DK1037991T3 - Celleoverfladeglycoproteiner associeret med humane B-cellelumfoner - ULBP, DNA og polypeptider - Google Patents
Celleoverfladeglycoproteiner associeret med humane B-cellelumfoner - ULBP, DNA og polypeptiderInfo
- Publication number
- DK1037991T3 DK1037991T3 DK98964802T DK98964802T DK1037991T3 DK 1037991 T3 DK1037991 T3 DK 1037991T3 DK 98964802 T DK98964802 T DK 98964802T DK 98964802 T DK98964802 T DK 98964802T DK 1037991 T3 DK1037991 T3 DK 1037991T3
- Authority
- DK
- Denmark
- Prior art keywords
- polypeptides
- ulbp
- cell
- isolated
- human
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 15
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 15
- 229920001184 polypeptide Polymers 0.000 title abstract 14
- 102000012750 Membrane Glycoproteins Human genes 0.000 title 1
- 108010090054 Membrane Glycoproteins Proteins 0.000 title 1
- 210000003719 b-lymphocyte Anatomy 0.000 title 1
- 102000039446 nucleic acids Human genes 0.000 abstract 2
- 108020004707 nucleic acids Proteins 0.000 abstract 2
- 150000007523 nucleic acids Chemical class 0.000 abstract 2
- 208000003950 B-cell lymphoma Diseases 0.000 abstract 1
- 102100037850 Interferon gamma Human genes 0.000 abstract 1
- 108010074328 Interferon-gamma Proteins 0.000 abstract 1
- 230000004663 cell proliferation Effects 0.000 abstract 1
- 239000002299 complementary DNA Substances 0.000 abstract 1
- 230000002596 correlated effect Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000013604 expression vector Substances 0.000 abstract 1
- 210000005260 human cell Anatomy 0.000 abstract 1
- 230000003211 malignant effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 210000000822 natural killer cell Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cell Biology (AREA)
- Oncology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6985797P | 1997-12-17 | 1997-12-17 | |
| US9294698P | 1998-07-15 | 1998-07-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1037991T3 true DK1037991T3 (da) | 2006-01-09 |
Family
ID=26750491
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK98964802T DK1037991T3 (da) | 1997-12-17 | 1998-12-17 | Celleoverfladeglycoproteiner associeret med humane B-cellelumfoner - ULBP, DNA og polypeptider |
Country Status (12)
| Country | Link |
|---|---|
| US (7) | US6653447B1 (OSRAM) |
| EP (1) | EP1037991B1 (OSRAM) |
| JP (1) | JP4255211B2 (OSRAM) |
| AT (1) | ATE305510T1 (OSRAM) |
| AU (1) | AU742757C (OSRAM) |
| CA (1) | CA2315251A1 (OSRAM) |
| DE (1) | DE69831754T2 (OSRAM) |
| DK (1) | DK1037991T3 (OSRAM) |
| ES (1) | ES2251120T3 (OSRAM) |
| IL (2) | IL136621A0 (OSRAM) |
| NZ (1) | NZ505500A (OSRAM) |
| WO (1) | WO1999031241A1 (OSRAM) |
Families Citing this family (63)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020137890A1 (en) * | 1997-03-31 | 2002-09-26 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| CA2364941A1 (en) * | 1999-03-15 | 2000-09-21 | Takeda Chemical Industries, Ltd. | Novel protein and its use |
| WO2002062997A1 (fr) * | 2001-02-05 | 2002-08-15 | Takeda Chemical Industries, Ltd. | Nouvelle proteine et son utilisation |
| US6821522B2 (en) * | 2001-05-31 | 2004-11-23 | The Regents Of The University Of California | Tumor Therapy |
| US7364890B2 (en) | 2001-07-28 | 2008-04-29 | Midwest Research Institute | Thermal tolerant avicelase from Acidothermus cellulolyticus |
| MXPA04003057A (es) * | 2001-10-04 | 2005-06-20 | Immunex Corp | Proteina 4 de enlace ul16. |
| CA2483343A1 (en) * | 2002-04-22 | 2003-10-30 | Fred Hutchinson Cancer Research Center | Soluble mic polypeptides as markers for diagnosis, prognosis and treatment of cancer and autoimmune diseases or conditions |
| AU2003270063A1 (en) * | 2002-09-04 | 2004-03-29 | The Trustees Of The University Of Pennsylvania | Immune cell receptor ligand and immune cell receptor |
