DK1034251T3 - Simuleret biologisk oplösnings- og absorptionssystem - Google Patents

Simuleret biologisk oplösnings- og absorptionssystem

Info

Publication number
DK1034251T3
DK1034251T3 DK98956732T DK98956732T DK1034251T3 DK 1034251 T3 DK1034251 T3 DK 1034251T3 DK 98956732 T DK98956732 T DK 98956732T DK 98956732 T DK98956732 T DK 98956732T DK 1034251 T3 DK1034251 T3 DK 1034251T3
Authority
DK
Denmark
Prior art keywords
chamber
dissolution
cell culture
filter
active compound
Prior art date
Application number
DK98956732T
Other languages
English (en)
Inventor
Keith Edward Anderson
Yun K Tam
Original Assignee
Yun K Tam
Keith Edward Anderson
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yun K Tam, Keith Edward Anderson filed Critical Yun K Tam
Application granted granted Critical
Publication of DK1034251T3 publication Critical patent/DK1034251T3/da

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N13/00Investigating surface or boundary effects, e.g. wetting power; Investigating diffusion effects; Analysing materials by determining surface, boundary, or diffusion effects
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M25/00Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
    • C12M25/10Hollow fibers or tubes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M27/00Means for mixing, agitating or circulating fluids in the vessel
    • C12M27/14Rotation or movement of the cells support, e.g. rotated hollow fibers
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/16Hollow fibers
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N13/00Investigating surface or boundary effects, e.g. wetting power; Investigating diffusion effects; Analysing materials by determining surface, boundary, or diffusion effects
    • G01N2013/006Dissolution of tablets or the like

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Sustainable Development (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Microscoopes, Condenser (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
DK98956732T 1997-12-02 1998-11-30 Simuleret biologisk oplösnings- og absorptionssystem DK1034251T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/982,692 US6022733A (en) 1997-12-02 1997-12-02 Simulated biological dissolution and absorption system
PCT/CA1998/001090 WO1999028437A1 (en) 1997-12-02 1998-11-30 Simulated biological dissolution and absorption system

Publications (1)

Publication Number Publication Date
DK1034251T3 true DK1034251T3 (da) 2004-05-17

Family

ID=25529415

Family Applications (1)

Application Number Title Priority Date Filing Date
DK98956732T DK1034251T3 (da) 1997-12-02 1998-11-30 Simuleret biologisk oplösnings- og absorptionssystem

Country Status (11)

Country Link
US (1) US6022733A (da)
EP (1) EP1034251B1 (da)
CN (1) CN1179035C (da)
AT (1) ATE258221T1 (da)
AU (1) AU1328499A (da)
CA (1) CA2312833A1 (da)
DE (1) DE69821259T2 (da)
DK (1) DK1034251T3 (da)
ES (1) ES2214751T3 (da)
HK (1) HK1034993A1 (da)
WO (1) WO1999028437A1 (da)

