DK0995743T3 - Dihydro- og tetrahydroquinolinderivater, som medicinsk antioxidant - Google Patents
Dihydro- og tetrahydroquinolinderivater, som medicinsk antioxidantInfo
- Publication number
- DK0995743T3 DK0995743T3 DK99402624T DK99402624T DK0995743T3 DK 0995743 T3 DK0995743 T3 DK 0995743T3 DK 99402624 T DK99402624 T DK 99402624T DK 99402624 T DK99402624 T DK 99402624T DK 0995743 T3 DK0995743 T3 DK 0995743T3
- Authority
- DK
- Denmark
- Prior art keywords
- alkyl
- optionally substituted
- cycloalkyl
- aryl
- heterocycloalkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/04—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms
- C07D215/06—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms having only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/20—Spiro-condensed ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/12—Ophthalmic agents for cataracts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Ophthalmology & Optometry (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Quinoline Compounds (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Materials For Medical Uses (AREA)
- Anti-Oxidant Or Stabilizer Compositions (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9813306A FR2784988B1 (fr) | 1998-10-23 | 1998-10-23 | Nouveaux composes dihydro et tetrahydroquinoleiniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0995743T3 true DK0995743T3 (da) | 2003-07-21 |
Family
ID=9531911
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK99402624T DK0995743T3 (da) | 1998-10-23 | 1999-10-22 | Dihydro- og tetrahydroquinolinderivater, som medicinsk antioxidant |
Country Status (20)
Country | Link |
---|---|
US (1) | US6350759B1 (xx) |
EP (1) | EP0995743B1 (xx) |
JP (1) | JP3159971B2 (xx) |
KR (1) | KR100421074B1 (xx) |
CN (1) | CN1255493A (xx) |
AT (1) | ATE236129T1 (xx) |
AU (1) | AU753044B2 (xx) |
BR (1) | BR9905587A (xx) |
CA (1) | CA2287046C (xx) |
DE (1) | DE69906445T2 (xx) |
DK (1) | DK0995743T3 (xx) |
EA (1) | EA003272B1 (xx) |
ES (1) | ES2196742T3 (xx) |
FR (1) | FR2784988B1 (xx) |
NO (1) | NO313590B1 (xx) |
NZ (1) | NZ500574A (xx) |
PL (1) | PL336139A1 (xx) |
PT (1) | PT995743E (xx) |
SI (1) | SI0995743T1 (xx) |
ZA (1) | ZA996667B (xx) |
Families Citing this family (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6703384B2 (en) | 1998-09-23 | 2004-03-09 | Research Development Foundation | Tocopherols, tocotrienols, other chroman and side chain derivatives and uses thereof |
DE60132171D1 (de) * | 2000-02-11 | 2008-02-14 | Res Dev Foundation | Tocopherole, tocotrienole, andere chrome und seitenketten-derivate und ihre verwendung |
WO2002047610A2 (en) * | 2000-11-16 | 2002-06-20 | The Regents Of The University Of California | Marine actinomycete taxon for drug and fermentation product dicovery |
KR100488444B1 (ko) * | 2001-12-31 | 2005-05-11 | 한국과학기술연구원 | 퀴놀론 유도체 및 그 제조 방법 |
US7176232B2 (en) | 2002-06-24 | 2007-02-13 | The Regents Of The University Of California | Salinosporamides and methods for use thereof |
ATE374767T1 (de) * | 2002-08-02 | 2007-10-15 | Nereus Pharmaceuticals Inc | Dehydrophenylahistine und analoge davon sowie ein verfahren zur herstellung von dehydrophenylahistinen und analogen davon |
US7935704B2 (en) * | 2003-08-01 | 2011-05-03 | Nereus Pharmaceuticals, Inc. | Dehydrophenylahistins and analogs thereof and the synthesis of dehydrophenylahistins and analogs thereof |
US7919497B2 (en) | 2002-08-02 | 2011-04-05 | Nereus Pharmaceuticals, Inc. | Analogs of dehydrophenylahistins and their therapeutic use |
