PT1137416E - Uso de derivados n-alquilo de cadeia longa de desoxinojirimicina para o fabrico de um medicamento para o tratamento de doencas ligadas ao armazenamento de glicolipidos - Google Patents
Uso de derivados n-alquilo de cadeia longa de desoxinojirimicina para o fabrico de um medicamento para o tratamento de doencas ligadas ao armazenamento de glicolipidosInfo
- Publication number
- PT1137416E PT1137416E PT99967135T PT99967135T PT1137416E PT 1137416 E PT1137416 E PT 1137416E PT 99967135 T PT99967135 T PT 99967135T PT 99967135 T PT99967135 T PT 99967135T PT 1137416 E PT1137416 E PT 1137416E
- Authority
- PT
- Portugal
- Prior art keywords
- long
- treatment
- glycolipidos
- deoxinojyrimicin
- drug
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11168398P | 1998-12-10 | 1998-12-10 |
Publications (1)
Publication Number | Publication Date |
---|---|
PT1137416E true PT1137416E (pt) | 2003-01-31 |
Family
ID=22339901
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT99967135T PT1137416E (pt) | 1998-12-10 | 1999-12-08 | Uso de derivados n-alquilo de cadeia longa de desoxinojirimicina para o fabrico de um medicamento para o tratamento de doencas ligadas ao armazenamento de glicolipidos |
Country Status (11)
Country | Link |
---|---|
US (1) | US6610703B1 (pt) |
EP (1) | EP1137416B1 (pt) |
JP (1) | JP2002531505A (pt) |
AT (1) | ATE226821T1 (pt) |
AU (1) | AU2347500A (pt) |
CA (1) | CA2352544C (pt) |
DE (1) | DE69903750T2 (pt) |
DK (1) | DK1137416T3 (pt) |
ES (1) | ES2190674T3 (pt) |
PT (1) | PT1137416E (pt) |
WO (1) | WO2000033843A1 (pt) |
Families Citing this family (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6465488B1 (en) | 1997-12-11 | 2002-10-15 | Chancellor, Masters & Scholars Of The University Of Oxford | Inhibition of glycolipid biosynthesis |
US6274597B1 (en) | 1998-06-01 | 2001-08-14 | Mount Sinai School Of Medicine Of New York University | Method of enhancing lysosomal α-Galactosidase A |
GB9909066D0 (en) * | 1999-04-20 | 1999-06-16 | Oxford Glycosciences Uk Ltd | Therapies |
GB9909064D0 (en) * | 1999-04-20 | 1999-06-16 | Oxford Glycosciences Uk Ltd | Therapies |
GB0100889D0 (en) | 2001-01-12 | 2001-02-21 | Oxford Glycosciences Uk Ltd | Compounds |
WO2001097829A2 (en) * | 2000-06-19 | 2001-12-27 | Genzyme Corporation | Combination enzyme replacement, gene therapy and small molecule therapy for lysosomal storage diseases |
AU2003248960B2 (en) | 2002-07-17 | 2009-06-25 | Idorsia Pharmaceuticals Ltd | Piperidinetriol derivatives as inhibitors of glycosylceramidsynthase |
AU2003246942B2 (en) | 2002-07-17 | 2009-06-25 | Idorsia Pharmaceuticals Ltd | Piperidinetriol derivatives as inhibitors of glycosylceramide synthase |
GB0313677D0 (en) | 2003-06-13 | 2003-07-16 | Oxford Glycosciences Uk Ltd | Novel compound |
GB0313678D0 (en) | 2003-06-13 | 2003-07-16 | Oxford Glycosciences Uk Ltd | Novel compounds |
EP1811991B1 (en) | 2004-11-10 | 2018-11-07 | Genzyme Corporation | Treatment of type 2 diabetes using inhibitors of glycosphingolipid synthesis |
PL2032134T3 (pl) | 2006-05-09 | 2015-11-30 | Genzyme Corp | Sposoby leczenia stłuszczeniowej choroby wątroby obejmujące hamowanie syntezy glikosfingolipidów |
GB0614947D0 (en) * | 2006-07-27 | 2006-09-06 | Isis Innovation | Epitope reduction therapy |
US8097728B2 (en) * | 2007-04-30 | 2012-01-17 | Philadelphia Health & Education Corporation | Iminosugar compounds with antiflavirus activity |
EP2167485B1 (en) * | 2007-05-31 | 2015-09-30 | Genzyme Corporation | 2-acylaminopropoanol-type glucosylceramide synthase inhibitors |
KR20160085917A (ko) | 2007-10-05 | 2016-07-18 | 젠자임 코포레이션 | 세라마이드 유도체로 다낭성 신장질환을 치료하는 방법 |
EP2320886B1 (en) * | 2008-07-28 | 2017-06-28 | Genzyme Corporation | Glucosylceramide synthase inhibition for the treatment of collapsing glomerulopathy and other glomerular disease |
CN102271678B (zh) | 2008-10-03 | 2017-06-30 | 简詹姆公司 | 2‑酰胺基丙醇型葡糖神经酰胺合成酶抑制剂 |
