DE69323131D1 - Rekombinierte alkalische phosphatase aus kälberdarm - Google Patents

Rekombinierte alkalische phosphatase aus kälberdarm

Info

Publication number
DE69323131D1
DE69323131D1 DE69323131T DE69323131T DE69323131D1 DE 69323131 D1 DE69323131 D1 DE 69323131D1 DE 69323131 T DE69323131 T DE 69323131T DE 69323131 T DE69323131 T DE 69323131T DE 69323131 D1 DE69323131 D1 DE 69323131D1
Authority
DE
Germany
Prior art keywords
alkaline phosphatase
recombined
calf
colon
calf colon
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69323131T
Other languages
English (en)
Other versions
DE69323131T2 (de
Inventor
Jose Millan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanford Burnham Prebys Medical Discovery Institute
Original Assignee
Sanford Burnham Prebys Medical Discovery Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanford Burnham Prebys Medical Discovery Institute filed Critical Sanford Burnham Prebys Medical Discovery Institute
Publication of DE69323131D1 publication Critical patent/DE69323131D1/de
Application granted granted Critical
Publication of DE69323131T2 publication Critical patent/DE69323131T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/42—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving phosphatase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/535—Production of labelled immunochemicals with enzyme label or co-enzymes, co-factors, enzyme inhibitors or enzyme substrates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE69323131T 1992-03-10 1993-03-10 Rekombinierte alkalische phosphatase aus kälberdarm Expired - Fee Related DE69323131T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US84921992A 1992-03-10 1992-03-10
PCT/US1993/002172 WO1993018139A1 (en) 1992-03-10 1993-03-10 Recombinant calf intestinal alkaline phosphatase

Publications (2)

Publication Number Publication Date
DE69323131D1 true DE69323131D1 (de) 1999-03-04
DE69323131T2 DE69323131T2 (de) 1999-09-16

Family

ID=25305337

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69323131T Expired - Fee Related DE69323131T2 (de) 1992-03-10 1993-03-10 Rekombinierte alkalische phosphatase aus kälberdarm

Country Status (7)

Country Link
US (2) US5707853A (de)
EP (2) EP0584343B1 (de)
AT (1) ATE175998T1 (de)
CA (1) CA2102294A1 (de)
DE (1) DE69323131T2 (de)
DK (1) DK0584343T3 (de)
WO (1) WO1993018139A1 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19819962A1 (de) 1998-05-05 1999-11-11 Roche Diagnostics Gmbh Hochaktive alkalische Phosphatase
US7888372B2 (en) * 2001-03-23 2011-02-15 National Institutes Of Health (Nih) Compositions and methods for modulating bone mineral deposition
US20020183276A1 (en) * 2001-03-23 2002-12-05 Burnham Institute Compositions and methods for modulating bone mineral deposition
DE10213201A1 (de) 2002-03-25 2003-10-16 Roche Diagnostics Gmbh Erzeugung von schwach aktiven oder inaktiven Mutanten von Alkalischer Phosphatase und deren Expression in Hefe
WO2004047759A2 (en) * 2002-11-22 2004-06-10 Wyeth Composition for treating chlamydia infections and method for identifying same
JP4812617B2 (ja) * 2003-02-24 2011-11-09 ニュー・イングランド・バイオラブズ・インコーポレイティッド 熱不安定性ホスファターゼの過剰発現、精製及び性状分析
CA2554683C (en) 2004-02-04 2014-06-10 Pharmaaware Sepsis B.V. Use of alkaline phosphatase for the detoxification of lps present at mucosal barriers
US8129168B2 (en) 2009-01-14 2012-03-06 Affymetrix, Inc. Recombinant colwellia psychrerythraea alkaline phosphatase and uses thereof
DK3461891T3 (da) 2014-01-24 2020-08-10 Am-Pharma Bv Nedstrømsbehandling af en alkalisk phosphatase
PE20161442A1 (es) 2014-01-24 2017-01-12 Am-Pharma B V Proteinas quimericas tipo fosfatasa alcalina
CN105802979B (zh) * 2016-04-01 2019-09-06 郑州科蒂亚生物技术有限公司 一种小牛肠碱性磷酸酶的表达载体及表达方法
EP3538075A4 (de) * 2016-11-11 2020-08-05 Dnalite Therapeutics, Inc. Strukturen und verfahren zur gentherapie
CA3057089A1 (en) * 2017-03-21 2018-09-27 Synthetic Biologics, Inc. Alkaline phosphatase formulations
JPWO2019069977A1 (ja) 2017-10-03 2020-12-24 キッコーマン株式会社 アルカリホスファターゼの製造方法及びそれを用いて得られるアルカリホスファターゼ、並びにその製造のためのベクター及び形質転換体
WO2019139891A1 (en) 2018-01-09 2019-07-18 Synthetic Biologics, Inc. Alkaline phosphatase agents for treatment of neurodevelopmental disorders
EP3768302A4 (de) 2018-03-20 2021-12-15 Synthetic Biologics, Inc. Intestinale alkalische phosphataseformulierungen
EP3773686B1 (de) 2018-03-20 2023-06-07 Theriva Biologics, Inc. Alkalische phosphatasemittel zur behandlung von bestrahlungsstörungen
US20210189358A1 (en) * 2018-06-18 2021-06-24 Synthetic Biologics, Inc. Methods of making alkaline phosphatase agents
JP2021185806A (ja) 2020-05-28 2021-12-13 シスメックス株式会社 アルカリフォスファターゼ融合抗体及びその製造方法、並びに免疫測定用試薬及び免疫測定方法
CN113621079B (zh) * 2021-09-07 2023-04-11 金标优尼科(无锡)生物科技有限公司 Fab抗体与小牛肠碱性磷酸酶的融合蛋白及其制备方法

