DK1137416T3 - Anvendelse af langkædede N-alkylderivater af deoxynojirimycin til fremstilling af et lægemiddel til behandling af glycolipidophobnings-sygdomme - Google Patents
Anvendelse af langkædede N-alkylderivater af deoxynojirimycin til fremstilling af et lægemiddel til behandling af glycolipidophobnings-sygdommeInfo
- Publication number
- DK1137416T3 DK1137416T3 DK99967135T DK99967135T DK1137416T3 DK 1137416 T3 DK1137416 T3 DK 1137416T3 DK 99967135 T DK99967135 T DK 99967135T DK 99967135 T DK99967135 T DK 99967135T DK 1137416 T3 DK1137416 T3 DK 1137416T3
- Authority
- DK
- Denmark
- Prior art keywords
- deoxynojirimycin
- treatment
- glycolipid
- medicament
- manufacture
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11168398P | 1998-12-10 | 1998-12-10 | |
PCT/US1999/027918 WO2000033843A1 (en) | 1998-12-10 | 1999-12-08 | Use of long-chain n-alkyl derivatives of deoxynojirimycin for the manufacture of a medicament for the treatment of glycolipid storage diseases |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1137416T3 true DK1137416T3 (da) | 2003-03-03 |
Family
ID=22339901
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK99967135T DK1137416T3 (da) | 1998-12-10 | 1999-12-08 | Anvendelse af langkædede N-alkylderivater af deoxynojirimycin til fremstilling af et lægemiddel til behandling af glycolipidophobnings-sygdomme |
Country Status (11)
Country | Link |
---|---|
US (1) | US6610703B1 (de) |
EP (1) | EP1137416B1 (de) |
JP (1) | JP2002531505A (de) |
AT (1) | ATE226821T1 (de) |
AU (1) | AU2347500A (de) |
CA (1) | CA2352544C (de) |
DE (1) | DE69903750T2 (de) |
DK (1) | DK1137416T3 (de) |
ES (1) | ES2190674T3 (de) |
PT (1) | PT1137416E (de) |
WO (1) | WO2000033843A1 (de) |
Families Citing this family (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6465488B1 (en) | 1997-12-11 | 2002-10-15 | Chancellor, Masters & Scholars Of The University Of Oxford | Inhibition of glycolipid biosynthesis |
US6274597B1 (en) | 1998-06-01 | 2001-08-14 | Mount Sinai School Of Medicine Of New York University | Method of enhancing lysosomal α-Galactosidase A |
GB9909066D0 (en) * | 1999-04-20 | 1999-06-16 | Oxford Glycosciences Uk Ltd | Therapies |
GB9909064D0 (en) * | 1999-04-20 | 1999-06-16 | Oxford Glycosciences Uk Ltd | Therapies |
GB0100889D0 (en) | 2001-01-12 | 2001-02-21 | Oxford Glycosciences Uk Ltd | Compounds |
US20020095135A1 (en) * | 2000-06-19 | 2002-07-18 | David Meeker | Combination enzyme replacement, gene therapy and small molecule therapy for lysosomal storage diseases |
ES2393919T3 (es) | 2002-07-17 | 2013-01-02 | Actelion Pharmaceuticals Ltd. | Derivados de PIPERIDINETRIOL como inhibidores de GLUCOSILCERAMIDA SINTASA |
US7985760B2 (en) | 2002-07-17 | 2011-07-26 | Actelion Pharmaceuticals Ltd. | Piperidinetriol derivatives as inhibitors of glycosyceramid synthase |
GB0313678D0 (en) | 2003-06-13 | 2003-07-16 | Oxford Glycosciences Uk Ltd | Novel compounds |