| US9809654B2 (en) | 2002-09-27 | 2017-11-07 | Vaccinex, Inc. | Targeted CD1d molecules |
| EP1413316A1 (en) * | 2002-09-27 | 2004-04-28 | Bruno Robert | Bifunctional conjugates or fusion proteins |
| MXPA05010255A (es) * | 2003-03-24 | 2005-12-14 | Scripps Research Inst | Vacunas de adn contra crecimiento tumoral y metodos de uso de las mismas. |
| US7666417B2 (en) * | 2003-04-22 | 2010-02-23 | Fred Hutchinson Cancer Research Center | Methods and compositions for treating autoimmune diseases or conditions |
| GB0403491D0 (en) * | 2004-02-17 | 2004-03-24 | Univ Cambridge Tech | Polypeptides, methods and means |
| US7998481B2 (en) | 2004-04-05 | 2011-08-16 | The Regents Of The University Of California | Modulation of NKG2D for treating or preventing solid organ allograft rejection |
| DK1732588T3 (da) | 2004-04-05 | 2009-10-12 | Univ California | Modulation af NKG2D |
| JP5774805B2 (ja) | 2004-11-29 | 2015-09-09 | セクエノム,インコーポレイティド | メチル化dnaを検出する方法、及びキット |
| US9074013B2 (en) | 2004-11-29 | 2015-07-07 | Sequenom, Inc. | Means and methods for detecting methylated DNA |
| EP1909832A4 (en) * | 2005-06-29 | 2010-01-13 | Univ Miami | ANTIBODY IMMUNOCELL LIGAND FUSION PROTEIN FOR CANCER THERAPY |
| US7846712B2 (en) | 2006-06-01 | 2010-12-07 | Alliance For Sustainable Energy, Llc | L-arabinose fermenting yeast |
| WO2008103392A2 (en) | 2007-02-21 | 2008-08-28 | Vaccinex, Inc. | Modulation of nkt cell activity with antigen-loaded cdid molecules |
| US9611313B2 (en) | 2007-06-26 | 2017-04-04 | University Of Miami | Antibody-endostatin fusion protein and its variants |
| US20110038865A1 (en) * | 2007-06-26 | 2011-02-17 | University Of Miami | Antibody- endostatin fusion protein and its variants |
| US8070021B2 (en) * | 2007-10-31 | 2011-12-06 | Momentive Performance Materials | Hydraulic container evacuator and method |
| EP2385980B1 (en) | 2009-01-08 | 2018-04-18 | Albert Einstein College of Medicine, Inc. | Bacterial vaccines with cell wall-associated ceramide-like glycolipids and uses thereof |
| WO2011127418A1 (en) | 2010-04-09 | 2011-10-13 | Amgen Inc. | Btnl9 proteins, nucleic acids, and antibodies and uses thereof |
| WO2011130749A2 (en) | 2010-04-16 | 2011-10-20 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Identification of mutations in herpes simplex virus envelope glycoproteins that enable or enhance vector retargeting to novel non-hsv receptors |
| WO2012064743A2 (en) | 2010-11-08 | 2012-05-18 | The Johns Hopkins University | Methods for improving heart function |
| US10040853B2 (en) * | 2011-09-09 | 2018-08-07 | Fred Hutchinson Cancer Research Center | Methods and compositions involving NKG2D inhibitors and cancer |
| US10093705B2 (en) | 2011-09-13 | 2018-10-09 | Dana-Farber Cancer Institute, Inc. | Compositions and methods for brown fat induction and activity using FNDC5 |
| US20130156808A1 (en) * | 2011-11-22 | 2013-06-20 | Stipan Jonjic | Vaccine comprising beta-herpesvirus |
| WO2014015148A1 (en) | 2012-07-19 | 2014-01-23 | Amgen Inc. | Human btnl3 proteins, nucleic acids, and antibodies and uses thereof |
| UY35148A (es) | 2012-11-21 | 2014-05-30 | Amgen Inc | Immunoglobulinas heterodiméricas |
| US9371352B2 (en) | 2013-02-08 | 2016-06-21 | Vaccinex, Inc. | Modified glycolipids and methods of making and using the same |
| WO2014144817A2 (en) | 2013-03-15 | 2014-09-18 | Amgen Inc. | Inhibitory polypeptides specific to wnt inhibitors |
| WO2015017529A2 (en) | 2013-07-31 | 2015-02-05 | Dana-Farber Cancer Institute, Inc. | Compositions and methods for modulating thermogenesis using pth-related and egf-related molecules |
| WO2015035215A1 (en) | 2013-09-05 | 2015-03-12 | Amgen Inc. | Fc-containing molecules exhibiting predictable, consistent, and reproducible glycoform profiles |
| JP6588024B2 (ja) | 2013-10-28 | 2019-10-09 | ユニヴァーシティ オヴ ピッツバーグ オヴ ザ コモンウェルス システム オヴ ハイアー エデュケーション | 腫瘍溶解性hsvベクター |
