DK1050588T3 - Fremgangsmåde til fremstilling af en indretning til udförelse af et assay, anvendelse af en membran til fremstilling af indretningen, kit, der omfatter indretningen, og fremgangsmåde til påvisning af en analyt under anvendelse af en sådan indretning - Google Patents

Fremgangsmåde til fremstilling af en indretning til udförelse af et assay, anvendelse af en membran til fremstilling af indretningen, kit, der omfatter indretningen, og fremgangsmåde til påvisning af en analyt under anvendelse af en sådan indretning

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Publication number
DK1050588T3
DK1050588T3 DK00202824T DK00202824T DK1050588T3 DK 1050588 T3 DK1050588 T3 DK 1050588T3 DK 00202824 T DK00202824 T DK 00202824T DK 00202824 T DK00202824 T DK 00202824T DK 1050588 T3 DK1050588 T3 DK 1050588T3
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Prior art keywords
substrate
sample application
present
analyte
channels
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DK00202824T
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Danish (da)
English (en)
Inventor
Hermanus Johannes Mari Kreuwel
Damme Hendrik Sibolt Van
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Pamgene Bv
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Publication of DK1050588T3 publication Critical patent/DK1050588T3/da

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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5025—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures for parallel transport of multiple samples
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701—Specific hybridization probes
    • C12Q1/702—Specific hybridization probes for retroviruses
    • C12Q1/703—Viruses associated with AIDS
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/551—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being inorganic
    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00378—Piezoelectric or ink jet dispensers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
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    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/00511—Walls of reactor vessels
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
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    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/00527—Sheets
    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/0059—Sequential processes
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    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00596—Solid-phase processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
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    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B01J2219/00612—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports the surface being inorganic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
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    • B01J2219/00614—Delimitation of the attachment areas
    • B01J2219/00617—Delimitation of the attachment areas by chemical means
    • B01J2219/00619—Delimitation of the attachment areas by chemical means using hydrophilic or hydrophobic regions
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    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00639—Making arrays on substantially continuous surfaces the compounds being trapped in or bound to a porous medium
    • B01J2219/00641—Making arrays on substantially continuous surfaces the compounds being trapped in or bound to a porous medium the porous medium being continuous, e.g. porous oxide substrates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
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    • B01J2219/00603—Making arrays on substantially continuous surfaces
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    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
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    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
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    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/81—Packaged device or kit

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Clinical Laboratory Science (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • AIDS & HIV (AREA)
  • Inorganic Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
DK00202824T 1997-07-11 1998-07-07 Fremgangsmåde til fremstilling af en indretning til udförelse af et assay, anvendelse af en membran til fremstilling af indretningen, kit, der omfatter indretningen, og fremgangsmåde til påvisning af en analyt under anvendelse af en sådan indretning DK1050588T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP97202140 1997-07-11
EP98940253A EP0975427B1 (fr) 1997-07-11 1998-07-07 Dispositif permettant d'effectuer un dosage, utilisation d'une membrane dans la fabrication dudit dispositif, kit comprenant ledit dispositif et methode de detection d'un element utilisant ce dispositif.
EP00202824A EP1050588B1 (fr) 1997-07-11 1998-07-07 Procédé de fabrication d'un dispositif permettant d'effectuer un dosage, utilisation d'une membrane dans la fabrication dudit dispositif, kit comprenant ledit dispositif et méthode de détection d'un élément utilisant ce dispositif

Publications (1)

Publication Number Publication Date
DK1050588T3 true DK1050588T3 (da) 2005-04-25

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Application Number Title Priority Date Filing Date
DK00202824T DK1050588T3 (da) 1997-07-11 1998-07-07 Fremgangsmåde til fremstilling af en indretning til udförelse af et assay, anvendelse af en membran til fremstilling af indretningen, kit, der omfatter indretningen, og fremgangsmåde til påvisning af en analyt under anvendelse af en sådan indretning
DK98940253T DK0975427T3 (da) 1997-07-11 1998-07-07 Indretning til udførelse af et assay, anvendelse af en membran til fremstilling af indretningen, kit, der omfatter indretningen, og fremgangsmåde til påvisning af en analyt under anvendelse af en sådan indretning

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK98940253T DK0975427T3 (da) 1997-07-11 1998-07-07 Indretning til udførelse af et assay, anvendelse af en membran til fremstilling af indretningen, kit, der omfatter indretningen, og fremgangsmåde til påvisning af en analyt under anvendelse af en sådan indretning

Country Status (13)

