DK125421B - Analogifremgangsmåde til fremstilling af 5-substituerede-aza-dibenzo-cycloheptener eller syreadditionssalte deraf. - Google Patents

Analogifremgangsmåde til fremstilling af 5-substituerede-aza-dibenzo-cycloheptener eller syreadditionssalte deraf.

Info

Publication number
DK125421B
DK125421B DK205164AA DK205164A DK125421B DK 125421 B DK125421 B DK 125421B DK 205164A A DK205164A A DK 205164AA DK 205164 A DK205164 A DK 205164A DK 125421 B DK125421 B DK 125421B
Authority
DK
Denmark
Prior art keywords
cycloheptenes
dibenzo
aza
substituted
preparation
Prior art date
Application number
DK205164AA
Other languages
English (en)
Inventor
F Villani
Original Assignee
Scherico Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scherico Ltd filed Critical Scherico Ltd
Publication of DK125421B publication Critical patent/DK125421B/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/06—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
    • C07D213/16—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom containing only one pyridine ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
    • C07D213/46—Oxygen atoms
    • C07D213/50—Ketonic radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
    • C07D213/53—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/57—Nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/84—Nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/16—Ring systems of three rings containing carbocyclic rings other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
DK205164AA 1963-04-24 1964-04-23 Analogifremgangsmåde til fremstilling af 5-substituerede-aza-dibenzo-cycloheptener eller syreadditionssalte deraf. DK125421B (da)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US27523763A 1963-04-24 1963-04-24
US330263A US3326924A (en) 1963-04-24 1963-12-13 Novel aza-dibenzo[a, d]-cycloheptene derivatives
US330244A US3366635A (en) 1963-04-24 1963-12-13 Aza-5h-dibenzo-[a,d]-(cycloheptenes and cycloheptene-5-ones) and the corresponding 10, 11-dihydro derivatives thereof
US42010164A 1964-12-21 1964-12-21
US580169A US3357986A (en) 1963-04-24 1966-09-19 1, 2, 3 or 4, aza,-[5-piperdyl or hydrocarbyl amino]-10, 11 dihydro-5h-dibenzo-[a, d]-cycloheptene

Publications (1)

Publication Number Publication Date
DK125421B true DK125421B (da) 1973-02-19

Family

ID=27540590

Family Applications (2)

Application Number Title Priority Date Filing Date
DK205164AA DK125421B (da) 1963-04-24 1964-04-23 Analogifremgangsmåde til fremstilling af 5-substituerede-aza-dibenzo-cycloheptener eller syreadditionssalte deraf.
DK482469AA DK125133B (da) 1963-04-24 1969-09-09 Aza-dibenzo-[a,d]-cyclohepten-derivater til anvendelse som mellemprodukter ved fremstilling af terapeutisk virksomme 5-substituerede aza-dibenzo-cycloheptener.

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK482469AA DK125133B (da) 1963-04-24 1969-09-09 Aza-dibenzo-[a,d]-cyclohepten-derivater til anvendelse som mellemprodukter ved fremstilling af terapeutisk virksomme 5-substituerede aza-dibenzo-cycloheptener.

Country Status (17)

Country Link
US (3) US3366635A (da)
JP (3) JPS4840356B1 (da)
BE (1) BE647043A (da)
BR (1) BR6458580D0 (da)
CH (2) CH535769A (da)
CY (1) CY543A (da)
DE (2) DE1795744A1 (da)
DK (2) DK125421B (da)
FI (1) FI52220C (da)
FR (1) FR4013M (da)
GB (1) GB1065191A (da)
IL (1) IL21208A (da)
IT (2) IT1149233B (da)
MY (1) MY7000130A (da)
NL (2) NL6404490A (da)
NO (3) NO120935B (da)
SE (4) SE379765B (da)

