DK1042358T3 - Fremgangsmåde til molekylær separation af ligandinteraktion i fri oplösning - Google Patents

Fremgangsmåde til molekylær separation af ligandinteraktion i fri oplösning

Info

Publication number
DK1042358T3
DK1042358T3 DK98963036T DK98963036T DK1042358T3 DK 1042358 T3 DK1042358 T3 DK 1042358T3 DK 98963036 T DK98963036 T DK 98963036T DK 98963036 T DK98963036 T DK 98963036T DK 1042358 T3 DK1042358 T3 DK 1042358T3
Authority
DK
Denmark
Prior art keywords
species
interest
free solution
molecular weight
present
Prior art date
Application number
DK98963036T
Other languages
Danish (da)
English (en)
Inventor
Reis Robert D Van
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Application granted granted Critical
Publication of DK1042358T3 publication Critical patent/DK1042358T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/34—Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/20—Partition-, reverse-phase or hydrophobic interaction chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/30—Extraction; Separation; Purification by precipitation
    • C07K1/32—Extraction; Separation; Purification by precipitation as complexes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • G01N2030/8809—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
    • G01N2030/8813—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • G01N2030/8809—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
    • G01N2030/8813—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials
    • G01N2030/8827—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials involving nucleic acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • G01N2030/8809—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
    • G01N2030/8813—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials
    • G01N2030/8831—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials involving peptides or proteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/04—Preparation or injection of sample to be analysed
    • G01N30/06—Preparation
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/828—Protein A

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Water Supply & Treatment (AREA)
  • Peptides Or Proteins (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Extraction Or Liquid Replacement (AREA)
  • Steroid Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
DK98963036T 1997-12-24 1998-12-10 Fremgangsmåde til molekylær separation af ligandinteraktion i fri oplösning DK1042358T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/998,413 US6077940A (en) 1997-12-24 1997-12-24 Free solution ligand interaction molecular separation method

Publications (1)

Publication Number Publication Date
DK1042358T3 true DK1042358T3 (da) 2006-07-03

Family

ID=25545184

Family Applications (1)

Application Number Title Priority Date Filing Date
DK98963036T DK1042358T3 (da) 1997-12-24 1998-12-10 Fremgangsmåde til molekylær separation af ligandinteraktion i fri oplösning

Country Status (13)