AU2003296908A1 (en) * | 2002-09-27 | 2004-05-04 | Nereus Pharmaceuticals, Inc. | Macrocyclic lactams |
CN1791408A (zh) * | 2003-04-03 | 2006-06-21 | 普拉纳生物技术有限公司 | 神经系统疾病的治疗 |
EP2441767B1 (en) * | 2003-06-20 | 2015-06-10 | The Regents of The University of California | Salinosporamides and methods for use thereof |
WO2005002572A2 (en) * | 2003-06-20 | 2005-01-13 | Nereus Pharmaceuticals, Inc. | Use of [3.2.0] heterocyclic compounds and analogs thereof for the treatment of cancer, inflammation and infectious diseases |
WO2005070922A2 (en) * | 2004-01-23 | 2005-08-04 | Nereus Pharmaceuticals, Inc. | Bis-indole pyrroles useful as antimicrobials agents |
AU2005283141B2 (en) | 2004-04-30 | 2012-05-10 | Nereus Pharmaceuticals, Inc. | (3.2.0) heterocyclic compounds and methods of using the same |
US7579371B2 (en) | 2004-04-30 | 2009-08-25 | Nereus Pharmaceuticals, Inc. | Methods of using [3.2.0] heterocyclic compounds and analogs thereof |
NZ555439A (en) * | 2004-12-03 | 2010-12-24 | Dana Farber Cancer Inst Inc | Use of salinosporamide A for treating neoplastic diseases which are resistant to the chemotherapeutic agents bortezomib, dexamethasone, doxorubicin or thalidomide |
WO2006065686A2 (en) * | 2004-12-13 | 2006-06-22 | Galileo Pharmaceuticals, Inc. | Spiro derivatives as lipoxygenase inhibitors |
NZ572026A (en) | 2006-04-06 | 2011-12-22 | Nereus Pharmaceuticals Inc | Total synthesis of salinosporamide a and analogs thereof |
US8129527B2 (en) * | 2006-11-03 | 2012-03-06 | Nereus Pharmacuticals, Inc. | Analogs of dehydrophenylahistins and their therapeutic use |
WO2008095195A2 (en) * | 2007-02-02 | 2008-08-07 | Nereus Pharmaceuticals, Inc. | Lyophilized formulations of salinosporamide a |
TWI366565B (en) * | 2007-06-06 | 2012-06-21 | Otsuka Pharma Co Ltd | Quinolone compound and pharmaceutical composition |
US8394816B2 (en) * | 2007-12-07 | 2013-03-12 | Irene Ghobrial | Methods of using [3.2.0] heterocyclic compounds and analogs thereof in treating Waldenstrom's Macroglobulinemia |
MX2010012341A (es) | 2008-05-12 | 2010-12-06 | Nereus Pharmaceuticals Inc | Derivados de salinosporamida como inhibidores de proteasoma. |
JP5247667B2 (ja) * | 2008-12-05 | 2013-07-24 | 大塚製薬株式会社 | 医薬 |
KR101053329B1 (ko) * | 2009-07-09 | 2011-08-01 | 삼성전기주식회사 | 세라믹 전자부품 |
CN102958919A (zh) * | 2010-07-02 | 2013-03-06 | 霍夫曼-拉罗奇有限公司 | 新的四氢喹啉衍生物 |
CN103159676B (zh) * | 2011-12-16 | 2015-07-15 | 卢忠林 | 一种式i化合物的制备方法 |
US8835643B2 (en) | 2012-02-23 | 2014-09-16 | Empire Technology Development Llc | Molecules, compositions, and methods for light absorption |
TW202231278A (zh) | 2014-09-14 | 2022-08-16 | 美商阿瓦尼爾製藥股份有限公司 | 用於治療失智症中躁動行為之包含右旋美索芬(dextromethorphan)化合物及奎尼丁(quinidine)的藥學組成物 |
SG11201707127VA (en) | 2015-03-06 | 2017-09-28 | Beyondspring Pharmaceuticals Inc | Method of treating cancer associated with a ras mutation |
MX2017011375A (es) | 2015-03-06 | 2018-01-23 | Beyondspring Pharmaceuticals Inc | Método para tratar un tumor cerebral. |
EP3334726B1 (en) | 2015-07-13 | 2022-03-16 | Beyondspring Pharmaceuticals, Inc. | Plinabulin compositions |
US10912748B2 (en) | 2016-02-08 | 2021-02-09 | Beyondspring Pharmaceuticals, Inc. | Compositions containing tucaresol or its analogs |
CN107304184A (zh) * | 2016-04-18 | 2017-10-31 | 诺华丝国际股份有限公司 | 用于从取代的1,2‑二氢喹啉除去污染物的方法 |
US11229642B2 (en) | 2016-06-06 | 2022-01-25 | Beyondspring Pharmaceuticals, Inc. | Composition and method for reducing neutropenia |
CN110431135A (zh) | 2017-01-06 | 2019-11-08 | 大连万春布林医药有限公司 | 微管蛋白结合化合物及其治疗用途 |
