ES2190674T3 - Uso de n-alquil derivados de cadena larga de desoxinojirimicina para la fabricacion de un medicamento para el tratamiento de enfermedades de acumulacion de glucolipidos. - Google Patents

Uso de n-alquil derivados de cadena larga de desoxinojirimicina para la fabricacion de un medicamento para el tratamiento de enfermedades de acumulacion de glucolipidos.

Info

Publication number
ES2190674T3
ES2190674T3 ES99967135T ES99967135T ES2190674T3 ES 2190674 T3 ES2190674 T3 ES 2190674T3 ES 99967135 T ES99967135 T ES 99967135T ES 99967135 T ES99967135 T ES 99967135T ES 2190674 T3 ES2190674 T3 ES 2190674T3
Authority
ES
Spain
Prior art keywords
treatment
deoxinojirimicine
glucolipid
rent
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES99967135T
Other languages
English (en)
Inventor
Gary S Jacob
Frances M Platt
Terry D Butters
Raymond A Dwek
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Oxford
GD Searle LLC
Original Assignee
University of Oxford
GD Searle LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Oxford, GD Searle LLC filed Critical University of Oxford
Application granted granted Critical
Publication of ES2190674T3 publication Critical patent/ES2190674T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism

Abstract

Uso de un N-alquil derivado de cadena larga de desoxinojirimicina que tiene de nueve a veinte átomos de carbono en la cadena alquilo, para la preparación de un medicamento para el tratamiento de un paciente que padece una enfermedad de acumulación de glucolípidos.
ES99967135T 1998-12-10 1999-12-08 Uso de n-alquil derivados de cadena larga de desoxinojirimicina para la fabricacion de un medicamento para el tratamiento de enfermedades de acumulacion de glucolipidos. Expired - Lifetime ES2190674T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US11168398P 1998-12-10 1998-12-10

Publications (1)

Publication Number Publication Date
ES2190674T3 true ES2190674T3 (es) 2003-08-01

Family

ID=22339901

Family Applications (1)

Application Number Title Priority Date Filing Date
ES99967135T Expired - Lifetime ES2190674T3 (es) 1998-12-10 1999-12-08 Uso de n-alquil derivados de cadena larga de desoxinojirimicina para la fabricacion de un medicamento para el tratamiento de enfermedades de acumulacion de glucolipidos.

Country Status (11)

Country Link
US (1) US6610703B1 (es)
EP (1) EP1137416B1 (es)
JP (1) JP2002531505A (es)
AT (1) ATE226821T1 (es)
AU (1) AU2347500A (es)
CA (1) CA2352544C (es)
DE (1) DE69903750T2 (es)
DK (1) DK1137416T3 (es)
ES (1) ES2190674T3 (es)
PT (1) PT1137416E (es)
WO (1) WO2000033843A1 (es)

