DK1097159T3 - Phosphin- og phosphonsyrederivater som lægemidler - Google Patents

Phosphin- og phosphonsyrederivater som lægemidler

Info

Publication number
DK1097159T3
DK1097159T3 DK99932841T DK99932841T DK1097159T3 DK 1097159 T3 DK1097159 T3 DK 1097159T3 DK 99932841 T DK99932841 T DK 99932841T DK 99932841 T DK99932841 T DK 99932841T DK 1097159 T3 DK1097159 T3 DK 1097159T3
Authority
DK
Denmark
Prior art keywords
phosphine
drugs
acid derivatives
phosphonic acid
phosphonic
Prior art date
Application number
DK99932841T
Other languages
Danish (da)
English (en)
Inventor
Manfred Schudok
Gerhard Zoller
Eckart Bartnik
Frank Buettner
Klaus-Ulrich Weithmann
Wilfried Schwab
Original Assignee
Aventis Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19831980A external-priority patent/DE19831980A1/de
Priority claimed from DE19921680A external-priority patent/DE19921680A1/de
Application filed by Aventis Pharma Gmbh filed Critical Aventis Pharma Gmbh
Application granted granted Critical
Publication of DK1097159T3 publication Critical patent/DK1097159T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/572—Five-membered rings
    • C07F9/5728—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3808—Acyclic saturated acids which can have further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/572—Five-membered rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Oncology (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK99932841T 1998-07-16 1999-07-07 Phosphin- og phosphonsyrederivater som lægemidler DK1097159T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19831980A DE19831980A1 (de) 1998-07-16 1998-07-16 Sulfonylaminophosphin- und phosphonsäurederivate
DE19921680A DE19921680A1 (de) 1999-05-12 1999-05-12 Sulfonylaminophosphin- und phosphonsäurederivate
PCT/EP1999/004740 WO2000004030A1 (de) 1998-07-16 1999-07-07 Phosphin- und phosphonsäurederivate als arzneimittel

Publications (1)

Publication Number Publication Date
DK1097159T3 true DK1097159T3 (da) 2003-03-10

Family

ID=26047473

Family Applications (1)

Application Number Title Priority Date Filing Date
DK99932841T DK1097159T3 (da) 1998-07-16 1999-07-07 Phosphin- og phosphonsyrederivater som lægemidler

Country Status (22)

Country Link
US (2) US6235727B1 (zh)
EP (1) EP1097159B1 (zh)
JP (1) JP4567886B2 (zh)
KR (1) KR100615345B1 (zh)
CN (1) CN1194978C (zh)
AR (1) AR019390A1 (zh)
AT (1) ATE227295T1 (zh)
AU (1) AU754050B2 (zh)
BR (1) BR9912085A (zh)
CA (1) CA2337828C (zh)
CZ (1) CZ300780B6 (zh)
DE (1) DE59903329D1 (zh)
DK (1) DK1097159T3 (zh)
ES (1) ES2187171T3 (zh)
HK (1) HK1038363A1 (zh)
HU (1) HUP0102837A3 (zh)
ID (1) ID27133A (zh)
PL (1) PL199234B1 (zh)
PT (1) PT1097159E (zh)
RU (1) RU2224762C2 (zh)
TR (1) TR200100084T2 (zh)
WO (1) WO2000004030A1 (zh)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6472406B1 (en) 1999-07-06 2002-10-29 Methylgene, Inc. Sulfonamidomethyl phosphonate inhibitors of beta-lactamase
PL375532A1 (en) * 2002-08-08 2005-11-28 Smithkline Beecham Corporation Benzimidazol-1-yl-thiophene compounds for the treatment of cancer
JP4450192B2 (ja) 2004-07-01 2010-04-14 信越化学工業株式会社 珪素複合体及びその製造方法並びに非水電解質二次電池用負極材
CA2652995A1 (en) * 2006-05-22 2008-06-19 Merck & Co., Inc. Novel inhibitors of beta-lactamase
AU2007268081A1 (en) * 2006-05-22 2007-12-06 Methylgene Inc. Novel sulfonamidomethylphosphonate inhibitors of beta-lactamase
JP5399219B2 (ja) * 2009-11-24 2014-01-29 株式会社ケイティーバイオ 関節リウマチに対するヒト型抗ＴＮＦα抗体薬の薬効予測方法、及び薬効予測装置
CN108676031A (zh) * 2018-05-29 2018-10-19 重庆威鹏药业有限公司 水溶性三唑类抗真菌膦酸化合物及其制备方法和应用

