DK1155004T3 - Fremgangsmåde til krystallisation af N-(4-trifluormethylphenyl)-5-methyl-isoxazol-4-carboxamid - Google Patents
Fremgangsmåde til krystallisation af N-(4-trifluormethylphenyl)-5-methyl-isoxazol-4-carboxamidInfo
- Publication number
- DK1155004T3 DK1155004T3 DK00916829T DK00916829T DK1155004T3 DK 1155004 T3 DK1155004 T3 DK 1155004T3 DK 00916829 T DK00916829 T DK 00916829T DK 00916829 T DK00916829 T DK 00916829T DK 1155004 T3 DK1155004 T3 DK 1155004T3
- Authority
- DK
- Denmark
- Prior art keywords
- trifluoromethylphenyl
- isoxazole
- crystallizing
- carboxamide
- methyl
- Prior art date
Links
- VHOGYURTWQBHIL-UHFFFAOYSA-N leflunomide Chemical compound O1N=CC(C(=O)NC=2C=CC(=CC=2)C(F)(F)F)=C1C VHOGYURTWQBHIL-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D261/18—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19908527A DE19908527C2 (de) | 1999-02-26 | 1999-02-26 | Verfahren zur Kristallisation von N-(4-Trifluormethylphenyl)-5-methyl-isoxazol-4-carboxamid |
| PCT/EP2000/001151 WO2000050411A1 (fr) | 1999-02-26 | 2000-02-12 | Procede de cristallisation de n-(4-trifluoromethylphenyl)-5-methyl-isoxazole-4-carboxamide |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1155004T3 true DK1155004T3 (da) | 2004-04-13 |
Family
ID=7899073
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK00916829T DK1155004T3 (da) | 1999-02-26 | 2000-02-12 | Fremgangsmåde til krystallisation af N-(4-trifluormethylphenyl)-5-methyl-isoxazol-4-carboxamid |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US6303792B1 (fr) |
| EP (1) | EP1155004B1 (fr) |
| JP (1) | JP4625187B2 (fr) |
| KR (1) | KR100626110B1 (fr) |
| CN (1) | CN1127491C (fr) |
| AR (1) | AR022737A1 (fr) |
| AT (1) | ATE257828T1 (fr) |
| AU (1) | AU762394B2 (fr) |
| BR (1) | BR0008566B1 (fr) |
| CA (1) | CA2363875C (fr) |
| DE (2) | DE19908527C2 (fr) |
| DK (1) | DK1155004T3 (fr) |
| ES (1) | ES2214259T3 (fr) |
| HK (1) | HK1043787B (fr) |
| HU (1) | HU228918B1 (fr) |
| IL (2) | IL144867A0 (fr) |
| NO (1) | NO319830B1 (fr) |
| NZ (1) | NZ513777A (fr) |
| PL (1) | PL199365B1 (fr) |
| PT (1) | PT1155004E (fr) |
| WO (1) | WO2000050411A1 (fr) |
| ZA (1) | ZA200106973B (fr) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19610955A1 (de) * | 1996-03-20 | 1997-09-25 | Hoechst Ag | Kombinationspräparat, enthaltend 5-Methylisoxazol-4-carbonsäure-(4-trifluormethyl)- anilid und N-(4-Trifluormethylphenyl)-2-cyan-3- hydroxycrotonsäureamid |
| ATE207065T1 (de) * | 1997-08-08 | 2001-11-15 | Aventis Pharma Gmbh | Kristallform von n-(4-trifluormethylphenyl)-5- methylisoxazol-4-carbonsäureamid |
| CZ20022000A3 (cs) * | 1999-12-16 | 2003-02-12 | Teva Pharmaceuticals Industries Ltd. | Způsoby přípravy a nová krystalická forma leflunomidu |
| EP1257270B1 (fr) * | 2000-02-15 | 2005-04-13 | Teva Pharmaceutical Industries Ltd. | Procede permettant d'effectuer la synthese du leflunomide |
| CN107311954B (zh) * | 2017-05-17 | 2020-04-07 | 力赛生物医药科技（厦门）有限公司 | 来氟米特晶型化合物、制备方法及其应用 |
