DK1037991T3 - Celleoverfladeglycoproteiner associeret med humane B-cellelumfoner - ULBP, DNA og polypeptider - Google Patents

Celleoverfladeglycoproteiner associeret med humane B-cellelumfoner - ULBP, DNA og polypeptider

Info

Publication number
DK1037991T3
DK1037991T3 DK98964802T DK98964802T DK1037991T3 DK 1037991 T3 DK1037991 T3 DK 1037991T3 DK 98964802 T DK98964802 T DK 98964802T DK 98964802 T DK98964802 T DK 98964802T DK 1037991 T3 DK1037991 T3 DK 1037991T3
Authority
DK
Denmark
Prior art keywords
polypeptides
ulbp
cell
isolated
human
Prior art date
Application number
DK98964802T
Other languages
Danish (da)
English (en)
Inventor
Richard J Armitage
David John Cosman
Jurgen H Mullberg
William Cristian Fanslow
Marek Kubin
Original Assignee
Immunex Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immunex Corp filed Critical Immunex Corp
Application granted granted Critical
Publication of DK1037991T3 publication Critical patent/DK1037991T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/30Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cell Biology (AREA)
  • Oncology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DK98964802T 1997-12-17 1998-12-17 Celleoverfladeglycoproteiner associeret med humane B-cellelumfoner - ULBP, DNA og polypeptider DK1037991T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6985797P 1997-12-17 1997-12-17
US9294698P 1998-07-15 1998-07-15

Publications (1)

Publication Number Publication Date
DK1037991T3 true DK1037991T3 (da) 2006-01-09

Family

ID=26750491

Family Applications (1)

Application Number Title Priority Date Filing Date
DK98964802T DK1037991T3 (da) 1997-12-17 1998-12-17 Celleoverfladeglycoproteiner associeret med humane B-cellelumfoner - ULBP, DNA og polypeptider

Country Status (12)

Country Link
US (7) US6653447B1 (OSRAM)
EP (1) EP1037991B1 (OSRAM)
JP (1) JP4255211B2 (OSRAM)
AT (1) ATE305510T1 (OSRAM)
AU (1) AU742757C (OSRAM)
CA (1) CA2315251A1 (OSRAM)
DE (1) DE69831754T2 (OSRAM)
DK (1) DK1037991T3 (OSRAM)
ES (1) ES2251120T3 (OSRAM)
IL (2) IL136621A0 (OSRAM)
NZ (1) NZ505500A (OSRAM)
WO (1) WO1999031241A1 (OSRAM)

