DK117587B - Fremgangsmåde til fremstilling af stabile vandige opløsninger af oxytetracyclin egnet til parenteral, peroral og topisk indgivelse. - Google Patents

Fremgangsmåde til fremstilling af stabile vandige opløsninger af oxytetracyclin egnet til parenteral, peroral og topisk indgivelse.

Info

Publication number
DK117587B
DK117587B DK282167AA DK282167A DK117587B DK 117587 B DK117587 B DK 117587B DK 282167A A DK282167A A DK 282167AA DK 282167 A DK282167 A DK 282167A DK 117587 B DK117587 B DK 117587B
Authority
DK
Denmark
Prior art keywords
oxytetracycline
parenteral
oral
preparation
aqueous solutions
Prior art date
Application number
DK282167AA
Other languages
Danish (da)
English (en)
Inventor
H Weber
A Molenaar
Original Assignee
Koninklijke Gist Spiritus
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Koninklijke Gist Spiritus filed Critical Koninklijke Gist Spiritus
Publication of DK117587B publication Critical patent/DK117587B/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/785—Polymers containing nitrogen
    • A61K31/787—Polymers containing nitrogen containing heterocyclic rings having nitrogen as a ring hetero atom
    • A61K31/79—Polymers of vinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/65—Tetracyclines

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
DK282167AA 1966-05-31 1967-05-30 Fremgangsmåde til fremstilling af stabile vandige opløsninger af oxytetracyclin egnet til parenteral, peroral og topisk indgivelse. DK117587B (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NL6607516A NL6607516A (cs) 1966-05-31 1966-05-31

Publications (1)

Publication Number Publication Date
DK117587B true DK117587B (da) 1970-05-11

Family

ID=19796753

Family Applications (1)

Application Number Title Priority Date Filing Date
DK282167AA DK117587B (da) 1966-05-31 1967-05-30 Fremgangsmåde til fremstilling af stabile vandige opløsninger af oxytetracyclin egnet til parenteral, peroral og topisk indgivelse.

Country Status (22)

Country Link
US (1) US3557280A (cs)
JP (1) JPS5010373B1 (cs)
AT (1) AT272522B (cs)
BE (1) BE699091A (cs)
CH (1) CH490087A (cs)
CS (1) CS151454B2 (cs)
DE (1) DE1617576C3 (cs)
DK (1) DK117587B (cs)
ES (1) ES340956A1 (cs)
FI (1) FI43622B (cs)
FR (1) FR5953M (cs)
GB (1) GB1131007A (cs)
GR (1) GR33861B (cs)
IL (1) IL28009A (cs)
IT (1) IT1140250B (cs)
LU (1) LU53788A1 (cs)
MY (1) MY7100015A (cs)
NL (1) NL6607516A (cs)
NO (1) NO126298B (cs)
SE (1) SE354417B (cs)
SU (1) SU510986A3 (cs)
YU (1) YU31326B (cs)