Families Citing this family (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3378567A (en) * 1965-12-20 1968-04-16 Schering Corp 5-diloweralkylaminoalkoxy ethers of 4-aza-10, 11-dihydro-5h-dibenzo[a, d]-cycloheptene derivatives
US3409621A (en) * 1966-04-01 1968-11-05 Schering Corp Piperazino-aza-dibenzo-[a, d]-cycloheptenes
US3458522A (en) * 1967-05-17 1969-07-29 Sandoz Ag 4-piperidine substituted benzocycloheptaoxazoles and benzocycloheptathiazoles
US3458524A (en) * 1968-03-27 1969-07-29 Schering Corp Novel 5-alkylaminoalkoximino-aza-dibenzo-(a,d)-cycloheptenes
DE2640022A1 (de) * 1975-09-15 1977-03-24 Sandoz Ag Neue organische verbindungen, ihre herstellung und verwendung
US4092322A (en) * 1977-02-14 1978-05-30 Warner-Lambert Company 1-Benzoxepino[4,3-c]pyridines
US4282233B1 (en) * 1980-06-19 2000-09-05 Schering Corp Antihistaminic 11-(4-piperidylidene)-5h-benzoÄ5,6Ü-cyclohepta-Ä1,2Ü-pyridines
US4355036A (en) * 1980-06-19 1982-10-19 Schering Corporation Tricyclic-substituted piperidine antihistamines
US4454143A (en) * 1981-03-16 1984-06-12 Schering Corporation Tricyclic antihistamines
JPS61501205A (ja) * 1984-02-15 1986-06-19 シェリング・コ−ポレ−ション ８↓−クロル↓−６，１１↓−ジヒドロ↓−１１↓−（４↓−ピペリジリデン）↓−５Ｈ↓−ベンゾ〔５，６〕シクロヘプタ〔１，２−ｂ〕ピリジンおよびその塩、これらの化合物の製造方法、ならびにこれらの化合物を含有する医薬組成物
US4834980A (en) * 1984-07-23 1989-05-30 Schering Corporation Transdermal delivery of azatidine
US4731447A (en) * 1985-05-13 1988-03-15 Schering Corporation Process for preparing piperidylidene dihydro-dibenzo(a,d)-cycloheptenes or aza-derivatives thereof
EP0208855B1 (en) * 1985-05-13 1991-03-06 Schering Corporation process for preparing piperidylidene dihydrodibenzo(a,d)cycloheptenes and aza derivatives thereof, compounds obtained by such process and the use of such compounds for preparing useful pharmaceutical compositions
US4804666A (en) * 1985-08-14 1989-02-14 Schering Corporation Antiallergic 6,11-dihydro-11-(4-piperidylidene)-5H-benzo(5,6)cyclohepta(1,2-B)pyridines
US4639457A (en) * 1985-08-19 1987-01-27 Merck & Co., Inc. Benzocycloheptapyridone compounds for treating congestive heart failure
US4873335A (en) * 1986-03-12 1989-10-10 Schering Corporation 3-phenethyl-2-benzene-amides or aza-derivatives thereof
US5011860A (en) * 1986-04-11 1991-04-30 Schering Corporation Aryl-substituted naphthyridine and pyridopyrazine derivatives and their use in treating hyperproliferative skin diseases
US5438062A (en) * 1986-10-31 1995-08-01 Schering Corporation Benzo(5,6)cycloheptapyridines, compositions and methods of use
US5665726A (en) * 1986-10-31 1997-09-09 Schering Corporation Benzo[5,6]cycloheptapyridines, compositions and methods of use
US4826853A (en) * 1986-10-31 1989-05-02 Schering Corporation 6,11-Dihydro-11-(N-substituted-4-piperidylidene)-5H-benzo(5,6)cyclohepta(1,2-B)pyridines and compositions and methods of use
US5089496A (en) * 1986-10-31 1992-02-18 Schering Corporation Benzo[5,6]cycloheptapyridine compounds, compositions and method of treating allergies
US4843163A (en) * 1987-12-02 1989-06-27 Smithkline Beckman Corporation Certain 3-(2-phenethyl)-1-carbamoyloxypyridinium halide intermediates
JP2766266B2 (ja) * 1988-06-20 1998-06-18 協和醗酵工業株式会社 ピリジン誘導体およびその中間体
US4863931A (en) * 1988-09-15 1989-09-05 Schering Corporation Antihistaminic fluoro substituted benzocycloheptapyridines
US4996321A (en) * 1990-02-26 1991-02-26 Merck & Co., Inc. Dibenzo[a,d]cycloheptenylidene compounds
IE68935B1 (en) * 1990-06-22 1996-07-24 Schering Corp Bis-benzo or benzopyrido cyclohepta piperidene piperidylidene and piperazine compounds compositions and methods of use
AU8854091A (en) * 1990-10-10 1992-05-20 Schering Corporation Bis-benzo cyclohepta piperidylidene, piperidine and piperazine compounds, compositions and methods of use
JPH06508129A (ja) * 1991-05-23 1994-09-14 シェリング・コーポレーション 新規のベンゾピリドピペリジリデン化合物、組成物、製造法および使用法
WO1993002081A1 (en) * 1991-07-23 1993-02-04 Schering Corporation Novel benzopyrido piperylidene compounds, compositions, methods of manufacture and methods of use
