DK1140803T3 - ((aminoiminomethyl)amino)alkancarboxamider og anvendelse deraf i terapi - Google Patents

((aminoiminomethyl)amino)alkancarboxamider og anvendelse deraf i terapi

Info

Publication number
DK1140803T3
DK1140803T3 DK99964687T DK99964687T DK1140803T3 DK 1140803 T3 DK1140803 T3 DK 1140803T3 DK 99964687 T DK99964687 T DK 99964687T DK 99964687 T DK99964687 T DK 99964687T DK 1140803 T3 DK1140803 T3 DK 1140803T3
Authority
DK
Denmark
Prior art keywords
aminoiminomethyl
therapy
amino
carboxamides
alkane
Prior art date
Application number
DK99964687T
Other languages
Danish (da)
English (en)
Inventor
Gerard Moinet
Daniel Cravo
Didier Mesangeau
Liliane Doare
Micheline Kergoat
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Application granted granted Critical
Publication of DK1140803T3 publication Critical patent/DK1140803T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C279/14—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/70—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
DK99964687T 1999-01-11 1999-12-30 ((aminoiminomethyl)amino)alkancarboxamider og anvendelse deraf i terapi DK1140803T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9900194A FR2788275B1 (fr) 1999-01-11 1999-01-11 ((aminoiminomethyl)amino) alcane carboxamides et leurs applications en therapeutique
PCT/EP1999/010468 WO2000042001A1 (en) 1999-01-11 1999-12-30 ((aminoiminomethyl) amino) alkanecarboxamides and their applications in therapy

Publications (1)

Publication Number Publication Date
DK1140803T3 true DK1140803T3 (da) 2003-12-22

Family

ID=9540749

Family Applications (1)

Application Number Title Priority Date Filing Date
DK99964687T DK1140803T3 (da) 1999-01-11 1999-12-30 ((aminoiminomethyl)amino)alkancarboxamider og anvendelse deraf i terapi

Country Status (27)

Country Link
US (1) US6518458B1 (id)
EP (1) EP1140803B1 (id)
JP (1) JP4567889B2 (id)
KR (1) KR100630291B1 (id)
CN (1) CN1182109C (id)
AR (1) AR022221A1 (id)
AT (1) ATE252553T1 (id)
AU (1) AU760147B2 (id)
BR (1) BR9916858A (id)
CA (1) CA2359454C (id)
CZ (1) CZ20012482A3 (id)
DE (1) DE69912315T2 (id)
DK (1) DK1140803T3 (id)
EE (1) EE200100363A (id)
ES (1) ES2207325T3 (id)
FR (1) FR2788275B1 (id)
HK (1) HK1041689B (id)
HU (1) HUP0200023A3 (id)
ID (1) ID29586A (id)
IL (1) IL144225A0 (id)
NO (1) NO20013420D0 (id)
NZ (1) NZ513467A (id)
PT (1) PT1140803E (id)
RU (1) RU2236401C2 (id)
SK (1) SK285130B6 (id)
WO (1) WO2000042001A1 (id)
ZA (1) ZA200106606B (id)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA06012722A (es) * 2004-05-05 2007-02-14 Atugen Ag Lipidos, complejos de lipido y su uso.
KR101366482B1 (ko) 2004-12-27 2014-02-21 사일런스 테라퓨틱스 아게 코팅된 지질 복합체 및 이들의 용도
TW200808705A (en) * 2006-06-15 2008-02-16 Sanofi Aventis Aryl- and heteroaryl-ethyl-acylguanidine derivatives, their preparation and their application in therapeutics
WO2008009477A2 (en) * 2006-07-21 2008-01-24 Silence Therapeutics Ag Means for inhibiting the expression of protein kinase 3
WO2010074591A1 (ru) * 2008-12-24 2010-07-01 Закрытое Акционерное Общество "Beptekc" Амиды креатина, способ их получения, средство, обладающее нейропротекторным действием

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1153424A (en) * 1965-04-15 1969-05-29 Horlicks Ltd Pharmaceutical Compositions
US5654451B1 (en) * 1993-01-14 2000-02-22 Magainin Pharma Amino acids and peptides having modified c-terminals and modified n-terminals
JPH0841008A (ja) * 1994-07-29 1996-02-13 Ono Pharmaceut Co Ltd 一酸化窒素合成酵素阻害剤
CA2217550A1 (en) * 1996-10-22 1998-04-22 F. Hoffmann-La Roche Ag Cationic lipids for gene therapy
US6395713B1 (en) * 1997-07-23 2002-05-28 Ribozyme Pharmaceuticals, Inc. Compositions for the delivery of negatively charged molecules
DE19748697A1 (de) * 1997-11-04 1999-05-06 Basf Ag Verfahren zur Herstellung von substituierten Guanidinderivaten