GB0313677D0 (en) | 2003-06-13 | 2003-07-16 | Oxford Glycosciences Uk Ltd | Novel compound |
BRPI0517701A8 (pt) | 2004-11-10 | 2018-01-23 | Genzyme Corp | métodos de tratamento de diabetes mellitus |
PL2032134T3 (pl) | 2006-05-09 | 2015-11-30 | Genzyme Corp | Sposoby leczenia stłuszczeniowej choroby wątroby obejmujące hamowanie syntezy glikosfingolipidów |
GB0614947D0 (en) * | 2006-07-27 | 2006-09-06 | Isis Innovation | Epitope reduction therapy |
US8097728B2 (en) * | 2007-04-30 | 2012-01-17 | Philadelphia Health & Education Corporation | Iminosugar compounds with antiflavirus activity |
WO2008150486A2 (en) | 2007-05-31 | 2008-12-11 | Genzyme Corporation | 2-acylaminopropoanol-type glucosylceramide synthase inhibitors |
SG184721A1 (en) * | 2007-10-05 | 2012-10-30 | Genzyme Corp | Method of treating polycystic kidney diseases with ceramide derivatives |
US8389517B2 (en) * | 2008-07-28 | 2013-03-05 | Genzyme Corporation | Glucosylceramide synthase inhibition for the treatment of collapsing glomerulopathy and other glomerular disease |
WO2010039256A1 (en) | 2008-10-03 | 2010-04-08 | Genzyme Corporation | 2-acylaminopropoanol-type glucosylceramide synthase inhibitors |
ES2735023T3 (es) | 2008-12-16 | 2019-12-13 | Genzyme Corp | Intermedios sintéticos para preparar conjugados de oligosacáridos-proteínas |
KR101755133B1 (ko) * | 2009-02-23 | 2017-07-06 | 유나이티드 세러퓨틱스 코오포레이션 | 이미노슈가 및 바이러스성 질환을 치료하는 방법 |
KR20170117614A (ko) * | 2009-02-24 | 2017-10-23 | 유나이티드 세러퓨틱스 코오포레이션 | 이미노슈가 및 아레나바이러스성 감염을 치료하는 방법 |
CA2793276A1 (en) * | 2009-03-27 | 2010-09-30 | Zacharon Pharmaceuticals, Inc. | Ganglioside biosynthesis modulators |
US8426445B2 (en) | 2009-06-12 | 2013-04-23 | United Therapeutics Corporation | Iminosugars and methods of treating bunyaviral and togaviral diseases |
KR20120081990A (ko) * | 2009-09-04 | 2012-07-20 | 더 챈슬러 마스터즈 앤드 스칼라스 오브 더 유니버시티 오브 옥스포드 | 이미노당 및 필로바이러스 질환의 치료 방법 |
JP5653438B2 (ja) * | 2009-09-04 | 2015-01-14 | ユナイテッド セラピューティクス コーポレイション | オルトミクソウイルス感染の治療方法 |
KR101459530B1 (ko) * | 2009-09-04 | 2014-11-07 | 유나이티드 세러퓨틱스 코오포레이션 | 폭스바이러스 감염의 치료 방법 |
PT3133070T (pt) | 2009-11-27 | 2019-11-11 | Genzyme Corp | Eliglustat (genz 112638) como inibidor de glicosilceramida-sintase para utilização num método de tratamento de doença de fabry ou de gaucher, o método compreendendo ajustar a dose terapêutica individual ao metabolismo do p-450 do doente |
US8961959B2 (en) | 2011-10-17 | 2015-02-24 | The Regents Of The University Of Michigan | Glucosylceramide synthase inhibitors and therapeutic methods using the same |
WO2014017915A2 (en) | 2012-07-27 | 2014-01-30 | Universiteit Utrecht Holding B.V. | Urea and guanidinium derivatives of iminosugars |
US20160075651A1 (en) * | 2013-05-02 | 2016-03-17 | Unither Virology, Llc | Glycolipid inhibition using iminosugars |
JP6749923B2 (ja) | 2015-02-02 | 2020-09-02 | ザ リージェンツ オブ ザ ユニバーシティー オブ ミシガン | グルコシルセラミドシンターゼ阻害剤及びそれを使用した治療方法 |
