DK1015568T3 - Fremgangsmåde til produktion af rDSPAalfa1 - Google Patents

Fremgangsmåde til produktion af rDSPAalfa1

Info

Publication number
DK1015568T3
DK1015568T3 DK97901624T DK97901624T DK1015568T3 DK 1015568 T3 DK1015568 T3 DK 1015568T3 DK 97901624 T DK97901624 T DK 97901624T DK 97901624 T DK97901624 T DK 97901624T DK 1015568 T3 DK1015568 T3 DK 1015568T3
Authority
DK
Denmark
Prior art keywords
chromatography
production
rdspaalfa1
rdspa
ending
Prior art date
Application number
DK97901624T
Other languages
Danish (da)
English (en)
Inventor
Michael Mccaman
Erno Pungor
Carol Souders
Mei P Tan
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Application granted granted Critical
Publication of DK1015568T3 publication Critical patent/DK1015568T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
DK97901624T 1996-02-05 1997-01-31 Fremgangsmåde til produktion af rDSPAalfa1 DK1015568T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/597,059 US5731186A (en) 1996-02-05 1996-02-05 Method for the production of rDSPA α1
PCT/EP1997/000441 WO1997029188A1 (en) 1996-02-05 1997-01-31 METHOD FOR THE PRODUCTION OF rDSPA α1

Publications (1)

Publication Number Publication Date
DK1015568T3 true DK1015568T3 (da) 2003-06-10

Family

ID=24389906

Family Applications (1)

Application Number Title Priority Date Filing Date
DK97901624T DK1015568T3 (da) 1996-02-05 1997-01-31 Fremgangsmåde til produktion af rDSPAalfa1

Country Status (23)

Country Link
US (1) US5731186A (ja)
EP (1) EP1015568B1 (ja)
JP (1) JP3805378B2 (ja)
KR (1) KR100508043B1 (ja)
CN (1) CN1242059C (ja)
AT (1) ATE233316T1 (ja)
AU (1) AU706286B2 (ja)
CZ (1) CZ294827B6 (ja)
DE (1) DE69719382T2 (ja)
DK (1) DK1015568T3 (ja)
ES (1) ES2193349T3 (ja)
HK (1) HK1018795A1 (ja)
HU (1) HU223902B1 (ja)
IL (1) IL124952A (ja)
NO (1) NO322527B1 (ja)
PL (1) PL186410B1 (ja)
PT (1) PT1015568E (ja)
RU (1) RU2223315C2 (ja)
SK (1) SK284179B6 (ja)
TW (1) TW385313B (ja)
UA (1) UA62925C2 (ja)
WO (1) WO1997029188A1 (ja)
ZA (1) ZA97948B (ja)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100436655B1 (ko) * 2001-07-25 2004-06-22 (주)엘피스바이오텍 광범위한 단백질에 적용할 수 있는 단백질의 농축 및정제 방법
DE10153601A1 (de) * 2001-11-02 2003-05-22 Paion Gmbh DSPA zur Behandlung von Schlaganfall
DE202006015207U1 (de) * 2006-05-19 2007-08-16 Paion Deutschland Gmbh Verwendung vn Plasminogenaktivatoren zur Behandlung einer Venenthromboembolie
AR068914A1 (es) * 2007-10-18 2009-12-16 Paion Deutschland Gmbh Uso de un activador de plasminogeno para la preparacion de un medicamento para el tratamiento de apoplejia
EP2558580A2 (en) * 2010-04-16 2013-02-20 H. Lundbeck A/S Method for the manufacture of recombinant dspa alpha1
US20120258519A1 (en) * 2011-04-10 2012-10-11 Therapeutic Proteins Inc. Protein Harvesting
EP3302784B1 (en) 2015-06-05 2021-10-06 W.R. Grace & Co.-Conn. Adsorbent bioprocessing clarification agents and methods of making and using the same

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3512910A1 (de) * 1985-04-11 1986-10-16 Behringwerke Ag, 3550 Marburg Verfahren zur reinigung von plasminogenaktivatoren
US4721572A (en) * 1985-07-12 1988-01-26 Miles Laboratories, Inc. Purfication of blood clotting factors and other blood proteins on non-carbohydrate sulfated matrices
US4898825A (en) * 1986-05-07 1990-02-06 Mitsui Toatsu Chemicals, Incorporated Methods for purification of single-chain and double-chain tissue plasminogen activator
JPS6463378A (en) * 1986-08-11 1989-03-09 Mitsui Toatsu Chemicals Separation of single stranded tpa and double standard tpa
US4929560A (en) * 1988-02-03 1990-05-29 Damon Biotech, Inc. Recovery of tissue plasminogen activator
IE69054B1 (en) * 1988-07-20 1996-08-07 Schering Ag Vampire bat salivary plasminogen activators
UA34415C2 (uk) * 1989-02-13 2001-03-15 Шерінг Аг Берлін Унд Бергкамен Істотно чистий білок, що є тромболітиком, виділена днк, що його кодує, культура яйцеклітин xenopus laevis, трансформованих вектором, спосіб одержання активатора плазміногена, лікарський тромболітичний засіб
DE3943241A1 (de) * 1989-12-22 1991-06-27 Schering Ag Thrombolytisch wirkendes kombinationspraeparat
US5141862A (en) * 1990-04-17 1992-08-25 Smithkline Beecham Corporation Method of purifying tpa or plasminogen activator using a tripeptide of the formula: -X-Y-argininal wherein X and Y are selected from the group consisting of pro,phe,trp and tyr

