DK1242118T3 - Fremgangsmåder til behandling af iskæmisk eller hæmorrhagisk beskadigelse af centralnervesystemet under anvendelse af anti-alfa4-integrin-antagonister - Google Patents
Fremgangsmåder til behandling af iskæmisk eller hæmorrhagisk beskadigelse af centralnervesystemet under anvendelse af anti-alfa4-integrin-antagonisterInfo
- Publication number
- DK1242118T3 DK1242118T3 DK00984395T DK00984395T DK1242118T3 DK 1242118 T3 DK1242118 T3 DK 1242118T3 DK 00984395 T DK00984395 T DK 00984395T DK 00984395 T DK00984395 T DK 00984395T DK 1242118 T3 DK1242118 T3 DK 1242118T3
- Authority
- DK
- Denmark
- Prior art keywords
- methods
- nervous system
- central nervous
- integrin antagonists
- treating ischemic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
- C07K16/2842—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily against integrin beta1-subunit-containing molecules, e.g. CD29, CD49
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Cardiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Rheumatology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Dermatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US17126599P | 1999-12-16 | 1999-12-16 | |
PCT/US2000/033942 WO2001043774A1 (en) | 1999-12-16 | 2000-12-14 | Methods of treating central nervous system ischemic or hemorrhagic injury using anti alpha4 integrin antagonists |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1242118T3 true DK1242118T3 (da) | 2010-01-11 |
Family
ID=22623149
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK00984395T DK1242118T3 (da) | 1999-12-16 | 2000-12-14 | Fremgangsmåder til behandling af iskæmisk eller hæmorrhagisk beskadigelse af centralnervesystemet under anvendelse af anti-alfa4-integrin-antagonister |
DK09012818.2T DK2140881T3 (da) | 1999-12-16 | 2000-12-14 | Fremgangsmåder til behandling af iskæmisk eller hæmoragisk læsion i centralnervesystemet ved anvendelse af anti-alpha-4-integrin-antagonister |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK09012818.2T DK2140881T3 (da) | 1999-12-16 | 2000-12-14 | Fremgangsmåder til behandling af iskæmisk eller hæmoragisk læsion i centralnervesystemet ved anvendelse af anti-alpha-4-integrin-antagonister |
Country Status (11)
Country | Link |
---|---|
US (1) | US20020197233A1 (de) |
EP (3) | EP2140881B1 (de) |
JP (3) | JP2003517023A (de) |
AT (1) | ATE447969T1 (de) |
AU (1) | AU783110B2 (de) |
CA (1) | CA2394431C (de) |
DE (1) | DE60043308D1 (de) |
DK (2) | DK1242118T3 (de) |
ES (2) | ES2335643T3 (de) |
NZ (1) | NZ519447A (de) |
WO (1) | WO2001043774A1 (de) |
Families Citing this family (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2106864C1 (ru) * | 1995-10-23 | 1998-03-20 | Николай Серафимович Зефиров | Средство для лечения болезни альцгеймера |
CA2384948C (en) * | 1999-09-14 | 2013-07-16 | Biogen, Inc. | Therapies for chronic renal failure using one or more integrin antagonists |
US6960597B2 (en) * | 2000-06-30 | 2005-11-01 | Orth-Mcneil Pharmaceutical, Inc. | Aza-bridged-bicyclic amino acid derivatives as α4 integrin antagonists |
FR2827174B1 (fr) * | 2001-07-13 | 2004-08-06 | Soc Extraction Principes Actif | Utilisation de peptides pour augmenter l'adhesion cellulaire |
MXPA05007843A (es) | 2003-01-24 | 2005-10-18 | Elan Pharm Inc | Composicion y tratamiento de enfermedades desmielinizantes y paralisis por administracion de agentes de remielinizantes. |