EP3318277A1 (de) | 2016-11-04 | 2018-05-09 | Institut du Cerveau et de la Moelle Epiniere-ICM | Inhibitoren der glucosylceramidsynthase zur behandlung von motoneuronerkrankungen |
WO2020193746A1 (en) | 2019-03-28 | 2020-10-01 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for predicting the survival of patients suffering from melanoma |
JP2022553107A (ja) | 2019-10-23 | 2022-12-21 | ザ・リージェンツ・オブ・ザ・ユニバーシティ・オブ・ミシガン | グルコシルセラミドシンターゼ阻害剤およびそれを使用する治療方法 |
EP4142878B1 (de) | 2020-04-28 | 2024-06-26 | The Regents of The University of Michigan | Pyridinhemmer der glucosylceramidsynthase und therapeutische verfahren damit |
KR20240061713A (ko) * | 2022-11-01 | 2024-05-08 | 차의과학대학교 산학협력단 | N-노닐데옥시노지리마이신을 포함하는 피부 가려움증의 억제, 경감, 개선, 또는 치료를 위한 조성물 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3507019A1 (de) * | 1985-02-28 | 1986-08-28 | Bayer Ag, 5090 Leverkusen | Neue derivate von 3,4,5-trihydroxypiperidin, verfahren zu ihrer herstellung und ihre verwendung |
US5030638A (en) | 1990-02-26 | 1991-07-09 | G. D. Searle & Co. | Method of antiviral enhancement |
US5798366A (en) | 1993-05-13 | 1998-08-25 | Monsanto Company | Method for treatment of CNS-involved lysosomal storage diseases |
US6291657B1 (en) | 1993-05-13 | 2001-09-18 | Monsanto Company | Deoxygalactonojirimycin derivatives |
US5399567A (en) | 1993-05-13 | 1995-03-21 | Monsanto Company | Method of treating cholera |
AU732552B2 (en) | 1996-07-15 | 2001-04-26 | Genzyme Corporation | Deoxynojirimycin derivatives and their uses as glucosylceramidase inhibitors |
CA2252238A1 (en) | 1997-10-31 | 1999-04-30 | Sun Microsystems, Inc. | Method and apparatus for sharing a time quantum |
-
1999
- 1999-12-02 US US09/453,754 patent/US6610703B1/en not_active Expired - Fee Related
- 1999-12-08 DE DE69903750T patent/DE69903750T2/de not_active Expired - Fee Related
- 1999-12-08 ES ES99967135T patent/ES2190674T3/es not_active Expired - Lifetime
- 1999-12-08 WO PCT/US1999/027918 patent/WO2000033843A1/en active IP Right Grant
- 1999-12-08 PT PT99967135T patent/PT1137416E/pt unknown
- 1999-12-08 DK DK99967135T patent/DK1137416T3/da active
- 1999-12-08 EP EP99967135A patent/EP1137416B1/de not_active Expired - Lifetime
- 1999-12-08 JP JP2000586335A patent/JP2002531505A/ja active Pending
- 1999-12-08 AT AT99967135T patent/ATE226821T1/de not_active IP Right Cessation
- 1999-12-08 AU AU23475/00A patent/AU2347500A/en not_active Abandoned
- 1999-12-08 CA CA002352544A patent/CA2352544C/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
AU2347500A (en) | 2000-06-26 |
EP1137416A1 (de) | 2001-10-04 |
JP2002531505A (ja) | 2002-09-24 |
ES2190674T3 (es) | 2003-08-01 |
DE69903750T2 (de) | 2003-06-12 |
EP1137416B1 (de) | 2002-10-30 |
PT1137416E (pt) | 2003-01-31 |
CA2352544C (en) | 2007-11-13 |
CA2352544A1 (en) | 2000-06-15 |
WO2000033843A1 (en) | 2000-06-15 |
DE69903750D1 (de) | 2002-12-05 |
ATE226821T1 (de) | 2002-11-15 |
US6610703B1 (en) | 2003-08-26 |
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