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE159993C (de) *
DD246686A (de) *
DE246686C (de) *
DE298424C (de) *
DD159993B1 (de) * 1981-06-29 1987-05-13 Anton Horn Immunosorbentchromatographische reinigung von alkalischer phosphatase aus kaelberdarm
US5084379A (en) * 1983-04-29 1992-01-28 Biowhittaker, Inc. Fluorometric assay of chymopapain hypersensitivity and reagents therefor
US4707438A (en) * 1984-08-22 1987-11-17 Tel Aviv University Immunoassay for breast cancer employing monoclonal antibodies
FI71433C (fi) * 1985-05-14 1986-12-19 Orion Yhtymae Oy Apparat foer immunokemisk bestaemning
ATE78262T1 (de) * 1985-06-11 1992-08-15 Ciba Geigy Ag Hybrid-interferone.
JP2564540B2 (ja) * 1987-04-01 1996-12-18 株式会社日立製作所 免疫分析方法
US5204244A (en) * 1987-10-27 1993-04-20 Oncogen Production of chimeric antibodies by homologous recombination
GB8800078D0 (en) * 1988-01-05 1988-02-10 Ciba Geigy Ag Novel antibodies
US5089424A (en) * 1988-06-14 1992-02-18 Abbott Laboratories Method and apparatus for heterogeneous chemiluminescence assay
US5079171A (en) * 1988-09-15 1992-01-07 Adeza Biomedical Corporation Determining pregnancy induced hypertension and eclampsia by immunoassay of cellular fibronectin
US5079170A (en) * 1989-05-18 1992-01-07 Quidel Corporation Method of sample transfer using a filter applicator
DD298424A5 (de) * 1989-11-22 1992-02-20 Universitaet Leipzig,De Verfahren zur gewinnung von alkalischer phosphatase aus kaelberdarm

Also Published As

Publication number Publication date
CA2102294A1 (en) 1993-09-11
EP0584343A4 (en) 1996-03-20
EP0584343B1 (de) 1999-01-20
US5773226A (en) 1998-06-30
US5707853A (en) 1998-01-13
DK0584343T3 (da) 1999-09-13
DE69323131T2 (de) 1999-09-16
EP0584343A1 (de) 1994-03-02
WO1993018139A1 (en) 1993-09-16
ATE175998T1 (de) 1999-02-15
EP0867511A1 (de) 1998-09-30

Similar Documents

Publication Publication Date Title
DE69323131D1 (de) Rekombinierte alkalische phosphatase aus kälberdarm
ATE158300T1 (de) Neue 7-beta-substituierte-4-aza-5-alpha-cholestan-on n als inhibitoren 5-alpha-reduktases
FI872432A (fi) Indirekt kolorimetrisk bestaemning av en analyt i ett prov med hjaelp av ljussignalers foerhaollande.
NO822199L (no) Vaskemiddelforbindelser og -blandinger.
DE3866016D1 (de) Mos-transistor-brueckenschaltung.
FI904851A0 (fi) Radiomaerkta antikoagulantpeptider.
ATE148923T1 (de) Funktioneller test und reagenz zur bestimmung von fibrinogen
ATE312909T1 (de) Diagnostika und behandlungen von peridontalen erkrankungen
DE69300284T2 (de) Vorrichtung für reproduzierbare Ausrichtung von Halbleiter-Scheibe.
NO163745C (no) Stabiliseringsmetode.
TR199801027T2 (xx) Epitelyom te�his ve tedavisi i�in y�ntem.
FI904852A0 (fi) Antikoagulantpeptider.
DE3789252D1 (de) ROM-Fassung für Ausrufempfänger und andere.
FI852588A0 (fi) Analys av material ur borrhaol.
DK614489A (da) Peptidderivater
DE3482947D1 (de) Musterinspektion.
ATE251457T1 (de) Substituierte 1,2,3,4-tetrahydro-2- dibenzofuranamine und 2- aminocyclohepta(b)benzofurane
FI873408A (fi) Anestetisk komposition och foerfarande foer dess anvaendning.
FI930265A0 (fi) Antikoagulantpeptider
DE3885624T2 (de) UV-Lichtdurchlässiges Gehäuse für integrierte Schaltungen.
DE58909418D1 (de) Gehäuse für infrarotempfindliche Bauelemente.
DE3583337D1 (de) Zusammensetzung zur behandlung von haemorroiden.
NO874807D0 (no) Membranaffinitets konsentrasjons-immunoanalyse.
ES2085953T3 (es) Ionoforos hemisferandos que tienen lipofilidad aumentada.
ATA443380A (de) Mittel zur bekaempfung von queckengras

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee