DK1129091T3 - Antagonister for CRF-receptorer og fremgangsmåder med relation dertil - Google Patents
Antagonister for CRF-receptorer og fremgangsmåder med relation dertilInfo
- Publication number
- DK1129091T3 DK1129091T3 DK99960363T DK99960363T DK1129091T3 DK 1129091 T3 DK1129091 T3 DK 1129091T3 DK 99960363 T DK99960363 T DK 99960363T DK 99960363 T DK99960363 T DK 99960363T DK 1129091 T3 DK1129091 T3 DK 1129091T3
- Authority
- DK
- Denmark
- Prior art keywords
- antagonists
- crf
- associated methods
- crf receptors
- crf receptor
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/16—Peri-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/16—Peri-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
- Input Circuits Of Receivers And Coupling Of Receivers And Audio Equipment (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US19107398A | 1998-11-12 | 1998-11-12 | |
| US37083799A | 1999-08-09 | 1999-08-09 | |
| US40136499A | 1999-09-21 | 1999-09-21 | |
| PCT/US1999/027054 WO2000027846A2 (en) | 1998-11-12 | 1999-11-12 | Crf receptor antagonists and methods relating thereto |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1129091T3 true DK1129091T3 (da) | 2002-11-04 |
Family
ID=27392849
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK99960363T DK1129091T3 (da) | 1998-11-12 | 1999-11-12 | Antagonister for CRF-receptorer og fremgangsmåder med relation dertil |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US6514982B1 (es) |
| EP (1) | EP1129091B1 (es) |
| JP (1) | JP2002529465A (es) |
| KR (1) | KR20010080990A (es) |
| CN (1) | CN1217945C (es) |
| AT (1) | ATE225349T1 (es) |
| AU (1) | AU755552B2 (es) |
| CA (1) | CA2350642A1 (es) |
| DE (1) | DE69903333T2 (es) |
| DK (1) | DK1129091T3 (es) |
| ES (1) | ES2180338T3 (es) |
| HK (1) | HK1038926B (es) |
| IL (1) | IL142893A0 (es) |
| NO (1) | NO20012194D0 (es) |
| NZ (1) | NZ510955A (es) |
| PT (1) | PT1129091E (es) |
| WO (1) | WO2000027846A2 (es) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6531475B1 (en) * | 1998-11-12 | 2003-03-11 | Neurocrine Biosciences, Inc. | CRF receptor antagonists and methods relating thereto |
| JP2002529465A (ja) * | 1998-11-12 | 2002-09-10 | ニューロクライン バイオサイエンシーズ， インコーポレイテッド | Ｃｒｆレセプターアンタゴニストおよびｃｒｆレセプターアンタゴニストに関する方法 |
| WO2001058489A1 (fr) * | 2000-02-14 | 2001-08-16 | Japan Tobacco Inc. | Agents prophylactiques/therapeutiques contre le stress postoperatoire |
| AU2001263288A1 (en) | 2000-05-18 | 2001-11-26 | Neurocrine Biosciences, Inc. | Crf receptor antagonists |
| AU2002239589B2 (en) | 2000-11-03 | 2005-04-21 | Neurocrine Biosciences, Inc. | CRF receptor antagonists and methods relating thereto |
| US6583143B2 (en) | 2000-12-28 | 2003-06-24 | Neurocrine Biosciences, Inc. | CRF receptor antagonists and methods relating thereto |
| DK1354884T3 (da) | 2000-12-28 | 2008-03-03 | Ono Pharmaceutical Co | Cyklopenta[d]pyrazolo[1,5-a]pyrimidinforbindelse som CRF-receptorantagonist |
| MXPA03009930A (es) | 2001-04-30 | 2004-01-29 | Glaxo Group Ltd | Antagonistas del receptor del factor liberador de corticotropina. |
| JP2004530702A (ja) * | 2001-05-21 | 2004-10-07 | ニューロクライン バイオサイエンシーズ， インコーポレイテッド | Ｃｒｆ受容体アンタゴニストとしてのトリ−およびテトラアザ−アセナフチレン誘導体 |