Country Link
US (3) US6077940A (enExample)
EP (2) EP1634889A3 (enExample)
JP (1) JP4303885B2 (enExample)
AT (1) ATE318836T1 (enExample)
AU (1) AU750674B2 (enExample)
CA (1) CA2315887C (enExample)
CY (1) CY1105346T1 (enExample)
DE (1) DE69833690T2 (enExample)
DK (1) DK1042358T3 (enExample)
ES (1) ES2259822T3 (enExample)
IL (1) IL136655A (enExample)
WO (1) WO1999033862A1 (enExample)
ZA (1) ZA9811519B (enExample)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6077940A (en) * 1997-12-24 2000-06-20 Genentech, Inc. Free solution ligand interaction molecular separation method
US6315900B1 (en) * 1998-06-03 2001-11-13 Accurate Polymers Static separation method using non-porous cellulose beads
ES2395096T3 (es) * 1999-06-29 2013-02-08 Mannkind Corporation Purificación y estabilización de agentes farmacéuticos a base de péptidos y proteínas
US9006175B2 (en) 1999-06-29 2015-04-14 Mannkind Corporation Potentiation of glucose elimination
DE19945351C2 (de) * 1999-09-22 2002-04-18 Lohmann Therapie Syst Lts Verfahren zum Auffinden und zur Isolierung pharmakologisch wirksamer Verbindungen aus Substanzgemischen
JP4681231B2 (ja) 2002-03-20 2011-05-11 マンカインド コーポレイション 吸入装置
WO2004072647A1 (en) * 2003-02-07 2004-08-26 Beyond Genomics Removal of proteins from a sample
ATE486064T1 (de) 2004-08-20 2010-11-15 Mannkind Corp Katalyse der diketopiperazinsynthese
HUE025151T2 (en) 2004-08-23 2016-01-28 Mannkind Corp Diceto-piperazine salts for drug delivery
DE102005022057B3 (de) * 2005-05-09 2007-02-08 Analyticon Biotechnologies Ag Verfahren zur Herstellung von Liganden, Liganden und Test-Kit
MX373000B (es) 2005-09-14 2020-05-21 Mannkind Corp Metodo para formulacion de farmaco basado en el aumento de la afinidad de agentes activos hacia las superficies de microparticulas cristalinas.
AU2006331512B2 (en) * 2005-12-22 2012-02-23 Pacific Biosciences Of California, Inc. Active surface coupled polymerases
CA2633520A1 (en) * 2005-12-22 2007-07-05 Pacific Biosciences Of California, Inc. Protein engineering strategies to optimize activity of surface attached proteins
JP2009521227A (ja) * 2005-12-22 2009-06-04 パシフィック バイオサイエンシーズ オブ カリフォルニア， インコーポレイテッド ヌクレオチドアナログ組込み用ポリメラーゼ
CN104383546B (zh) 2006-02-22 2021-03-02 曼金德公司 用于改善包含二酮哌嗪和活性剂的微粒的药物性质的方法
EP2089517A4 (en) * 2006-10-23 2010-10-20 Pacific Biosciences California POLYMERASEENZYME AND REAGENTS FOR ADVANCED NUCKIC ACID SEQUENCING
US8485180B2 (en) 2008-06-13 2013-07-16 Mannkind Corporation Dry powder drug delivery system
MY155524A (en) 2008-06-13 2015-10-30 Mannkind Corp A dry powder inhaler and system for drug delivery
EP2609954B1 (en) 2008-06-20 2021-12-29 MannKind Corporation An interactive apparatus for real-time profiling of inhalation efforts
TWI494123B (zh) 2008-08-11 2015-08-01 Mannkind Corp 超快起作用胰島素之用途
US8314106B2 (en) 2008-12-29 2012-11-20 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
US8538707B2 (en) 2009-03-11 2013-09-17 Mannkind Corporation Apparatus, system and method for measuring resistance of an inhaler
AU2010259943C1 (en) 2009-06-12 2016-03-03 Mannkind Corporation Diketopiperazine microparticles with defined specific surface areas
JP5784622B2 (ja) 2009-11-03 2015-09-24 マンカインド コーポレ−ション 吸入活動をシミュレートするための装置及び方法
RU2531455C2 (ru) 2010-06-21 2014-10-20 Маннкайнд Корпорейшн Системы и способы доставки сухих порошковых лекарств
MX353285B (es) 2011-04-01 2018-01-05 Mannkind Corp Paquete de blister para cartuchos farmaceuticos.
WO2012174472A1 (en) 2011-06-17 2012-12-20 Mannkind Corporation High capacity diketopiperazine microparticles
HK1201475A1 (en) 2011-10-24 2015-09-04 Mannkind Corporation Methods and compositions for treating pain
AU2013289957B2 (en) 2012-07-12 2017-02-23 Mannkind Corporation Dry powder drug delivery systems and methods
WO2014066856A1 (en) 2012-10-26 2014-05-01 Mannkind Corporation Inhalable influenza vaccine compositions and methods
BR112015023168B1 (pt) 2013-03-15 2021-08-10 Mannkind Corporation Composição de 3,6-bis(n-fumaril-4-aminobutil)-2,5-dicetopiperazina cristalina, método de produção de partículas de 3,6-bis(n-fumaril-4-aminobutil)-2,5-dicetopiperazina e uso de uma composição de dicetopiperazina cristalina
BR122019026637B1 (pt) 2013-07-18 2023-09-26 Mannkind Corporation Formulações farmacêuticas de pó seco e método para a fabricação de uma formulação de pó seco
CA2920488C (en) 2013-08-05 2022-04-26 Mannkind Corporation Insufflation apparatus and methods
US10307464B2 (en) 2014-03-28 2019-06-04 Mannkind Corporation Use of ultrarapid acting insulin
US10561806B2 (en) 2014-10-02 2020-02-18 Mannkind Corporation Mouthpiece cover for an inhaler
US10845276B2 (en) 2016-02-29 2020-11-24 Hewlett-Packard Development, L.P. Enzymatic sample purification
CN109982772B (zh) * 2016-11-17 2021-12-10 日东电工株式会社 分离膜及层叠体
WO2020004583A1 (ja) * 2018-06-29 2020-01-02 三菱ケミカル株式会社 ポリペプチドの分離方法、ポリペプチドの製造方法及びポリペプチドの精製装置