| CN114436894A (zh) * | 2020-11-04 | 2022-05-06 | 欣凯医药化工中间体（上海）有限公司 | 泰瑞米特钠晶型及制备方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2854439A1 (de) | 1978-12-16 | 1980-07-03 | Hoechst Ag | Ein isoxazolderivat, verfahren zu seiner herstellung, diese verbindung enthaltende mittel und verwendung |
| DE3534440A1 (de) * | 1985-09-27 | 1987-04-02 | Hoechst Ag | Arzneimittel gegen chronische graft-versus-host-krankheiten sowie gegen autoimmunerkrankungen, insbesondere systemischen lupus erythematodes |
| AU649421B2 (en) * | 1990-05-18 | 1994-05-26 | Sanofi-Aventis Deutschland Gmbh | Isoxazole-4-carboxamides and hydroxyalkylidene-cyanoacetamides, drugs containing these compounds and use of such drugs |
| DE4127737A1 (de) * | 1991-08-22 | 1993-02-25 | Hoechst Ag | Arzneimittel zur behandlung von abstossungsreaktionen bei organverpflanzungen |
| US5519042A (en) * | 1994-01-13 | 1996-05-21 | Hoechst Aktiengesellschaft | Method of treating hyperproliferative vascular disease |
| ATE207065T1 (de) | 1997-08-08 | 2001-11-15 | Aventis Pharma Gmbh | Kristallform von n-(4-trifluormethylphenyl)-5- methylisoxazol-4-carbonsäureamid |
| DE19734438A1 (de) * | 1997-08-08 | 1999-02-11 | Hoechst Marion Roussel De Gmbh | Kristallform von N-(4-Trifluormethylphenyl)-5-methyl-isoxazole-4-carboxamid |
-
1999
- 1999-02-26 DE DE19908527A patent/DE19908527C2/de not_active Expired - Lifetime
-
2000
- 2000-02-12 JP JP2000600994A patent/JP4625187B2/ja not_active Expired - Lifetime
- 2000-02-12 HU HU0200058A patent/HU228918B1/hu unknown
- 2000-02-12 CN CN00804234A patent/CN1127491C/zh not_active Expired - Lifetime
- 2000-02-12 CA CA002363875A patent/CA2363875C/fr not_active Expired - Fee Related
- 2000-02-12 AU AU38038/00A patent/AU762394B2/en not_active Expired
- 2000-02-12 EP EP00916829A patent/EP1155004B1/fr not_active Expired - Lifetime
- 2000-02-12 DE DE50005025T patent/DE50005025D1/de not_active Expired - Lifetime
- 2000-02-12 AT AT00916829T patent/ATE257828T1/de active
- 2000-02-12 NZ NZ513777A patent/NZ513777A/xx not_active IP Right Cessation
- 2000-02-12 IL IL14486700A patent/IL144867A0/xx active IP Right Grant
- 2000-02-12 PL PL350422A patent/PL199365B1/pl unknown
- 2000-02-12 PT PT00916829T patent/PT1155004E/pt unknown
- 2000-02-12 DK DK00916829T patent/DK1155004T3/da active
- 2000-02-12 KR KR1020017010843A patent/KR100626110B1/ko active IP Right Grant
- 2000-02-12 WO PCT/EP2000/001151 patent/WO2000050411A1/fr active IP Right Grant
- 2000-02-12 ES ES00916829T patent/ES2214259T3/es not_active Expired - Lifetime
- 2000-02-12 BR BRPI0008566-9A patent/BR0008566B1/pt not_active IP Right Cessation
- 2000-02-22 US US09/510,157 patent/US6303792B1/en not_active Expired - Lifetime
- 2000-02-24 AR ARP000100788A patent/AR022737A1/es active IP Right Grant
-
2001
- 2001-08-13 IL IL144867A patent/IL144867A/en not_active IP Right Cessation
- 2001-08-22 NO NO20014077A patent/NO319830B1/no not_active IP Right Cessation
- 2001-08-23 ZA ZA200106973A patent/ZA200106973B/en unknown
-
2002
- 2002-05-31 HK HK02104056.1A patent/HK1043787B/zh not_active IP Right Cessation
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