Families Citing this family (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020137890A1 (en) * 1997-03-31 2002-09-26 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
CA2364941A1 (en) * 1999-03-15 2000-09-21 Takeda Chemical Industries, Ltd. Novel protein and its use
WO2002062997A1 (fr) * 2001-02-05 2002-08-15 Takeda Chemical Industries, Ltd. Nouvelle proteine et son utilisation
US6821522B2 (en) * 2001-05-31 2004-11-23 The Regents Of The University Of California Tumor Therapy
US7364890B2 (en) 2001-07-28 2008-04-29 Midwest Research Institute Thermal tolerant avicelase from Acidothermus cellulolyticus
MXPA04003057A (es) * 2001-10-04 2005-06-20 Immunex Corp Proteina 4 de enlace ul16.
CA2483343A1 (en) * 2002-04-22 2003-10-30 Fred Hutchinson Cancer Research Center Soluble mic polypeptides as markers for diagnosis, prognosis and treatment of cancer and autoimmune diseases or conditions
AU2003270063A1 (en) * 2002-09-04 2004-03-29 The Trustees Of The University Of Pennsylvania Immune cell receptor ligand and immune cell receptor
US9809654B2 (en) 2002-09-27 2017-11-07 Vaccinex, Inc. Targeted CD1d molecules
EP1413316A1 (en) * 2002-09-27 2004-04-28 Bruno Robert Bifunctional conjugates or fusion proteins
MXPA05010255A (es) * 2003-03-24 2005-12-14 Scripps Research Inst Vacunas de adn contra crecimiento tumoral y metodos de uso de las mismas.
US7666417B2 (en) * 2003-04-22 2010-02-23 Fred Hutchinson Cancer Research Center Methods and compositions for treating autoimmune diseases or conditions
GB0403491D0 (en) * 2004-02-17 2004-03-24 Univ Cambridge Tech Polypeptides, methods and means
US7998481B2 (en) 2004-04-05 2011-08-16 The Regents Of The University Of California Modulation of NKG2D for treating or preventing solid organ allograft rejection
DK1732588T3 (da) 2004-04-05 2009-10-12 Univ California Modulation af NKG2D
JP5774805B2 (ja) 2004-11-29 2015-09-09 セクエノム,インコーポレイティド メチル化dnaを検出する方法、及びキット
US9074013B2 (en) 2004-11-29 2015-07-07 Sequenom, Inc. Means and methods for detecting methylated DNA
EP1909832A4 (en) * 2005-06-29 2010-01-13 Univ Miami ANTIBODY IMMUNOCELL LIGAND FUSION PROTEIN FOR CANCER THERAPY
US7846712B2 (en) 2006-06-01 2010-12-07 Alliance For Sustainable Energy, Llc L-arabinose fermenting yeast
WO2008103392A2 (en) 2007-02-21 2008-08-28 Vaccinex, Inc. Modulation of nkt cell activity with antigen-loaded cdid molecules
US9611313B2 (en) 2007-06-26 2017-04-04 University Of Miami Antibody-endostatin fusion protein and its variants
US20110038865A1 (en) * 2007-06-26 2011-02-17 University Of Miami Antibody- endostatin fusion protein and its variants
US8070021B2 (en) * 2007-10-31 2011-12-06 Momentive Performance Materials Hydraulic container evacuator and method
EP2385980B1 (en) 2009-01-08 2018-04-18 Albert Einstein College of Medicine, Inc. Bacterial vaccines with cell wall-associated ceramide-like glycolipids and uses thereof
WO2011127418A1 (en) 2010-04-09 2011-10-13 Amgen Inc. Btnl9 proteins, nucleic acids, and antibodies and uses thereof
WO2011130749A2 (en) 2010-04-16 2011-10-20 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Identification of mutations in herpes simplex virus envelope glycoproteins that enable or enhance vector retargeting to novel non-hsv receptors
WO2012064743A2 (en) 2010-11-08 2012-05-18 The Johns Hopkins University Methods for improving heart function
US10040853B2 (en) * 2011-09-09 2018-08-07 Fred Hutchinson Cancer Research Center Methods and compositions involving NKG2D inhibitors and cancer
US10093705B2 (en) 2011-09-13 2018-10-09 Dana-Farber Cancer Institute, Inc. Compositions and methods for brown fat induction and activity using FNDC5
US20130156808A1 (en) * 2011-11-22 2013-06-20 Stipan Jonjic Vaccine comprising beta-herpesvirus
WO2014015148A1 (en) 2012-07-19 2014-01-23 Amgen Inc. Human btnl3 proteins, nucleic acids, and antibodies and uses thereof
UY35148A (es) 2012-11-21 2014-05-30 Amgen Inc Immunoglobulinas heterodiméricas