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4495175A (en) * 1982-08-05 1985-01-22 University Of Rochester Preparation of highly purified human antihemophilic factor
US4960702A (en) * 1985-09-06 1990-10-02 Codon Methods for recovery of tissue plasminogen activator
GB8600582D0 (en) * 1986-01-10 1986-02-19 Ca Minister Nat Defence Purifying biological materials
IL82746A (en) * 1986-06-06 1994-10-07 Genentech Inc Process for producing biologically active tissue-type plasminogen activator
US4762617A (en) * 1987-01-15 1988-08-09 The United States Of America As Represented By The United States Department Of Energy Size-exclusion chromatography system for macromolecular interaction analysis
BE1003298A3 (nl) * 1990-01-12 1992-02-18 Tessenderlo Chem Nv Werkwijze voor het bereiden van een enzymatisch hydrolysaat.
US5256294A (en) * 1990-09-17 1993-10-26 Genentech, Inc. Tangential flow filtration process and apparatus
SE9303790D0 (sv) * 1993-11-17 1993-11-17 Pharmacia Lkb Biotech A method for separation and synthetic polymers that can be used as separation media in the method
US6077940A (en) * 1997-12-24 2000-06-20 Genentech, Inc. Free solution ligand interaction molecular separation method

Also Published As

Publication number Publication date
EP1634889A3 (en) 2007-04-04
EP1042358A1 (en) 2000-10-11
ES2259822T3 (es) 2006-10-16
JP4303885B2 (ja) 2009-07-29
JP2001526960A (ja) 2001-12-25
EP1042358B1 (en) 2006-03-01
CY1105346T1 (el) 2010-03-03
CA2315887C (en) 2011-02-01
US6509454B1 (en) 2003-01-21
AU1814599A (en) 1999-07-19
US20030121854A1 (en) 2003-07-03
AU750674B2 (en) 2002-07-25
ZA9811519B (en) 2000-06-15
IL136655A0 (en) 2001-06-14
CA2315887A1 (en) 1999-07-08
ATE318836T1 (de) 2006-03-15
US6077940A (en) 2000-06-20
DE69833690D1 (de) 2006-04-27
WO1999033862A1 (en) 1999-07-08
DE69833690T2 (de) 2006-10-19
EP1634889A2 (en) 2006-03-15
IL136655A (en) 2007-02-11

Similar Documents

Publication Publication Date Title
ZA9811519B (en) Free solution ligand interaction molecular separation method.
DK1123389T3 (da) Fremgangsmåde til affinitetsseparation samt ligander til anvendelse derved
ATE150871T1 (de) Verfahren zur herstellung von biologisch aktiven reagentien aus succinimid enthaltenden polymeren, analytisches element und verwendungsmethoden
DE69113872D1 (de) Biologisch aktive Reagenzien aus Carboxylgruppenhaltigen Polymerisaten, analytisches Element und Verfahren zur Verwendung.
DK0559164T3 (da) Immunologisk fremgangsmåde til bestemmelse af HbA1c
SE459005B (sv) Saett att framstaella sfaeriska polymerpartiklar
DE60235525D1 (de) Verfahren zur herstellung von porösen hybridteilchen mit von der oberfläche entfernten organischen gruppen
ATE48157T1 (de) Ein zwitterion als bindungsmittel enthaltende zusammensetzung und testvorrichtung zum nachweis von leukozyten.
DE3070502D1 (en) Process for the separation of a proteinic substance starting from a solution containing it upon affinity filtration, and application of the process to enzymatic analyses
DE69612457D1 (de) Screening-Verfahren zur Ligand-Identifizierung von Zielproteinen
DK314987D0 (da) Fremgangsmaade til specifik bestemmelse af serumfructosaminindhold samt hertil egnet reagensblanding
DE69323131D1 (de) Rekombinierte alkalische phosphatase aus kälberdarm
DE69016304D1 (de) Agglomerieren von Teilchen.
DE68929334D1 (de) Verfahren zumm Assay von Endotoxin-Konzentration
ATE322685T1 (de) Verfahren zum erlangen von rezeptor- freigabeligand (reland)-komplexen und testansätze
DE68916454D1 (de) Verfahren zur Abtrennung von Schwefel aus Gasgemischen aus dem Claus-Verfahren.
DE69115518D1 (de) Verfahren zur Abtrennung und Messung von Spurbestandteilen
SE8400374D0 (sv) Sett att anrika och detektera biomolekyler och -celler och anordning derfor
ATE182215T1 (de) Verfahren zur bestimmung von rheumafaktoren und mittel zur durchführung des verfahrens
DE50211233D1 (de) Verfahren zur messung von mikroviskositätsveränderungen als immuntest
WO2003025120A3 (en) Clasp membrane proteins
Nienhaus et al. The test of flavan derivates as a staining method for the preselection of leafroll-diseased grapevines.
ATE22178T1 (de) Verfahren und vorrichtungen zur messung des staubgehaltes von gasstroemungen.
YU4797A (sh) Žučne kiseline i njihovi derivati kao hipoglikemična sredstva
ATA253989A (de) Vorrichtung zur anreicherung von analyten aus flüssigen proben