Families Citing this family (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5942443A (en) * 1996-06-28 1999-08-24 Caliper Technologies Corporation High throughput screening assay systems in microscale fluidic devices
US6429025B1 (en) * 1996-06-28 2002-08-06 Caliper Technologies Corp. High-throughput screening assay systems in microscale fluidic devices
US20060000722A1 (en) * 1996-06-28 2006-01-05 Caliper Life Sciences, Inc. High throughput screening assay systems in microscale fluidic devices
GB9805519D0 (en) * 1998-03-17 1998-05-13 Zeneca Ltd Processes
US6485963B1 (en) * 2000-06-02 2002-11-26 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Growth stimulation of biological cells and tissue by electromagnetic fields and uses thereof
US6667172B2 (en) * 2001-09-19 2003-12-23 The Cleveland Clinic Foundation Cell and tissue culture modeling device and apparatus and method of using same
US7027970B2 (en) * 2001-10-19 2006-04-11 Globomax Llc Tool for in vitro-in vivo correlation
US6799123B2 (en) * 2001-11-05 2004-09-28 Lyn Hughes Dissolution test equipment and method
AU2003265228A1 (en) * 2002-03-12 2003-12-22 Surface Logix, Inc. Assay device that analyzes the absorption, metabolism, permeability and/or toxicity of a candidate compound
US6673598B1 (en) * 2002-10-29 2004-01-06 Synthecon, Inc. Disposable culture bag
US7390653B2 (en) * 2002-12-04 2008-06-24 Synthecon, Inc. Culture chamber for biologicals
US7144727B2 (en) * 2003-04-14 2006-12-05 Synthecon, Inc. Interlinked culture chamber for biologicals
WO2005095950A1 (en) * 2004-03-30 2005-10-13 Pfizer Products Inc. Method and device for evaluation of pharmaceutical compositions
GB0514702D0 (en) * 2005-07-18 2005-08-24 Plant Bioscience Ltd Apparatus, system and method
EP1777510A1 (en) * 2005-10-21 2007-04-25 Rohm and Haas Company Dissolution test equipment and methods for testing
MX2009010534A (es) * 2007-03-30 2009-12-01 9898 Ltd Tecnologia de plataforma farmaceutica para el desarollo de productos naturales.
FR2923065B1 (fr) * 2007-10-30 2009-12-11 Univ Dauvergne Clermont 1 Dispositif de simulation d'un estomac d'un mammifere monogastrique ou d'un etre humain
FR2937455B1 (fr) 2008-10-20 2010-12-03 Gen Biscuit Methode in vitro modelisant la consistance generee in vivo par un aliment au cours de sa digestion
EP2182342A1 (en) * 2008-10-28 2010-05-05 LEK Pharmaceuticals D.D. Two-Compartment Dissolution Apparatus and Process
DE102009022354B4 (de) * 2009-05-15 2015-05-07 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Bioreaktorsystem
JP5257960B2 (ja) 2009-06-09 2013-08-07 株式会社ジェイテック 回転培養ベッセル及びそれを用いた自動細胞培養装置
US20100321028A1 (en) * 2009-06-18 2010-12-23 The Hong Kong Polytechnic University System and method for determining the performance of a wearable electrode
EP2284821A1 (en) * 2009-08-07 2011-02-16 Nederlandse Organisatie voor toegepast -natuurwetenschappelijk onderzoek TNO Method, device and computer program product for assessing the disintegration of a dosage form in the gastrointestinal tract
EP2302353A1 (en) * 2009-09-28 2011-03-30 Sanofi-Aventis Online TEER measurement in a system for permeation determination by means of a flow-through permeation cell (FTPC) having structurally integrated electrodes
CN101968480B (zh) * 2009-10-27 2013-09-11 闽南师范大学 药物中可被人体吸收的微量元素含量的模拟检测方法
GB0921048D0 (en) * 2009-12-01 2010-01-13 Health Prot Agency Assay method and apparatus
US8993042B2 (en) * 2010-01-06 2015-03-31 Toyota Motor Engineering & Manufacturing North America, Inc. Method for determining the production parameters for a substrate coating process
US20110177179A1 (en) * 2010-01-18 2011-07-21 Sinoveda Canada, Inc. Preparation of botanical extracts containing absorbable components using pharmaceutical platform technology
US20110195462A1 (en) * 2010-02-08 2011-08-11 Renewable Process Technologies, Llc System and method for producing biomaterials
JP5576337B2 (ja) * 2010-06-30 2014-08-20 ローム アンド ハース カンパニー 医薬剤形を溶出試験装置に分配するための送達装置
US9475709B2 (en) 2010-08-25 2016-10-25 Lockheed Martin Corporation Perforated graphene deionization or desalination
EP2529770A1 (en) * 2011-05-31 2012-12-05 Nederlandse Organisatie voor toegepast -natuurwetenschappelijk onderzoek TNO A digestion system
US20130074587A1 (en) * 2011-09-28 2013-03-28 Mel Merciadez System and method for dissolution analysis of drug-eluting medical devices
US9870895B2 (en) 2014-01-31 2018-01-16 Lockheed Martin Corporation Methods for perforating two-dimensional materials using a broad ion field
US9834809B2 (en) 2014-02-28 2017-12-05 Lockheed Martin Corporation Syringe for obtaining nano-sized materials for selective assays and related methods of use
US10213746B2 (en) 2016-04-14 2019-02-26 Lockheed Martin Corporation Selective interfacial mitigation of graphene defects
