DK1011637T3 - Modulation af fyldning af lægemiddel i multivesikulære liposomer - Google Patents
Modulation af fyldning af lægemiddel i multivesikulære liposomerInfo
- Publication number
- DK1011637T3 DK1011637T3 DK98945975T DK98945975T DK1011637T3 DK 1011637 T3 DK1011637 T3 DK 1011637T3 DK 98945975 T DK98945975 T DK 98945975T DK 98945975 T DK98945975 T DK 98945975T DK 1011637 T3 DK1011637 T3 DK 1011637T3
- Authority
- DK
- Denmark
- Prior art keywords
- liposomes
- osmolarity
- aqueous component
- active agent
- lipid
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/925,532 US6106858A (en) | 1997-09-08 | 1997-09-08 | Modulation of drug loading in multivescular liposomes |
PCT/US1998/018739 WO1999012523A1 (en) | 1997-09-08 | 1998-09-08 | Modulation of drug loading in multivesicular liposomes |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1011637T3 true DK1011637T3 (da) | 2007-05-21 |
Family
ID=25451864
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK98945975T DK1011637T3 (da) | 1997-09-08 | 1998-09-08 | Modulation af fyldning af lægemiddel i multivesikulære liposomer |
Country Status (14)
Country | Link |
---|---|
US (1) | US6106858A (ja) |
EP (1) | EP1011637B1 (ja) |
JP (3) | JP3676976B2 (ja) |
AT (1) | ATE356614T1 (ja) |
AU (1) | AU741784B2 (ja) |
CA (1) | CA2303432C (ja) |
DE (1) | DE69837339T2 (ja) |
DK (1) | DK1011637T3 (ja) |
ES (1) | ES2283071T3 (ja) |
IL (1) | IL134703A (ja) |
NO (1) | NO20001179L (ja) |
NZ (1) | NZ503309A (ja) |
PT (1) | PT1011637E (ja) |
WO (1) | WO1999012523A1 (ja) |
Families Citing this family (53)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6858589B2 (en) * | 1996-01-25 | 2005-02-22 | Pharmacy And Therapeutic Advisory Consultancy Pty Ltd | Methods of and compositions for potentiating the action of agents active on cell wall sites of the susceptible bacteria |
US6106858A (en) * | 1997-09-08 | 2000-08-22 | Skyepharma, Inc. | Modulation of drug loading in multivescular liposomes |
DE69841598D1 (de) * | 1997-09-18 | 2010-05-20 | Pacira Pharmaceuticals Inc | Retardierte freisetzung liposmaler anesthetischer zusammensetzungen. |
US20020039596A1 (en) * | 1997-11-14 | 2002-04-04 | Hartoun Hartounian | Production of multivesicular liposomes |
US6740643B2 (en) * | 1999-01-21 | 2004-05-25 | Mirus Corporation | Compositions and methods for drug delivery using amphiphile binding molecules |
JP2003514832A (ja) * | 1999-11-19 | 2003-04-22 | ザイコス インク. | 微粒子製造に関する連続フロー法 |
DE10109897A1 (de) * | 2001-02-21 | 2002-11-07 | Novosom Ag | Fakultativ kationische Liposomen und Verwendung dieser |
DE10154464B4 (de) * | 2001-11-08 | 2005-10-20 | Max Delbrueck Centrum | Oral verabreichbare pharmazeutische Zubereitung umfassend liposomal verkapseltes Taxol |
EP1448165B1 (en) * | 2001-11-13 | 2007-09-19 | Celator Pharmaceuticals, Inc. | Lipid carrier compositions and methods for improved drug retention |
US20040082521A1 (en) * | 2002-03-29 | 2004-04-29 | Azaya Therapeutics Inc. | Novel formulations of digitalis glycosides for treating cell-proliferative and other diseases |
US7718189B2 (en) | 2002-10-29 | 2010-05-18 | Transave, Inc. | Sustained release of antiinfectives |
AU2003287526A1 (en) * | 2002-11-06 | 2004-06-03 | Protein-stabilized liposomal formulations of pharmaceutical agents | |
US20050129753A1 (en) * | 2003-11-14 | 2005-06-16 | Gabizon Alberto A. | Method for drug loading in liposomes |
JP4638500B2 (ja) | 2004-10-06 | 2011-02-23 | ビーシー キャンサー エージェンシー | 治療剤を封入するためのリポソームからなる組成物及び治療剤のリポソーム内での保持性を高めるための方法 |
CN1315530C (zh) * | 2005-07-04 | 2007-05-16 | 重庆大学 | 蛋白质类药物控制释放系统制备方法 |