Country Link
US (3) US6225131B1 (fr)
EP (2) EP1050588B1 (fr)
JP (1) JP3208390B2 (fr)
KR (1) KR100421262B1 (fr)
AT (2) ATE284451T1 (fr)
AU (1) AU724382B2 (fr)
CA (1) CA2290945C (fr)
DE (2) DE69828083T2 (fr)
DK (2) DK1050588T3 (fr)
ES (2) ES2157669T3 (fr)
GR (1) GR3036010T3 (fr)
PT (2) PT975427E (fr)
WO (1) WO1999002266A1 (fr)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6521187B1 (en) 1996-05-31 2003-02-18 Packard Instrument Company Dispensing liquid drops onto porous brittle substrates
EP1050588B1 (fr) 1997-07-11 2004-12-08 PamGene B.V. Procédé de fabrication d'un dispositif permettant d'effectuer un dosage, utilisation d'une membrane dans la fabrication dudit dispositif, kit comprenant ledit dispositif et méthode de détection d'un élément utilisant ce dispositif
US6855539B2 (en) * 1997-07-11 2005-02-15 Pamgene International B.V. Device for performing an assay, a method for manufacturing said device, and use of a membrane in the manufacture of said device
GB9820163D0 (en) * 1998-09-17 1998-11-11 Sentec Ltd Micro-fabricated coded labels, reading systems and their applications
CA2378717A1 (fr) * 1999-08-16 2001-02-22 Pamgene B.V. Preparation de supports d'oxydes metalliques charges de biomolecules
US6383748B1 (en) 1999-09-14 2002-05-07 Pamgene B.V. Analytical test device with substrate having oriented through going channels and improved methods and apparatus for using same
US6656432B1 (en) * 1999-10-22 2003-12-02 Ngk Insulators, Ltd. Micropipette and dividedly injectable apparatus
JP2001186880A (ja) * 1999-10-22 2001-07-10 Ngk Insulators Ltd Ｄｎａチップの製造方法
US6503736B1 (en) * 1999-11-12 2003-01-07 BIOMéRIEUX, INC. Antibodies to crosslinkers and methods for using the same
US20030091477A1 (en) * 1999-12-22 2003-05-15 Paul Eric A. Flow-thru chip cartridge, chip holder, system & method thereof
US20010044112A1 (en) * 2000-03-24 2001-11-22 Lyles Mark B. High throughput screening array containing porous material
US6676904B1 (en) * 2000-07-12 2004-01-13 Us Gov Sec Navy Nanoporous membrane immunosensor
US7105134B2 (en) 2001-03-13 2006-09-12 Pamgene B.V. Device for holding a substrate
US6886409B2 (en) 2001-03-13 2005-05-03 Pamgene International B.V. System for controlling the flow of a fluid through a substrate
US6869532B2 (en) 2001-06-04 2005-03-22 Cuno Incorporated Nucleic acid binding matrix
CA2453207A1 (fr) * 2001-07-06 2003-01-16 454 Corporation Methode utilisant un filtre poreux pour isoler en parallele des micro-reactions chimiques independantes
EP1499441A1 (fr) * 2002-04-19 2005-01-26 PamGene B.V. Systeme, plaque de substrat et incubateur permettant de realiser des essais biologiques
US20030207099A1 (en) * 2002-05-01 2003-11-06 Gillmor Susan D. Low-contact-angle polymer membranes and method for fabricating micro-bioarrays
AU2003273530A1 (en) * 2002-06-03 2003-12-19 Pamgene B.V. Biomolecular kinetics method using a flow-through microarray
US7473562B2 (en) 2002-06-03 2009-01-06 Pamgene B.V. Method for high-throughput integrated chemical and biochemical reactions
WO2003102578A2 (fr) * 2002-06-03 2003-12-11 Pamgene B.V. Methode d'analyse a haut rendement de cellules, faisant intervenir des microreseaux vivants polyvalents
US7153687B2 (en) 2002-08-13 2006-12-26 Hong Kong Dna Chips Limited Apparatus and methods for detecting DNA in biological samples
AU2007224397B2 (en) * 2002-08-13 2011-06-02 Hai Kang Life Corporation Limited Apparatus and Methods for Detecting DNA in Biological Samples
JP2005537002A (ja) * 2002-09-02 2005-12-08 パムジーン ベー．ベー． 新規な一体化したマイクロアレイ分析
US7597936B2 (en) * 2002-11-26 2009-10-06 University Of Utah Research Foundation Method of producing a pigmented composite microporous material
WO2004048936A2 (fr) * 2002-11-26 2004-06-10 University Of Utah Research Foundation Materiaux microporeux, procedes, et articles permettant de localiser et de quantifier des analytes
US20060228813A1 (en) * 2003-04-10 2006-10-12 Ying Wu Method for immobilizing biomolecules on metal oxide substrates
WO2004104584A1 (fr) * 2003-05-26 2004-12-02 Olympus Corporation Procede pour tester des substances apparentees a la biologie, appareil et procede de transfert fluidique associes
US20040259142A1 (en) * 2003-06-04 2004-12-23 Imperial College Innovations Limited Products and methods
GB0312747D0 (en) * 2003-06-04 2003-07-09 Imp College Innovations Ltd Products and methods
US20060286555A1 (en) * 2003-08-21 2006-12-21 Van Beuningen Marinus G J Microarray support for bioprobe synthesis
WO2005052582A2 (fr) * 2003-11-28 2005-06-09 Pamgene B.V. Nouveaux procedes et appareils pour realiser des dosages sur des jeux ordonnes de microechantillons a base de cellules
JP2005204609A (ja) 2004-01-26 2005-08-04 Canon Inc 有機物固定化用キット、有機物固定化構造体及びその製造方法
US20070160998A1 (en) * 2004-02-11 2007-07-12 Van Beuningen Marinus G J Device for analyzing an interaction between target and probe molecules
CN101116086A (zh) 2004-11-16 2008-01-30 伊路敏纳公司 读取编码微珠的方法和设备
US20060141486A1 (en) * 2004-12-29 2006-06-29 Coonan Everett W Porous substrates and arrays comprising the same
CN101278187A (zh) * 2005-10-03 2008-10-01 皇家飞利浦电子股份有限公司 具有光学匹配基板的生物传感器
US20080245971A1 (en) * 2005-10-03 2008-10-09 Koninklijke Philips Electronics, N.V. Biosensors with Improved Sensitivity
EP1931979B1 (fr) * 2005-10-04 2015-11-18 Headway Technologies, Inc. Detection microfluidique d'analytes
JP2009517650A (ja) * 2005-11-25 2009-04-30 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ 有孔性膜及び未分岐チャネルを有するマイクロ流体素子
WO2007085980A1 (fr) 2006-01-25 2007-08-02 Koninklijke Philips Electronics N. V. Dispositif pour analyser des fluides
US7830575B2 (en) 2006-04-10 2010-11-09 Illumina, Inc. Optical scanner with improved scan time
US7492312B2 (en) * 2006-11-14 2009-02-17 Fam Adly T Multiplicative mismatched filters for optimum range sidelobe suppression in barker code reception
JP2008249534A (ja) * 2007-03-30 2008-10-16 Sanyo Chem Ind Ltd 免疫測定用担体
EP2260943A1 (fr) * 2009-06-11 2010-12-15 Innosieve Diagnostics B.V. Tuyau centrifuge microfiltre
US20140342931A1 (en) 2011-09-16 2014-11-20 Pamgene B.V. Method for predicting response to endocrine therapy
CA3162780A1 (en) 2015-04-09 2016-10-13 Angle Europe Limited Microporous substrate for detection of surface bound target analyte molecules