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US6465488B1 (en) 1997-12-11 2002-10-15 Chancellor, Masters & Scholars Of The University Of Oxford Inhibition of glycolipid biosynthesis
US6274597B1 (en) 1998-06-01 2001-08-14 Mount Sinai School Of Medicine Of New York University Method of enhancing lysosomal α-Galactosidase A
GB9909064D0 (en) * 1999-04-20 1999-06-16 Oxford Glycosciences Uk Ltd Therapies
GB0100889D0 (en) 2001-01-12 2001-02-21 Oxford Glycosciences Uk Ltd Compounds
GB9909066D0 (en) * 1999-04-20 1999-06-16 Oxford Glycosciences Uk Ltd Therapies
AU2001269923A1 (en) * 2000-06-19 2002-01-02 Genzyme Corporation Combination enzyme replacement, gene therapy and small molecule therapy for lysosomal storage diseases
AU2003248960B2 (en) 2002-07-17 2009-06-25 Idorsia Pharmaceuticals Ltd Piperidinetriol derivatives as inhibitors of glycosylceramidsynthase
JP4575156B2 (ja) 2002-07-17 2010-11-04 アクテリオン ファーマシューティカルズ リミテッド グルコシルセラミドシンターゼの阻害剤としてのピペリジントリオール誘導体
GB0313678D0 (en) 2003-06-13 2003-07-16 Oxford Glycosciences Uk Ltd Novel compounds
GB0313677D0 (en) 2003-06-13 2003-07-16 Oxford Glycosciences Uk Ltd Novel compound
CA2586761A1 (en) * 2004-11-10 2006-05-18 Genzyme Corporation Methods of treating diabetes mellitus
HUE026057T2 (en) 2006-05-09 2016-05-30 Genzyme Corp Procedures for the Treatment of Fatty Liver Disease, which comprises inhibition of glycosphingolipid synthesis
GB0614947D0 (en) * 2006-07-27 2006-09-06 Isis Innovation Epitope reduction therapy
US8097728B2 (en) * 2007-04-30 2012-01-17 Philadelphia Health & Education Corporation Iminosugar compounds with antiflavirus activity
US8304447B2 (en) 2007-05-31 2012-11-06 Genzyme Corporation 2-acylaminopropoanol-type glucosylceramide synthase inhibitors
SG10201707161PA (en) * 2007-10-05 2017-10-30 Genzyme Corp Method of treating polycystic kidney diseases with ceramide derivatives
WO2010014554A1 (en) 2008-07-28 2010-02-04 Genzyme Corporation Glucosylceramide synthase inhibition for the treatment of collapsing glomerulopathy and other glomerular disease
CN107935983A (zh) 2008-10-03 2018-04-20 简詹姆公司 2‑酰胺基丙醇型葡糖神经酰胺合酶抑制剂
EP3608330B1 (en) 2008-12-16 2022-11-09 Genzyme Corporation Synthetic intermediates for preparing oligosaccharide-protein conjugates
WO2010096764A1 (en) 2009-02-23 2010-08-26 United Therapeutics Corporation Iminosugars and methods of treating viral diseases
EP2400843B1 (en) * 2009-02-24 2015-11-11 United Therapeutics Corporation Iminosugars and methods of treating arenaviral infections
US20100248365A1 (en) * 2009-03-27 2010-09-30 Zacharon Pharmaceuticals, Inc. Ganglioside biosynthesis modulators
CA2765086C (en) * 2009-06-12 2015-12-15 United Therapeutics Corporation Iminosugars and methods of treating bunyaviral and togaviral diseases
BR112012004676A2 (pt) * 2009-09-04 2019-09-24 United Therapeutics Corp método de tratar infecções orotomixovirais.
EP2473493B1 (en) * 2009-09-04 2014-04-30 United Therapeutics Corporation Methods of treating poxviral infections
KR20120081990A (ko) * 2009-09-04 2012-07-20 더 챈슬러 마스터즈 앤드 스칼라스 오브 더 유니버시티 오브 옥스포드 이미노당 및 필로바이러스 질환의 치료 방법
SI2796457T1 (sl) 2009-11-27 2016-10-28 Genzyme Corporation Genz 112638 za zdravljenje Gaucherjeve ali Fabryjeve bolezni v kombinirani terapiji
WO2013059119A1 (en) 2011-10-17 2013-04-25 The Regents Of The University Of Michigan Glucosylceramide synthase inhibitors and therapeutic methods using the same
WO2014017915A2 (en) 2012-07-27 2014-01-30 Universiteit Utrecht Holding B.V. Urea and guanidinium derivatives of iminosugars
CN106102464A (zh) * 2013-05-02 2016-11-09 牛津大学之校长及学者 采用亚氨基糖的糖脂抑制
JP6749923B2 (ja) 2015-02-02 2020-09-02 ザ リージェンツ オブ ザ ユニバーシティー オブ ミシガン グルコシルセラミドシンターゼ阻害剤及びそれを使用した治療方法
EP3318277A1 (en) 2016-11-04 2018-05-09 Institut du Cerveau et de la Moelle Epiniere-ICM Inhibitors of glucosylceramide synthase for the treatment of motor neuron diseases
WO2020193746A1 (en) 2019-03-28 2020-10-01 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for predicting the survival of patients suffering from melanoma
US11220479B2 (en) 2019-10-23 2022-01-11 The Regents Of The University Of Michigan Glucosylceramide synthase inhibitors and therapeutic methods using the same
EP4142878A1 (en) 2020-04-28 2023-03-08 The Regents of The University of Michigan Pyridine inhibitors of glucosylceramide synthase and therapeutic methods using the same

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DE3507019A1 (de) * 1985-02-28 1986-08-28 Bayer Ag, 5090 Leverkusen Neue derivate von 3,4,5-trihydroxypiperidin, verfahren zu ihrer herstellung und ihre verwendung
US5030638A (en) 1990-02-26 1991-07-09 G. D. Searle & Co. Method of antiviral enhancement
US6291657B1 (en) 1993-05-13 2001-09-18 Monsanto Company Deoxygalactonojirimycin derivatives
US5798366A (en) 1993-05-13 1998-08-25 Monsanto Company Method for treatment of CNS-involved lysosomal storage diseases
US5399567A (en) 1993-05-13 1995-03-21 Monsanto Company Method of treating cholera
WO1998002161A1 (en) 1996-07-15 1998-01-22 Universiteit Van Amsterdam Deoxynojirimycin derivatives and their uses as glucosylceramidase inhibitors
CA2252238A1 (en) 1997-10-31 1999-04-30 Sun Microsystems, Inc. Method and apparatus for sharing a time quantum

Also Published As

Publication number Publication date
WO2000033843A1 (en) 2000-06-15
EP1137416A1 (en) 2001-10-04
DK1137416T3 (da) 2003-03-03
DE69903750T2 (de) 2003-06-12
PT1137416E (pt) 2003-01-31
US6610703B1 (en) 2003-08-26
CA2352544A1 (en) 2000-06-15
AU2347500A (en) 2000-06-26
DE69903750D1 (de) 2002-12-05
ATE226821T1 (de) 2002-11-15
EP1137416B1 (en) 2002-10-30
JP2002531505A (ja) 2002-09-24
CA2352544C (en) 2007-11-13

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