AT272522B - Verfahren zur Herstellung von stabilen, für die parenterale und perorale Verabreichung geeigneten wässerigen Lösungen von Oxytetracyclin - Google Patents

Verfahren zur Herstellung von stabilen, für die parenterale und perorale Verabreichung geeigneten wässerigen Lösungen von Oxytetracyclin

Info

Publication number
AT272522B
AT272522B AT502267A AT502267A AT272522B AT 272522 B AT272522 B AT 272522B AT 502267 A AT502267 A AT 502267A AT 502267 A AT502267 A AT 502267A AT 272522 B AT272522 B AT 272522B
Authority
AT
Austria
Prior art keywords
oxytetracycline
parenteral
preparation
aqueous solutions
stable aqueous
Prior art date
Application number
AT502267A
Other languages
English (en)
Original Assignee
Koninklijke Gist Spiritus
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Koninklijke Gist Spiritus filed Critical Koninklijke Gist Spiritus
Application granted granted Critical
Publication of AT272522B publication Critical patent/AT272522B/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/785—Polymers containing nitrogen
    • A61K31/787—Polymers containing nitrogen containing heterocyclic rings having nitrogen as a ring hetero atom
    • A61K31/79—Polymers of vinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/65—Tetracyclines

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
AT502267A 1966-05-31 1967-05-30 Verfahren zur Herstellung von stabilen, für die parenterale und perorale Verabreichung geeigneten wässerigen Lösungen von Oxytetracyclin AT272522B (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NL6607516A NL6607516A (de) 1966-05-31 1966-05-31

Publications (1)

Publication Number Publication Date
AT272522B true AT272522B (de) 1969-07-10

Family

ID=19796753

Family Applications (1)

Application Number Title Priority Date Filing Date
AT502267A AT272522B (de) 1966-05-31 1967-05-30 Verfahren zur Herstellung von stabilen, für die parenterale und perorale Verabreichung geeigneten wässerigen Lösungen von Oxytetracyclin

Country Status (22)

Country Link
US (1) US3557280A (de)
JP (1) JPS5010373B1 (de)
AT (1) AT272522B (de)
BE (1) BE699091A (de)
CH (1) CH490087A (de)
CS (1) CS151454B2 (de)
DE (1) DE1617576C3 (de)
DK (1) DK117587B (de)
ES (1) ES340956A1 (de)
FI (1) FI43622B (de)
FR (1) FR5953M (de)
GB (1) GB1131007A (de)
GR (1) GR33861B (de)
IL (1) IL28009A (de)
IT (1) IT1140250B (de)
LU (1) LU53788A1 (de)
MY (1) MY7100015A (de)
NL (1) NL6607516A (de)
NO (1) NO126298B (de)
SE (1) SE354417B (de)
SU (1) SU510986A3 (de)
YU (1) YU31326B (de)