ES2040177B1 (es) * 1992-03-06 1994-05-16 S A Tamarang Procedimiento para la sintesis de la 8-cloro-6, 11-dihidro-11, (1-etoxicarbonil-4-piperidiliden) -5h-benzo (5,6) ciclohepta-(1,2-b) piridina.
HUT71132A (en) * 1992-03-27 1995-11-28 Schering Corp Bis-aryl-carbinol derivatives, pharmaceutical compositions containing them and process for producing
ATE140224T1 (de) * 1992-03-27 1996-07-15 Schering Corp Unverbrückte bis-aryl-carbinol-derivate, zusammensetzungen und ihre verwendung
WO1993023400A1 (en) * 1992-05-19 1993-11-25 Schering Corporation Pentacyclic antihistamines
US5464840A (en) * 1993-12-06 1995-11-07 Schering Corporation Tricyclic derivatives, compositions and methods of use
US7211582B1 (en) * 1994-12-30 2007-05-01 Sepracor Inc. Methods for treating urticaria using descarboethoxyloratadine
US5801175A (en) 1995-04-07 1998-09-01 Schering Corporation Tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
ATE244219T1 (de) * 1996-04-25 2003-07-15 Nissan Chemical Ind Ltd Ethylenderivate und pestizide
US6509346B2 (en) * 1998-01-21 2003-01-21 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
WO2000005215A1 (en) * 1998-07-24 2000-02-03 Russinsky Limited A process for preparing benzocycloheptapyridin-11-ones
US6267986B1 (en) 1999-09-24 2001-07-31 Ranbaxy Laboratories Limited Process for the preparation of a controlled drug delivery system containing pseudoephedrine and a long acting antihistamine
US7541365B2 (en) 2001-11-21 2009-06-02 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
WO2003084931A1 (en) * 2002-04-02 2003-10-16 Merck & Co., Inc. 5h-benzo[4,5]cyclohepta[1,2-b]pyridine nmda/nr2b antagonists
ES2393864T3 (es) 2002-08-30 2012-12-28 Nycomed Gmbh El uso de la asociación de ciclesonida y antihistaminas para el tratamiento de rinitis alérgica
TWI291467B (en) 2002-11-13 2007-12-21 Millennium Pharm Inc CCR1 antagonists and methods of use therefor
US20040242619A1 (en) * 2003-03-12 2004-12-02 Toth Zoltan G. Processes for preparation of polymorphic forms of desloratadine
NL1026634C2 (nl) * 2004-07-12 2006-01-16 Willem Jacob Van Der Burg Psychofarmaceutisch preparaat en werkzame stof daarin.
JP4119478B1 (ja) 2005-06-23 2008-07-16 メルク エンド カムパニー インコーポレーテッド チロシンキナーゼインヒビター
US20070036859A1 (en) * 2005-08-11 2007-02-15 Perry Ronald L Sustained release antihistamine and decongestant composition
CA2624656A1 (en) * 2005-10-21 2007-05-03 Merck & Co., Inc. Tyrosine kinase inhibitors
EP2034970B1 (en) 2006-06-01 2012-08-01 MSD Consumer Care, Inc. Sustained release pharmaceutical formulation comprising phenylephrine
NZ573174A (en) 2006-06-01 2012-01-12 Msd Consumer Care Inc Sustained release pharmaceutical dosage form containing phenylephrine
TW200813021A (en) * 2006-07-10 2008-03-16 Merck & Co Inc Tyrosine kinase inhibitors
US20090082385A1 (en) * 2007-09-26 2009-03-26 Protia, Llc Deuterium-enriched desloratidine
BRPI0821647A2 (pt) * 2007-12-21 2015-06-16 Schering Plough Healthcare Realce da fotosestabillização de oximetazolina
CN102993172B (zh) * 2012-12-19 2014-04-02 天津大学 具有抗组胺活性的三环类化合物、制备方法及用途
GB202103803D0 (en) 2021-03-18 2021-05-05 Queens Univ Of Belfast Anti-viral therapy
CN112898268A (zh) * 2021-04-07 2021-06-04 深圳振强生物技术有限公司 一种地氯雷他定杂质的制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB858187A (en) * 1958-04-03 1961-01-11 Hoffmann La Roche Novel dibenzocycloheptaenes and salts thereof and a process for the manufacture of same
GB858186A (en) * 1958-04-03 1961-01-11 Hoffmann La Roche Novel dibenzoheptaenes and salts thereof and a process for the manufacture of same
US3014911A (en) * 1958-09-29 1961-12-26 Merck & Co Inc Derivatives of dibenzo[a, e]cycloheptatriene
US3073847A (en) * 1959-02-12 1963-01-15 Hoffmann La Roche 9-(3-amino-1-propynyl) derivatives of 9-xanthenols and 9-thioxanthenols and a process for their preparation
DE1160442B (de) * 1959-03-18 1964-01-02 Degussa Verfahren zur Herstellung von 3-Trifluormethylphenthiazinen
US3086972A (en) * 1960-03-24 1963-04-23 Sandoz Ag Aza-thiaxanthene derivatives
US3127409A (en) * 1962-08-08 1964-03-31 Olin Mathieson Novel dihydropyridobenzoxazepines and dihydropyridobenzthiazepines