US20070110674A1 (en) * | 2005-07-29 | 2007-05-17 | Yuhong Xu | Sono-active liposomes and lipid particles and use thereof as contrast agents and active-agent delivery systems |
PL1962805T3 (pl) | 2005-12-08 | 2017-01-31 | Insmed Incorporated | Kompozycje środków przeciwzapalnych oparte na lipidach do leczenia infekcji płucnych |
WO2008137717A1 (en) | 2007-05-04 | 2008-11-13 | Transave, Inc. | Compositions of multicationic drugs for reducing interactions with polyanionic biomolecules and methods and uses thereof |
US9114081B2 (en) | 2007-05-07 | 2015-08-25 | Insmed Incorporated | Methods of treating pulmonary disorders with liposomal amikacin formulations |
WO2008137917A1 (en) * | 2007-05-07 | 2008-11-13 | Transave, Inc. | Method of treating bacterial infections with antibacterial formulations |
US9119783B2 (en) | 2007-05-07 | 2015-09-01 | Insmed Incorporated | Method of treating pulmonary disorders with liposomal amikacin formulations |
US9333214B2 (en) | 2007-05-07 | 2016-05-10 | Insmed Incorporated | Method for treating pulmonary disorders with liposomal amikacin formulations |
JP5371030B2 (ja) * | 2008-05-23 | 2013-12-18 | 国立大学法人 筑波大学 | ベシクルの製造方法、この製造方法によって得られるベシクルおよびベシクルを製造するためのw/o/wエマルション |
EP2450031B1 (en) * | 2009-07-02 | 2018-08-29 | Konica Minolta Holdings, Inc. | Method for producing liposomes by two-stage emulsification method using outer aqueous phase containing specific dispersing agent, method for producing liposome dispersion or dry powder thereof using the method for producing liposomes, and liposome dispersion or dry powder thereof produced thereby |
JPWO2011062255A1 (ja) * | 2009-11-20 | 2013-04-11 | コニカミノルタホールディングス株式会社 | 混合有機溶媒を油相として用いる二段階乳化によるリポソームの製造方法 |
WO2011127456A2 (en) | 2010-04-09 | 2011-10-13 | Pacira Pharmaceuticals, Inc. | Method for formulating large diameter synthetic membrane vesicles |
EP2394640A1 (en) | 2010-05-21 | 2011-12-14 | MediGene AG | Improved liposomal formulations of lipophilic compounds |
CN101912363A (zh) * | 2010-07-29 | 2010-12-15 | 蔡海德 | 溶解超滤-喷雾干燥-分子分散包衣-水化制粒-冷冻干燥生产脂质体组合药物 |
DE102010042615A1 (de) | 2010-10-19 | 2012-04-19 | Wacker Chemie Ag | 1:1, 2:1- oder 3:1-Komplex bestehend aus einem Cyclodextrin oder Cyclodextrinderivat und einem halogeniertem Ether, seine Herstellung und seine Verwendung als Schlafmittel |
EP2632553B1 (en) | 2010-10-28 | 2020-01-01 | Pacira Pharmaceuticals, Inc. | A sustained release formulation of a non-steroidal anti-inflammatory drug |
US9226984B2 (en) * | 2010-12-14 | 2016-01-05 | Technical University of Denmark and Rigshospitalet | Entrapment of radionuclides in nanoparticle compositions |
EP2672958A1 (en) | 2011-02-08 | 2013-12-18 | Halozyme, Inc. | Composition and lipid formulation of a hyaluronan-degrading enzyme and the use thereof for treatment of benign prostatic hyperplasia |
CA2830948A1 (en) * | 2011-03-25 | 2012-10-04 | Selecta Biosciences, Inc. | Osmotic mediated release synthetic nanocarriers |
GB201119032D0 (en) | 2011-11-03 | 2011-12-14 | Isis Innovation | Multisomes: encapsulated droplet networks |
US9717801B2 (en) * | 2012-03-15 | 2017-08-01 | Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A. | Glycogen-based cationic polymers |
WO2013168167A1 (en) | 2012-05-10 | 2013-11-14 | Painreform Ltd. | Depot formulations of a hydrophobic active ingredient and methods for preparation thereof |
JP6402097B2 (ja) | 2012-05-21 | 2018-10-10 | インスメッド インコーポレイテッド | 肺感染症を処置するためのシステム |
GB201219196D0 (en) | 2012-10-25 | 2012-12-12 | Isis Innovation | Droplet assembly method |
GB201219201D0 (en) | 2012-10-25 | 2012-12-12 | Isis Innovation | Hydrogel network |
ES2743039T3 (es) | 2012-11-29 | 2020-02-18 | Insmed Inc | Formulaciones de vancomicina estabilizada |
WO2014087175A2 (en) | 2012-12-07 | 2014-06-12 | Isis Innovation Limited | Droplet assembly by 3d printing |
CA2942478A1 (en) * | 2013-03-13 | 2014-10-02 | Stemetrix, Inc. | Skin compositions and uses |
US9993427B2 (en) | 2013-03-14 | 2018-06-12 | Biorest Ltd. | Liposome formulation and manufacture |
US10238675B2 (en) | 2014-05-15 | 2019-03-26 | Insmed Incorporated | Methods for treating pulmonary non-tuberculous mycobacterial infections |
EP3186281B1 (en) | 2014-08-28 | 2019-04-10 | Halozyme, Inc. | Combination therapy with a hyaluronan-degrading enzyme and an immune checkpoint inhibitor |
DK3291797T3 (da) | 2015-05-04 | 2020-09-21 | Versantis AG | Metode til forberedelse af transmembran ph-gradiente vesikler |
CN109983013A (zh) | 2016-11-18 | 2019-07-05 | 帕西拉制药有限公司 | 美洛昔康锌复合物微粒多囊脂质体制剂及其制备方法 |
KR102069680B1 (ko) * | 2017-03-02 | 2020-01-23 | 단디바이오사이언스 주식회사 | 면역억제인자 제어물질을 포함하는 다중도메인캡슐, 이의 제조방법, 및 이를 포함하는 면역조절 조성물 |
WO2019191627A1 (en) | 2018-03-30 | 2019-10-03 | Insmed Incorporated | Methods for continuous manufacture of liposomal drug products |
JP2019218392A (ja) * | 2019-08-30 | 2019-12-26 | ズリ・ホールディングス・リミテッドZuli Holdings Ltd | リポソーム、およびリポソームを含む処方剤 |
US11033495B1 (en) | 2021-01-22 | 2021-06-15 | Pacira Pharmaceuticals, Inc. | Manufacturing of bupivacaine multivesicular liposomes |
US11278494B1 (en) | 2021-01-22 | 2022-03-22 | Pacira Pharmaceuticals, Inc. | Manufacturing of bupivacaine multivesicular liposomes |
US11357727B1 (en) * | 2021-01-22 | 2022-06-14 | Pacira Pharmaceuticals, Inc. | Manufacturing of bupivacaine multivesicular liposomes |
Family Cites Families (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US35192A (en) * | 1862-05-06 | Improved nutmeg-grater | ||
JPH0768117B2 (ja) * | 1983-05-06 | 1995-07-26 | ベスター・インコーポレイテツド | 薬剤放出調整用小胞製剤 |
US5077056A (en) * | 1984-08-08 | 1991-12-31 | The Liposome Company, Inc. | Encapsulation of antineoplastic agents in liposomes |
CA1270198A (en) * | 1984-08-08 | 1990-06-12 | Marcel B. Bally | Encapsulation of antineoplastic agents in liposomes |
US5244678A (en) * | 1986-01-14 | 1993-09-14 | Ire-Celltarg S.A. | Pharmaceutical composition containing a local anesthetic and/or centrally acting analgesic encapsulated in liposomes |
US5204112A (en) * | 1986-06-16 | 1993-04-20 | The Liposome Company, Inc. | Induction of asymmetry in vesicles |
CA1335348C (en) * | 1988-03-04 | 1995-04-25 | Yasuaki Ogawa | Liposome composition |
US5261903A (en) * | 1988-04-11 | 1993-11-16 | M.D. Inc. | Composite anesthetic article and method of use |
BE1001869A3 (fr) * | 1988-10-12 | 1990-04-03 | Franz Legros | Procede d'encapsulation liposomiale d'antibiotiques aminoglucosidiques, en particulier de la gentamycine. |
US5049392A (en) * | 1989-01-18 | 1991-09-17 | The Liposome Company, Inc. | Osmotically dependent vesicles |
US5227170A (en) * | 1989-06-22 | 1993-07-13 | Vestar, Inc. | Encapsulation process |
US5227165A (en) * | 1989-11-13 | 1993-07-13 | Nova Pharmaceutical Corporation | Liposphere delivery systems for local anesthetics |
US5334381A (en) * | 1989-12-22 | 1994-08-02 | Unger Evan C | Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same |
US5091187A (en) * | 1990-04-26 | 1992-02-25 | Haynes Duncan H | Phospholipid-coated microcrystals: injectable formulations of water-insoluble drugs |
