WO2002000217A1 (fr) | 2000-06-29 | 2001-06-14 | Utilisation de derives d'oxindole 3-substitue comme modulateurs du canal potassique kcnq |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1303269T3 true DK1303269T3 (da) | 2006-03-20 |
Family
ID=26068847
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK01940246T DK1303269T3 (da) | 2000-06-29 | 2001-06-14 | 3-substituerede oxindolderivater og deres anvendelse som KCNQ-kaliumkanalmodulatorer |
Country Status (12)
Country | Link |
---|---|
US (1) | US20030181507A1 (fr) |
EP (2) | EP1634594A1 (fr) |
JP (1) | JP2004501192A (fr) |
CN (1) | CN1222288C (fr) |
AT (1) | ATE311879T1 (fr) |
AU (2) | AU2001273887B9 (fr) |
CA (1) | CA2412208C (fr) |
DE (1) | DE60115656T2 (fr) |
DK (1) | DK1303269T3 (fr) |
MX (1) | MXPA03000032A (fr) |
NZ (1) | NZ522794A (fr) |
WO (1) | WO2002000217A1 (fr) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6855829B2 (en) * | 2001-02-20 | 2005-02-15 | Bristol-Myers Squibb Company | 3-fluoro-2-oxindole modulators of KCNQ potassium channels and use thereof in treating migraine and mechanistically related disease |
AR033095A1 (es) | 2001-04-04 | 2003-12-03 | Wyeth Corp | Metodos para el tratamiento de motilidad gastrica hiperactiva |
WO2005035498A1 (fr) * | 2003-10-08 | 2005-04-21 | Dainippon Sumitomo Pharma Co., Ltd. | Utilisation d'un compose bicyclique azote comme agent de regulation alimentaire |
EP1688141A1 (fr) | 2005-01-31 | 2006-08-09 | elbion AG | Utilisation de flupirtine pour le traitement de la vessie hyperactive et des maladies associées et pour le traitement du syndrome du colon irritable |
UA92340C2 (en) * | 2005-03-03 | 2010-10-25 | Х. Луннбек А/С | Substituted pyridine derivatives |
WO2007009462A2 (fr) * | 2005-07-15 | 2007-01-25 | Region Hovedstaden V/Glostrup Hospital | Traitement de la migraine et des cephalees |
FR2941947B1 (fr) * | 2009-02-12 | 2011-03-25 | Sanofi Aventis | Derives de 3-benzofuranyl-indol-2-one subtitues en 3, leur preparation et leur application en therapeutique |
FR2941946B1 (fr) * | 2009-02-12 | 2011-03-25 | Sanofi Aventis | Derives de 3-benzofuranyl-indol-2-one-3-acetamidopiperazines substitues, leur preparation et leur application en therapeutique |
WO2010105189A1 (fr) * | 2009-03-12 | 2010-09-16 | The Johns Hopkins University | Procédé d'identification de composés atténuant la fonction ou réduisant l'abondance d'un canal potassique sensible au potentiel et étant associés au maintien de la fonction cognitive lors de la vieillesse |
DK2437744T3 (en) | 2009-06-03 | 2015-07-27 | Univ Marquette | The modulation of the KCNQ potassium channel activity for the treatment of psychiatric disorders and symptoms thereof |
NZ628871A (en) * | 2010-10-20 | 2015-07-31 | Gruenenthal Chemie | Substituted 6-amino-nicotinamides as kcnq2/3 modulators |
BR112016026596A2 (pt) * | 2014-06-26 | 2017-08-15 | Hoffmann La Roche | Derivados de indolin-2-ona ou pirrolo-piridin-2-ona, seu uso, composição farmacêutica e combinação |
GB201502412D0 (en) * | 2015-02-13 | 2015-04-01 | Canbex Therapeutics Ltd | Therapeutic use |
EP3371168B1 (fr) | 2015-11-06 | 2020-05-27 | H. Hoffnabb-La Roche Ag | Dérivés d'indoline-2-one |
CN108349942B (zh) | 2015-11-06 | 2021-03-30 | 豪夫迈·罗氏有限公司 | 用于治疗cns和相关疾病的二氢吲哚-2-酮衍生物 |