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3996040A (en) * 1974-06-28 1976-12-07 Monsanto Company Increasing sucrose content of sugar cane employing N-phenylsulfonamido-N-phosphonomethyl glycine and certain derivatives thereof
JPS6137800A (ja) * 1984-07-31 1986-02-22 Kyowa Hakko Kogyo Co Ltd 含リンペプチド
DE3435156A1 (de) * 1984-09-25 1986-04-03 Boehringer Mannheim Gmbh, 6800 Mannheim Verfahren zur herstellung der stereoisomeren von 1-amino-alkylphosphonsaeuren oder 1-aminoalkylphosphinsaeuren
JPS62148493A (ja) * 1985-12-24 1987-07-02 Teijin Ltd 新規ホスホン酸誘導体および除草剤
DE3770982D1 (de) * 1986-04-24 1991-08-01 Fujisawa Pharmaceutical Co Diphosphonsaeure-verbindungen, verfahren zu deren herstellung und sie enthaltende arzneimittel.
JP2764262B2 (ja) 1987-08-28 1998-06-11 持田製薬株式会社 ヒダントイン誘導体及びそれを有効成分とする医薬組成物
TW201303B (zh) 1990-07-05 1993-03-01 Hoffmann La Roche
JP2525977B2 (ja) * 1991-10-17 1996-08-21 昭和電工株式会社 Ｎ−アシルアミノメチルホスホン酸の製造法
US5455258A (en) 1993-01-06 1995-10-03 Ciba-Geigy Corporation Arylsulfonamido-substituted hydroxamic acids
US6022898A (en) 1994-06-22 2000-02-08 British Biotech Pharmaceuticals Limited Metalloproteinase inhibitors
US5863949A (en) 1995-03-08 1999-01-26 Pfizer Inc Arylsulfonylamino hydroxamic acid derivatives
KR980009238A (ko) * 1995-07-28 1998-04-30 우에노 도시오 설포닐아미노산 유도체
EA001561B1 (ru) * 1996-05-17 2001-04-23 Варнер-Ламберт Компани Бифенилсульфонамидные ингибиторы матричных металлопротеиназ
WO1998032738A1 (de) * 1997-01-27 1998-07-30 Nycomed Austria Gmbh Neue verbindungen mit hämoregulatorischer wirkung
ES2165640T3 (es) * 1997-05-09 2002-03-16 Hoechst Ag Acidos diaminocarboxilicos sustituidos.
WO1998050348A1 (en) * 1997-05-09 1998-11-12 Agouron Pharmaceuticals, Inc. Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses
DE19719621A1 (de) * 1997-05-09 1998-11-12 Hoechst Ag Sulfonylaminocarbonsäuren

Also Published As

Publication number Publication date
BR9912085A (pt) 2001-04-10
CA2337828C (en) 2010-08-17
KR100615345B1 (ko) 2006-08-25
AU754050B2 (en) 2002-10-31
ATE227295T1 (de) 2002-11-15
CN1309660A (zh) 2001-08-22
JP4567886B2 (ja) 2010-10-20
PL345653A1 (en) 2002-01-02
JP2002520418A (ja) 2002-07-09
US6500811B2 (en) 2002-12-31
RU2224762C2 (ru) 2004-02-27
TR200100084T2 (tr) 2001-07-23
US6235727B1 (en) 2001-05-22
AU4908299A (en) 2000-02-07
ES2187171T3 (es) 2003-05-16
CZ2001144A3 (en) 2001-05-16
HUP0102837A2 (hu) 2001-12-28
CA2337828A1 (en) 2000-01-27
WO2000004030A1 (de) 2000-01-27
KR20010071940A (ko) 2001-07-31
HUP0102837A3 (en) 2002-04-29
CZ300780B6 (cs) 2009-08-12
EP1097159B1 (de) 2002-11-06
DE59903329D1 (en) 2002-12-12
PL199234B1 (pl) 2008-08-29
PT1097159E (pt) 2003-03-31
EP1097159A1 (de) 2001-05-09
HK1038363A1 (en) 2002-03-15
US20020082246A1 (en) 2002-06-27
CN1194978C (zh) 2005-03-30
ID27133A (id) 2001-03-01
AR019390A1 (es) 2002-02-20

Similar Documents

Publication Publication Date Title
NO20012915D0 (no) Ny farmasöytisk formulering
NO20010046D0 (no) Dolastatin-15-derivater
DK1111996T3 (da) Glyphosat-formulering
ATE248812T1 (de) Arylsulfonylhydroxamsäurederivate
DK1003720T3 (da) Aryloxyarylsulfonylaminohydroxamsyrederivater
ID23299A (id) Formulasi-formulasi farmasi
IS5744A (is) Nýjar 3-arýl-própíónsýruafleiður og -hliðstæður
ID24654A (id) Formulasi farmasi omeprazola
DE69935681D1 (de) Vorrichtungen zur Medikamentverabreichung
NO20012116D0 (no) Vitamin D analoger
IS5248A (is) Lyfjasamsetningar sem innihalda vorikónasól
EE04772B1 (et) 3-arüül-2-hüdroksüpropaanhappe derivaat (I)
AU6972398A (en) Phosphonic acid derivatives
NO20000231D0 (no) Dolastatin-15-derivater
DK1466615T3 (da) Farmaceutisk præparat
NO985262D0 (no) Fosfonsyresubstituerte benzazepinon-N-edikksyrederivater, fremgangsmÕte for deres fremstilling og legemidler inneholdende slike
NO993001D0 (no) Farmas°ytiske aminofosfonsyrederivater
NO20006646L (no) Aminosyrederivater og legemidler inneholdende de samme som aktiv bestanddel
IS5562A (is) Nýjar díhýdroxýhexanósýru afleiður
ATE309838T1 (de) Pharmazeutisches implantat
PT868911E (pt) Formulacoes de rapamicina para administracao oral
IS2258B (is) Setin tríasóló-pýridasín afleiða, lyfjasamsetningar gerðar úr henni
BR9704595A (pt) Preparação de 3-amino-1-hidroxipropano-1, 1-ácido difosfõnico
DK1097159T3 (da) Phosphin- og phosphonsyrederivater som lægemidler
ID30032A (id) Formulasi farmasi