Families Citing this family (77)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5418330B2 (cs) * 1973-03-16 1979-07-06
US3966905A (en) * 1973-05-29 1976-06-29 Barnes-Hind Pharmaceuticals, Inc. Stabilized catechol amine solutions
US3929989A (en) * 1974-06-14 1975-12-30 Wendt Lab Inc Stable suspension of calcium-magnesium oxytetracycline for intrauterine administration in treatment of bovine metritis
GB1538903A (en) * 1975-04-11 1979-01-24 Nelson Res & Dev Carrier for a topically applied physiologically active agent or cosmetic agent
US4018889A (en) * 1976-01-02 1977-04-19 Pfizer Inc. Oxytetracycline compositions
DE2602363C2 (de) * 1976-01-22 1984-04-12 Bayer Ag, 5090 Leverkusen Wäßrige, injizierbare Niclofolan- Formulierungen
GB1592053A (en) * 1976-12-16 1981-07-01 Norbrook Lab Ltd Oxytetracycline compositions
US4213963A (en) * 1978-12-14 1980-07-22 Janssen Pharmaceutica N.V. Fluspirilene-containing compositions
US4259331A (en) * 1979-04-16 1981-03-31 Pfizer Inc. Oxytetracycline compositions
US4386083A (en) * 1980-04-10 1983-05-31 Walter Hacke Injectable oxytetracycline compositions
US4399127A (en) * 1980-04-10 1983-08-16 Diamond Shamrock Corporation Injectable oxytetracycline compositions
IE74244B1 (en) * 1985-10-01 1997-07-16 Bimeda Res Dev Ltd A process for preparing an antibiotic composition
US5071643A (en) * 1986-10-17 1991-12-10 R. P. Scherer Corporation Solvent system enhancing the solubility of pharmaceuticals for encapsulation
US6756365B2 (en) * 1991-11-06 2004-06-29 Trustees Of Tufts College Reducing tetracycline resistance in living cells
EP0626171A1 (de) * 1993-05-26 1994-11-30 Winfried Dörnhöfer Injektionslösung für die intravenöse oder intramuskuläre Verabreichung an Tiere
US6383515B2 (en) 1999-05-28 2002-05-07 Sawyer Maryjean Solvent system for enhancing solubility
US8106225B2 (en) * 1999-09-14 2012-01-31 Trustees Of Tufts College Methods of preparing substituted tetracyclines with transition metal-based chemistries
US6849615B2 (en) 1999-09-14 2005-02-01 Paratek Pharmaceuticals, Inc. 13-substituted methacycline compounds
ATE523485T1 (de) 1999-09-14 2011-09-15 Tufts College Verfahren zur herstellung von substituierten tetracyclinen mit hilfe von auf übergangsmetalle basierten chemikalien
US6500812B2 (en) 1999-09-14 2002-12-31 Paratek Pharmaceuticals, Inc. 13-substituted methacycline compounds
AU3105801A (en) * 2000-01-24 2001-07-31 Trustees Of Tufts College Tetracycline compounds for treatment of cryptosporidium parvum related disorders
ES2288945T3 (es) * 2000-03-31 2008-02-01 Trustees Of Tufts College Compuestos de tetraciclina 7 y 9-carbamato, urea, tiourea, tiocarbamato y heteroaril-amino sustituidos.
JP2003533504A (ja) 2000-05-15 2003-11-11 パラテック ファーマシューティカルズ インコーポレイテッド ７置換型縮合環テトラサイクリン化合物
US20040224927A1 (en) * 2000-06-16 2004-11-11 Trustees Of Tufts College 7-N-substituted phenyl tetracycline compounds
US20020128238A1 (en) * 2000-06-16 2002-09-12 Nelson Mark L. 7-phenyl-substituted tetracycline compounds
US20020132798A1 (en) * 2000-06-16 2002-09-19 Nelson Mark L. 7-phenyl-substituted tetracycline compounds
US6624168B2 (en) 2000-07-07 2003-09-23 Trustees Of Tufts College 7,8 and 9-substituted tetracycline compounds
EP2204361B1 (en) 2000-07-07 2011-09-28 Trustees Of Tufts College 13-substituted methacycline compounds
SI1301467T1 (sl) * 2000-07-07 2007-02-28 Tufts College 9-substituirane minociklinske spojine
US20050143353A1 (en) * 2000-07-07 2005-06-30 Paratek Pharmaceuticals, Inc. 13-Substituted methacycline compounds
KR101027625B1 (ko) 2000-07-07 2011-04-06 파라테크 파마슈티컬스, 인크. 7-치환 테트라사이클린 화합물
US7094806B2 (en) * 2000-07-07 2006-08-22 Trustees Of Tufts College 7, 8 and 9-substituted tetracycline compounds
AU2002250331A1 (en) * 2001-03-13 2002-09-24 Paratek Pharmaceuticals, Inc. 7-pyrollyl tetracycline compounds and methods of use thereof
EP1955996A1 (en) 2001-03-13 2008-08-13 Paratek Pharmaceuticals, Inc. 7, 9-Substituted tetracycline compounds
EP1379255A2 (en) * 2001-03-14 2004-01-14 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds as antifungal agents
WO2002072031A2 (en) 2001-03-14 2002-09-19 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds as synergistic antifungal agents
US8088820B2 (en) * 2001-04-24 2012-01-03 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds for the treatment of malaria
ATE455092T1 (de) 2001-04-24 2010-01-15 Paratek Pharm Innc Substituierte tetracyclin-verbindungen zur behandlung von malaria
EP2311797A1 (en) 2002-01-08 2011-04-20 Paratek Pharmaceuticals, Inc. 4-dedimethylamino tetracycline compounds
CN101307017A (zh) 2002-03-08 2008-11-19 帕拉特克药品公司 氨基-甲基取代的四环素类化合物
IL164180A0 (en) 2002-03-21 2005-12-18 Paratek Pharm Innc Substituted tetracycline compounds