| CA2935804A1 (en) | 2014-01-14 | 2015-07-23 | Dana-Farber Cancer Institute, Inc. | Compositions and methods for identification, assessment, prevention, and treatment of melanoma using pd-l1 isoforms |
| AU2015259053B2 (en) | 2014-05-16 | 2020-12-24 | Amgen Inc. | Assay for detecting Th1 and Th2 cell populations |
| US11117969B2 (en) * | 2014-12-05 | 2021-09-14 | Xyphos Biosciences Inc. | Insertable variable fragments of antibodies and modified α1-α2 domains of NKG2D ligands |
| AU2015357578B2 (en) | 2014-12-05 | 2018-11-08 | Xyphos Biosciences Inc. | Insertable variable fragments of antibodies and modified a1-a2 domains of NKG2D ligands |
| EP3368157B1 (en) | 2015-10-29 | 2022-06-29 | Dana-Farber Cancer Institute, Inc. | Methods for identification, assessment, prevention, and treatment of metabolic disorders using pm20d1 and n-lipidated amino acids |
| BR112018015390A2 (pt) | 2016-01-27 | 2018-12-18 | Oncorus, Inc. | vetores virais oncolíticos e usos dos mesmos |
| WO2017218689A1 (en) | 2016-06-14 | 2017-12-21 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Expression of nkg2d activating ligand proteins for sensitizing cancer cells to attack by cytotoxic immune cells |
| WO2018006005A1 (en) | 2016-06-30 | 2018-01-04 | Oncorus, Inc. | Pseudotyped oncolytic viral delivery of therapeutic polypeptides |
| WO2018112636A1 (en) | 2016-12-21 | 2018-06-28 | Creatus Biosciences Inc. | Method and organism expressing metschnikowia xylose transporters for increased xylose uptake |
| US10435721B2 (en) | 2016-12-21 | 2019-10-08 | Creatus Biosciences Inc. | Xylitol producing metschnikowia species |
| JP7672196B2 (ja) | 2017-03-14 | 2025-05-07 | アムジエン・インコーポレーテツド | 細胞培養において産生される抗体の総非フコシル化グリコフォームの調節 |
| WO2019023483A1 (en) | 2017-07-26 | 2019-01-31 | Oncorus, Inc. | ONCOLYTIC VIRAL VECTORS AND USES THEREOF |
| US11865081B2 (en) | 2017-12-29 | 2024-01-09 | Virogin Biotech Canada Ltd. | Oncolytic viral delivery of therapeutic polypeptides |
| EP3775251A1 (en) | 2018-03-26 | 2021-02-17 | Amgen Inc. | Total afucosylated glycoforms of antibodies produced in cell culture |
| CN112074532B (zh) | 2018-03-27 | 2025-02-28 | 修普霍斯生物科学有限公司 | 结合非天然NKG2D受体的非天然NKG2D配体的修饰的α1-α2结构域 |
| WO2020051013A2 (en) * | 2018-08-24 | 2020-03-12 | The Trustees Of Columbia University In The City Of New York | Anti-cd33 and nkg2d ligand chimeras for treatment of myeloid malignancies |
| CA3152547A1 (en) | 2019-09-26 | 2021-04-01 | Amgen Inc. | Methods of producing antibody compositions |
| US20230273126A1 (en) | 2020-06-04 | 2023-08-31 | Amgen Inc. | Assessment of cleaning procedures of a biotherapeutic manufacturing process |
| JP2023548767A (ja) | 2020-10-15 | 2023-11-21 | アムジエン・インコーポレーテツド | 抗体製造方法における相対不対グリカン |
| WO2022261021A1 (en) | 2021-06-07 | 2022-12-15 | Amgen Inc. | Using fucosidase to control afucosylation level of glycosylated proteins |
| EP4413377A1 (en) | 2021-10-05 | 2024-08-14 | Amgen Inc. | Fc-gamma receptor ii binding and glycan content |
| US20250161413A1 (en) | 2022-02-16 | 2025-05-22 | Dana-Farber Cancer Institute, Inc. | Methods for decreasing pathologic alpha-synuclein using agents that modulate fndc5 or biologically active fragments thereof |
| WO2023215725A1 (en) | 2022-05-02 | 2023-11-09 | Fred Hutchinson Cancer Center | Compositions and methods for cellular immunotherapy |
| AU2024256160A1 (en) | 2023-04-20 | 2025-10-02 | Amgen Inc. | Methods of determining relative unpaired glycan content |
| WO2025038600A1 (en) | 2023-08-14 | 2025-02-20 | Amgen Inc. | Methods for reducing yellow color |
| WO2025101820A1 (en) | 2023-11-08 | 2025-05-15 | Fred Hutchinson Cancer Center | Compositions and methods for cellular immunotherapy |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4959314A (en) * | 1984-11-09 | 1990-09-25 | Cetus Corporation | Cysteine-depleted muteins of biologically active proteins |
