DK1054885T3 - Benzisoxasolderivater med D4-antagonistisk virkning - Google Patents

Benzisoxasolderivater med D4-antagonistisk virkning

Info

Publication number
DK1054885T3
DK1054885T3 DK99914450T DK99914450T DK1054885T3 DK 1054885 T3 DK1054885 T3 DK 1054885T3 DK 99914450 T DK99914450 T DK 99914450T DK 99914450 T DK99914450 T DK 99914450T DK 1054885 T3 DK1054885 T3 DK 1054885T3
Authority
DK
Denmark
Prior art keywords
amino
sulfonyl
group
dialkyl
alkoxy
Prior art date
Application number
DK99914450T
Other languages
Danish (da)
English (en)
Inventor
Hartog Jacobus A J Den
Steen Bartholomeus J Van
Martinus T M Tulp
Eric Ronken
Cornelis G Kruse
Josephus H M Lange
Gerben M Visser
Original Assignee
Duphar Int Res
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Duphar Int Res filed Critical Duphar Int Res
Application granted granted Critical
Publication of DK1054885T3 publication Critical patent/DK1054885T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
DK99914450T 1998-02-09 1999-02-05 Benzisoxasolderivater med D4-antagonistisk virkning DK1054885T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP98200400 1998-02-09
PCT/EP1999/000852 WO1999040067A2 (fr) 1998-02-09 1999-02-05 Derives de benzisoxasole ayant une activite antagoniste du recepteur d4

Publications (1)

Publication Number Publication Date
DK1054885T3 true DK1054885T3 (da) 2007-10-15

Family

ID=8233376

Family Applications (1)

Application Number Title Priority Date Filing Date
DK99914450T DK1054885T3 (da) 1998-02-09 1999-02-05 Benzisoxasolderivater med D4-antagonistisk virkning

Country Status (11)

Country Link
US (1) US6335326B1 (fr)
EP (1) EP1054885B1 (fr)
JP (1) JP4627882B2 (fr)
AT (1) ATE367389T1 (fr)
AU (1) AU3327399A (fr)
CA (1) CA2320120C (fr)
DE (1) DE69936572T2 (fr)
DK (1) DK1054885T3 (fr)
ES (1) ES2291023T3 (fr)
PT (1) PT1054885E (fr)
WO (1) WO1999040067A2 (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU3327399A (en) 1998-02-09 1999-08-23 Duphar International Research B.V. Benzisoxazole derivatives having d4-antagonistic activity
EE200200134A (et) * 1999-09-14 2003-04-15 Aventis Pharmaceuticals Inc. D4 retseptori antagonistidena toimivad bensisoksasolüül-, püridoisoksasolüül- ja benstienüülfenoksüderivaadid
US7091199B1 (en) 1999-09-14 2006-08-15 Aventis Pharmaceuticals Inc. Thienoisoxazole phenoxy unsubstituted ethyl and propyl derivatives useful as d4 antagonists
US7125903B1 (en) 1999-09-14 2006-10-24 Aventis Pharmaceuticals Inc. Thienoisoxazolyl-and thienylpyrrazolyl-phenoxy substituted propyl derivatives useful as D4 antagonists
US7253165B2 (en) 1999-09-14 2007-08-07 Aventis Pharmaceuticals Inc. Benzisoxazolyl-, pyridoisoxazolyl-and benzthienyl-phenoxy derivatives useful as D4 antagonists
JP4717306B2 (ja) * 1999-09-14 2011-07-06 アベンティスユービー・セカンド・インコーポレイテッド Ｄ４拮抗剤として有用なチエノイソキサゾールフェノキシ非置換エチルおよびプロピル誘導体
BR0014515A (pt) * 1999-09-14 2002-06-25 Aventis Pharma Inc Derivados de propil tienoisoxazolil- e tienilpirrazolil-fenóxi substituìdos úteis como antagonistas de d4
AU2002258506A1 (en) 2001-03-12 2002-09-24 The Mclean Hospital Corporation Dopamine d4 receptor antagonists as treatment for attention deficit-hyperactivity disorder
EP1856114B1 (fr) * 2005-02-25 2014-08-20 Pfizer Inc. Derives de benzisoxazole
EP2183245B1 (fr) * 2007-07-26 2014-07-09 F. Hoffmann-La Roche AG Modulateurs doubles de récepteurs 5-ht2a et d3
US8877778B2 (en) 2010-12-15 2014-11-04 Hoffmann-La Roche Inc. Benzofurane compounds
US8921397B2 (en) 2011-05-04 2014-12-30 Hoffmann-La Roche Inc. Benzofurane-piperidine compounds

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4352811A (en) * 1981-11-12 1982-10-05 Hoechst-Roussel Pharmaceuticals Inc. 3-(1-Substituted-4-piperidyl)-1,2-benzisoxazoles
EP0602242A4 (en) 1991-08-22 1994-06-29 Yoshitomi Pharmaceutical Benzisoxazole compound and use thereof.
JPH0641125A (ja) * 1992-03-26 1994-02-15 Yoshitomi Pharmaceut Ind Ltd ベンゾイソオキサゾール化合物およびその用途
DK60593D0 (da) * 1993-05-26 1993-05-26 Novo Nordisk As Kemiske forbindelser, deres fremstilling og anvendelse
FR2749304B1 (fr) * 1996-06-04 1998-06-26 Adir Nouveaux derives du 3-(piperid-4-yl)1,2-benzisoxazole et du 3-(piperazin-4-yl)1,2-benzisoxazole, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
AU3327399A (en) 1998-02-09 1999-08-23 Duphar International Research B.V. Benzisoxazole derivatives having d4-antagonistic activity

Also Published As

Publication number Publication date
EP1054885B1 (fr) 2007-07-18
PT1054885E (pt) 2007-10-03
JP4627882B2 (ja) 2011-02-09
WO1999040067A3 (fr) 1999-11-25
EP1054885A2 (fr) 2000-11-29
WO1999040067A2 (fr) 1999-08-12
AU3327399A (en) 1999-08-23
CA2320120A1 (fr) 1999-08-12
JP2002502842A (ja) 2002-01-29
ES2291023T3 (es) 2008-02-16
ATE367389T1 (de) 2007-08-15
DE69936572T2 (de) 2008-06-19
DE69936572D1 (de) 2007-08-30
US6335326B1 (en) 2002-01-01
CA2320120C (fr) 2009-08-11

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