US11400086B2 (en) | 2017-02-01 | 2022-08-02 | Beyondspring Pharmaceuticals, Inc. | Method of reducing chemotherapy-induced neutropenia |
CN109553575B (zh) * | 2017-09-27 | 2022-06-03 | 泰兴瑞泰化工有限公司 | 一种高纯乙氧基喹啉的吸附除杂方法 |
JP7350015B2 (ja) | 2018-01-24 | 2023-09-25 | ビヨンドスプリング ファーマシューティカルズ,インコーポレイテッド | プリナブリンの投与による血小板減少症を軽減するための組成物および方法 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3331846A (en) * | 1963-08-28 | 1967-07-18 | Lilly Co Eli | Metal catalyst process for converting alpha-amino-acetylenes to dihydroquinoline |
IL51342A (en) * | 1977-01-27 | 1980-11-30 | Abic Ltd | Ethoxyquin derivatives,their preparation and pharmaceutical and veterinary compositions comprising them |
GB8816269D0 (en) * | 1988-07-08 | 1988-08-10 | Int Assn Of Fish Meal Manufact | Compounds for use as anti-oxidants in fish meal/fish oil |
US5688810A (en) * | 1994-12-22 | 1997-11-18 | Ligand Pharmaceuticals Incorporated | Steroid receptor modulator compounds and methods |
JPH09301953A (ja) * | 1996-03-12 | 1997-11-25 | Sanwa Kagaku Kenkyusho Co Ltd | マロン酸ジアミド誘導体及びその用途 |
-
1998
- 1998-10-23 FR FR9813306A patent/FR2784988B1/fr not_active Expired - Fee Related
-
1999
- 1999-10-20 CA CA002287046A patent/CA2287046C/fr not_active Expired - Fee Related
- 1999-10-21 JP JP29930399A patent/JP3159971B2/ja not_active Expired - Fee Related
- 1999-10-21 PL PL99336139A patent/PL336139A1/xx not_active Application Discontinuation
- 1999-10-22 NZ NZ500574A patent/NZ500574A/en unknown
- 1999-10-22 DE DE69906445T patent/DE69906445T2/de not_active Expired - Fee Related
- 1999-10-22 AU AU56009/99A patent/AU753044B2/en not_active Ceased
- 1999-10-22 ES ES99402624T patent/ES2196742T3/es not_active Expired - Lifetime
- 1999-10-22 AT AT99402624T patent/ATE236129T1/de not_active IP Right Cessation
- 1999-10-22 US US09/425,267 patent/US6350759B1/en not_active Expired - Fee Related
- 1999-10-22 EP EP99402624A patent/EP0995743B1/fr not_active Expired - Lifetime
- 1999-10-22 ZA ZA9906667A patent/ZA996667B/xx unknown
- 1999-10-22 NO NO19995175A patent/NO313590B1/no not_active IP Right Cessation
- 1999-10-22 EA EA199900865A patent/EA003272B1/ru not_active IP Right Cessation
- 1999-10-22 BR BR9905587-2A patent/BR9905587A/pt not_active IP Right Cessation
- 1999-10-22 PT PT99402624T patent/PT995743E/pt unknown
- 1999-10-22 DK DK99402624T patent/DK0995743T3/da active
- 1999-10-22 SI SI9930251T patent/SI0995743T1/xx unknown
- 1999-10-22 CN CN99125591A patent/CN1255493A/zh active Pending
- 1999-10-23 KR KR10-1999-0046162A patent/KR100421074B1/ko not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
FR2784988B1 (fr) | 2002-09-20 |
FR2784988A1 (fr) | 2000-04-28 |
KR20000029268A (ko) | 2000-05-25 |
NO313590B1 (no) | 2002-10-28 |
AU5600999A (en) | 2000-05-04 |
EP0995743A1 (fr) | 2000-04-26 |
ATE236129T1 (de) | 2003-04-15 |
BR9905587A (pt) | 2001-12-11 |
NO995175L (no) | 2000-04-25 |
CA2287046C (fr) | 2003-12-02 |
ES2196742T3 (es) | 2003-12-16 |
EA003272B1 (ru) | 2003-02-27 |
SI0995743T1 (en) | 2003-08-31 |
NO995175D0 (no) | 1999-10-22 |
DE69906445T2 (de) | 2004-04-08 |
EA199900865A3 (ru) | 2000-10-30 |
EA199900865A2 (ru) | 2000-04-24 |
AU753044B2 (en) | 2002-10-03 |
JP3159971B2 (ja) | 2001-04-23 |
KR100421074B1 (ko) | 2004-03-04 |
PL336139A1 (en) | 2000-04-25 |
NZ500574A (en) | 2000-08-25 |
EP0995743B1 (fr) | 2003-04-02 |
CA2287046A1 (fr) | 2000-04-23 |
PT995743E (pt) | 2003-07-31 |
DE69906445D1 (de) | 2003-05-08 |
US6350759B1 (en) | 2002-02-26 |
CN1255493A (zh) | 2000-06-07 |
ZA996667B (en) | 2000-05-02 |
JP2000128865A (ja) | 2000-05-09 |
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