DK1067910T3 - Komposition med styret afgivelse - Google Patents

Komposition med styret afgivelse

Info

Publication number
DK1067910T3
DK1067910T3 DK99911627T DK99911627T DK1067910T3 DK 1067910 T3 DK1067910 T3 DK 1067910T3 DK 99911627 T DK99911627 T DK 99911627T DK 99911627 T DK99911627 T DK 99911627T DK 1067910 T3 DK1067910 T3 DK 1067910T3
Authority
DK
Denmark
Prior art keywords
composition
matrix
water
aqueous medium
erosion
Prior art date
Application number
DK99911627T
Other languages
Danish (da)
English (en)
Inventor
Daniel Bar-Shalom
Original Assignee
Egalet As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Egalet As filed Critical Egalet As
Application granted granted Critical
Publication of DK1067910T3 publication Critical patent/DK1067910T3/da

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0087Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0092Hollow drug-filled fibres, tubes of the core-shell type, coated fibres, coated rods, microtubules or nanotubes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/2031Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/205Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Nanotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
DK99911627T 1998-04-03 1999-03-25 Komposition med styret afgivelse DK1067910T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP98610009 1998-04-03

Publications (1)

Publication Number Publication Date
DK1067910T3 true DK1067910T3 (da) 2004-10-04

Family

ID=8235847

Family Applications (1)

Application Number Title Priority Date Filing Date
DK99911627T DK1067910T3 (da) 1998-04-03 1999-03-25 Komposition med styret afgivelse

Country Status (10)

Country Link
US (1) US7883722B2 (fr)
EP (1) EP1067910B1 (fr)
JP (1) JP4533531B2 (fr)
AT (1) ATE267589T1 (fr)
AU (1) AU3024399A (fr)
CA (1) CA2327685C (fr)
DE (1) DE69917618T2 (fr)
DK (1) DK1067910T3 (fr)
ES (1) ES2221370T3 (fr)
WO (1) WO1999051208A1 (fr)