US10653824B2 (en) 2012-05-25 2020-05-19 Lockheed Martin Corporation Two-dimensional materials and uses thereof
US10980919B2 (en) 2016-04-14 2021-04-20 Lockheed Martin Corporation Methods for in vivo and in vitro use of graphene and other two-dimensional materials
US9744617B2 (en) 2014-01-31 2017-08-29 Lockheed Martin Corporation Methods for perforating multi-layer graphene through ion bombardment
US9610546B2 (en) 2014-03-12 2017-04-04 Lockheed Martin Corporation Separation membranes formed from perforated graphene and methods for use thereof
US9592475B2 (en) 2013-03-12 2017-03-14 Lockheed Martin Corporation Method for forming perforated graphene with uniform aperture size
US9572918B2 (en) 2013-06-21 2017-02-21 Lockheed Martin Corporation Graphene-based filter for isolating a substance from blood
JP6087264B2 (ja) 2013-11-29 2017-03-01 株式会社日立ハイテクノロジーズ 成分分析装置、薬効分析装置、及び分析方法
SG11201606287VA (en) 2014-01-31 2016-08-30 Lockheed Corp Processes for forming composite structures with a two-dimensional material using a porous, non-sacrificial supporting layer
AU2015229331A1 (en) 2014-03-12 2016-10-27 Lockheed Martin Corporation Separation membranes formed from perforated graphene
WO2016036888A1 (en) 2014-09-02 2016-03-10 Lockheed Martin Corporation Hemodialysis and hemofiltration membranes based upon a two-dimensional membrane material and methods employing same
WO2016081810A1 (en) 2014-11-21 2016-05-26 Absorption Systems Group, Llc System for the concomitant assessment of drug dissolution, absorption and permeation and methods of using the same
US10228358B2 (en) 2015-04-17 2019-03-12 Pion Inc. Apparatus and method for the assessment of concentration profiling and permeability rates
WO2017023376A1 (en) 2015-08-05 2017-02-09 Lockheed Martin Corporation Perforatable sheets of graphene-based material
AU2016303049A1 (en) 2015-08-06 2018-03-01 Lockheed Martin Corporation Nanoparticle modification and perforation of graphene
KR20190018410A (ko) 2016-04-14 2019-02-22 록히드 마틴 코포레이션 흐름 통로들을 갖는 2차원 막 구조들
SG11201808961QA (en) 2016-04-14 2018-11-29 Lockheed Corp Methods for in situ monitoring and control of defect formation or healing
WO2017180135A1 (en) 2016-04-14 2017-10-19 Lockheed Martin Corporation Membranes with tunable selectivity
SG11201808962RA (en) 2016-04-14 2018-11-29 Lockheed Corp Method for treating graphene sheets for large-scale transfer using free-float method
EP3412762A1 (en) * 2017-06-06 2018-12-12 ProDigest BVBA Gastrointestinal tract simulation system, compartments therefor, and method
CN108682252B (zh) * 2018-06-11 2020-07-03 江南大学 一种基于连杆运动的食物吞咽模拟装置
CN108735060A (zh) * 2018-08-14 2018-11-02 晓东宜健(苏州)仪器设备有限公司 一种仿生人体食道和胃消化系统
WO2020117855A1 (en) * 2018-12-03 2020-06-11 Lyndra, Inc. Stomach simulating device
US11668723B2 (en) 2019-07-09 2023-06-06 Logan Instruments Corporation Automated dissolution/permeation testing system
CN113174312A (zh) * 2021-05-08 2021-07-27 苏州珀罗汀生物技术有限公司 一种蛋白生产装置及方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5266480A (en) * 1986-04-18 1993-11-30 Advanced Tissue Sciences, Inc. Three-dimensional skin culture system
CA1274159A (en) * 1986-06-19 1990-09-18 Joseph K.S. Lee Dissolution cell and method for determining the in- vitro release of a drug
US4667504A (en) * 1986-10-02 1987-05-26 The United States Of America As Represented By The Secretary Of The Air Force Flow through device for determination of the penetration rate of chemicals across biological membranes in vitro
US5153132A (en) * 1988-06-30 1992-10-06 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Three-dimensional co-culture process
US4988623A (en) * 1988-06-30 1991-01-29 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Rotating bio-reactor cell culture apparatus
US5026650A (en) * 1988-06-30 1991-06-25 The United States Of Amercia As Represented By The Administrator Of The National Aeronautics And Space Administration Horizontally rotated cell culture system with a coaxial tubular oxygenator
US5153131A (en) * 1990-12-11 1992-10-06 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration High aspect reactor vessel and method of use
US5181518A (en) * 1991-02-04 1993-01-26 Mcdonagh Paul F Method of evaluating cardioprotective agents
NL9201907A (nl) * 1992-11-02 1994-06-01 Tno Peristaltisch mengende reactor en peristaltische kleppenpomp.
US5698413A (en) * 1993-05-05 1997-12-16 The United States Of America As Represented By The Department Of Health And Human Services Method of evaluating chemotherapeutic agents in vivo
DE69502814T2 (de) * 1994-02-25 1998-11-12 Distek Inc Auflösungsprüfgerät
US5527705A (en) * 1994-09-12 1996-06-18 Becton, Dickinson And Company Roller bottle for trans-membrane co-culture of cells and method for its use
CA2201159A1 (en) * 1994-09-27 1996-04-04 Edward F. Myers Artificial liver apparatus and method