| USRE38824E1 (en) * | 1986-08-04 | 2005-10-11 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Antibodies against human herpes virus-6(HHV-6) and method of use |
| US5834229A (en) * | 1991-05-24 | 1998-11-10 | Genentech, Inc. | Nucleic acids vectors and host cells encoding and expressing heregulin 2-α |
| US5474771A (en) * | 1991-11-15 | 1995-12-12 | The Trustees Of Columbia University In The City Of New York | Murine monoclonal antibody (5c8) recognizes a human glycoprotein on the surface of T-lymphocytes, compositions containing same |
| US5464771A (en) * | 1994-04-29 | 1995-11-07 | The United States Of America As Represented By The Secretary Of Agriculture | Biologically pure culture of Actinomyces viscosus strain used for the bioremediation of chlorinated hydrocarbons |
| US6060241A (en) * | 1996-04-05 | 2000-05-09 | Kieta Holding Sa | Compositions and methods relating to drug discovery and detection and treatment of gastrointestinal diseases |
| US5912415A (en) * | 1996-05-16 | 1999-06-15 | Regents Of The University Of Minnesota | Arabidopsis spindly gene, methods of identification and use |
| US20030068623A1 (en) * | 1997-06-16 | 2003-04-10 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
-
1998
- 1998-12-17 AT AT98964802T patent/ATE305510T1/de not_active IP Right Cessation
- 1998-12-17 JP JP2000539141A patent/JP4255211B2/ja not_active Expired - Fee Related
- 1998-12-17 CA CA002315251A patent/CA2315251A1/en not_active Abandoned
- 1998-12-17 DK DK98964802T patent/DK1037991T3/da active
- 1998-12-17 AU AU20045/99A patent/AU742757C/en not_active Ceased
- 1998-12-17 IL IL13662198A patent/IL136621A0/xx unknown
- 1998-12-17 DE DE69831754T patent/DE69831754T2/de not_active Expired - Lifetime
- 1998-12-17 WO PCT/US1998/027048 patent/WO1999031241A1/en not_active Ceased
- 1998-12-17 NZ NZ505500A patent/NZ505500A/xx unknown
- 1998-12-17 EP EP98964802A patent/EP1037991B1/en not_active Expired - Lifetime
- 1998-12-17 ES ES98964802T patent/ES2251120T3/es not_active Expired - Lifetime
-
2000
- 2000-03-13 US US09/524,100 patent/US6653447B1/en not_active Expired - Fee Related
- 2000-03-22 US US09/532,856 patent/US6458350B1/en not_active Expired - Lifetime
- 2000-06-07 IL IL136621A patent/IL136621A/en not_active IP Right Cessation
-
2002
- 2002-08-05 US US10/212,507 patent/US6774224B2/en not_active Expired - Fee Related
-
2004
- 2004-06-23 US US10/875,869 patent/US7193058B2/en not_active Expired - Fee Related
-
2006
- 2006-12-13 US US11/638,966 patent/US7427669B2/en not_active Expired - Fee Related
-
2008
- 2008-08-04 US US12/221,490 patent/US7807796B2/en not_active Expired - Fee Related
-
2010
- 2010-08-24 US US12/862,629 patent/US8410252B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| WO1999031241A1 (en) | 1999-06-24 |
| DE69831754T2 (de) | 2006-06-29 |
| US20040235058A1 (en) | 2004-11-25 |
| ATE305510T1 (de) | 2005-10-15 |
| IL136621A0 (en) | 2001-06-14 |
| NZ505500A (en) | 2002-12-20 |
| US6458350B1 (en) | 2002-10-01 |
| US8410252B2 (en) | 2013-04-02 |
| ES2251120T3 (es) | 2006-04-16 |
| JP2002508183A (ja) | 2002-03-19 |
| AU742757B2 (en) | 2002-01-10 |
| US20110281789A1 (en) | 2011-11-17 |
| IL136621A (en) | 2008-07-08 |
| DE69831754D1 (de) | 2006-02-09 |
| AU2004599A (en) | 1999-07-05 |
| CA2315251A1 (en) | 1999-06-24 |
| US6653447B1 (en) | 2003-11-25 |
| US7193058B2 (en) | 2007-03-20 |
| EP1037991B1 (en) | 2005-09-28 |
| US20030147847A1 (en) | 2003-08-07 |
| AU742757C (en) | 2007-05-17 |
| US20090324597A1 (en) | 2009-12-31 |
| US7807796B2 (en) | 2010-10-05 |
| US6774224B2 (en) | 2004-08-10 |
| US20080008715A1 (en) | 2008-01-10 |
| US7427669B2 (en) | 2008-09-23 |
| JP4255211B2 (ja) | 2009-04-15 |
| EP1037991A1 (en) | 2000-09-27 |
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