DK1087966T3 - Kemisk syntese af morpholinderivater - Google Patents

Kemisk syntese af morpholinderivater

Info

Publication number
DK1087966T3
DK1087966T3 DK99957055T DK99957055T DK1087966T3 DK 1087966 T3 DK1087966 T3 DK 1087966T3 DK 99957055 T DK99957055 T DK 99957055T DK 99957055 T DK99957055 T DK 99957055T DK 1087966 T3 DK1087966 T3 DK 1087966T3
Authority
DK
Denmark
Prior art keywords
chemical synthesis
morpholine derivatives
morpholine
derivatives
synthesis
Prior art date
Application number
DK99957055T
Other languages
Danish (da)
English (en)
Inventor
Ian Frank Cottrell
Ulf H Dolling
David Hands
Robert Darrin Wilson
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Application granted granted Critical
Publication of DK1087966T3 publication Critical patent/DK1087966T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurosurgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Psychiatry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK99957055T 1998-06-16 1999-06-10 Kemisk syntese af morpholinderivater DK1087966T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9813025.5A GB9813025D0 (en) 1998-06-16 1998-06-16 Chemical synthesis
PCT/GB1999/001842 WO1999065900A1 (en) 1998-06-16 1999-06-10 Chemical synthesis of morpholine derivatives

Publications (1)

Publication Number Publication Date
DK1087966T3 true DK1087966T3 (da) 2002-07-08

Family

ID=10833892

Family Applications (1)

Application Number Title Priority Date Filing Date
DK99957055T DK1087966T3 (da) 1998-06-16 1999-06-10 Kemisk syntese af morpholinderivater

Country Status (28)

Country Link
US (2) US6297376B1 (cs)
EP (1) EP1087966B1 (cs)
JP (2) JP4647783B2 (cs)
KR (1) KR100619589B1 (cs)
CN (1) CN1131864C (cs)
AR (1) AR018877A1 (cs)
AT (1) ATE217308T1 (cs)
AU (1) AU746721B2 (cs)
BR (1) BR9911250A (cs)
CA (1) CA2334821C (cs)
CZ (1) CZ299257B6 (cs)
DE (1) DE69901444T2 (cs)
DK (1) DK1087966T3 (cs)
EA (1) EA003468B1 (cs)
ES (1) ES2176036T3 (cs)
GB (1) GB9813025D0 (cs)
HR (1) HRP20000878B1 (cs)
HU (1) HUP0102867A3 (cs)
IL (2) IL139946A0 (cs)
NZ (1) NZ508558A (cs)
PL (1) PL196778B1 (cs)
PT (1) PT1087966E (cs)
SI (1) SI1087966T1 (cs)
SK (1) SK283380B6 (cs)
TW (1) TW526199B (cs)
UA (1) UA66866C2 (cs)
WO (1) WO1999065900A1 (cs)
YU (1) YU76500A (cs)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR030284A1 (es) 2000-06-08 2003-08-20 Merck & Co Inc Proceso para la sintesis de (2r, 2-alfa-r,3a) -2-[1-(3,5-bis(trifluorometil) fenil) etoxi]-3-(4-fluorofenil)-1,4-oxazina; dicho compuesto y sus formas polimorficas
GB0014876D0 (en) * 2000-06-16 2000-08-09 Merck Sharp & Dohme Chemical synthesis
UA76810C2 (uk) 2001-12-10 2006-09-15 Мерк Енд Ко., Інк. Фармацевтична композиція антагоніста рецептора тахікініну у формі наночастинок
AR039625A1 (es) * 2002-04-18 2005-03-02 Merck & Co Inc Proceso para la preparacion de 5-((2(r)--(1(r)- (3,5-bis (trifluormetil) fenil)etoxi-3 (s) - (4-fluorfenil) -4-morfolinil) metil) -1,2-dihidro-3h-1,2,4-triazol-3-ona
WO2004017898A2 (en) * 2002-08-21 2004-03-04 Merck & Co., Inc. Process for preparing 3-chloromethyl-1,2,4-triazolin-5-one
WO2007088483A1 (en) * 2006-02-03 2007-08-09 Glenmark Pahrmaceuticals Limited Amorphous and crystalline forms of aprepitant and processes for the preparation thereof
WO2012146692A1 (en) 2011-04-29 2012-11-01 Sandoz Ag Novel intermediates for the preparation of highly pure aprepitant or fosaprepitant
ITMI20130273A1 (it) * 2013-02-26 2014-08-27 Olon Spa Procedimento per la preparazione di aprepitant
CN103288813A (zh) * 2013-06-04 2013-09-11 四川百利药业有限责任公司 一种阿瑞匹坦的制备方法
CN104628663A (zh) * 2013-11-08 2015-05-20 中山奕安泰医药科技有限公司 3-氯甲基-1,2,4-三唑啉-5-酮的合成方法
CN107698574B (zh) * 2017-11-23 2020-12-01 中山奕安泰医药科技有限公司 一种高纯度阿瑞匹坦的精制制备工艺
CN109485613B (zh) * 2018-11-21 2022-05-13 江苏慧聚药业股份有限公司 阿瑞匹坦和福沙匹坦边链片段的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL111960A (en) * 1993-12-17 1999-12-22 Merck & Co Inc Morpholines and thiomorpholines their preparation and pharmaceutical compositions containing them
DE69434063D1 (de) * 1993-12-29 2004-11-11 Merck Sharp & Dohme Substituierte Morpholinderivate und ihre Verwendung als therapeutische Mittel
TW385308B (en) * 1994-03-04 2000-03-21 Merck & Co Inc Prodrugs of morpholine tachykinin receptor antagonists
EP0758329A1 (en) * 1994-05-05 1997-02-19 MERCK SHARP & DOHME LTD. Morpholine derivatives and their use as antagonists of tachikinins