EP3608330B1 (en) | 2008-12-16 | 2022-11-09 | Genzyme Corporation | Synthetic intermediates for preparing oligosaccharide-protein conjugates |
KR20120042716A (ko) | 2009-02-23 | 2012-05-03 | 유나이티드 세러퓨틱스 코오포레이션 | 이미노슈가 및 바이러스성 질환을 치료하는 방법 |
WO2010099064A1 (en) * | 2009-02-24 | 2010-09-02 | United Therapeutics Corporation | Iminosugars and methods of treating arenaviral infections |
EP2411526A4 (en) * | 2009-03-27 | 2012-09-19 | Zacharon Pharmaceuticals Inc | MODULATORS OF GANGLIOSID BIOSYNTHESIS |
EP2440205B1 (en) | 2009-06-12 | 2014-08-27 | United Therapeutics Corporation | Iminosugars for use in the treatment of bunyaviral and togaviral diseases |
BR112012004676A2 (pt) * | 2009-09-04 | 2019-09-24 | United Therapeutics Corp | método de tratar infecções orotomixovirais. |
CN102625801B (zh) * | 2009-09-04 | 2015-09-09 | 联合治疗公司 | 治疗痘病毒感染的方法 |
CN105748476A (zh) * | 2009-09-04 | 2016-07-13 | 联合治疗公司 | 亚氨基糖以及治疗丝状病毒性疾病的方法 |
SG10201407881WA (en) | 2009-11-27 | 2015-01-29 | Genzyme Corp | An amorphous and a crystalline form of genz 112638 hemitartrate as inhibitor of glucosylceramide synthase |
WO2013059119A1 (en) | 2011-10-17 | 2013-04-25 | The Regents Of The University Of Michigan | Glucosylceramide synthase inhibitors and therapeutic methods using the same |
WO2014017915A2 (en) | 2012-07-27 | 2014-01-30 | Universiteit Utrecht Holding B.V. | Urea and guanidinium derivatives of iminosugars |
WO2014179438A2 (en) * | 2013-05-02 | 2014-11-06 | The Chancellor, Masters And Scholars Of The University Of Oxford | Glycolipid inhibition using iminosugars |
WO2016126572A2 (en) | 2015-02-02 | 2016-08-11 | The Regents Of The University Of Michigan | Glucosylceramide synthase inhibitors and therapeutic methods using the same |
EP3318277A1 (en) | 2016-11-04 | 2018-05-09 | Institut du Cerveau et de la Moelle Epiniere-ICM | Inhibitors of glucosylceramide synthase for the treatment of motor neuron diseases |
WO2020193746A1 (en) | 2019-03-28 | 2020-10-01 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for predicting the survival of patients suffering from melanoma |
EP4048397B1 (en) | 2019-10-23 | 2023-08-16 | The Regents Of The University Of Michigan | Glucosylceramide synthase inhibitors for therapeutic applications |
JP2023523454A (ja) | 2020-04-28 | 2023-06-05 | ザ・リージェンツ・オブ・ザ・ユニバーシティ・オブ・ミシガン | グルコシルセラミド合成酵素のピリジン阻害剤及びそれらを使用する治療方法 |
KR20240061713A (ko) * | 2022-11-01 | 2024-05-08 | 차의과학대학교 산학협력단 | N-노닐데옥시노지리마이신을 포함하는 피부 가려움증의 억제, 경감, 개선, 또는 치료를 위한 조성물 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3507019A1 (de) * | 1985-02-28 | 1986-08-28 | Bayer Ag, 5090 Leverkusen | Neue derivate von 3,4,5-trihydroxypiperidin, verfahren zu ihrer herstellung und ihre verwendung |
US5030638A (en) | 1990-02-26 | 1991-07-09 | G. D. Searle & Co. | Method of antiviral enhancement |
US5798366A (en) | 1993-05-13 | 1998-08-25 | Monsanto Company | Method for treatment of CNS-involved lysosomal storage diseases |
US6291657B1 (en) | 1993-05-13 | 2001-09-18 | Monsanto Company | Deoxygalactonojirimycin derivatives |
US5399567A (en) | 1993-05-13 | 1995-03-21 | Monsanto Company | Method of treating cholera |
AU732552B2 (en) | 1996-07-15 | 2001-04-26 | Genzyme Corporation | Deoxynojirimycin derivatives and their uses as glucosylceramidase inhibitors |
CA2252238A1 (en) | 1997-10-31 | 1999-04-30 | Sun Microsystems, Inc. | Method and apparatus for sharing a time quantum |
-
1999
- 1999-12-02 US US09/453,754 patent/US6610703B1/en not_active Expired - Fee Related
- 1999-12-08 AU AU23475/00A patent/AU2347500A/en not_active Abandoned
- 1999-12-08 DE DE69903750T patent/DE69903750T2/de not_active Expired - Fee Related
- 1999-12-08 ES ES99967135T patent/ES2190674T3/es not_active Expired - Lifetime
- 1999-12-08 EP EP99967135A patent/EP1137416B1/en not_active Expired - Lifetime
- 1999-12-08 AT AT99967135T patent/ATE226821T1/de not_active IP Right Cessation