Families Citing this family (77)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5418330B2 (de) * 1973-03-16 1979-07-06
US3966905A (en) * 1973-05-29 1976-06-29 Barnes-Hind Pharmaceuticals, Inc. Stabilized catechol amine solutions
US3929989A (en) * 1974-06-14 1975-12-30 Wendt Lab Inc Stable suspension of calcium-magnesium oxytetracycline for intrauterine administration in treatment of bovine metritis
GB1538903A (en) * 1975-04-11 1979-01-24 Nelson Res & Dev Carrier for a topically applied physiologically active agent or cosmetic agent
US4018889A (en) * 1976-01-02 1977-04-19 Pfizer Inc. Oxytetracycline compositions
DE2602363C2 (de) * 1976-01-22 1984-04-12 Bayer Ag, 5090 Leverkusen Wäßrige, injizierbare Niclofolan- Formulierungen
GB1592053A (en) * 1976-12-16 1981-07-01 Norbrook Lab Ltd Oxytetracycline compositions
US4213963A (en) * 1978-12-14 1980-07-22 Janssen Pharmaceutica N.V. Fluspirilene-containing compositions
US4259331A (en) * 1979-04-16 1981-03-31 Pfizer Inc. Oxytetracycline compositions
US4386083A (en) * 1980-04-10 1983-05-31 Walter Hacke Injectable oxytetracycline compositions
US4399127A (en) * 1980-04-10 1983-08-16 Diamond Shamrock Corporation Injectable oxytetracycline compositions
IE74244B1 (en) * 1985-10-01 1997-07-16 Bimeda Res Dev Ltd A process for preparing an antibiotic composition
US5071643A (en) * 1986-10-17 1991-12-10 R. P. Scherer Corporation Solvent system enhancing the solubility of pharmaceuticals for encapsulation
US6756365B2 (en) * 1991-11-06 2004-06-29 Trustees Of Tufts College Reducing tetracycline resistance in living cells
EP0626171A1 (de) * 1993-05-26 1994-11-30 Winfried Dörnhöfer Injektionslösung für die intravenöse oder intramuskuläre Verabreichung an Tiere
US6383515B2 (en) 1999-05-28 2002-05-07 Sawyer Maryjean Solvent system for enhancing solubility
US8106225B2 (en) * 1999-09-14 2012-01-31 Trustees Of Tufts College Methods of preparing substituted tetracyclines with transition metal-based chemistries
US6849615B2 (en) 1999-09-14 2005-02-01 Paratek Pharmaceuticals, Inc. 13-substituted methacycline compounds
US6500812B2 (en) 1999-09-14 2002-12-31 Paratek Pharmaceuticals, Inc. 13-substituted methacycline compounds
EP1666454B1 (de) * 1999-09-14 2011-09-07 Trustees Of Tufts College Verfahren zur Herstellung von substituierten Tetracyclinen mit Hilfe von auf Übergangsmetalle basierten Chemikalien
JP2003523963A (ja) 2000-01-24 2003-08-12 トラスティーズ・オブ・タフツ・カレッジ クリプトスポリジウム・パルヴム関連疾患の治療のためのテトラサイクリン化合物
BR0109725A (pt) 2000-03-31 2003-02-04 Tufts College Composto de tetraciclina substituìdo, método para tratar um estado responsivo a tetraciclina em um mamìfero, composição farmacêutica, método para sintetizar um composto de tetraciclina 7- ou 9-substituìdo, e, intermediário reativo
EP1286954B1 (de) * 2000-05-15 2004-04-14 Paratek Pharmaceuticals, Inc. 7-substituierte kondensierte ring-tetrazyclin- verbindungen
US20020132798A1 (en) * 2000-06-16 2002-09-19 Nelson Mark L. 7-phenyl-substituted tetracycline compounds
US20040224927A1 (en) * 2000-06-16 2004-11-11 Trustees Of Tufts College 7-N-substituted phenyl tetracycline compounds
AU2001268475A1 (en) * 2000-06-16 2002-01-02 Trustees Of Tufts College 7-phenyl-substituted tetracycline compounds
DE60141994D1 (de) 2000-07-07 2010-06-10 Tufts College 13-substituierte Methacyclinverbindungen
KR100674047B1 (ko) 2000-07-07 2007-01-25 트러스티즈 오브 터프츠 칼리지 9-치환된 미노사이클린 화합물
WO2002004404A2 (en) 2000-07-07 2002-01-17 Trustees Of Tufts College 7,8 and 9-substituted tetracycline compounds
CN1450989A (zh) * 2000-07-07 2003-10-22 塔夫茨大学信托人 7－取代的四环素化合物
US20050143353A1 (en) * 2000-07-07 2005-06-30 Paratek Pharmaceuticals, Inc. 13-Substituted methacycline compounds
US7094806B2 (en) 2000-07-07 2006-08-22 Trustees Of Tufts College 7, 8 and 9-substituted tetracycline compounds
IL157860A0 (en) 2001-03-13 2004-03-28 Paratek Pharm Innc 7,9-substituted tetracycline compounds
WO2002072506A2 (en) * 2001-03-13 2002-09-19 Paratek Pharmaceuticals, Inc. 7-pyrollyl tetracycline compounds and methods of use thereof
CA2457234A1 (en) * 2001-03-14 2002-09-19 Mark L. Nelson Substituted tetracycline compounds as antifungal agents
JP2005504722A (ja) 2001-03-14 2005-02-17 パラテック ファーマシューティカルズ インコーポレイテッド 相乗的抗真菌薬剤としての置換テトラサイクリン化合物
US8088820B2 (en) * 2001-04-24 2012-01-03 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds for the treatment of malaria
CA2444899C (en) 2001-04-24 2011-06-21 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds for the treatment of malaria
EP2311798A1 (de) 2002-01-08 2011-04-20 Paratek Pharmaceuticals, Inc. 4-Dedimethylamin-Tetracyclinverbindungen
WO2003075857A2 (en) 2002-03-08 2003-09-18 Paratek Pharmaceuticals, Inc. Amino-methyl substituted tetracycline compounds
CA2479877C (en) 2002-03-21 2012-08-21 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds
AU2003261161B2 (en) 2002-07-12 2009-09-10 Paratek Pharmaceuticals, Inc 3, 10, and 12a substituted tetracycline compounds
JP2006503898A (ja) 2002-10-24 2006-02-02 パラテック ファーマシューティカルズ， インク． マラリア治療のための置換テトラサイクリン化合物
JP2006514119A (ja) * 2003-02-12 2006-04-27 アール アンド ピー コリア カンパニー リミテッド 溶解率が向上した難溶性薬剤の溶媒系
WO2005009943A2 (en) 2003-07-09 2005-02-03 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds
US20060287283A1 (en) * 2003-07-09 2006-12-21 Paratek Pharmaceuticals, Inc. Prodrugs of 9-aminomethyl tetracycline compounds
EP1656341A1 (de) 2003-07-09 2006-05-17 Paratek Pharmaceuticals, Inc. Prodrugs von 9-aminomethyltetracyclinverbindungen
EP2332904A3 (de) 2004-01-15 2012-04-11 Paratek Pharmaceuticals, Inc. Derivate von Tetracyclin-Verbindungen
TWI261038B (en) * 2004-08-11 2006-09-01 Bo-Cheng Chen Bicycle gear-shifting handgrip
EP2269978A3 (de) 2004-10-25 2011-09-21 Paratek Pharmaceuticals, Inc. Substituierte Tetracyclinverbindungen
EP2301916A3 (de) 2004-10-25 2011-09-28 Paratek Pharmaceuticals, Inc. 4-Aminotetracycline und Verfahren zu ihrer Verwendung
CA2597212A1 (en) 2005-02-04 2006-08-10 Paratek Pharmaceuticals, Inc. 11a, 12-derivatives of tetracycline compounds
DE102005012595A1 (de) * 2005-03-18 2006-09-21 Lanxess Deutschland Gmbh Herstellung von Tri(chlorpropyl)phosphat
US20070093455A1 (en) * 2005-07-21 2007-04-26 Paul Abato 10-substituted tetracyclines and methods of use thereof
EP1926481A2 (de) * 2005-09-19 2008-06-04 Albermarle Corporation Hochkonzentrierte giessbare wässrige lösungen von kalium-ibuprofen, ihre herstellung und verwendung
EP2298324A1 (de) 2006-01-24 2011-03-23 Paratek Pharmaceuticals, Inc. Verfahren zur Verbesserung der oralen Bioverfügbarkeit von Tetracyclinen
EP2007713A2 (de) * 2006-04-17 2008-12-31 Teva Pharmaceutical Industries Ltd Isolierung von tetracyclinderivaten
ES2622356T3 (es) * 2006-04-24 2017-07-06 Teva Pharmaceutical Industries, Ltd. Formas cristalinas de tigeciclina y procesos para su preparación
US8198470B2 (en) * 2006-04-24 2012-06-12 Teva Pharmaceutical Industries Ltd. Crystalline form II of tigecycline and processes for preparation thereof
CA2652347A1 (en) * 2006-05-15 2007-11-22 Paratek Pharmaceuticals, Inc. Methods of regulating expression of genes or of gene products using substituted tetracycline compounds
US8440646B1 (en) 2006-10-11 2013-05-14 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds for treatment of Bacillus anthracis infections
IL270446B2 (en) 2006-12-21 2023-10-01 Paratek Pharm Innc A tetracycline compound, a pharmaceutical preparation containing the tetracycline compound, and the tetracycline compound or the pharmaceutical preparation for the treatment of the tetracycline-responsive condition
EP2120963B1 (de) 2006-12-21 2018-09-12 Paratek Pharmaceuticals, Inc. Substituierte tetracyclinverbindungen zur behandlung von entzündlichen hautstörungen
JP2010523684A (ja) 2007-04-12 2010-07-15 パラテック ファーマシューティカルズ インコーポレイテッド テトラサイクリン化合物を用いる、脊髄筋委縮症を治療するための方法
EP2213655A1 (de) * 2007-04-27 2010-08-04 Paratek Pharmaceuticals, Inc. Verfahren zur Reinigung von Aminoalkyl-Tetracyclinverbindungen
EA201070233A1 (ru) 2007-07-06 2010-08-30 Паратек Фармасьютикалс, Инк. Способы синтеза замещённых соединений тетрациклина (варианты)
AU2009220171A1 (en) 2008-03-05 2009-09-11 Paratek Pharmaceuticals, Inc. Minocycline compounds and methods of use thereof
PT2271348T (pt) 2008-03-28 2018-04-16 Paratek Pharm Innc Formulação de comprimido oral de composto de tetraciclina
JP2011517697A (ja) * 2008-04-14 2011-06-16 パラテック ファーマシューティカルズ インコーポレイテッド 置換テトラサイクリン化合物
TW202332671A (zh) * 2008-05-19 2023-08-16 美商Ｐｒｔｋ Ｓｐｖ２公司 四環素化合物之甲苯磺酸鹽及同素異形體
US9629809B2 (en) 2008-07-21 2017-04-25 Si Group, Inc. High content sodium ibuprofen granules, their preparation and their use in preparing non-effervescent solid dosage forms
EP2309988B1 (de) * 2008-07-21 2015-11-25 SI Group, Inc. Granulat mit hohem ibuprofen-natriumgehalt, seine herstellung und seine verwendung bei der herstellung von nichtsprudelnden festen dosierformen
MX2011002780A (es) * 2008-09-19 2011-04-27 Paratek Pharm Innc Compuestos de tetraciclina para el tratamiento de artritis reumatoide y metodos relacionados de tratamiento.
WO2010118435A2 (en) 2009-04-10 2010-10-14 Tufts Medical Center, Inc. Par-1 activation by metalloproteinase-1 (mmp-1)
EP3574908B8 (de) 2011-05-12 2024-09-11 Almirall LLC Pharmazeutische zubereiting für orale verabreichung mit kristallinen salzen von (4s, 4as, 5ar, 12as)-4-dimethylamino-3,10,12,12a-tetrahydroxy-7-[(methoxy(methyl)amino)-methyl]-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacen-2-carbonsäureamid
US10383884B2 (en) 2016-11-01 2019-08-20 Paratek Pharmaceuticals, Inc. 9-aminomethyl minocycline compounds and use thereof in treating community-acquired bacterial pneumonia (CABP)
CA3070663A1 (en) 2017-07-21 2019-01-24 Almirall, Llc Treatment of non-inflammatory lesions