JP4416652B2 (ja) 2002-07-12 2010-02-17 パラテック ファーマシューティカルズ インコーポレイテッド ３、１０、および１２ａ置換されたテトラサイクリン化合物
CA2502464A1 (en) 2002-10-24 2004-05-06 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds for the treatment of malaria
WO2004071490A1 (en) * 2003-02-12 2004-08-26 R & P Korea Co., Ltd. Solvent system of hardly soluble drug with improved elution rate
US20060287283A1 (en) * 2003-07-09 2006-12-21 Paratek Pharmaceuticals, Inc. Prodrugs of 9-aminomethyl tetracycline compounds
CA2531728A1 (en) 2003-07-09 2005-02-03 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds
EP2292590A3 (en) 2003-07-09 2012-05-02 Paratek Pharmaceuticals, Inc. Prodrugs of 9-aminomethyl tetracycline compounds
EP2332904A3 (en) 2004-01-15 2012-04-11 Paratek Pharmaceuticals, Inc. Derivatives of tetracycline compounds
TWI261038B (en) * 2004-08-11 2006-09-01 Bo-Cheng Chen Bicycle gear-shifting handgrip
CA2585418A1 (en) * 2004-10-25 2006-05-04 Paratek Pharmaceuticals, Inc. 4-aminotetracyclines and methods of use thereof
EP2284156A3 (en) 2004-10-25 2011-09-21 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds
WO2006084265A1 (en) 2005-02-04 2006-08-10 Paratek Pharmaceuticals, Inc. 11a, 12-DERIVATIVES OF TETRACYCLINE COMPOUNDS
DE102005012595A1 (de) * 2005-03-18 2006-09-21 Lanxess Deutschland Gmbh Herstellung von Tri(chlorpropyl)phosphat
CA2616224A1 (en) * 2005-07-21 2007-02-01 Paratek Pharmaceuticals, Inc. 10-substituted tetracyclines and methods of use thereof
WO2007035448A2 (en) * 2005-09-19 2007-03-29 Albemarle Corporation Highly concentrated pourable aqueous solutions of potassium ibuprofen their preparation and their uses
EP1991236A2 (en) * 2006-01-24 2008-11-19 Paratek Pharmaceuticals, Inc. Methods of increasing oral bioavailability of tetracyclines
US20070244335A1 (en) * 2006-04-17 2007-10-18 Teva Pharmaceutical Industries Ltd. Isolation of tetracycline derivatives
US8198470B2 (en) * 2006-04-24 2012-06-12 Teva Pharmaceutical Industries Ltd. Crystalline form II of tigecycline and processes for preparation thereof
US7871993B2 (en) * 2006-04-24 2011-01-18 Teva Pharmaceutical Industries Ltd. Tigecycline crystalline forms and processes for preparation thereof
AU2007249696A1 (en) * 2006-05-15 2007-11-22 Paratek Pharmaceuticals, Inc. Methods of regulating expression of genes or of gene products using substituted tetracycline compounds
WO2008045507A2 (en) 2006-10-11 2008-04-17 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds for treatment of bacillus anthracis infections
WO2008079363A2 (en) 2006-12-21 2008-07-03 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds for treatment of inflammatory skin disorders
BRPI0720569B8 (pt) 2006-12-21 2021-05-25 Paratek Pharm Innc compostos de tetraciclina substituída e uso dos ditos compostos para o tratamento de uma infecção bacteriana, viral ou parasitária
US7935687B2 (en) * 2007-04-12 2011-05-03 Paratek Pharmaceuticals, Inc. Methods for treating spinal muscular atrophy using tetracycline compounds
EP2144870A2 (en) 2007-04-27 2010-01-20 Paratek Pharmaceuticals, Inc. Methods for synthesizing and purifying aminoalkyl tetracycline compounds
EA201070233A1 (ru) 2007-07-06 2010-08-30 Паратек Фармасьютикалс, Инк. Способы синтеза замещённых соединений тетрациклина (варианты)
RU2010140682A (ru) 2008-03-05 2012-04-10 Пэрэтек Фамэсьютикэлс, Инк. (US) Способ лечения пациента от инфекции, фармацевтическая композиция (варианты) и лекарственное средство
PT2271348T (pt) 2008-03-28 2018-04-16 Paratek Pharm Innc Formulação de comprimido oral de composto de tetraciclina
WO2009128913A1 (en) * 2008-04-14 2009-10-22 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds
TW202216656A (zh) 2008-05-19 2022-05-01 美商Ｐｒｔｋ Ｓｐｖ２公司 四環素化合物之甲苯磺酸鹽及同素異形體
US9629809B2 (en) 2008-07-21 2017-04-25 Si Group, Inc. High content sodium ibuprofen granules, their preparation and their use in preparing non-effervescent solid dosage forms
JP5553830B2 (ja) * 2008-07-21 2014-07-16 アルベマール・コーポレーシヨン 高含量イブプロフェンナトリウム顆粒、その調製、および非発泡性固体剤形を調製する際のその使用
CN102215681A (zh) * 2008-09-19 2011-10-12 帕拉特克药品公司 用于治疗类风湿性关节炎的四环素化合物和相关的治疗方法
EP2990051B1 (en) 2009-04-10 2016-10-26 Tufts Medical Center, Inc. Par-1 activation by metalloproteinase-1 (mmp-1)
HRP20191295T8 (hr) 2011-05-12 2020-02-07 Paratek Pharmaceuticals, Inc. Kristalne soli amida (4s,4as,5ar,12as)-4-dimetilamino-3,10,12,12a-tetrahidroksi-7-[(metoksi(metil)amino)-metil]-1,11-diokso-1,4,4a,5,5a,6,11,12a-oktahidro-naftacen-2-karboksilne kiseline i postupci uporabe istih
WO2018085216A1 (en) 2016-11-01 2018-05-11 Paratek Pharmaceuticals, Inc. 9-aminomethyl minocycline compounds and use thereof in treating community-acquire bacterial pneumonia (cabp)
AU2018303807B2 (en) 2017-07-21 2023-08-24 Almirall, Llc Treatment of non-inflammatory lesions