Families Citing this family (71)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2327685C (fr) 1998-04-03 2008-11-18 Bm Research A/S Composition a liberation lente
EP1429739A1 (fr) 2001-09-21 2004-06-23 Egalet A/S Systeme de liberation a base de polymere
US20050019399A1 (en) 2001-09-21 2005-01-27 Gina Fischer Controlled release solid dispersions
US20040253310A1 (en) 2001-09-21 2004-12-16 Gina Fischer Morphine polymer release system
GB0203296D0 (en) 2002-02-12 2002-03-27 Glaxo Group Ltd Novel composition
US7776314B2 (en) 2002-06-17 2010-08-17 Grunenthal Gmbh Abuse-proofed dosage system
US8637512B2 (en) 2002-07-29 2014-01-28 Glaxo Group Limited Formulations and method of treatment
GB0222612D0 (en) * 2002-09-30 2002-11-06 Univ Gent Controlled delivery system for bioactive substances
MY148805A (en) 2002-10-16 2013-05-31 Takeda Pharmaceutical Controlled release preparation
WO2004041252A1 (fr) 2002-11-08 2004-05-21 Egalet A/S Compositions de carvedilol a liberation commandee
EP1610767B1 (fr) 2003-03-26 2011-01-19 Egalet A/S Systeme de liberation regulee de morphine
ATE399538T1 (de) * 2003-03-26 2008-07-15 Egalet As Matrixzubereitungen für die kontrollierte darreichung von arzneistoffen
ATE512659T1 (de) 2003-04-24 2011-07-15 Jagotec Ag Tablette mit verzögerter wirkstofffreigabe und bestimmter formgeometrie
DE10361596A1 (de) 2003-12-24 2005-09-29 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
DE102005005446A1 (de) 2005-02-04 2006-08-10 Grünenthal GmbH Bruchfeste Darreichungsformen mit retardierter Freisetzung
DE10336400A1 (de) 2003-08-06 2005-03-24 Grünenthal GmbH Gegen Missbrauch gesicherte Darreichungsform
US20070048228A1 (en) 2003-08-06 2007-03-01 Elisabeth Arkenau-Maric Abuse-proofed dosage form
GB0318824D0 (en) * 2003-08-11 2003-09-10 Glaxo Group Ltd Novel composition
DE102004032049A1 (de) 2004-07-01 2006-01-19 Grünenthal GmbH Gegen Missbrauch gesicherte, orale Darreichungsform
US20060078622A1 (en) * 2004-08-13 2006-04-13 Emisphere Technologies, Inc. Pharmaceutical formulations containing microparticles or nanoparticles of a delivery agent
DE102004043863A1 (de) 2004-09-10 2006-03-16 Nitec Pharma Ag Tabletten mit orts- und zeitgesteuerter Wirkstofffreisetzung im Gastrointestinum
PT2801355E (pt) * 2004-10-08 2015-09-18 Forward Pharma As Composições farmacêuticas de libertação controlada compreendendo um éster de ácido fumárico
AU2005320547B2 (en) * 2004-12-27 2009-02-05 Eisai R & D Management Co., Ltd. Method for stabilizing anti-dementia drug
US20060246003A1 (en) * 2004-12-27 2006-11-02 Eisai Co. Ltd. Composition containing anti-dementia drug
US20090208579A1 (en) * 2004-12-27 2009-08-20 Eisai R & D Management Co., Ltd. Matrix Type Sustained-Release Preparation Containing Basic Drug or Salt Thereof, and Method for Manufacturing the Same
US20060280789A1 (en) * 2004-12-27 2006-12-14 Eisai Research Institute Sustained release formulations
DE102005005449A1 (de) 2005-02-04 2006-08-10 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
AU2006254554B2 (en) * 2005-06-03 2011-11-24 Egalet Ltd A solid pharmaceutical composition with a first fraction of a dispersion medium and a second fraction of a matrix, the latter being at least partially first exposed to gastrointestinal fluids
DK2049123T4 (en) 2006-08-03 2016-11-28 Horizon Pharma Ag LATE discharge-glucocorticoid treatment of rheumatoid ILLNESS
EP1920767A1 (fr) * 2006-11-09 2008-05-14 Abbott GmbH & Co. KG Forme posologique d'Imatinib préparée à l'état fondu.
CA2930487A1 (fr) * 2007-01-16 2008-07-24 Egalet Ltd. Utilisation (i) d'un polyglycol et (ii) d'une substance medicamenteuse active dans la preparation d'une composition pharmaceutique destinee (i) a reduire le risque de liberation massive induite par l'alcool et/ou (ii) a reduire le risque de toxicomanie medicamenteuse
US8821928B2 (en) 2007-06-04 2014-09-02 Egalet Ltd. Controlled release pharmaceutical compositions for prolonged effect
BRPI0906467C1 (pt) 2008-01-25 2021-05-25 Gruenenthal Gmbh forma de dosagem farmacêutica com formato exterior modificado resistente à ruptura e com liberação controlada
EP2259803B2 (fr) 2008-02-29 2019-03-13 Ferrosan Medical Devices A/S Dispositif pour la promotion de l homéostasie et/ou la cicatrisation des plaies
KR101690094B1 (ko) 2008-05-09 2016-12-27 그뤼넨탈 게엠베하 분무 응결 단계의 사용하에 중간 분말 제형 및 최종 고체 제형을 제조하는 방법