US20050037947A1 (en) * | 2003-05-06 | 2005-02-17 | Bitonti Alan J. | Inhibition of drug binding to serum albumin |
US20050176755A1 (en) * | 2003-10-31 | 2005-08-11 | Dyatkin Alexey B. | Aza-bridged-bicyclic amino acid derivatives as alpha4 integrin antagonists |
RU2283108C2 (ru) * | 2003-12-08 | 2006-09-10 | Сергей Олегович Бачурин | ГЕРОПРОТЕКТОР НА ОСНОВЕ ГИДРИРОВАННЫХ ПИРИДО(4,3-b) ИНДОЛОВ (ВАРИАНТЫ), ФАРМАКОЛОГИЧЕСКОЕ СРЕДСТВО НА ЕГО ОСНОВЕ И СПОСОБ ЕГО ПРИМЕНЕНИЯ |
US20070179174A1 (en) * | 2003-12-08 | 2007-08-02 | Bachurin Sergei O | Methods and compositions for slowing aging |
EP1718310A4 (de) | 2004-02-06 | 2009-05-06 | Elan Pharm Inc | Verfahren und zusammensetzungen zur behandlung von tumoren und metastasen |
US20050209232A1 (en) * | 2004-02-10 | 2005-09-22 | Kent Barbay | Pyridazinone ureas as antagonists of alpha4 integrins |
US8518021B2 (en) * | 2004-05-27 | 2013-08-27 | Baxter International Inc. | Apparatus and method for therapeutic delivery of medication |
US20060104969A1 (en) * | 2004-08-16 | 2006-05-18 | Massachusetts Institute Of Technology | Compositions and methods for enhancing structural and functional nervous system reorganization and recovery |
CA2624731A1 (en) * | 2005-10-04 | 2007-04-12 | Medivation, Inc. | Hydrogenated pyrido-indole compounds for the treatment of huntington's disease |
LT2676967T (lt) | 2006-02-28 | 2019-09-10 | Biogen Ma Inc. | Uždegiminių ir autoimuninių ligų gydymo būdai su natalizumabu |
US8410115B2 (en) * | 2006-02-28 | 2013-04-02 | Elan Pharmaceuticals, Inc. | Methods of treating inflammatory and autoimmune diseases with alpha-4 inhibitory compounds |
ES2663377T3 (es) | 2006-03-03 | 2018-04-12 | Biogen Ma Inc. | Métodos para el tratamiento de enfermedades inflamatorias y autoinmunes con natalizumab |
BRPI0712607A8 (pt) * | 2006-05-25 | 2019-06-04 | Biogen Idec Inc | métodos de tratamento de acidente vascular cerebral |
WO2010072228A1 (en) | 2008-12-22 | 2010-07-01 | Xigen S.A. | Novel transporter constructs and transporter cargo conjugate molecules |
US20120258093A1 (en) | 2009-08-20 | 2012-10-11 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Vla-4 as a biomarker for prognosis and target for therapy in duchenne muscular dystrophy |
US11287423B2 (en) | 2010-01-11 | 2022-03-29 | Biogen Ma Inc. | Assay for JC virus antibodies |
DK2524060T3 (en) | 2010-01-11 | 2018-03-12 | Biogen Ma Inc | ASSAY FOR JC VIRUS ANTIBODIES |
JP5857056B2 (ja) | 2010-10-14 | 2016-02-10 | ザイジェン インフラメーション エルティーディー | 慢性又は非慢性の炎症性眼疾患を治療するためのjnkシグナル伝達経路の細胞透過性ペプチド阻害剤の使用 |
KR20140043795A (ko) * | 2011-06-30 | 2014-04-10 | 가부시키가이샤 멘에키세이부츠 켄큐죠 | 가용성 인테그린 α4 변이체 |
WO2013091670A1 (en) * | 2011-12-21 | 2013-06-27 | Xigen S.A. | Novel jnk inhibitor molecules for treatment of various diseases |
WO2014193804A1 (en) | 2013-05-28 | 2014-12-04 | Biogen Idec Ma Inc. | Method of assessing risk of pml |
WO2015197097A1 (en) | 2014-06-26 | 2015-12-30 | Xigen Inflammation Ltd. | New use for jnk inhibitor molecules for treatment of various diseases |
KR20160023669A (ko) | 2013-06-26 | 2016-03-03 | 자이겐 인플라메이션 리미티드 | 다양한 질병의 치료를 위한 jnk 신호 전달 경로의 세포 투과성 펩타이드 억제자의 새로운 용도 |
WO2014206427A1 (en) | 2013-06-26 | 2014-12-31 | Xigen Inflammation Ltd. | New use of cell-permeable peptide inhibitors of the jnk signal transduction pathway for the treatment of various diseases |