Also Published As

Publication number Publication date
CH490087A (de) 1970-05-15
SU510986A3 (ru) 1976-04-15
DE1617576C3 (de) 1980-12-11
SE354417B (cs) 1973-03-12
IT1140250B (it) 1986-09-24
GR33861B (el) 1968-02-09
YU31326B (en) 1973-04-30
AT272522B (de) 1969-07-10
NO126298B (cs) 1973-01-22
MY7100015A (en) 1971-12-31
LU53788A1 (cs) 1967-07-31
BE699091A (cs) 1967-11-27
ES340956A1 (es) 1968-06-16
IL28009A (en) 1970-08-19
JPS5010373B1 (cs) 1975-04-21
GB1131007A (en) 1968-10-16
DE1617576B2 (de) 1980-04-10
NL6607516A (cs) 1967-12-01
CS151454B2 (cs) 1973-10-19
US3557280A (en) 1971-01-19
DE1617576A1 (de) 1972-04-27
FR5953M (cs) 1968-04-16
FI43622B (cs) 1971-02-01

Similar Documents

Publication Publication Date Title
DK117587B (da) Fremgangsmåde til fremstilling af stabile vandige opløsninger af oxytetracyclin egnet til parenteral, peroral og topisk indgivelse.
DK127168B (da) Fremgangsmåde til fremstilling af klare, stabile vandige opløsninger af doxycyclin, som er egnede til parenteral, oral og topisk brug.
DK136246B (da) Fremgangsmåde til fremstilling af N-alkyl-1,4-dihydropyridiner.
DK138974B (da) Fremgangsmåde til fremstilling af vandige oxytetracyclinopløsninger til parenteral, peroral og lokal anvendelse.
DK129390B (da) Fremgangsmåde til fremstilling af til parenteral indgift egnede anæstetisk virksomme opløsninger af et steroid.
DK131905B (da) Analogifremgangsmåde til fremstilling af 3,1-benzoxazinderivater og syreadditionssalte deraf.
FI49301C (fi) Menetelmä uusien substituoitujen aminopyridiinien valmistamiseksi, joi lla on tulehduksenvastainen ja kipua lieventävä vaikutus.
DK123351B (da) Analogifremgangsmåde til fremstilling af trifluormethyl-derivater af phenylaminopropan.
DK119005B (da) Fremgangsmåde til fremstilling af 3-alkoxy-13-alkylgona-1,3,5(10),8,14-penten-17-oner.
DK117832B (da) Fremgangsmåde til fremstilling af ɛ-caprolactam og ω-decalactam.
DK115178B (da) Analogifremgangsmåde til fremstilling af acylderivater af proscillaridin A.
DK123299B (da) Analogifremgangsmåde til fremstilling af pyridazonderivater.
DK117961B (da) Analogifremgangsmåde til fremstilling af guanidinderivater.
DK130796B (da) Fremgangsmåde til fremstilling af et stabilt cellefrit viruspræparat.
DK114556B (da) Fremgangsmåde til fremstilling af 1,4-benzodiazepin-2-on-4-oxider.
DK118261B (da) Fremgangsmåde til fremstilling af til parenteral indgift egnede stabile opløsninger af benzodiazepinderivater.
DK122761B (da) Analogifremgangsmåde til fremstilling af arylsulfonylurinstofderivater.
DK126105B (da) Fremgangsmåde til fremstilling af meget ren 2,6-xylenol.
DK117703B (da) Analogifremgangsmåde til fremstilling af anticoccidielt aktive quinolinderivater.
DK127418B (da) Fremgangsmåde til fremstilling af 13-alkyl-gona-1,3,5(10),6,8,14-hexaener.
DK124401B (da) Analogifremgangsmåde til fremstilling af benzensulfonylurinstoffer.
DK114270B (da) Fremgangsmåde til fremstilling af benzazolderivater.
DK122080B (da) Fremgangsmåde til fremstilling af 1,4-benzodiazepinderivater.
DK112241B (da) Fremgangsmåde til fremstilling af pyrazinderivater.
DK127327B (da) Fremgangsmåde til fremstilling af 1,2,3,4-tetrahydronaphthalen-2-on-derivater.