Also Published As

Publication number Publication date
DE69821259D1 (de) 2004-02-26
EP1034251B1 (en) 2004-01-21
CN1284127A (zh) 2001-02-14
ATE258221T1 (de) 2004-02-15
DE69821259T2 (de) 2004-11-18
ES2214751T3 (es) 2004-09-16
HK1034993A1 (en) 2001-11-09
WO1999028437A1 (en) 1999-06-10
CA2312833A1 (en) 1999-06-10
EP1034251A1 (en) 2000-09-13
AU1328499A (en) 1999-06-16
CN1179035C (zh) 2004-12-08
US6022733A (en) 2000-02-08

Similar Documents

Publication Publication Date Title
DK1034251T3 (da) Simuleret biologisk oplösnings- og absorptionssystem
DE69738200D1 (de) Verwendung eines emulgatorsystems zur erhöhung des penetrationsflusses pharmazeutischer wirkstoffe
SE9801287D0 (sv) Incorporation of active substances in carrier matrixes
DE69524035D1 (de) Blutsammelsystem
DK318788D0 (da) Generisk nul'te-ordens-styret laegemiddelafgivelsessystem
DE60331155D1 (de) Pulmonales System mit einer Vorkammer
PT1390492E (pt) Microestruturas e sua aplicação na evolução direccionada de biomoléculas
ATE547162T1 (de) Begasungsverfahren
BR0206144A (pt) Sistemas de processamento de sangue e métodos que empregam um filtro de leucócito em linha em um artefato de restrição
SE9804003D0 (sv) A method of producing drug particles
WO2001032828A3 (en) Biological fluid processing
MXPA99009389A (es) Dispositivo para sacar un liquido de un depositocerrado.
EP0926537A3 (en) Liquid crystal display device
WO2002059599A3 (en) System and method for in vitro analysis of therapeutic agents
CO2022003888A2 (es) Sistemas y métodos de uso y regeneración de cromatografía
AR038373A1 (es) Sistema de suministro osmotico
NO980861L (no) Granulat med risleevne og basert på organiske syrer, fremgangsmåte for fremstilling, samt anvendelse
IT1286010B1 (it) Apparecchio per la somministrazione di fluido
WO2004064097A3 (en) Charged particle beam device for inspecting or structuring a specimen
SE9900701L (sv) Filter för en vakuumpump av ejektortyp med ljuddämpare
UY25071A1 (es) Composiciones solubilizadas de sertralina
NO964320L (no) Fremgangsmåte og anordning for å karakterisere anisotropi i et poröst mediums permeabilitet
GB2378440A (en) Viologen linked acridine based molecule and process for the preparation thereof
Görög 5.5. Methodological aspects of quantitative drug stability studies based on degradates
ITTO20030996A1 (it) Metodo ed apparecchiatura per l'analisi della vinaccia per la produzione di distillati mediante l'uso di una matrice di sensori di gas.