WO2010017821A1 (fr) * 2008-08-14 2010-02-18 Daniel Bar-Shalom Comprimés enrobés avec une surface de dégradation résiduelle dans le temps
WO2010089132A1 (fr) 2009-02-06 2010-08-12 Egalet A/S Composition à libération immédiate résistant à une maltraitance par prise d'alcool
EP3184105A1 (fr) 2009-02-06 2017-06-28 Egalet Ltd. Compositions pharmaceutiques anti-abus
EP2429492B1 (fr) * 2009-05-13 2014-06-25 Basf Se Préparations pharmaceutiques solides contenant des copolymères à base de polyéthers en association avec des polymères peu solubles dans l'eau
EP2445487A2 (fr) 2009-06-24 2012-05-02 Egalet Ltd. Formulations à libération contrôlée
PE20121067A1 (es) 2009-07-22 2012-09-05 Gruenenthal Chemie Forma de dosificacion de liberacion controlada extruida por fusion en caliente
WO2011009604A1 (fr) 2009-07-22 2011-01-27 Grünenthal GmbH Forme galénique inviolable stabilisée à l’oxydation
WO2011102505A1 (fr) * 2010-02-22 2011-08-25 第一三共株式会社 Préparation solide à libération prolongée pour usage oral
CN102905732A (zh) 2010-03-15 2013-01-30 弗罗桑医疗设备公司 用于促进止血和/或伤口愈合的方法
CN103037870B (zh) 2010-05-12 2016-05-25 斯派克托姆制药公司 碱式碳酸镧、碳酸氧镧及其制造方法和用途
CA2808541C (fr) 2010-09-02 2019-01-08 Gruenenthal Gmbh Forme pharmaceutique inviolable comportant un polymere anionique
WO2012028319A1 (fr) 2010-09-02 2012-03-08 Grünenthal GmbH Forme pharmaceutique inviolable comportant un sel inorganique
KR20140053158A (ko) 2011-07-29 2014-05-07 그뤼넨탈 게엠베하 즉시 약물 방출을 제공하는 탬퍼-저항성 정제
AR087360A1 (es) 2011-07-29 2014-03-19 Gruenenthal Gmbh Tableta a prueba de manipulacion que proporciona liberacion de farmaco inmediato
CA2864949A1 (fr) 2012-02-28 2013-09-06 Grunenthal Gmbh Forme pharmaceutique inviolable comprenant un compose pharmacologiquement actif et un polymere anionique
CA2865349C (fr) 2012-03-06 2021-07-06 Ferrosan Medical Devices A/S Recipient mis sous pression contenant de la pate hemostatique
JP6282261B2 (ja) 2012-04-18 2018-02-21 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング 不正使用防止および過量放出防止医薬剤形
US10064945B2 (en) 2012-05-11 2018-09-04 Gruenenthal Gmbh Thermoformed, tamper-resistant pharmaceutical dosage form containing zinc
CA2874290C (fr) 2012-06-12 2020-02-25 Ferrosan Medical Devices A/S Composition hemostatique seche
JP2015521988A (ja) 2012-07-06 2015-08-03 イガレット・リミテッド 制御放出用乱用防止性医薬組成物
CA2913209A1 (fr) 2013-05-29 2014-12-04 Grunenthal Gmbh Forme dosifiee inviolable a profil de liberation bimodale
EP3003279A1 (fr) 2013-05-29 2016-04-13 Grünenthal GmbH Forme pharmaceutique inviolable contenant une ou plusieurs particules
US9724078B2 (en) 2013-06-21 2017-08-08 Ferrosan Medical Devices A/S Vacuum expanded dry composition and syringe for retaining same
AU2014289187B2 (en) 2013-07-12 2019-07-11 Grunenthal Gmbh Tamper-resistant dosage form containing ethylene-vinyl acetate polymer
MX371372B (es) 2013-11-26 2020-01-28 Gruenenthal Gmbh Preparacion de una composicion farmaceutica en polvo por medio de criomolienda.
CA2928963C (fr) 2013-12-11 2020-10-27 Ferrosan Medical Devices A/S Composition seche comprenant un ameliorateur d'extrusion
WO2015091352A1 (fr) 2013-12-16 2015-06-25 Grünenthal GmbH Forme galénique inviolable ayant un profil de libération bimodal et fabriqué par coextrusion
WO2015122477A1 (fr) * 2014-02-12 2015-08-20 沢井製薬株式会社 Comprimé à désintégration orale enrobé d'un film
CA2947786A1 (fr) 2014-05-12 2015-11-19 Grunenthal Gmbh Formulation pour capsule a liberation immediate resistant aux manipulations illicites comprenant du tapentadol
WO2015181059A1 (fr) 2014-05-26 2015-12-03 Grünenthal GmbH Microparticules protégées contre une libération massive dans l'éthanol
CN106999621B (zh) 2014-10-13 2020-07-03 弗罗桑医疗设备公司 用于止血和伤口愈合的干组合物
US10653837B2 (en) 2014-12-24 2020-05-19 Ferrosan Medical Devices A/S Syringe for retaining and mixing first and second substances
JP2018517676A (ja) 2015-04-24 2018-07-05 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング 即時放出および溶媒抽出に対する耐性を有する改変防止製剤
EP3316930B1 (fr) 2015-07-03 2019-07-31 Ferrosan Medical Devices A/S Seringue destinée à mélanger deux composants et à maintenir un vide dans une condition de stockage
WO2017042325A1 (fr) 2015-09-10 2017-03-16 Grünenthal GmbH Protection contre un surdosage par voie orale à l'aide de formulations à libération immédiate dissuasives d'abus
KR20210008479A (ko) 2018-05-09 2021-01-22 훼로산 메디칼 디바이스 에이/에스 지혈 조성물을 제조하는 방법