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3652761A (en) * 1969-09-04 1972-03-28 Corning Glass Works Immunochemical composites and antigen or antibody purification therewith
US3671410A (en) * 1970-02-16 1972-06-20 Philip Morris Inc Method for making metal oxide membranes
DE2429196A1 (de) * 1973-07-09 1975-02-06 Corning Glass Works Poroese anorganische traeger mit iminogruppen
US4427415A (en) 1979-01-05 1984-01-24 Cleveland Patrick H Manifold vacuum biochemical test method and device
US4693985A (en) * 1984-08-21 1987-09-15 Pall Corporation Methods of concentrating ligands and active membranes used therefor
GB8426264D0 (en) 1984-10-17 1984-11-21 Alcan Int Ltd Porous films
US4777021A (en) 1986-04-25 1988-10-11 Richard K. Wertz Manifold vacuum device for biochemical and immunological uses
AU700315B2 (en) * 1993-10-28 1998-12-24 Houston Advanced Research Center Microfabricated, flowthrough porous apparatus for discrete detection of binding reactions
US5772735A (en) * 1995-11-02 1998-06-30 University Of New Mexico Supported inorganic membranes
EP1050588B1 (fr) 1997-07-11 2004-12-08 PamGene B.V. Procédé de fabrication d'un dispositif permettant d'effectuer un dosage, utilisation d'une membrane dans la fabrication dudit dispositif, kit comprenant ledit dispositif et méthode de détection d'un élément utilisant ce dispositif

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JP3208390B2 (ja) 2001-09-10
US6864102B2 (en) 2005-03-08
ES2157669T3 (es) 2001-08-16
EP0975427B1 (fr) 2001-03-14
AU724382B2 (en) 2000-09-21
DE69828083T2 (de) 2005-09-08
PT1050588E (pt) 2005-04-29
JP2000515251A (ja) 2000-11-14
GR3036010T3 (en) 2001-09-28
KR20010020283A (ko) 2001-03-15
US20020102565A1 (en) 2002-08-01
EP1050588B1 (fr) 2004-12-08
KR100421262B1 (ko) 2004-03-10
ATE199663T1 (de) 2001-03-15
CA2290945C (fr) 2002-05-28
WO1999002266A1 (fr) 1999-01-21
DE69828083D1 (de) 2005-01-13
DE69800595D1 (de) 2001-04-19
US20020127738A1 (en) 2002-09-12
US6635493B2 (en) 2003-10-21
DE69800595T2 (de) 2001-10-18
CA2290945A1 (fr) 1999-01-21
EP1050588A1 (fr) 2000-11-08
US6225131B1 (en) 2001-05-01
EP0975427A1 (fr) 2000-02-02
ATE284451T1 (de) 2004-12-15
DK0975427T3 (da) 2001-07-09
AU8863298A (en) 1999-02-08
PT975427E (pt) 2001-08-30

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