DK1137416T3 - Anvendelse af langkædede N-alkylderivater af deoxynojirimycin til fremstilling af et lægemiddel til behandling af glycolipidophobnings-sygdomme - Google Patents

Anvendelse af langkædede N-alkylderivater af deoxynojirimycin til fremstilling af et lægemiddel til behandling af glycolipidophobnings-sygdomme

Info

Publication number
DK1137416T3
DK1137416T3 DK99967135T DK99967135T DK1137416T3 DK 1137416 T3 DK1137416 T3 DK 1137416T3 DK 99967135 T DK99967135 T DK 99967135T DK 99967135 T DK99967135 T DK 99967135T DK 1137416 T3 DK1137416 T3 DK 1137416T3
Authority
DK
Denmark
Prior art keywords
deoxynojirimycin
treatment
glycolipid
medicament
manufacture
Prior art date
Application number
DK99967135T
Other languages
English (en)
Inventor
Gary S Jacob
Frances M Platt
Terry D Butters
Raymond A Dwek
Original Assignee
Searle & Co
Univ Oxford
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Searle & Co, Univ Oxford filed Critical Searle & Co
Application granted granted Critical
Publication of DK1137416T3 publication Critical patent/DK1137416T3/da

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
DK99967135T 1998-12-10 1999-12-08 Anvendelse af langkædede N-alkylderivater af deoxynojirimycin til fremstilling af et lægemiddel til behandling af glycolipidophobnings-sygdomme DK1137416T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11168398P 1998-12-10 1998-12-10
PCT/US1999/027918 WO2000033843A1 (en) 1998-12-10 1999-12-08 Use of long-chain n-alkyl derivatives of deoxynojirimycin for the manufacture of a medicament for the treatment of glycolipid storage diseases

Publications (1)

Publication Number Publication Date
DK1137416T3 true DK1137416T3 (da) 2003-03-03

Family

ID=22339901

Family Applications (1)

Application Number Title Priority Date Filing Date
DK99967135T DK1137416T3 (da) 1998-12-10 1999-12-08 Anvendelse af langkædede N-alkylderivater af deoxynojirimycin til fremstilling af et lægemiddel til behandling af glycolipidophobnings-sygdomme

Country Status (11)

Country Link
US (1) US6610703B1 (da)
EP (1) EP1137416B1 (da)
JP (1) JP2002531505A (da)
AT (1) ATE226821T1 (da)
AU (1) AU2347500A (da)
CA (1) CA2352544C (da)
DE (1) DE69903750T2 (da)
DK (1) DK1137416T3 (da)
ES (1) ES2190674T3 (da)
PT (1) PT1137416E (da)
WO (1) WO2000033843A1 (da)