Also Published As

Publication number Publication date
CA2359454A1 (en) 2000-07-20
EP1140803A1 (en) 2001-10-10
NO20013420L (no) 2001-07-10
JP2002534496A (ja) 2002-10-15
DE69912315D1 (de) 2003-11-27
ATE252553T1 (de) 2003-11-15
NO20013420D0 (no) 2001-07-10
KR100630291B1 (ko) 2006-09-29
HK1041689B (zh) 2005-09-02
HK1041689A1 (en) 2002-07-19
CZ20012482A3 (cs) 2001-10-17
AU760147B2 (en) 2003-05-08
HUP0200023A3 (en) 2003-04-28
PT1140803E (pt) 2004-03-31
ZA200106606B (en) 2002-11-11
FR2788275B1 (fr) 2002-06-14
KR20010089822A (ko) 2001-10-08
ID29586A (id) 2001-09-06
IL144225A0 (en) 2002-05-23
AR022221A1 (es) 2002-09-04
FR2788275A1 (fr) 2000-07-13
RU2236401C2 (ru) 2004-09-20
EE200100363A (et) 2002-10-15
BR9916858A (pt) 2001-12-04
JP4567889B2 (ja) 2010-10-20
SK9842001A3 (en) 2001-12-03
HUP0200023A2 (hu) 2002-05-29
SK285130B6 (sk) 2006-07-07
WO2000042001A1 (en) 2000-07-20
EP1140803B1 (en) 2003-10-22
CN1333747A (zh) 2002-01-30
ES2207325T3 (es) 2004-05-16
CA2359454C (en) 2009-10-27
CN1182109C (zh) 2004-12-29
AU3044300A (en) 2000-08-01
US6518458B1 (en) 2003-02-11
NZ513467A (en) 2003-08-29
DE69912315T2 (de) 2004-08-05

Similar Documents

Publication Publication Date Title
NO20014560D0 (no) Quinasoliner og terapautisk anvendelse derav
IS6411A (is) Kaspasa tálmar og notkun þeirra
DK1354888T3 (da) Glukopyranosyloxypyrazolderivater og anvendelse deraf i medikamenter
NO20012245L (no) Anthranilsyreamider og anvendelse derav som medikamenter
DK1233964T3 (da) Ny anvendelse og hidtil ukendte N-azabicycloamidderivater
IS7185A (is) Glúkagon-líkir-peptíð-1 hermar í mönnum og notkunþeirra við meðhöndlun sykursýki og skylds ástands
NO993619D0 (no) Titandioksid, fremstilling og anvendelse derav
IL156565A0 (en) N-(phenylsulphonyl) glycine derivatives and their therapeutic use
NO20005990L (no) Platinumkompleks, dets fremstilling og terapeutiske anvendelse
AU2002346504A8 (en) Therapeutic protein and treatments
NO20033123D0 (no) Terapeutisk hinnedannende sammensetning og behandlingsplan derav
DK0984960T3 (da) N-triazol-2-indolcarboxamider og deres anvendelse som CCK-A-agonister
NO990300D0 (no) <Alfa>-aminosyreamider, fremstilling og terapeutisk anvendelse derav
NO20005919D0 (no) Platinakompleks, dets fremstilling og terapeutisk anvendelse
DK1140803T3 (da) ((aminoiminomethyl)amino)alkancarboxamider og anvendelse deraf i terapi
NO20012738D0 (no) Terapeutiske produkter og anvendelse derav
NO991581D0 (no) N-(benzotiazol-2-yl)piperidin-1-etanaminderivater, deres fremstilling og anvendelse i terapeutiske midler
NO20020919D0 (no) Irenprotein, dets fremstilling og anvendelse
NO20023015D0 (no) Humant heparanasebeslektet polypeptid og nukleinsyre
DK1372665T3 (da) Hormonerstatningsbehandling og administration
IS6660A (is) Ný bispídínefnasambönd og notkun þeirra í meðhöndlun á hjartsláttarglöpum
NO20044090L (no) Substituert 3-fenyl-5-alkoksy-1,3,4-oksadiazol-24neJr, fremstilling derav og anvendelse i medikamenter
NO20015922D0 (no) Nye calpainer og anvendelse derav
NO20022482L (no) 2-arylkinolinderivater, fremgangsmåte og terapeutisk anvendelse derav
NO20015906D0 (no) Spliceosomprotein og dets anvendelse