DK1301539T3 - Antigenbindende fragmenter, der er specifikke for dendristiske celler, sammensætninger og fremgangsmåder til anvendelse deraf, antigener, der genkendes deraf, og celler opnået derved - Google Patents

Antigenbindende fragmenter, der er specifikke for dendristiske celler, sammensætninger og fremgangsmåder til anvendelse deraf, antigener, der genkendes deraf, og celler opnået derved

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Publication number
DK1301539T3
DK1301539T3 DK00979855T DK00979855T DK1301539T3 DK 1301539 T3 DK1301539 T3 DK 1301539T3 DK 00979855 T DK00979855 T DK 00979855T DK 00979855 T DK00979855 T DK 00979855T DK 1301539 T3 DK1301539 T3 DK 1301539T3
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Prior art keywords
cells
dendristic
compositions
methods
antigen binding
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DK00979855T
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Danish (da)
English (en)
Inventor
Andrzej Dzionek
David William Buck
Juergen Schmitz
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Miltenyi Biotec Gmbh
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Application filed by Miltenyi Biotec Gmbh filed Critical Miltenyi Biotec Gmbh
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Publication of DK1301539T3 publication Critical patent/DK1301539T3/da

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DK00979855T 1999-11-15 2000-11-15 Antigenbindende fragmenter, der er specifikke for dendristiske celler, sammensætninger og fremgangsmåder til anvendelse deraf, antigener, der genkendes deraf, og celler opnået derved DK1301539T3 (da)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US16555599P 1999-11-15 1999-11-15
US16707699P 1999-11-23 1999-11-23
US17900300P 2000-01-28 2000-01-28
US18077500P 2000-02-07 2000-02-07
US19682400P 2000-04-11 2000-04-11
US19720500P 2000-04-13 2000-04-13
PCT/IB2000/001832 WO2001036487A2 (en) 1999-11-15 2000-11-15 Antigen-binding fragments specific for dendritic cells, compositions and methods of use thereof antigens recognized thereby and cells obtained thereby

Publications (1)

Publication Number Publication Date
DK1301539T3 true DK1301539T3 (da) 2007-05-21

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ID=27558547

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Application Number Title Priority Date Filing Date
DK00979855T DK1301539T3 (da) 1999-11-15 2000-11-15 Antigenbindende fragmenter, der er specifikke for dendristiske celler, sammensætninger og fremgangsmåder til anvendelse deraf, antigener, der genkendes deraf, og celler opnået derved

Country Status (11)

Country Link
EP (3) EP1301539B1 (https=)
JP (4) JP5007007B2 (https=)
KR (1) KR100868235B1 (https=)
CN (1) CN1454215B (https=)
AU (1) AU785198B2 (https=)
CA (2) CA2396428C (https=)
DE (1) DE60033062T2 (https=)
DK (1) DK1301539T3 (https=)
ES (1) ES2280264T3 (https=)
PT (1) PT1301539E (https=)
WO (1) WO2001036487A2 (https=)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU785198B2 (en) * 1999-11-15 2006-11-02 Miltenyi Biotec B.V. & Co. KG Antigen-binding fragments specific for dendritic cells, compositions and methods of use thereof antigens recognised thereby and cells obtained thereby
EP1351985A2 (en) * 2000-10-16 2003-10-15 Bayer Aktiengesellschaft Polynucleotide and polypeptide sequences of human dendritic cell immunoreceptors
AU2002245593A1 (en) * 2001-03-12 2002-09-24 Lexicon Genetics Incorporated Novel human dectin proteins and polynucleotides encoding the same
EP1395826A4 (en) * 2001-05-17 2005-11-09 Miltenyi Biotec Gmbh ANTIGEN-BINDING FRAGMENTS FOR A SUB-GROUP OF DENDRITIC CELLS AND USE THEREOF
KR100522526B1 (ko) * 2002-11-28 2005-10-19 주식회사 바이넥스 면역 치료용 수지상 세포의 제조방법
BRPI0516470A (pt) * 2004-10-07 2008-09-09 Universitot Zuerich uso de um agente de bloqueio do interferon tipo i, e, método de prevenção e tratamento da psorìase
WO2006086586A2 (en) 2005-02-10 2006-08-17 Baylor Research Institute Anti-interferon alpha monoclonal antibodies and methods for use
MX2010012052A (es) 2008-05-07 2010-12-14 Novo Nordisk As Anticuerpos humanizados contra interferon-alfa humano.
NZ601733A (en) * 2009-01-06 2013-05-31 Functional Genetics Inc Antibody with binding specificity for Robo1 protein for inhibiting the infectivity of HIV
FR2968561B1 (fr) 2010-12-13 2013-08-09 Lfb Biotechnologies Utilisation d'un anticorps dirige contre une proteine membranaire
WO2014047124A1 (en) * 2012-09-18 2014-03-27 University Of Washington Through Its Center For Commercialization Compositions and methods for delivery of antigens to plasmacytoid dendritic cells
CN111961134B (zh) * 2012-12-10 2024-04-05 比奥根Ma公司 抗血液树突细胞抗原2抗体及其用途
AU2014365838B2 (en) * 2013-12-16 2021-01-14 The University Of North Carolina At Chapel Hill Depletion of plasmacytoid dendritic cells
US10294301B2 (en) * 2013-12-24 2019-05-21 Astellas Pharma Inc. Anti-human BDCA-2 antibody
CN106659774A (zh) * 2014-05-16 2017-05-10 贝勒研究院 用于治疗自身免疫和炎性病症的方法和组合物
ES2946697T3 (es) 2014-09-10 2023-07-24 Miltenyi Biotec Bv & Co Kg Una población celular para su uso en el tratamiento de cáncer
CN107108743B (zh) 2014-12-03 2021-05-04 (株)爱恩德生物 结合神经毡蛋白1的抗体及其用途
FR3034420A1 (fr) * 2015-03-31 2016-10-07 Lab Francais Du Fractionnement Anticorps monoclonaux anti-cd303
FR3045386B1 (fr) * 2015-12-16 2018-02-02 Laboratoire Francais Du Fractionnement Et Des Biotechnologies Nouvelle utilisation d'un anticorps dirige contre une proteine membranaire
ES2883678T3 (es) * 2016-10-21 2021-12-09 Inst Nat Sante Rech Med Métodos para promover la respuesta de linfocitos T
FR3060395B1 (fr) * 2016-12-16 2019-05-24 Laboratoire Francais Du Fractionnement Et Des Biotechnologies Combinaison d'anticorps anti-cd303 et anti-her2
FR3060394B1 (fr) * 2016-12-16 2019-05-24 Laboratoire Francais Du Fractionnement Et Des Biotechnologies Combinaison d'anticorps anti-cd303 et anti-amhrii
JP7158642B2 (ja) * 2018-01-16 2022-10-24 国立大学法人山梨大学 質量分析装置及び質量分析システム
WO2020227595A1 (en) * 2019-05-09 2020-11-12 Atara Biotherapeutics, Inc. Clec4-targeted car-t-cells
CA3203971A1 (en) * 2020-12-03 2022-06-09 Biogen Ma Inc. Methods of treating cutaneous lupus erythematosus and systemic lupus erythematosus
CN114264825B (zh) * 2021-12-22 2023-08-15 重庆医科大学附属儿童医院 一种b淋巴细胞发育亚群免疫分型的方法和试剂盒