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US6274597B1 (en) 1998-06-01 2001-08-14 Mount Sinai School Of Medicine Of New York University Method of enhancing lysosomal α-Galactosidase A
GB9909066D0 (en) * 1999-04-20 1999-06-16 Oxford Glycosciences Uk Ltd Therapies
GB0100889D0 (en) 2001-01-12 2001-02-21 Oxford Glycosciences Uk Ltd Compounds
GB9909064D0 (en) * 1999-04-20 1999-06-16 Oxford Glycosciences Uk Ltd Therapies
US20020095135A1 (en) * 2000-06-19 2002-07-18 David Meeker Combination enzyme replacement, gene therapy and small molecule therapy for lysosomal storage diseases
ES2393331T3 (es) 2002-07-17 2012-12-20 Actelion Pharmaceuticals Ltd. Derivados de piperidintriol como inhibidores de la glucosiliceramida sintasa
US7994198B2 (en) 2002-07-17 2011-08-09 Actelion Pharmaceuticals Ltd. Piperidinetriol derivatives as inhibitors of glycosylceramidsynthase
GB0313677D0 (en) 2003-06-13 2003-07-16 Oxford Glycosciences Uk Ltd Novel compound
GB0313678D0 (en) 2003-06-13 2003-07-16 Oxford Glycosciences Uk Ltd Novel compounds
US8003617B2 (en) * 2004-11-10 2011-08-23 Genzyme Corporation Methods of treating diabetes mellitus
PT2032134E (pt) 2006-05-09 2015-10-07 Genzyme Corp Métodos de tratamento da doença do fígado gorduroso
GB0614947D0 (en) * 2006-07-27 2006-09-06 Isis Innovation Epitope reduction therapy
US8097728B2 (en) * 2007-04-30 2012-01-17 Philadelphia Health & Education Corporation Iminosugar compounds with antiflavirus activity
EP2594565B1 (en) 2007-05-31 2018-10-24 Genzyme Corporation 2-acylaminopropanol-type glucosylceramide synthase inhibitors
BRPI0823522A2 (pt) * 2007-10-05 2014-01-07 Genzyme Corp Uso de um composto derivado de ceramida
WO2010014554A1 (en) 2008-07-28 2010-02-04 Genzyme Corporation Glucosylceramide synthase inhibition for the treatment of collapsing glomerulopathy and other glomerular disease
WO2010039256A1 (en) * 2008-10-03 2010-04-08 Genzyme Corporation 2-acylaminopropoanol-type glucosylceramide synthase inhibitors
BR122020010601B8 (pt) 2008-12-16 2021-07-27 Genzyme Corp conjugados de proteína-oligossacarídeo, seus usos, e composições farmacêuticas
KR20120042716A (ko) 2009-02-23 2012-05-03 유나이티드 세러퓨틱스 코오포레이션 이미노슈가 및 바이러스성 질환을 치료하는 방법
CN102625660B (zh) * 2009-02-24 2015-03-11 联合治疗公司 亚氨基糖以及治疗沙粒病毒感染的方法
EP2411526A4 (en) * 2009-03-27 2012-09-19 Zacharon Pharmaceuticals Inc MODULATORS OF GANGLIOSID BIOSYNTHESIS
EP2440205B1 (en) * 2009-06-12 2014-08-27 United Therapeutics Corporation Iminosugars for use in the treatment of bunyaviral and togaviral diseases
WO2011028775A1 (en) * 2009-09-04 2011-03-10 United Therapeutics Corporation Methods of treating orthomyxoviral infections
KR101459530B1 (ko) * 2009-09-04 2014-11-07 유나이티드 세러퓨틱스 코오포레이션 폭스바이러스 감염의 치료 방법
ES2527623T3 (es) * 2009-09-04 2015-01-27 United Therapeutics Corporation Iminoazúcares para su uso en el tratamiento de enfermedades por filovirus
SI3133070T1 (sl) 2009-11-27 2019-11-29 Genzyme Corp Eliglustat (GENZ 112638) kot inhibitor sintaze glukozilceramida za uporabo v postopku zdravljenja Fabrjyeve ali Gaucherjeve bolezni, kjer postopek obsega prilagajanje individualnega terapevtskega odmerka metabolizmu P-450 pacienta
US8961959B2 (en) 2011-10-17 2015-02-24 The Regents Of The University Of Michigan Glucosylceramide synthase inhibitors and therapeutic methods using the same
WO2014017915A2 (en) 2012-07-27 2014-01-30 Universiteit Utrecht Holding B.V. Urea and guanidinium derivatives of iminosugars
CA2911149A1 (en) * 2013-05-02 2014-11-06 The Chancellor, Masters And Scholars Of The University Of Oxford Glycolipid inhibition using iminosugars
ES2856898T3 (es) 2015-02-02 2021-09-28 Univ Michigan Regents Inhibidores de glucosilceramida sintasa y métodos terapéuticos que usan los mismos
EP3318277A1 (en) 2016-11-04 2018-05-09 Institut du Cerveau et de la Moelle Epiniere-ICM Inhibitors of glucosylceramide synthase for the treatment of motor neuron diseases
WO2020193746A1 (en) 2019-03-28 2020-10-01 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for predicting the survival of patients suffering from melanoma
US11220479B2 (en) 2019-10-23 2022-01-11 The Regents Of The University Of Michigan Glucosylceramide synthase inhibitors and therapeutic methods using the same
US20230212123A1 (en) 2020-04-28 2023-07-06 The Regents Of The University Of Michigan Pyridine Inhibitors of Glucosylceramide Synthase and Therapeutic Methods Using the Same
KR20240061713A (ko) * 2022-11-01 2024-05-08 차의과학대학교 산학협력단 N-노닐데옥시노지리마이신을 포함하는 피부 가려움증의 억제, 경감, 개선, 또는 치료를 위한 조성물

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US5030638A (en) 1990-02-26 1991-07-09 G. D. Searle & Co. Method of antiviral enhancement
US5399567A (en) 1993-05-13 1995-03-21 Monsanto Company Method of treating cholera
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US6291657B1 (en) 1993-05-13 2001-09-18 Monsanto Company Deoxygalactonojirimycin derivatives
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CA2252238A1 (en) 1997-10-31 1999-04-30 Sun Microsystems, Inc. Method and apparatus for sharing a time quantum

Also Published As

Publication number Publication date
CA2352544A1 (en) 2000-06-15
ES2190674T3 (es) 2003-08-01
WO2000033843A1 (en) 2000-06-15
PT1137416E (pt) 2003-01-31
DE69903750D1 (de) 2002-12-05
ATE226821T1 (de) 2002-11-15
US6610703B1 (en) 2003-08-26
EP1137416A1 (en) 2001-10-04
EP1137416B1 (en) 2002-10-30
CA2352544C (en) 2007-11-13
JP2002531505A (ja) 2002-09-24
AU2347500A (en) 2000-06-26
DE69903750T2 (de) 2003-06-12

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