Family Cites Families (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1018456A (en) 1972-06-26 1977-10-04 Hans Lowey Prolonged release lozenges
US4330338A (en) 1978-10-02 1982-05-18 Purdue Research Foundation Pharmaceutical coating composition, and preparation and dosages so coated
US4389393A (en) 1982-03-26 1983-06-21 Forest Laboratories, Inc. Sustained release therapeutic compositions based on high molecular weight hydroxypropylmethylcellulose
DE3320583A1 (de) 1983-06-08 1984-12-13 Dr. Karl Thomae Gmbh, 7950 Biberach Neue galenische zubereitungsformen von oralen antidiabetika und verfahren zu ihrer herstellung
AU591171B2 (en) 1983-11-02 1989-11-30 Alza Corporation Dispenser for delivering thermo-responsive composition
US4844984A (en) 1984-03-19 1989-07-04 Alza Corporation Dispensing system with means for increasing delivery of beneficial agent from the system
JPH0246008B2 (ja) * 1984-06-01 1990-10-12 Takada Seiyaku Kk Nifuejipinjizokuseiseizainoseizohoho
GB2170104A (en) 1985-01-30 1986-07-30 Warner Lambert Co Coated pharmaceutical dosage forms
IE59066B1 (en) 1985-02-19 1993-12-15 Key Pharma Controlled release potassium chloride
US4898733A (en) 1985-11-04 1990-02-06 International Minerals & Chemical Corp. Layered, compression molded device for the sustained release of a beneficial agent
US4892742A (en) 1985-11-18 1990-01-09 Hoffmann-La Roche Inc. Controlled release compositions with zero order release
US4824675A (en) 1987-07-13 1989-04-25 Alza Corporation Dispenser with movable matrix comprising a plurality of tiny pills
AU3432689A (en) 1988-03-24 1989-10-16 Bukh Meditec A/S Controlled release composition
FI101344B (fi) 1988-03-31 1998-06-15 Tanabe Seiyaku Co Menetelmä valmistaa valmiste, josta kontrolloidusti vapautuu farmaseut tisesti aktiivista ainetta
WO1990008536A1 (fr) 1989-01-30 1990-08-09 Alza Corporation Forme de dosage pour administrer un antagoniste du calcium
JP2727009B2 (ja) * 1989-03-10 1998-03-11 ダイト株式会社 持続性製剤
DK469989D0 (da) * 1989-09-22 1989-09-22 Bukh Meditec Farmaceutisk praeparat
IT1237904B (it) 1989-12-14 1993-06-18 Ubaldo Conte Compresse a rilascio a velocita' controllata delle sostanze attive
US5102668A (en) * 1990-10-05 1992-04-07 Kingaform Technology, Inc. Sustained release pharmaceutical preparation using diffusion barriers whose permeabilities change in response to changing pH
US5683719A (en) 1990-11-22 1997-11-04 British Technology Group Limited Controlled release compositions
GB9025372D0 (en) 1990-11-22 1991-01-09 Nat Res Dev Pharmaceutical dosage forms
US5478577A (en) 1993-11-23 1995-12-26 Euroceltique, S.A. Method of treating pain by administering 24 hour oral opioid formulations exhibiting rapid rate of initial rise of plasma drug level
US5881926A (en) 1993-03-11 1999-03-16 Taro Pharmaceutical Industries, Ltd. Pharmaceutical compositions in semisolid form and a device for administration thereof
JPH071001A (ja) * 1993-06-21 1995-01-06 Nippon Steel Corp 鏡面材用ステンレス鋼板およびその製造方法
US5419917A (en) * 1994-02-14 1995-05-30 Andrx Pharmaceuticals, Inc. Controlled release hydrogel formulation
WO1995022962A1 (fr) * 1994-02-23 1995-08-31 Bm Research A/S Composition a liberation regulee
IL116674A (en) 1995-01-09 2003-05-29 Mendell Co Inc Edward Microcrystalline cellulose-based excipient having improved compressibility, pharmaceutical compositions containing the same and methods for the preparation of said excipient and of solid dosage form thereof
