CY1105346T1 - Μεθοδος μοριακου διαχωρισμου μεσω της αλληλεπιδρασης του ελευθepου συνδετη στο διαλυμα - Google Patents

Μεθοδος μοριακου διαχωρισμου μεσω της αλληλεπιδρασης του ελευθepου συνδετη στο διαλυμα

Info

Publication number
CY1105346T1
CY1105346T1 CY20061100659T CY061100659T CY1105346T1 CY 1105346 T1 CY1105346 T1 CY 1105346T1 CY 20061100659 T CY20061100659 T CY 20061100659T CY 061100659 T CY061100659 T CY 061100659T CY 1105346 T1 CY1105346 T1 CY 1105346T1
Authority
CY
Cyprus
Prior art keywords
species
interest
interactions
mixture
present
Prior art date
Application number
CY20061100659T
Other languages
English (en)
Inventor
Robert D. Van Reis
Original Assignee
Genentech, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech, Inc. filed Critical Genentech, Inc.
Publication of CY1105346T1 publication Critical patent/CY1105346T1/el

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/34—Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/20—Partition-, reverse-phase or hydrophobic interaction chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/30—Extraction; Separation; Purification by precipitation
    • C07K1/32—Extraction; Separation; Purification by precipitation as complexes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • G01N2030/8809—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
    • G01N2030/8813—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • G01N2030/8809—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
    • G01N2030/8813—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials
    • G01N2030/8827—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials involving nucleic acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • G01N2030/8809—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
    • G01N2030/8813—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials
    • G01N2030/8831—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials involving peptides or proteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/04—Preparation or injection of sample to be analysed
    • G01N30/06—Preparation
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/828—Protein A

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Water Supply & Treatment (AREA)
  • Peptides Or Proteins (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Extraction Or Liquid Replacement (AREA)
  • Steroid Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)

Abstract

Η παρούσα εφεύρεση κατευθύνεται σε νέες μεθόδους ενίσχυσης της ικανότητας διαχωρισμού ενός είδους του ενδιαφέροντος από άλλα είδη που είναι παρόντα σε ένα μίγμα ελεύθερου διαλύματός τους. ο οποίος (διαχωρισμός) χρησιμοποιεί το πλεονέκτημα των αλληλεπιδράσεων που λαμβάνουν χώρα μεταξύ των διαλυτών, μικρού μοριακού μεγέθους συνδετών και των ειδών του ενδιαφέροντος. Οι μικρού μοριακού βάρους συνδέτες που χρησιμοποιούνται στη παρούσα εφεύρεση λειτουργούν για να αλληλεπιδράσουν με ένα είδος του ενδιαφέροντος εντός ενός μίγματος διαφορετικών ειδών δια μέσω είτε των αλληλεπιδράσεων συγγένειας, των υδρόφοβων αλληλεπιδράσεων και/ή των ιοντικών αλληλεπιδράσεων, μεταβάλλοντας με αυτό τον τρόπο το μοριακό βάρος, τον υδροδυναμικό όγκο και/ή το ισοηλεκτρικό σημείο του είδους του ενδιαφέροντος και καθιστώντας το ικανό να διαχωριστεί από το/α άλλο/α στοιχείο/α του μίγματος.
CY20061100659T 1997-12-24 2006-05-22 Μεθοδος μοριακου διαχωρισμου μεσω της αλληλεπιδρασης του ελευθepου συνδετη στο διαλυμα CY1105346T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/998,413 US6077940A (en) 1997-12-24 1997-12-24 Free solution ligand interaction molecular separation method
PCT/US1998/026251 WO1999033862A1 (en) 1997-12-24 1998-12-10 Free solution ligand interaction molecular separation method

Publications (1)

Publication Number Publication Date
CY1105346T1 true CY1105346T1 (el) 2010-03-03

Family

ID=25545184

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20061100659T CY1105346T1 (el) 1997-12-24 2006-05-22 Μεθοδος μοριακου διαχωρισμου μεσω της αλληλεπιδρασης του ελευθepου συνδετη στο διαλυμα

Country Status (13)

Country Link
US (3) US6077940A (el)
EP (2) EP1634889A3 (el)
JP (1) JP4303885B2 (el)
AT (1) ATE318836T1 (el)
AU (1) AU750674B2 (el)
CA (1) CA2315887C (el)
CY (1) CY1105346T1 (el)
DE (1) DE69833690T2 (el)
DK (1) DK1042358T3 (el)
ES (1) ES2259822T3 (el)
IL (1) IL136655A (el)
WO (1) WO1999033862A1 (el)
ZA (1) ZA9811519B (el)

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DE102005022057B3 (de) * 2005-05-09 2007-02-08 Analyticon Biotechnologies Ag Verfahren zur Herstellung von Liganden, Liganden und Test-Kit
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Also Published As

Publication number Publication date
JP2001526960A (ja) 2001-12-25
US20030121854A1 (en) 2003-07-03
DE69833690D1 (de) 2006-04-27
CA2315887A1 (en) 1999-07-08
US6077940A (en) 2000-06-20
CA2315887C (en) 2011-02-01
ES2259822T3 (es) 2006-10-16
AU1814599A (en) 1999-07-19
US6509454B1 (en) 2003-01-21
EP1042358A1 (en) 2000-10-11
AU750674B2 (en) 2002-07-25
IL136655A (en) 2007-02-11
IL136655A0 (en) 2001-06-14
DK1042358T3 (da) 2006-07-03
EP1042358B1 (en) 2006-03-01
EP1634889A2 (en) 2006-03-15
ZA9811519B (en) 2000-06-15
JP4303885B2 (ja) 2009-07-29
ATE318836T1 (de) 2006-03-15
DE69833690T2 (de) 2006-10-19
EP1634889A3 (en) 2007-04-04
WO1999033862A1 (en) 1999-07-08

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