| GB0117395D0 (en) * | 2001-07-17 | 2001-09-05 | Glaxo Group Ltd | Chemical compounds |
| US7273871B2 (en) | 2001-07-17 | 2007-09-25 | Sb Pharmco Puerto Rico Inc. | Phenyl-5,6,6A,7,8,9-hexahydro-4H-1,4,9-triaza-phenalene derivatives as CRF antagonists |
| EP2335700A1 (en) | 2001-07-25 | 2011-06-22 | Boehringer Ingelheim (Canada) Ltd. | Hepatitis C virus polymerase inhibitors with a heterobicylic structure |
| MXPA05013917A (es) | 2003-06-25 | 2006-03-09 | Ono Pharmaceutical Co | Sal de acido metansulfonico de compuesto de pirazolpirimidina, cristal de la misma, y proceso para producirla. |
| US20060024661A1 (en) * | 2003-07-30 | 2006-02-02 | The Regents Of The University Of California | Modulation of CRF potentiation of NMDA receptor currents via CRF receptor 2 |
| CA2535249A1 (en) * | 2003-08-12 | 2005-02-17 | F. Hoffmann-La Roche Ag | Spiro-substituted tetrahydroquinazolines as corticotropin releasing factor (cfr) antagonists |
| WO2005063749A1 (en) * | 2003-12-22 | 2005-07-14 | Sb Pharmco Puerto Rico Inc | Crf receptor antagonists and methods relating thereto |
| ES2431314T3 (es) | 2004-02-20 | 2013-11-26 | Boehringer Ingelheim International Gmbh | Inhibidores de polimerasa vírica |
| WO2005087775A1 (ja) * | 2004-03-15 | 2005-09-22 | Ono Pharmaceutical Co., Ltd. | 三環式複素環化合物およびその化合物を有効成分として含有する医薬組成物 |
| WO2006031322A2 (en) * | 2004-08-09 | 2006-03-23 | Research Development Foundation | Determination of the 3d-structure of an extracellular domain of a b1 g-protein coupled receptor by nmr analysis |
| RU2009132605A (ru) | 2007-02-01 | 2011-03-10 | Астразенека Аб (Se) | Производные 5,6,7,8-тетрагидроптеридина в качестве ингибиторов hsp90 |
| EP2414359A1 (en) | 2009-03-31 | 2012-02-08 | ArQule, Inc. | Peri-fused pyrazolo-pyrimidine compounds |
| ES2540964T3 (es) | 2009-06-08 | 2015-07-15 | Takeda Pharmaceutical Company Limited | Compuestos de dihidropirrolonaftiridinona como inhibidores de JAK |
| AU2010339444A1 (en) * | 2009-12-30 | 2012-07-19 | Arqule, Inc. | Substituted pyrrolo-aminopyrimidine compounds |
| CN113416191A (zh) * | 2021-04-27 | 2021-09-21 | 西安交通大学 | 一种合成三环骨架2-吡啶酮/2-吡啶亚胺类化合物的方法 |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4605642A (en) | 1984-02-23 | 1986-08-12 | The Salk Institute For Biological Studies | CRF antagonists |
| US5013737A (en) * | 1988-02-22 | 1991-05-07 | American Cyanamid Company | 2,4,8-Trisubstituted-3H,6H-1,4,5A,8A-tetraazaacenaphtylene-3,5-(4H)-diones and 2,4-8-trisubstituted-4,5-dihydro-5-thioxo-3H,6H-1,4,5A,8A-tetrazaacenaphthylen-3-ones |
| US4904658A (en) | 1988-04-15 | 1990-02-27 | American Cyanamid Company | Substituted-6H,8H-pyrimido-[1,2,3-cd]purine-8,10-(9H)-diones and substituted-6H,10H-pyrimido[1,2-cd]purin-10-ones |
| US5063245A (en) | 1990-03-28 | 1991-11-05 | Nova Pharmaceutical Corporation | Corticotropin-releasing factor antagonism compounds |
| FR2692893B1 (fr) | 1992-06-24 | 1994-09-02 | Sanofi Elf | Dérivés alkylamino ramifiés du thiazole, leurs procédés de préparation et les compositions pharmaceutiques qui les contiennent. |
| TW444018B (en) * | 1992-12-17 | 2001-07-01 | Pfizer | Pyrazolopyrimidines |
| DE69323768T2 (de) * | 1992-12-17 | 1999-07-01 | Pfizer | Pyrrolopyrimidine als crf antagonisten |
| WO1994013661A1 (en) | 1992-12-17 | 1994-06-23 | Pfizer Inc. | Substituted pyrazoles as crf antagonists |
| WO1994013643A1 (en) | 1992-12-17 | 1994-06-23 | Pfizer Inc. | Pyrazoles and pyrazolopyrimidines having crf antagonist activity |
| TW336932B (en) | 1992-12-17 | 1998-07-21 | Pfizer | Amino-substituted pyrazoles |
| JP3398152B2 (ja) | 1993-10-12 | 2003-04-21 | ブリストル‐マイヤーズ・スクイブ・ファーマ・カンパニー | １ｎ−アルキル−ｎ−アリールピリミジンアミンおよびその誘導体 |
| TW530047B (en) | 1994-06-08 | 2003-05-01 | Pfizer | Corticotropin releasing factor antagonists |
| JP2891544B2 (ja) | 1994-06-16 | 1999-05-17 | ファイザー・インコーポレーテッド | ピラゾロおよびピロロピリジン類 |
| ATE182148T1 (de) | 1995-05-12 | 1999-07-15 | Neurogen Corp | Neue deazapurinderivate; eine neue klasse von crf1-spezifischen liganden |
| FR2735777B1 (fr) | 1995-06-21 | 1997-09-12 | Sanofi Sa | Derives de 4-phenylaminothiazole, leur procede de preparation et les compositions pharmaceutiques les contenant |
| CA2249598A1 (en) | 1996-03-26 | 1997-10-02 | Paul Joseph Gilligan | Aryloxy- and arylthio-fused pyridines and pyrimidines and derivatives |
| US6107300A (en) | 1996-03-27 | 2000-08-22 | Dupont Pharmaceuticals | Arylamino fused pyrimidines |
| US6326368B1 (en) | 1996-03-27 | 2001-12-04 | Dupont Pharmaceuticals Company | Aryloxy- and arylthiosubstituted pyrimidines and triazines and derivatives thereof |
| ZA973884B (en) * | 1996-05-23 | 1998-11-06 | Du Pont Merck Pharma | Tetrahydropteridines and pyridylpiperazines for treatment of neurological disorders |
| AU747708B2 (en) | 1996-07-24 | 2002-05-23 | Du Pont Pharmaceuticals Company | Azolo triazines and pyrimidines |
| PL331602A1 (en) | 1996-08-06 | 1999-08-02 | Pfizer | Pyrido- or pyrimido-substituted 6,6- or 6,7-bicyclic derivatives |
| TW477787B (en) | 1996-08-27 | 2002-03-01 | Pfizer | Pyrido six-membered nitrogen-containing cyclic ring derivatives having corticotropin releasing factor antagonist activity and pharmaceutical composition containing same |
| CA2263566C (en) * | 1996-08-28 | 2003-09-09 | Pfizer Inc. | Substituted 6,5-hetero-bicyclic derivatives |
| CA2265672C (en) | 1996-09-16 | 2008-12-02 | Du Pont Pharmaceuticals Company | Pyrazinones and triazinones and their derivatives thereof |
| FR2754258B1 (fr) | 1996-10-08 | 1998-12-31 | Sanofi Sa | Derives d'aminothiazole, leur procede de preparation et les compositions pharmaceutiques les contenant |
| US5760225A (en) | 1996-11-15 | 1998-06-02 | Neurogen Corporation | Certain pyrazole derivatives as corticotropin-releasing factor receptor CRF1 specific ligands |
| US5723608A (en) | 1996-12-31 | 1998-03-03 | Neurogen Corporation | 3-aryl substituted pyrazolo 4,3-d!pyrimidine derivatives; corticotropin-releasing factor receptor (CRF1) specific ligands |
| US6187777B1 (en) | 1998-02-06 | 2001-02-13 | Amgen Inc. | Compounds and methods which modulate feeding behavior and related diseases |
| JP2002529465A (ja) * | 1998-11-12 | 2002-09-10 | ニューロクライン バイオサイエンシーズ， インコーポレイテッド | Ｃｒｆレセプターアンタゴニストおよびｃｒｆレセプターアンタゴニストに関する方法 |
-
1999
- 1999-11-12 JP JP2000581024A patent/JP2002529465A/ja active Pending
- 1999-11-12 DK DK99960363T patent/DK1129091T3/da active