US5246707A (en) * | 1990-04-26 | 1993-09-21 | Haynes Duncan H | Sustained release delivery of water-soluble bio-molecules and drugs using phospholipid-coated microcrystals, microdroplets and high-concentration liposomes |
US5169934A (en) * | 1990-05-14 | 1992-12-08 | Anergen, Inc. | Intracellularly cleavable compounds |
USRE35192E (en) | 1990-11-13 | 1996-03-26 | Phoenix Surgical Products, Inc. | Post-surgical anesthesia at a continuous and progressively decreasing administration rate |
IS1685B (is) * | 1990-12-11 | 1998-02-24 | Bracco International B.V. | Aðferð við að búa til fitukúlur (liposomes) sem eru gæddar auknum hæfileika til að draga í sig og halda í sér aðskotaefnum |
CA2093381A1 (en) * | 1992-04-07 | 1993-10-08 | Hideyuki Sawahara | Liposome formulation and process for production thereof |
US5321012A (en) * | 1993-01-28 | 1994-06-14 | Virginia Commonwealth University Medical College | Inhibiting the development of tolerance to and/or dependence on a narcotic addictive substance |
CA2176712C (en) * | 1993-11-16 | 2000-05-23 | Mantripragada Sankaram | Synthetic membrane vesicles with controlled release of encapsulated biologically active substances |
US5451408A (en) * | 1994-03-23 | 1995-09-19 | Liposome Pain Management, Ltd. | Pain management with liposome-encapsulated analgesic drugs |
US5993850A (en) * | 1994-09-13 | 1999-11-30 | Skyepharma Inc. | Preparation of multivesicular liposomes for controlled release of encapsulated biologically active substances |
US6106858A (en) * | 1997-09-08 | 2000-08-22 | Skyepharma, Inc. | Modulation of drug loading in multivescular liposomes |
-
1997
- 1997-09-08 US US08/925,532 patent/US6106858A/en not_active Expired - Lifetime
-
1998
- 1998-09-08 AT AT98945975T patent/ATE356614T1/de not_active IP Right Cessation
- 1998-09-08 NZ NZ503309A patent/NZ503309A/en unknown
- 1998-09-08 PT PT98945975T patent/PT1011637E/pt unknown
- 1998-09-08 JP JP2000510422A patent/JP3676976B2/ja not_active Expired - Lifetime
- 1998-09-08 DE DE69837339T patent/DE69837339T2/de not_active Expired - Lifetime
- 1998-09-08 DK DK98945975T patent/DK1011637T3/da active
- 1998-09-08 AU AU93101/98A patent/AU741784B2/en not_active Ceased
- 1998-09-08 EP EP98945975A patent/EP1011637B1/en not_active Expired - Lifetime
- 1998-09-08 ES ES98945975T patent/ES2283071T3/es not_active Expired - Lifetime
- 1998-09-08 WO PCT/US1998/018739 patent/WO1999012523A1/en active IP Right Grant
- 1998-09-08 CA CA002303432A patent/CA2303432C/en not_active Expired - Lifetime
- 1998-09-08 IL IL13470398A patent/IL134703A/xx not_active IP Right Cessation
-
2000
- 2000-03-07 NO NO20001179A patent/NO20001179L/no not_active Application Discontinuation
-
2004
- 2004-10-21 JP JP2004307443A patent/JP2005120095A/ja active Pending
-
2007
- 2007-10-03 JP JP2007259556A patent/JP2008044962A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
IL134703A (en) | 2005-08-31 |
JP2008044962A (ja) | 2008-02-28 |
DE69837339D1 (de) | 2007-04-26 |
EP1011637B1 (en) | 2007-03-14 |
IL134703A0 (en) | 2001-04-30 |
US6106858A (en) | 2000-08-22 |
WO1999012523A1 (en) | 1999-03-18 |
AU741784B2 (en) | 2001-12-06 |
DE69837339T2 (de) | 2007-11-29 |
NO20001179L (no) | 2000-04-04 |
ATE356614T1 (de) | 2007-04-15 |
CA2303432A1 (en) | 1999-03-18 |
ES2283071T3 (es) | 2007-10-16 |
NO20001179D0 (no) | 2000-03-07 |
NZ503309A (en) | 2001-04-27 |
EP1011637A4 (en) | 2003-04-02 |
JP2001515853A (ja) | 2001-09-25 |
JP2005120095A (ja) | 2005-05-12 |
JP3676976B2 (ja) | 2005-07-27 |
PT1011637E (pt) | 2007-03-30 |
AU9310198A (en) | 1999-03-29 |
EP1011637A1 (en) | 2000-06-28 |
CA2303432C (en) | 2008-02-12 |
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