Also Published As

Publication number Publication date
TW385313B (en) 2000-03-21
ZA97948B (en) 1997-08-19
PT1015568E (pt) 2003-07-31
UA62925C2 (en) 2004-01-15
JP2000504565A (ja) 2000-04-18
KR19990082306A (ko) 1999-11-25
HK1018795A1 (en) 2000-01-07
ATE233316T1 (de) 2003-03-15
IL124952A (en) 2002-08-14
PL328146A1 (en) 1999-01-18
JP3805378B2 (ja) 2006-08-02
CN1242059C (zh) 2006-02-15
CN1210559A (zh) 1999-03-10
HUP9901029A2 (hu) 1999-07-28
NO983579D0 (no) 1998-08-04
AU706286B2 (en) 1999-06-10
CZ294827B6 (cs) 2005-03-16
RU2223315C2 (ru) 2004-02-10
CZ245598A3 (cs) 1999-01-13
DE69719382T2 (de) 2003-11-27
AU1546297A (en) 1997-08-28
US5731186A (en) 1998-03-24
WO1997029188A1 (en) 1997-08-14
SK284179B6 (sk) 2004-10-05
EP1015568B1 (en) 2003-02-26
NO983579L (no) 1998-10-05
HU223902B1 (hu) 2005-03-29
SK103298A3 (en) 1999-03-12
PL186410B1 (pl) 2004-01-30
HUP9901029A3 (en) 2001-10-29
KR100508043B1 (ko) 2005-12-21
NO322527B1 (no) 2006-10-16
ES2193349T3 (es) 2003-11-01
IL124952A0 (en) 1999-01-26
EP1015568A1 (en) 2000-07-05
DE69719382D1 (de) 2003-04-03

Similar Documents

Publication Publication Date Title
AU6305990A (en) Process for refrigerating, corresponding refrigerating cycle and their application to the distillation of air
EP1193271A3 (en) Compositions and methods for protein structural determinations
MX9801072A (es) Metodo para purificar virus por cromatografia.
DK639288D0 (da) Fremgangsmaade til rensning af serumalbumin
AU8802998A (en) Process to obtain a high-concentration colloidal silica suspension and product thus obtained
EP0242544A3 (en) Adsorbent for chromatography, method of producing the same, and column system for chromatography
AU2900997A (en) Method for fractionation of a solution by a chromatographic simulated moving be d process
AU3598284A (en) Factor viii:c purification
ES2150233T3 (es) Pirrolo(2,3-c)carbazol-6-onas condensadas que potencian la actividad de interferon gamma.
DK1015568T3 (da) Fremgangsmåde til produktion af rDSPAalfa1
DE69629299D1 (de) Prozess für die produktion von l-lysin durch fermentation
GR3032396T3 (en) Process for the purification of serum albumin.
MY119366A (en) A process for the preparation of factor ix from biological sources
EP0720618A4 (en) METHOD FOR CLEANING "BASIC" FIBROBLAST GROWTH FACTOR
CA2245554A1 (en) Method for the production of rdspa .alpha.1
DK0383645T3 (da) Fremgangsmåde til fremstilling af antihæmofilifaktor (FVIIIc) med meget høj renhed
HUT39184A (en) Process for producing christalline /5r,6s/-2-amino-metil-6-/ /1r/-1-hydroxy-ethyl/-2-penem-3-carboxylic acid
NO985775L (no) FremgangsmÕte til fremstilling av aminocyanacetamid
UA41926C2 (uk) Прокат бульбоподібного профілю та спосіб його виготовлення
EP0466164A3 (en) Process for the preparation of 2-chloro-1,7-dihydropurin-6-one and process for the purification of the same
DK0994841T3 (da) Fremgangsmåde til fremstilling af 3,3-dimethylbutyraldehyd
DE69526992D1 (de) Fermentationsprozess für die Herstellung von Phenylessigsäure mit Phenylalanin als Ausgangskomponente
ES295383U (es) Mesa desmontable para ordenadores
UA19734C2 (uk) Спосіб ректифікації етилового спирту