US5686106A (en) * 1995-05-17 1997-11-11 The Procter & Gamble Company Pharmaceutical dosage form for colonic delivery
WO1997044034A1 (fr) 1996-05-20 1997-11-27 Otsuka Pharmaceutical Co., Ltd. Remede pour le traitement de l'acne rosacee
EP0918513B1 (fr) 1996-08-15 2000-12-06 Losan Pharma GmbH Medicament a administration orale facile a avaler
GB9700624D0 (en) * 1997-01-14 1997-03-05 Danbiosyst Uk Drug delivery composition
WO1999001121A1 (fr) 1997-07-01 1999-01-14 Pfizer Inc. Sels de sertraline et formes posologiques de sertraline, a liberation prolongee
US20020054911A1 (en) 2000-05-11 2002-05-09 Boehringer Mannheim Pharmaceutical Corporation-Sm Ithkline Beckman Corporation, Limited Partnershi Novel oral dosage form for carvedilol
US6245357B1 (en) 1998-03-06 2001-06-12 Alza Corporation Extended release dosage form
CA2327685C (fr) 1998-04-03 2008-11-18 Bm Research A/S Composition a liberation lente
JP4812167B2 (ja) 1999-02-12 2011-11-09 モレキュラー インサイト ファーマスーティカルズ インコーポレイテッド 薬物輸送用マトリックス、ならびにその作成方法および使用方法
US6562375B1 (en) 1999-08-04 2003-05-13 Yamanouchi Pharmaceuticals, Co., Ltd. Stable pharmaceutical composition for oral use
US6534085B1 (en) 1999-09-23 2003-03-18 Bioresponse L.L.C. Phytochemicals for promoting weight loss
CA2392085A1 (fr) 1999-11-15 2001-05-25 Smithkline Beecham Corporation Methane-sulfonate de carvedilol
US6491949B2 (en) 2000-01-14 2002-12-10 Osmotica Corp. Osmotic device within an osmotic device
US6352721B1 (en) 2000-01-14 2002-03-05 Osmotica Corp. Combined diffusion/osmotic pumping drug delivery system
US20010036959A1 (en) 2000-04-03 2001-11-01 Gabel Rolf Dieter Carvedilol-hydrophilic solutions
US6488962B1 (en) 2000-06-20 2002-12-03 Depomed, Inc. Tablet shapes to enhance gastric retention of swellable controlled-release oral dosage forms
EP1335707A4 (fr) 2000-10-24 2005-07-06 Smithkline Beecham Corp Nouvelles formulations de carvedilol
IN191028B (fr) 2001-05-17 2003-09-13 Sun Pharmaceutical Ind Ltd
US20040253310A1 (en) 2001-09-21 2004-12-16 Gina Fischer Morphine polymer release system
US20050019399A1 (en) 2001-09-21 2005-01-27 Gina Fischer Controlled release solid dispersions
EP1429739A1 (fr) 2001-09-21 2004-06-23 Egalet A/S Systeme de liberation a base de polymere
CN1596101A (zh) 2001-09-28 2005-03-16 麦克内尔-Ppc股份有限公司 含有糖果组分的剂型
WO2004041252A1 (fr) 2002-11-08 2004-05-21 Egalet A/S Compositions de carvedilol a liberation commandee
ATE399538T1 (de) 2003-03-26 2008-07-15 Egalet As Matrixzubereitungen für die kontrollierte darreichung von arzneistoffen
EP1610767B1 (fr) 2003-03-26 2011-01-19 Egalet A/S Systeme de liberation regulee de morphine
CA2533165A1 (fr) 2003-07-21 2005-01-27 Bio-Dar Ltd. Formes dosifiees a liberation controlee a base de gomme gellane a administrer par voie orale, une nouvelle technologie pour la retention gastrique
AP2006003585A0 (en) 2003-09-19 2006-04-30 Penwest Pharmaceuticals Co Delayed release dosage forms.
WO2005065654A2 (fr) 2003-12-31 2005-07-21 Alpharma, Inc. Preparations de rosiglitazone
AU2006254554B2 (en) 2005-06-03 2011-11-24 Egalet Ltd A solid pharmaceutical composition with a first fraction of a dispersion medium and a second fraction of a matrix, the latter being at least partially first exposed to gastrointestinal fluids

