DK1092715T3 - Cyanoindolderivater som inhibitorer for serotoningenoptagelse, fremgangsmåde til fremstilling heraf og farmaceutiske sammensætninger indeholdende disse - Google Patents

Cyanoindolderivater som inhibitorer for serotoningenoptagelse, fremgangsmåde til fremstilling heraf og farmaceutiske sammensætninger indeholdende disse

Info

Publication number
DK1092715T3
DK1092715T3 DK00402799T DK00402799T DK1092715T3 DK 1092715 T3 DK1092715 T3 DK 1092715T3 DK 00402799 T DK00402799 T DK 00402799T DK 00402799 T DK00402799 T DK 00402799T DK 1092715 T3 DK1092715 T3 DK 1092715T3
Authority
DK
Denmark
Prior art keywords
preparation
pharmaceutical compositions
compositions containing
cyanoindole
inhibitors
Prior art date
Application number
DK00402799T
Other languages
Danish (da)
English (en)
Inventor
Gilbert Lavielle
Olivier Muller
Mark Millan
Anne Dekeyne
Didier Cussac
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Servier Lab filed Critical Servier Lab
Application granted granted Critical
Publication of DK1092715T3 publication Critical patent/DK1092715T3/da

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D513/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Addiction (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DK00402799T 1999-10-12 2000-10-11 Cyanoindolderivater som inhibitorer for serotoningenoptagelse, fremgangsmåde til fremstilling heraf og farmaceutiske sammensætninger indeholdende disse DK1092715T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9912668A FR2799463B1 (fr) 1999-10-12 1999-10-12 Nouveaux composes cyano-indoles inhibiteurs de recapture de serotonine, leur procede de preparation et ces compositions pharmaceutiques qui les contiennent
EP00402799A EP1092715B1 (fr) 1999-10-12 2000-10-11 Composés cyano-indoles inhibiteurs de recapture de sérotonine, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent

Publications (1)

Publication Number Publication Date
DK1092715T3 true DK1092715T3 (da) 2005-07-25

Family

ID=9550799

Family Applications (1)

Application Number Title Priority Date Filing Date
DK00402799T DK1092715T3 (da) 1999-10-12 2000-10-11 Cyanoindolderivater som inhibitorer for serotoningenoptagelse, fremgangsmåde til fremstilling heraf og farmaceutiske sammensætninger indeholdende disse

Country Status (23)

Country Link
US (1) US6492366B1 (pt)
EP (1) EP1092715B1 (pt)
JP (1) JP3274454B2 (pt)
KR (1) KR100470692B1 (pt)
CN (1) CN1146568C (pt)
AT (1) ATE291577T1 (pt)
AU (1) AU774741B2 (pt)
BR (1) BR0004764A (pt)
CA (1) CA2323703C (pt)
DE (1) DE60018869T2 (pt)
DK (1) DK1092715T3 (pt)
EA (1) EA003831B1 (pt)
ES (1) ES2238260T3 (pt)
FR (1) FR2799463B1 (pt)
HK (1) HK1036062A1 (pt)
HU (1) HUP0003991A2 (pt)
MX (1) MXPA00009642A (pt)
NO (1) NO321242B1 (pt)
NZ (1) NZ507458A (pt)
PL (1) PL343148A1 (pt)
PT (1) PT1092715E (pt)
SI (1) SI1092715T1 (pt)
ZA (1) ZA200005625B (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6693202B1 (en) 1999-02-16 2004-02-17 Theravance, Inc. Muscarinic receptor antagonists
US6559169B2 (en) 2001-04-24 2003-05-06 Wyeth Antidepressant azaheterocyclymethyl derivatives of 2,3-dihydro-1,4-benzodioxan
US7041683B2 (en) 2001-04-24 2006-05-09 Wyeth Antidepressant azaheterocyclylmethyl derivatives of 2,3-dihydro-1, 4-benzodiozan
US7276603B2 (en) * 2003-05-02 2007-10-02 Wyeth Benzofuranyl-and benzothienyl-piperazinyl quinolines and methods of their use
WO2005113833A2 (en) * 2004-05-21 2005-12-01 Duke University Polymorphism in tryptophan hydroxylase-2 controls brain serotonin synthesis
WO2012054815A1 (en) 2010-10-22 2012-04-26 Duke University Slow-release formulations of 5-hydroxytryptophan as an adjunct to pro-serotonergic therapies

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2043709C (en) * 1990-06-29 2002-01-22 David W. Smith Antimigraine alkoxypyrimidine derivatives
HUT64326A (en) * 1990-10-15 1993-12-28 Pfizer Process for production indole derivatives and pharmaceutical preparations containing these compounds
GB9208161D0 (en) * 1992-04-14 1992-05-27 Pfizer Ltd Indoles
FR2701026B1 (fr) * 1993-02-02 1995-03-31 Adir Nouveaux dérivés de l'indole, de l'indazole et du benzisoxazole, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
IT1271352B (it) * 1993-04-08 1997-05-27 Boehringer Ingelheim Italia Derivati dell'indolo utili nel trattamento dei disturbi del sistema nervoso centrale
ES2079323B1 (es) * 1994-06-21 1996-10-16 Vita Invest Sa Derivados de indol utiles para el tratamiento de la migraña, composicion y uso correspondientes.
AU2809295A (en) * 1994-07-11 1996-02-09 Dsm N.V. Multihydroxy-functional oligophenylene oxide
AR004229A1 (es) * 1995-11-06 1998-11-04 Wyeth Corp Derivados indolalquilo de benzodioxanmetilamina y su uso para preparar medicamentos
US5912256A (en) * 1996-06-20 1999-06-15 Eli Lilly And Company Compounds having effects on serotonin-related systems
US5998462A (en) * 1996-12-16 1999-12-07 Allelix Biopharmaceuticals Inc. 5-alkyl indole compounds

Also Published As

Publication number Publication date
BR0004764A (pt) 2001-05-29
DE60018869T2 (de) 2006-02-02
ES2238260T3 (es) 2005-09-01
JP3274454B2 (ja) 2002-04-15
EA200000929A3 (ru) 2001-06-25
KR100470692B1 (ko) 2005-03-07
HK1036062A1 (en) 2001-12-21
JP2001151772A (ja) 2001-06-05
MXPA00009642A (es) 2002-05-23
CA2323703A1 (fr) 2001-04-12
FR2799463A1 (fr) 2001-04-13
CN1146568C (zh) 2004-04-21
HUP0003991A2 (en) 2002-06-29
PT1092715E (pt) 2005-06-30
ATE291577T1 (de) 2005-04-15
AU774741B2 (en) 2004-07-08
EA003831B1 (ru) 2003-10-30
ZA200005625B (en) 2001-05-02
HU0003991D0 (en) 2000-12-28
US6492366B1 (en) 2002-12-10
EA200000929A2 (ru) 2001-04-23
KR20010050984A (ko) 2001-06-25
FR2799463B1 (fr) 2004-04-16
CA2323703C (fr) 2005-08-16
EP1092715A3 (fr) 2001-08-08
NZ507458A (en) 2002-03-28
NO321242B1 (no) 2006-04-10
SI1092715T1 (en) 2005-06-30
AU6547900A (en) 2001-04-26
PL343148A1 (en) 2001-04-23
NO20005103L (no) 2001-04-17
NO20005103D0 (no) 2000-10-10
CN1296010A (zh) 2001-05-23
EP1092715B1 (fr) 2005-03-23
DE60018869D1 (de) 2005-04-28
EP1092715A2 (fr) 2001-04-18

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