US10647679B2 (en) | 2015-03-15 | 2020-05-12 | Emory University | N-methyl-D-aspartate receptor (NMDAR) potentiators, pharmaceutical compositions, and uses related thereto |
JP7189368B2 (ja) | 2018-10-30 | 2022-12-13 | ギリアード サイエンシーズ, インコーポレイテッド | アルファ4ベータ7インテグリンの阻害のための化合物 |
WO2020092401A1 (en) | 2018-10-30 | 2020-05-07 | Gilead Sciences, Inc. | COMPOUNDS FOR INHIBITION OF ALPHA 4β7 INTEGRIN |
EP3873884A1 (de) | 2018-10-30 | 2021-09-08 | Gilead Sciences, Inc. | Chinolinderivate als alpha4beta7-integrininhibitoren |
KR102641718B1 (ko) | 2018-10-30 | 2024-02-29 | 길리애드 사이언시즈, 인코포레이티드 | 알파4베타7 인테그린 억제제로서의 이미다조피리딘 유도체 |
KR20220047323A (ko) | 2019-08-14 | 2022-04-15 | 길리애드 사이언시즈, 인코포레이티드 | 알파 4 베타 7 인테그린의 저해용 화합물 |
Family Cites Families (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4179337A (en) | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
IL47468A (en) | 1975-06-12 | 1979-05-31 | Rehovot Res Prod | Process for the cross-linking of proteins using water soluble cross-linking agents |
NZ215865A (en) | 1985-04-22 | 1988-10-28 | Commw Serum Lab Commission | Method of determining the active site of a receptor-binding analogue |
GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
ATE114723T1 (de) | 1987-03-02 | 1994-12-15 | Enzon Lab Inc | Organismus als träger für ''single chain antibody domain (scad)''. |
US5011691A (en) | 1988-08-15 | 1991-04-30 | Stryker Corporation | Osteogenic devices |
US5266683A (en) | 1988-04-08 | 1993-11-30 | Stryker Corporation | Osteogenic proteins |
US5284756A (en) | 1988-10-11 | 1994-02-08 | Lynn Grinna | Heterodimeric osteogenic factor |
US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
IL162181A (en) | 1988-12-28 | 2006-04-10 | Pdl Biopharma Inc | A method of producing humanized immunoglubulin, and polynucleotides encoding the same |
US5260210A (en) * | 1989-09-27 | 1993-11-09 | Rubin Lee L | Blood-brain barrier model |
US5192746A (en) | 1990-07-09 | 1993-03-09 | Tanabe Seiyaku Co., Ltd. | Cyclic cell adhesion modulation compounds |
US5789650A (en) | 1990-08-29 | 1998-08-04 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
US5260277A (en) | 1990-09-10 | 1993-11-09 | Tanabe Seiyaku Co., Ltd. | Guanidinyl and related cell adhesion modulation compounds |
WO1992008464A1 (en) | 1990-11-15 | 1992-05-29 | Tanabe Seiyaku Co. Ltd. | Substituted urea and related cell adhesion modulation compounds |
US5219990A (en) | 1991-01-28 | 1993-06-15 | Biogen, Inc. | Papillomavirus e2 trans-activation repressors |
ATE238417T1 (de) | 1991-11-04 | 2003-05-15 | Inst Genetics Llc | Rekombinante knochenmorphogenetische protein heterodimere, zusammensetzungen und verfahren zur verwendung |
WO1993008823A1 (en) | 1991-11-06 | 1993-05-13 | Tanabe Seiyaku Co., Ltd. | Guanidinyl and related cell adhesion modulation compounds |
US5932214A (en) | 1994-08-11 | 1999-08-03 | Biogen, Inc. | Treatment for inflammatory bowel disease with VLA-4 blockers |
SG52262A1 (en) | 1993-01-08 | 1998-09-28 | Tanabe Seiyaku Co | Peptide inhibitors of cell adhesion |
DE69419721T2 (de) | 1993-01-12 | 2000-04-27 | Biogen Inc | Rekombinante anti-vla4 antikörpermoleküle |
JP3593343B2 (ja) | 1993-02-09 | 2004-11-24 | バイオジェン インコーポレイテッド | インシュリン依存型糖尿病の治療 |
AU693143B2 (en) | 1993-12-06 | 1998-06-25 | Cytel Corporation | CS-1 peptidomimetics, compositions and methods of using the same |
ES2270425T3 (es) * | 1994-01-25 | 2007-04-01 | Elan Pharmaceuticals, Inc. | Anticuerpos humanizados contra la molecula de adhesion leucocitaria vla-4. |