- 1999-12-08 JP JP2000586335A patent/JP2002531505A/ja active Pending
- 1999-12-08 PT PT99967135T patent/PT1137416E/pt unknown
- 1999-12-08 DK DK99967135T patent/DK1137416T3/da active
- 1999-12-08 CA CA002352544A patent/CA2352544C/en not_active Expired - Fee Related
- 1999-12-08 WO PCT/US1999/027918 patent/WO2000033843A1/en active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
JP2002531505A (ja) | 2002-09-24 |
ATE226821T1 (de) | 2002-11-15 |
CA2352544C (en) | 2007-11-13 |
DE69903750T2 (de) | 2003-06-12 |
WO2000033843A1 (en) | 2000-06-15 |
US6610703B1 (en) | 2003-08-26 |
CA2352544A1 (en) | 2000-06-15 |
DK1137416T3 (da) | 2003-03-03 |
EP1137416B1 (en) | 2002-10-30 |
DE69903750D1 (de) | 2002-12-05 |
AU2347500A (en) | 2000-06-26 |
EP1137416A1 (en) | 2001-10-04 |
ES2190674T3 (es) | 2003-08-01 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
PT1137416E (pt) | Uso de derivados n-alquilo de cadeia longa de desoxinojirimicina para o fabrico de um medicamento para o tratamento de doencas ligadas ao armazenamento de glicolipidos | |
AU6050600A (en) | Use of long-chain n-alkyl derivates of deoxynojirimycin and a glucocerebrosidaseenzyme for the manufacture of medicament for the treatment of glycolipid storag e diseases | |
CA2289717A1 (en) | Novel therapy for constipation | |
EP1014996A4 (en) | SACCHARIDE COMPOSITIONS AND METHODS FOR SPECIFIC TREATMENT OF ALZHEIMER'S DISEASE AND OTHER AMYLOIDOSIS | |
PT1007043E (pt) | Metodo para o tratamento de doencas de armazeamento lisossomico com envolvimentode cns | |
MY137348A (en) | Highly selective norepinephrine reuptake inhibitors and methods of using the same | |
NO166448C (no) | Analogifremgangsmaate for fremstilling av terapeutisk aktive tiazolidindioner. | |
NO934768D0 (no) | Sammensetning av L-DOPA-estere | |
AU599792B2 (en) | Anti-parkinsonian indolone derivatives | |
BR9306841A (pt) | Composição farmacêutica processo para proporcionar um tratamento anti-histamínico o qual não induz qualquer arritmia cardíaca significativa em um paciente ser humano e uso de uma composição para a mnaufactura de um medicamento para uso em um tratamento anti-histamínico | |
MC2078A1 (fr) | Emploi d'alezastine comme matiere active contre le psoriasis et des maladies inflammatoires | |
KR920703041A (ko) | 통증을 수반하는 염증성 또는 알레르기성 질환치료에 사용되는 성분물과 그 방법 | |
BR9916114A (pt) | Uso de apomorfina na fabricação de um medicamento para tratamento de disfunção erétil orgânica masculina | |
NZ506408A (en) | Pharmaceutical compositions | |
GB2285219B (en) | Use of norastemizole for the treatment of allergic disorders | |
ES2161238T3 (es) | Uso de 2-fenil-3-aroilbenzotiofenos para la preparacion de un medicamento para inhibir la angiogenesis y enfermedades angiogenicas. | |
CO4960654A1 (es) | Metodo para el tratamiento de enfermedades fisiologicas relacionadas con el uso o con las secuelas provocadas por el uso de la cocaina u otros estimulantes psicomotores | |
AU1458495A (en) | Application of riluzole in the treatment of mitochondrial diseases | |
KR960703843A (ko) | 아실페닐글리신 유도체 및 그 화합물을 유효성분으로 하는, 콜라게나제 활성증진에 기인한 질환의 예방 및 치료 제(acylphenylglycine derivative and preventive and remedy for diseases caused by increased collagenase activity containing said compound as active ingredient) | |
AU1645897A (en) | Benzopyran derivative and use of said benzopyran derivative for treating heart disease | |
WO2001019359A3 (en) | Medicaments containing pantothenic acid for the treatment of inflammatory joint disease | |
KR910009255A (ko) | 과트리글리세라이드혈증과, 콜레스테롤혈증, 저레벨의 hdl질환 및 아테롬성 동맥경화증 치료제로서 사용되는 2-(페녹시 프로파놀아미노)에톡시 페녹시아세트산 유도체 | |
HUP0004647A2 (hu) | Glükóz-amino-glükánok alkalmazása diabétesszel társult szembetegségek kezelésére szolgáló gyógyszerkészítmények előállítására | |
NO960347D0 (no) | Anvendelse av benzydamid ved behandling av patologiske tilstander forårsaket av TNF | |
PT986390E (pt) | Composicoes farmaceuticas que contem cicloridrato de cinchonina |