Also Published As

Publication number Publication date
NO121949B (da) 1971-05-03
DE1795745B2 (de) 1976-04-08
IL21208A (en) 1968-10-24
US3326924A (en) 1967-06-20
NL132137C (da)
US3357986A (en) 1967-12-12
DK125133B (da) 1973-01-02
NO120935B (da) 1970-12-28
FR4013M (da) 1966-03-21
CY543A (en) 1970-06-26
NO120938B (da) 1970-12-28
JPS4840356B1 (da) 1973-11-30
NL6404490A (da) 1964-10-26
DE1695853B2 (de) 1976-06-16
IT1123902B (it) 1986-04-30
MY7000130A (en) 1970-12-31
DE1695853A1 (de) 1972-03-02
SE349030B (da) 1972-09-18
SE338317B (da) 1971-09-06
DE1795744A1 (de) 1974-11-21
CH544091A (de) 1973-12-28
JPS5030077B1 (da) 1975-09-29
FI52220B (da) 1977-03-31
SE379765B (da) 1975-10-20
SE347745B (da) 1972-08-14
DE1795745A1 (de) 1974-08-29
IT1149233B (it) 1986-12-03
BE647043A (da) 1964-10-26
FI52220C (fi) 1977-07-11
BR6458580D0 (pt) 1973-09-11
US3366635A (en) 1968-01-30
GB1065191A (en) 1967-04-12
JPS5030078B1 (da) 1975-09-29
CH535769A (de) 1973-04-15