US5840299A (en) | 1994-01-25 | 1998-11-24 | Athena Neurosciences, Inc. | Humanized antibodies against leukocyte adhesion molecule VLA-4 |
US5510332A (en) | 1994-07-07 | 1996-04-23 | Texas Biotechnology Corporation | Process to inhibit binding of the integrin α4 62 1 to VCAM-1 or fibronectin and linear peptides therefor |
DE69530392D1 (de) | 1994-07-11 | 2003-05-22 | Athena Neurosciences Inc | Inhibitoren der leukozytenadhäsion |
US5811391A (en) | 1994-08-25 | 1998-09-22 | Cytel Corporation | Cyclic CS-1 peptidomimetics, compositions and methods of using same |
GB9524630D0 (en) | 1994-12-24 | 1996-01-31 | Zeneca Ltd | Chemical compounds |
US6306840B1 (en) | 1995-01-23 | 2001-10-23 | Biogen, Inc. | Cell adhesion inhibitors |
WO1996040781A1 (en) | 1995-06-07 | 1996-12-19 | Tanabe Seiyaku Co., Ltd. | CYCLIC PEPTIDE INHIBITORS OF β1 AND β2 INTEGRIN-MEDIATED ADHESION |
AU6311996A (en) | 1995-07-06 | 1997-02-05 | Zeneca Limited | Peptide inhibitors of fibronectine |
US6248713B1 (en) | 1995-07-11 | 2001-06-19 | Biogen, Inc. | Cell adhesion inhibitors |
DE19541844C1 (de) | 1995-11-09 | 1997-07-24 | Gsf Forschungszentrum Umwelt | Verfahren zur Herstellung von menschlichen Antikörpern und deren Verwendung |
EP1001764A4 (de) | 1997-05-29 | 2005-08-24 | Merck & Co Inc | Heterozyklische amide als zelladhäsionshemmern |
JP2001512138A (ja) * | 1997-07-31 | 2001-08-21 | エラン・ファーマシューティカルズ・インコーポレーテッド | Vla−4が介在する白血球付着を阻害するベンジル化合物 |
US6153653A (en) * | 1997-11-26 | 2000-11-28 | Protarga, Inc. | Choline compositions and uses thereof |
WO2000051628A2 (en) * | 1999-03-03 | 2000-09-08 | Biogen, Inc. | Methods of modulating lipid metabolism and storage |
US9501219B2 (en) | 2012-01-25 | 2016-11-22 | Oracle International Corporation | 2D line data cursor |
US9713013B2 (en) | 2013-03-15 | 2017-07-18 | Elwha Llc | Protocols for providing wireless communications connectivity maps |
US9400266B2 (en) | 2013-03-14 | 2016-07-26 | Rosemount Analytical Inc. | Gas chromatograph with improved operation |
US9104862B2 (en) | 2013-04-01 | 2015-08-11 | Uniquesoft, Llc | Secure computing device using new software versions |
-
2000
- 2000-12-14 JP JP2001544910A patent/JP2003517023A/ja active Pending
- 2000-12-14 CA CA2394431A patent/CA2394431C/en not_active Expired - Lifetime
- 2000-12-14 WO PCT/US2000/033942 patent/WO2001043774A1/en active IP Right Grant
- 2000-12-14 ES ES00984395T patent/ES2335643T3/es not_active Expired - Lifetime
- 2000-12-14 ES ES09012818T patent/ES2415708T3/es not_active Expired - Lifetime
- 2000-12-14 AT AT00984395T patent/ATE447969T1/de not_active IP Right Cessation
- 2000-12-14 EP EP09012818.2A patent/EP2140881B1/de not_active Expired - Lifetime
- 2000-12-14 NZ NZ519447A patent/NZ519447A/en not_active IP Right Cessation
- 2000-12-14 EP EP10185454A patent/EP2332578A1/de not_active Withdrawn
- 2000-12-14 EP EP00984395A patent/EP1242118B1/de not_active Expired - Lifetime
- 2000-12-14 AU AU21020/01A patent/AU783110B2/en not_active Expired
- 2000-12-14 DE DE60043308T patent/DE60043308D1/de not_active Expired - Lifetime
- 2000-12-14 DK DK00984395T patent/DK1242118T3/da active
- 2000-12-14 DK DK09012818.2T patent/DK2140881T3/da active
-
2002
- 2002-06-13 US US10/170,841 patent/US20020197233A1/en not_active Abandoned
-
2011
- 2011-10-21 JP JP2011232255A patent/JP5519612B2/ja not_active Expired - Lifetime