WO2017076842A1 (fr) | 2015-11-06 | 2017-05-11 | F. Hoffmann-La Roche Ag | Dérivés d'indolin-2-one |
EP3371170B1 (fr) | 2015-11-06 | 2019-07-31 | H. Hoffnabb-La Roche Ag | Dérivés d'indoline-2-one utiles dans le traitement de maladies du système nerveux central |
US10774064B2 (en) | 2016-06-02 | 2020-09-15 | Cadent Therapeutics, Inc. | Potassium channel modulators |
EP3571193B1 (fr) | 2017-01-23 | 2021-12-01 | Cadent Therapeutics, Inc. | Modulateurs de canaux potassiques |
US20180207138A1 (en) * | 2017-01-23 | 2018-07-26 | Cadent Therapeutics, Inc. | Methods for the treatment of tremors by positive modulation of sk channels |
JP2020508328A (ja) * | 2017-02-24 | 2020-03-19 | オービッド・セラピューティクス・インコーポレイテッドOvid Therapeutics Inc. | 発作性障害の治療方法 |
EP3912625A1 (fr) | 2020-05-20 | 2021-11-24 | Kaerus Bioscience Limited | Nouveaux ouvreurs de canaux potassiques maxi-k pour le traitement de troubles liés à l'x fragile |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5736578A (en) * | 1995-06-06 | 1998-04-07 | Bristol-Myers Squibb Company | Ethylamido fluorenes and improved method of making same |
US5565483A (en) * | 1995-06-07 | 1996-10-15 | Bristol-Myers Squibb Company | 3-substituted oxindole derivatives as potassium channel modulators |
TW457233B (en) * | 1996-10-11 | 2001-10-01 | Bristol Myers Squibb Co | Preparation of 3-fluoro oxindole derivatives |
DK1147134T3 (da) * | 1999-01-26 | 2007-02-05 | Neurosearch As | Hidtil ukendte kaliumkanaler og gener, der koder for disse kaliumkanaler |
NZ516743A (en) * | 1999-08-04 | 2004-02-27 | Icagen Inc | Methods for treating or preventing pain and anxiety |
-
2001
- 2001-06-14 EP EP05111686A patent/EP1634594A1/fr not_active Withdrawn
- 2001-06-14 DK DK01940246T patent/DK1303269T3/da active
- 2001-06-14 NZ NZ522794A patent/NZ522794A/en unknown
- 2001-06-14 AT AT01940246T patent/ATE311879T1/de not_active IP Right Cessation
- 2001-06-14 WO PCT/DK2001/000412 patent/WO2002000217A1/fr active IP Right Grant
- 2001-06-14 AU AU2001273887A patent/AU2001273887B9/en not_active Ceased
- 2001-06-14 DE DE60115656T patent/DE60115656T2/de not_active Expired - Lifetime
- 2001-06-14 CA CA002412208A patent/CA2412208C/fr not_active Expired - Fee Related
- 2001-06-14 JP JP2002504999A patent/JP2004501192A/ja not_active Withdrawn
- 2001-06-14 US US10/312,123 patent/US20030181507A1/en not_active Abandoned
- 2001-06-14 AU AU7388701A patent/AU7388701A/xx active Pending
- 2001-06-14 EP EP01940246A patent/EP1303269B1/fr not_active Expired - Lifetime
- 2001-06-14 MX MXPA03000032A patent/MXPA03000032A/es active IP Right Grant
- 2001-06-14 CN CNB018119476A patent/CN1222288C/zh not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CA2412208C (fr) | 2009-08-18 |
DE60115656D1 (de) | 2006-01-12 |
AU7388701A (en) | 2002-01-08 |
EP1303269A1 (fr) | 2003-04-23 |
AU2001273887B9 (en) | 2006-02-02 |
MXPA03000032A (es) | 2003-08-19 |
EP1303269B1 (fr) | 2005-12-07 |
DE60115656T2 (de) | 2006-06-14 |
NZ522794A (en) | 2005-04-29 |
ATE311879T1 (de) | 2005-12-15 |
CA2412208A1 (fr) | 2002-01-03 |
EP1634594A1 (fr) | 2006-03-15 |
CN1222288C (zh) | 2005-10-12 |
AU2001273887B2 (en) | 2005-12-15 |
JP2004501192A (ja) | 2004-01-15 |
WO2002000217A1 (fr) | 2002-01-03 |
CN1438885A (zh) | 2003-08-27 |
US20030181507A1 (en) | 2003-09-25 |
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