- 1999-11-12 DE DE69903333T patent/DE69903333T2/de not_active Expired - Lifetime
- 1999-11-12 PT PT99960363T patent/PT1129091E/pt unknown
- 1999-11-12 CA CA002350642A patent/CA2350642A1/en not_active Abandoned
- 1999-11-12 CN CN998131717A patent/CN1217945C/zh not_active Expired - Fee Related
- 1999-11-12 IL IL14289399A patent/IL142893A0/xx unknown
- 1999-11-12 KR KR1020017005924A patent/KR20010080990A/ko not_active Application Discontinuation
- 1999-11-12 ES ES99960363T patent/ES2180338T3/es not_active Expired - Lifetime
- 1999-11-12 NZ NZ510955A patent/NZ510955A/xx unknown
- 1999-11-12 US US09/439,840 patent/US6514982B1/en not_active Expired - Lifetime
- 1999-11-12 AU AU17258/00A patent/AU755552B2/en not_active Ceased
- 1999-11-12 EP EP99960363A patent/EP1129091B1/en not_active Expired - Lifetime
- 1999-11-12 WO PCT/US1999/027054 patent/WO2000027846A2/en not_active Application Discontinuation
- 1999-11-12 AT AT99960363T patent/ATE225349T1/de not_active IP Right Cessation
-
2001
- 2001-05-03 NO NO20012194A patent/NO20012194D0/no not_active Application Discontinuation
-
2002
- 2002-01-29 HK HK02100690.1A patent/HK1038926B/zh not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| JP2002529465A (ja) | 2002-09-10 |
| WO2000027846A2 (en) | 2000-05-18 |
| PT1129091E (pt) | 2003-02-28 |
| AU755552B2 (en) | 2002-12-12 |
| HK1038926A1 (en) | 2002-05-10 |
| DE69903333T2 (de) | 2003-08-07 |
| CN1217945C (zh) | 2005-09-07 |
| DE69903333D1 (de) | 2002-11-07 |
| NO20012194L (no) | 2001-05-03 |
| CN1328559A (zh) | 2001-12-26 |
| IL142893A0 (en) | 2002-04-21 |
| US6514982B1 (en) | 2003-02-04 |
| EP1129091B1 (en) | 2002-10-02 |
| WO2000027846A3 (en) | 2000-11-16 |
| HK1038926B (zh) | 2003-07-18 |
| CA2350642A1 (en) | 2000-05-18 |
| AU1725800A (en) | 2000-05-29 |
| NO20012194D0 (no) | 2001-05-03 |
| EP1129091A2 (en) | 2001-09-05 |
| NZ510955A (en) | 2003-01-31 |
| KR20010080990A (ko) | 2001-08-25 |
| ES2180338T3 (es) | 2003-02-01 |
| ATE225349T1 (de) | 2002-10-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK1129091T3 (da) | Antagonister for CRF-receptorer og fremgangsmåder med relation dertil | |
| DK1129096T3 (da) | CRF-receptorantagonister og fremgangsmåder, der er relateret dertil | |
| EA199800340A1 (ru) | Производные пиримидина как антагонисты 5нт2с | |
| IL155702A0 (en) | Piperazinylpyrazine compounds as agonist or antagonist of serotonin 5-ht2 receptor | |
| DK0776893T3 (da) | Azaheterocykliske forbindelser med tachykininreceptorantagonistaktivitet; NK1 og NK2 | |
| GB0130347D0 (en) | Compounds | |
| ATE424194T1 (de) | Adenosin-a2a-rezeptor-antagonisten in kombination mit verbindungen mit neurotrophischer aktivität bei der behandlung von morbus parkinson | |
| BRPI0417943A (pt) | antagonistas de receptor de crf e métodos relacionados para essa finalidade | |
| ATE343578T1 (de) | Tri- und tetraaza-acenaphthylen-derivate als crf- rezeptor-antagonisten | |
| EP1473295A4 (en) | BICYCLIC FUSIONED PYRIMIDINE DERIVATIVES | |
| ATE250058T1 (de) | Crf rezeptor-antagonisten und darauf bezogene methoden | |
| DE60102231D1 (de) | Crf rezeptor-antagonisten und darauf bezogene methoden | |
| DE602004012318D1 (de) | Crf-rezeptorantagonisten und diese betreffende verfahren |