-
2012
- 2012-06-12 JP JP2012133117A patent/JP2012167128A/ja not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
EP1242118A1 (de) | 2002-09-25 |
JP5519612B2 (ja) | 2014-06-11 |
EP2140881B1 (de) | 2013-04-17 |
JP2012017345A (ja) | 2012-01-26 |
CA2394431C (en) | 2015-06-30 |
AU2102001A (en) | 2001-06-25 |
ES2415708T3 (es) | 2013-07-26 |
AU783110B2 (en) | 2005-09-22 |
WO2001043774A1 (en) | 2001-06-21 |
CA2394431A1 (en) | 2001-06-21 |
NZ519447A (en) | 2004-03-26 |
DK2140881T3 (da) | 2013-05-06 |
ES2335643T3 (es) | 2010-03-31 |
DE60043308D1 (de) | 2009-12-24 |
EP2140881A1 (de) | 2010-01-06 |
EP2332578A1 (de) | 2011-06-15 |
US20020197233A1 (en) | 2002-12-26 |
JP2012167128A (ja) | 2012-09-06 |
ATE447969T1 (de) | 2009-11-15 |
JP2003517023A (ja) | 2003-05-20 |
EP1242118B1 (de) | 2009-11-11 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DK1242118T3 (da) | Fremgangsmåder til behandling af iskæmisk eller hæmorrhagisk beskadigelse af centralnervesystemet under anvendelse af anti-alfa4-integrin-antagonister | |
BRPI0415361A (pt) | antagonistas do receptor muscarìnico de acetilcolina | |
BR0015963A (pt) | Compostos de uréia antagonistas receptor muscarìnico, composições farmacêuticas compreendendo tais compostos e método de preparação destes compostos | |
DK1135153T3 (da) | Anvendelser af EPH-receptorantagonister og -agonister til behandling af vaskulære forstyrrelser | |
IT1313625B1 (it) | Derivati benzimidazolonici aventi affinita' mista per i recettori diserotonina e dopamina. | |
TR200101398T2 (tr) | Pirolidin türevleri-CCR-3 reseptörü antagonistleri. | |
ATE505190T1 (de) | Azabicycloalkane als ccr5-modulatoren | |
FI952064A0 (fi) | Takykiniinireseptoriantagonisteja, joilla ei ole peptidyylirakennetta | |
BR9709072A (pt) | Derivados indol úteis como antagonistas dos receptores endotelina | |
BRPI0417343A (pt) | antagonistas do receptor muscarìnico m3 de acetilcolina | |
ATE295839T1 (de) | N-(3-ethinylphenylamino)-6,7-bis(2-methoxyethox )-4-chinazolinamin-mesylat-anhydrat und -monohydrat | |
NO20025640L (no) | Substituerte 1-aminoalkyl-laktamer og deres anvendelse som muscarin-reseptorantagonister | |
EA199900912A1 (ru) | Фармацевтические средства | |
DE60032905D1 (de) | Selektive iglur5 rezeptorantagonisten zur behandlung der migräne | |
IS5295A (is) | Azetidínýlprópýlpíperidín afleiður, milliefni og notkun sem mótlyf gegn kínínhröðun | |
DE69816290D1 (de) | Chinolin-4-carboxamidderivate als nk-2 und nk-3 rezeptor antagonisten | |
BR9909486A (pt) | Compostos calcilìticos | |
PT1237559E (pt) | Combinacoes farmaceuticas compreendendo um antagonista do receptor p2t e megalatrano | |
NO20014486D0 (no) | Nye LHRH antagonister med forbedrede opplöselighetsegenskaper | |
PE20010956A1 (es) | Derivados de isoquinolina y quinazolina con afinidad por los receptores de serotonina combinados 5-ht1a, 5-ht1b, 5-ht1d | |
DE10003866B8 (de) | Zusammensetzungen enthaltend stabilisierte Metallocen-Polyolefine, sowie Verfahren zum Stabilisieren von Metallocen-Polyolefinen | |
BRPI0415281A (pt) | antagonistas de receptor de acetilcolina muscarìnico | |
NO20004144D0 (no) | Heterocykliske forbindelser, deres fremstilling og anvendelse som takykinin reseptor antagonister | |
IT1270612B (it) | Derivati eterociclo-condensatori di morfinoidi | |
DE69703242D1 (de) | Indolin-derivate verwendbar als 5-ht-2c rezeptor-antagonisten |