Also Published As

Publication number Publication date
IL28009A (en) 1970-08-19
FR5953M (de) 1968-04-16
SE354417B (de) 1973-03-12
JPS5010373B1 (de) 1975-04-21
ES340956A1 (es) 1968-06-16
GB1131007A (en) 1968-10-16
FI43622B (de) 1971-02-01
DE1617576C3 (de) 1980-12-11
SU510986A3 (ru) 1976-04-15
YU31326B (en) 1973-04-30
BE699091A (de) 1967-11-27
NL6607516A (de) 1967-12-01
LU53788A1 (de) 1967-07-31
IT1140250B (it) 1986-09-24
DE1617576A1 (de) 1972-04-27
NO126298B (de) 1973-01-22
US3557280A (en) 1971-01-19
DE1617576B2 (de) 1980-04-10
GR33861B (el) 1968-02-09
CS151454B2 (de) 1973-10-19
CH490087A (de) 1970-05-15
DK117587B (da) 1970-05-11
MY7100015A (en) 1971-12-31

Similar Documents

Publication Publication Date Title
AT272522B (de) Verfahren zur Herstellung von stabilen, für die parenterale und perorale Verabreichung geeigneten wässerigen Lösungen von Oxytetracyclin
AT294853B (de) Verfahren zur Herstellung von neuen Polysaccharidderivaten
CH490319A (de) Verfahren zur Herstellung von neuen Amino-dihalogen-phenyläthylaminen
AT277475B (de) Verfahren zur herstellung von neuen n6-aralkyl-adenosinderivaten
CH484049A (de) Verfahren zur Herstellung von neuen Hydroxycyclohexylaminen
AT272343B (de) Verfahren zur Herstellung von neuen 2-Cycloalkylamino-oxazolinen
AT269855B (de) Verfahren zur Herstellung von neuen 5-Nitrofuran- bzw. 5-Nitrothiopen-Derivaten
AT278254B (de) Verfahren zur Herstellung von neuen 1,6,-Dimethyl-10α-ergolinen
CH490300A (de) Verfahren zur Herstellung von 3,5-Dimethylphenol
AT272527B (de) Verfahren zur Herstellung von neuen Derivaten des Proscillaridin A
AT275758B (de) Verfahren zur Herstellung von neuen 4-Oxa-9β,10α-Steroiden
CH487887A (de) Verfahren zur Herstellung von neuen 1-Aryl-3-alkylaminopyrrolidinen
AT283356B (de) Verfahren zur Herstellung von neuen 1,2,4-Oxdiazolidin-Derivaten
AT281851B (de) Verfahren zur Herstellung von neuen Phenazinderivaten
CH558810A (de) Verfahren zur herstellung von neuen cephalosporinen und deren saeurederivaten.
CH540896A (de) Verfahren zur Herstellung von 15,16B-Methylensteroiden
CH491863A (de) Verfahren zur Herstellung von neuen Diphenylamin-Derivaten
CH503048A (de) Verfahren zur Herstellung von neuen 1-Acyl-3-indolyl-carbonsäurederivaten
AT267712B (de) Verfahren zur Herstellung von neuen Aminodiphenyl-indolyl-methanfarbstoffen
CH482727A (de) Verfahren zur Herstellung von neuen Phosphinylimiden
CH517756A (de) Verfahren zur Herstellung von neuen 11-Amino-5,6-dihydro-6-morphantridonen
CH497411A (de) Verfahren zur Herstellung von neuen Homogonan-Derivaten
AT266141B (de) Verfahren zur Herstellung von neuen Haxahydropyrimidinderivaten
CH509972A (de) Verfahren zur Herstellung von neuen Diisoeugenol-Derivaten
CH523275A (de) Verfahren zur Herstellung von 3,1-Benzothiazin-Derivaten