Also Published As

Publication number Publication date
JP2002510616A (ja) 2002-04-09
US7883722B2 (en) 2011-02-08
EP1067910B1 (fr) 2004-05-26
EP1067910A1 (fr) 2001-01-17
CA2327685A1 (fr) 1999-10-14
AU3024399A (en) 1999-10-25
US20050089569A1 (en) 2005-04-28
JP4533531B2 (ja) 2010-09-01
CA2327685C (fr) 2008-11-18
WO1999051208A1 (fr) 1999-10-14
DE69917618T2 (de) 2005-06-23
ATE267589T1 (de) 2004-06-15
DE69917618D1 (de) 2004-07-01
ES2221370T3 (es) 2004-12-16

Similar Documents

Publication Publication Date Title
DK1067910T3 (da) Komposition med styret afgivelse
ATE331024T1 (de) Wasserlösliche packung enthaltend eine flüssige zusammensetzung mit einer visuell unterscheidbaren kapsel oder emulsion oder dispersionsschicht
MX160901A (es) Composicion mejorada para el acondicionamiento de la piel
DE69406272D1 (de) Feuchttigkeitsbeständige zusammensetzung
PT754032E (pt) Composicoes liquidas para difusao
FI863113A0 (fi) Tvaettmedelskompositioner med kontrollerad loeddring.
ES551505A0 (es) Un sistema osmotico lipidico para dispersar agentes farmacologicamente activos.
TR199901250T2 (xx) Tedavi ama�l� ajanlar.
SE0004671D0 (sv) Pharmaceutical formulation
IE882898L (en) Solubility modulated drug delivery device
DK1129052T3 (da) Sammensætninger indeholdende antiafdriftsmidler og fremgangsmåder til anvendelse deraf
DE69901567D1 (de) Zur bildung einer mikroemulsion fähigen zusammensetzung mit verlängerter freisetzung des wirkstoffs
ATE221771T1 (de) Perorale zusammensetzung zur kontrollierten freisetzungen in dem unteren teil des gastrointestinaltraktes
DE60040034D1 (de) Polymer in umgekehrter Emulsion und dessen Herstellung
GB9816784D0 (en) Soil treatment compositions and their use
ES8601756A1 (es) Metodo de fabricar una estructura compuesta coherente.
ZA932831B (en) Fire retardant and intumescent compositions for cellulosic material
DK1018345T3 (da) Vandoplöselige, törre sammensætninger
JPS5681105A (en) Treatment of membrane
JPS5774384A (en) Antioxidant compsition
GB2333451A (en) Use of a bolus with a differential surface coating to administer beneficial substances to ruminant animals at a uniform rate of release
JPS5615202A (en) Agricultural drug composition
JPS55127109A (en) Coagulant
JPS54116036A (en) Quick-curing film-forming composition
JPS5517326A (en) Creamy drug for external use, and its preparation