Similar Documents

Publication Publication Date Title
DK125421B (da) Analogifremgangsmåde til fremstilling af 5-substituerede-aza-dibenzo-cycloheptener eller syreadditionssalte deraf.
DK108972C (da) Fremgangsmåde til fremstilling af lipoylpyridoxamin eller syreadditionssalte deraf.
DK108495C (da) Fremgangsmåde til fremstilling af substituerede 6,7-benzomorphaner eller syreadditionssalte deraf.
DK108169C (da) Fremgangsmåde til fremstilling af 3-hydroxy-5-aminomethyl-isoxasol eller syreadditionssalte deraf.
DK120493B (da) Analogifremgangsmåde til fremstilling af amino-halogen-benzylaminer eller syreadditionssalte heraf.
DK125701B (da) Analogifremgangsmåde til fremstilling af N-monosubstituerede 1-aminoindaner eller syreadditionssalte deraf.
DK111894B (da) Fremgangsmåde til fremstilling af diphenylalkylaminer eller syreadditionssalte deraf.
DK103831C (da) Fremgangsmåde til fremstilling af 4-azathioxanthenderivater eller syreadditionssalte deraf.
DK106335C (da) Fremgangsmåde til fremstilling af derivater af 16-hydroxymethylenyohimbanforbindelser eller syreadditionssalte deraf.
DK108394C (da) Fremgangsmåde til fremstilling af substituerede imidazo- eller pyrimido-quinazoliner eller syreadditionssalte deraf.
DK112029B (da) Fremgangsmåde til fremstilling af basiske ethano-anthracenderivater eller syreadditionssalte deraf.
DK108973C (da) Fremgangsmåde til fremstilling af kinolinforbindelser eller syreadditionssaltene deraf.
DK121604B (da) Fremgangsmåde til fremstilling af substituerede iminocycloheptatrienderivater eller syreadditionssalte heraf.
DK108494C (da) Fremgangsmåde til fremstilling af basiske ketoner eller syreadditionssalte deraf.
DK105649C (da) Fremgangsmåde til fremstilling af 2-dimethylaminopyrazin eller syreadditionssalte deraf.
DK111893B (da) Fremgangsmåde til fremstilling af substituerede methylhydraziner eller syreadditionssalte deraf.
DK107098C (da) Fremgangsmåde til fremstilling af 5-hydrazino-pyrazol-derivater eller syreadditionssalte deraf.
DK122227B (da) Fremgangsmåde til fremstilling af 3-sulfamyl-4-halogen-benzamider eller syreadditionssalte heref.
DK112171B (da) Fremgangsmåde til fremstilling af benzimidazoler eller syreadditionssalte deraf.
DK135037B (da) Analogifremgangsmåde til fremstilling af amino-halogen-benzylaminer eller syreadditionssalte heraf.
DK119309B (da) Analogifremgangsmåde til fremstilling af phenylcyclohexylalkylaminer eller syreadditionssalte deraf.
DK123863B (da) Analogifremgangsmåde til fremstilling af N-monophenylethylneomycin B eller syreadditionssalte heraf.
DK112530B (da) Fremgangsmåde til fremstilling af α-phenyl-β-tetrahydofuryl-2-propionitriler eller syreadditionssalte heraf.
DK118241B (da) Fremgangsmåde til fremstilling af 2-amino-oxazoliner eller syreadditionssalte heraf.
DK105764C (da) Fremgangsmåde til fremstilling af 1-azathioxanthenderivater eller syreadditionssalte deraf.