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0760102A1 (en) * 1995-03-15 1997-03-05 Miltenyi Biotech, Inc. Isolation of hematopoietic dendritic cells by high gradient magnetic cell sorting
US5871728A (en) * 1995-03-31 1999-02-16 University Of Pittsburgh Method of regulating dendritic cell maturation
US5788963A (en) * 1995-07-31 1998-08-04 Pacific Northwest Cancer Foundation Isolation and/or preservation of dendritic cells for prostate cancer immunotherapy
US6046158A (en) * 1996-12-20 2000-04-04 Board Of Regents The University Of Texas Systems Unique dendritic cell-associated C-type lectins, dectin-1 and dectin-2; compositions and uses thereof
AR014891A1 (es) * 1997-07-09 2001-04-11 Schering Corp Genes aislados de proteinas de membranas de mamiferos; reactivos relacionados
FI973762A0 (fi) * 1997-09-23 1997-09-23 Krohn Kai Ny gen
CA2307014A1 (en) * 1997-10-28 1999-05-06 Immunex Corporation Viral encoded semaphorin protein receptor dna and polypeptides
JP2002506645A (ja) * 1998-03-17 2002-03-05 シェーリング コーポレイション 単離された哺乳動物膜タンパク質遺伝子および関連試薬
AU785198B2 (en) * 1999-11-15 2006-11-02 Miltenyi Biotec B.V. & Co. KG Antigen-binding fragments specific for dendritic cells, compositions and methods of use thereof antigens recognised thereby and cells obtained thereby

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CA2664137A1 (en) 2009-07-16
CA2396428C (en) 2014-03-11
DE60033062T2 (de) 2007-08-23
JP2011092210A (ja) 2011-05-12
WO2001036487A2 (en) 2001-05-25
JP5355602B2 (ja) 2013-11-27
JP5007007B2 (ja) 2012-08-22
ES2280264T3 (es) 2007-09-16
KR20030032904A (ko) 2003-04-26
JP2012152215A (ja) 2012-08-16
WO2001036487A3 (en) 2002-05-10
EP1301539B1 (en) 2007-01-17
JP5599834B2 (ja) 2014-10-01
JP2008148700A (ja) 2008-07-03
CN1454215B (zh) 2013-01-02
JP2004512006A (ja) 2004-04-22
CA2396428A1 (en) 2001-05-25
EP1813626A1 (en) 2007-08-01
DE60033062D1 (de) 2007-03-08
PT1301539E (pt) 2007-04-30
CN1454215A (zh) 2003-11-05
AU1723301A (en) 2001-05-30
KR100868235B1 (ko) 2008-11-12
EP1301539A2 (en) 2003-04-16
CA2664137C (en) 2012-09-25
AU785198B2 (en) 2006-11-02
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