US9371352B2 (en) 2013-02-08 2016-06-21 Vaccinex, Inc. Modified glycolipids and methods of making and using the same
WO2014144817A2 (en) 2013-03-15 2014-09-18 Amgen Inc. Inhibitory polypeptides specific to wnt inhibitors
WO2015017529A2 (en) 2013-07-31 2015-02-05 Dana-Farber Cancer Institute, Inc. Compositions and methods for modulating thermogenesis using pth-related and egf-related molecules
WO2015035215A1 (en) 2013-09-05 2015-03-12 Amgen Inc. Fc-containing molecules exhibiting predictable, consistent, and reproducible glycoform profiles
JP6588024B2 (ja) 2013-10-28 2019-10-09 ユニヴァーシティ オヴ ピッツバーグ オヴ ザ コモンウェルス システム オヴ ハイアー エデュケーション 腫瘍溶解性hsvベクター
CA2935804A1 (en) 2014-01-14 2015-07-23 Dana-Farber Cancer Institute, Inc. Compositions and methods for identification, assessment, prevention, and treatment of melanoma using pd-l1 isoforms
AU2015259053B2 (en) 2014-05-16 2020-12-24 Amgen Inc. Assay for detecting Th1 and Th2 cell populations
US11117969B2 (en) * 2014-12-05 2021-09-14 Xyphos Biosciences Inc. Insertable variable fragments of antibodies and modified α1-α2 domains of NKG2D ligands
AU2015357578B2 (en) 2014-12-05 2018-11-08 Xyphos Biosciences Inc. Insertable variable fragments of antibodies and modified a1-a2 domains of NKG2D ligands
EP3368157B1 (en) 2015-10-29 2022-06-29 Dana-Farber Cancer Institute, Inc. Methods for identification, assessment, prevention, and treatment of metabolic disorders using pm20d1 and n-lipidated amino acids
BR112018015390A2 (pt) 2016-01-27 2018-12-18 Oncorus, Inc. vetores virais oncolíticos e usos dos mesmos
WO2017218689A1 (en) 2016-06-14 2017-12-21 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Expression of nkg2d activating ligand proteins for sensitizing cancer cells to attack by cytotoxic immune cells
WO2018006005A1 (en) 2016-06-30 2018-01-04 Oncorus, Inc. Pseudotyped oncolytic viral delivery of therapeutic polypeptides
WO2018112636A1 (en) 2016-12-21 2018-06-28 Creatus Biosciences Inc. Method and organism expressing metschnikowia xylose transporters for increased xylose uptake
US10435721B2 (en) 2016-12-21 2019-10-08 Creatus Biosciences Inc. Xylitol producing metschnikowia species
JP7672196B2 (ja) 2017-03-14 2025-05-07 アムジエン・インコーポレーテツド 細胞培養において産生される抗体の総非フコシル化グリコフォームの調節
WO2019023483A1 (en) 2017-07-26 2019-01-31 Oncorus, Inc. ONCOLYTIC VIRAL VECTORS AND USES THEREOF
US11865081B2 (en) 2017-12-29 2024-01-09 Virogin Biotech Canada Ltd. Oncolytic viral delivery of therapeutic polypeptides
EP3775251A1 (en) 2018-03-26 2021-02-17 Amgen Inc. Total afucosylated glycoforms of antibodies produced in cell culture
CN112074532B (zh) 2018-03-27 2025-02-28 修普霍斯生物科学有限公司 结合非天然NKG2D受体的非天然NKG2D配体的修饰的α1-α2结构域
WO2020051013A2 (en) * 2018-08-24 2020-03-12 The Trustees Of Columbia University In The City Of New York Anti-cd33 and nkg2d ligand chimeras for treatment of myeloid malignancies
CA3152547A1 (en) 2019-09-26 2021-04-01 Amgen Inc. Methods of producing antibody compositions
US20230273126A1 (en) 2020-06-04 2023-08-31 Amgen Inc. Assessment of cleaning procedures of a biotherapeutic manufacturing process
JP2023548767A (ja) 2020-10-15 2023-11-21 アムジエン・インコーポレーテツド 抗体製造方法における相対不対グリカン
WO2022261021A1 (en) 2021-06-07 2022-12-15 Amgen Inc. Using fucosidase to control afucosylation level of glycosylated proteins
EP4413377A1 (en) 2021-10-05 2024-08-14 Amgen Inc. Fc-gamma receptor ii binding and glycan content
US20250161413A1 (en) 2022-02-16 2025-05-22 Dana-Farber Cancer Institute, Inc. Methods for decreasing pathologic alpha-synuclein using agents that modulate fndc5 or biologically active fragments thereof
WO2023215725A1 (en) 2022-05-02 2023-11-09 Fred Hutchinson Cancer Center Compositions and methods for cellular immunotherapy
AU2024256160A1 (en) 2023-04-20 2025-10-02 Amgen Inc. Methods of determining relative unpaired glycan content
WO2025038600A1 (en) 2023-08-14 2025-02-20 Amgen Inc. Methods for reducing yellow color
WO2025101820A1 (en) 2023-11-08 2025-05-15 Fred Hutchinson Cancer Center Compositions and methods for cellular immunotherapy