Also Published As

Publication number Publication date
CN1305475A (zh) 2001-07-25
CZ20004734A3 (cs) 2001-08-15
WO1999065900A1 (en) 1999-12-23
GB9813025D0 (en) 1998-08-12
SI1087966T1 (en) 2002-10-31
HRP20000878B1 (hr) 2009-09-30
TW526199B (en) 2003-04-01
IL139946A (en) 2007-05-15
BR9911250A (pt) 2001-03-13
AR018877A1 (es) 2001-12-12
YU76500A (sh) 2003-02-28
HUP0102867A3 (en) 2004-06-28
KR100619589B1 (ko) 2006-09-05
CZ299257B6 (cs) 2008-05-28
DE69901444D1 (de) 2002-06-13
JP2002518388A (ja) 2002-06-25
PL196778B1 (pl) 2008-01-31
PT1087966E (pt) 2002-10-31
US6297376B1 (en) 2001-10-02
UA66866C2 (uk) 2004-06-15
JP2010195808A (ja) 2010-09-09
JP4647783B2 (ja) 2011-03-09
ES2176036T3 (es) 2002-11-16
CA2334821C (en) 2009-02-03
CA2334821A1 (en) 1999-12-23
PL344581A1 (en) 2001-11-05
JP5285652B2 (ja) 2013-09-11
EP1087966B1 (en) 2002-05-08
US6407255B2 (en) 2002-06-18
AU4281399A (en) 2000-01-05
EA003468B1 (ru) 2003-06-26
HUP0102867A2 (hu) 2002-05-29
IL139946A0 (en) 2002-02-10
EA200100040A1 (ru) 2001-06-25
KR20010052886A (ko) 2001-06-25
NZ508558A (en) 2003-07-25
US20020019524A1 (en) 2002-02-14
SK19212000A3 (sk) 2001-07-10
DE69901444T2 (de) 2002-11-28
SK283380B6 (sk) 2003-06-03
HRP20000878A2 (en) 2001-12-31
CN1131864C (zh) 2003-12-24
EP1087966A1 (en) 2001-04-04
AU746721B2 (en) 2002-05-02
ATE217308T1 (de) 2002-05-15

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