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4959314A (en) * 1984-11-09 1990-09-25 Cetus Corporation Cysteine-depleted muteins of biologically active proteins
USRE38824E1 (en) * 1986-08-04 2005-10-11 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Antibodies against human herpes virus-6(HHV-6) and method of use
US5834229A (en) * 1991-05-24 1998-11-10 Genentech, Inc. Nucleic acids vectors and host cells encoding and expressing heregulin 2-α
US5474771A (en) * 1991-11-15 1995-12-12 The Trustees Of Columbia University In The City Of New York Murine monoclonal antibody (5c8) recognizes a human glycoprotein on the surface of T-lymphocytes, compositions containing same
US5464771A (en) * 1994-04-29 1995-11-07 The United States Of America As Represented By The Secretary Of Agriculture Biologically pure culture of Actinomyces viscosus strain used for the bioremediation of chlorinated hydrocarbons
US6060241A (en) * 1996-04-05 2000-05-09 Kieta Holding Sa Compositions and methods relating to drug discovery and detection and treatment of gastrointestinal diseases
US5912415A (en) * 1996-05-16 1999-06-15 Regents Of The University Of Minnesota Arabidopsis spindly gene, methods of identification and use
US20030068623A1 (en) * 1997-06-16 2003-04-10 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same

Also Published As

Publication number Publication date
WO1999031241A1 (en) 1999-06-24
DE69831754T2 (de) 2006-06-29
US20040235058A1 (en) 2004-11-25
ATE305510T1 (de) 2005-10-15
IL136621A0 (en) 2001-06-14
NZ505500A (en) 2002-12-20
US6458350B1 (en) 2002-10-01
US8410252B2 (en) 2013-04-02
ES2251120T3 (es) 2006-04-16
JP2002508183A (ja) 2002-03-19
AU742757B2 (en) 2002-01-10
US20110281789A1 (en) 2011-11-17
IL136621A (en) 2008-07-08
DE69831754D1 (de) 2006-02-09
AU2004599A (en) 1999-07-05
CA2315251A1 (en) 1999-06-24
US6653447B1 (en) 2003-11-25
US7193058B2 (en) 2007-03-20
EP1037991B1 (en) 2005-09-28
US20030147847A1 (en) 2003-08-07
AU742757C (en) 2007-05-17
US20090324597A1 (en) 2009-12-31
US7807796B2 (en) 2010-10-05
US6774224B2 (en) 2004-08-10
US20080008715A1 (en) 2008-01-10
US7427669B2 (en) 2008-09-23
JP4255211B2 (ja) 2009-04-15
EP1037991A1 (en) 2000-09-27

Similar Documents

Publication Publication Date Title
DK1037991T3 (da) Celleoverfladeglycoproteiner associeret med humane B-cellelumfoner - ULBP, DNA og polypeptider
Von Der Helm et al. Translation of Rous sarcoma virus RNA in a cell-free system from ascites Krebs II cells.
DK1129190T3 (da) Human TSLP DNA og polypeptider
ATE301195T1 (de) Acpl dna und polypeptide
ES2080809T3 (es) Receptores de factor de necrosis tumoral alfa y beta.
BG100771A (bg) Хематопоетичен протеин и материали и методи за неговото получаване
DK1265914T3 (da) WNT-1-relaterede polypeptider og nukleinsyrer, der koder for samme
ATE365796T1 (de) Tumornekrosefaktor-rezeptoren 6 alpha& 6 beta
DK1005540T3 (da) IKK-beta-proteiner, nukleinsyrer og fremgangsmåder
DE60030450D1 (de) Von MUC-1 abgeleitete Peptide
DK1032668T3 (da) Fibroblast vækstfaktor 19
NZ222856A (en) Equine interferon gamma (eq ifn alpha), dna sequences for its recombinant production and monoclonal antibodies thereto
DK611386A (da) Recombinant humant fsh, fremgangsmaade til fremstilling deraf og vektorer og celler til anvendelse ved fremgangsmaaden
DE69331501D1 (de) Unterdrückung der Proliferation von T-Zellen mittels Peptidfragmenten des basischen Proteins aus Myelin
EP0528686A3 (OSRAM)
DE69837086D1 (de) Verbesserte prokariontische proteinenexpression
DK0833948T3 (da) Tyktarmspecifikt gen og protein
DE60031414D1 (de) Einkettige polypeptide enthaltend n-terminale troponin i fragmente und troponin c
Tamatani et al. Purification of guinea pig tumor necrosis factor (TNF): comparison of its antiproliferative and differentiative activities for myeloid leukemic cell lines with those of recombinant human TNF
DE3751646D1 (de) Rekombinantes Produkt
ATE332373T1 (de) Menschlisches il-1 epsilon dna und polypeptide
EP0750040A3 (en) Macrophage stimulating protein variant and method for producing the same
CHEN et al. RIBOSOMALSUBUNITOF ESCHERZCHIA COLI
ATE81591T1 (de) Interleukin-2 induziertes antineoplastisches peptid.
Beare et al. Characterization and antiproliferative activity of an α-type murine interferon from embryonic fibroblasts