ATE236129T1 - Dihydro- und tetrahydrochinolinderivate als medizinisches antioxydans - Google Patents
Dihydro- und tetrahydrochinolinderivate als medizinisches antioxydansInfo
- Publication number
- ATE236129T1 ATE236129T1 AT99402624T AT99402624T ATE236129T1 AT E236129 T1 ATE236129 T1 AT E236129T1 AT 99402624 T AT99402624 T AT 99402624T AT 99402624 T AT99402624 T AT 99402624T AT E236129 T1 ATE236129 T1 AT E236129T1
- Authority
- AT
- Austria
- Prior art keywords
- alkyl
- optionally substituted
- cycloalkyl
- aryl
- heterocycloalkyl
- Prior art date
Links
- 239000003963 antioxidant agent Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 20
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 10
- 125000003118 aryl group Chemical group 0.000 abstract 8
- 125000000592 heterocycloalkyl group Chemical group 0.000 abstract 8
- 125000001072 heteroaryl group Chemical group 0.000 abstract 7
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 6
- 125000003545 alkoxy group Chemical group 0.000 abstract 4
- 125000004446 heteroarylalkyl group Chemical group 0.000 abstract 4
- 125000003342 alkenyl group Chemical group 0.000 abstract 3
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 3
- 125000000304 alkynyl group Chemical group 0.000 abstract 3
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 3
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 3
- 125000001475 halogen functional group Chemical group 0.000 abstract 3
- 125000005885 heterocycloalkylalkyl group Chemical group 0.000 abstract 3
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 3
- 125000003107 substituted aryl group Chemical group 0.000 abstract 3
- IRFSXVIRXMYULF-UHFFFAOYSA-N 1,2-dihydroquinoline Chemical compound C1=CC=C2C=CCNC2=C1 IRFSXVIRXMYULF-UHFFFAOYSA-N 0.000 abstract 2
- -1 1-6C perhaloalkyl Chemical group 0.000 abstract 2
- SMWDFEZZVXVKRB-UHFFFAOYSA-N Quinoline Chemical compound N1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 abstract 2
- 125000002947 alkylene group Chemical group 0.000 abstract 2
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 2
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N diphenyl Chemical compound C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- 229910052717 sulfur Inorganic materials 0.000 abstract 2
- 125000000147 tetrahydroquinolinyl group Chemical class N1(CCCC2=CC=CC=C12)* 0.000 abstract 2
- DDVIUSBRMFDHGP-UHFFFAOYSA-N 7-methoxy-2,2-diphenyl-1h-quinoline Chemical compound N1C2=CC(OC)=CC=C2C=CC1(C=1C=CC=CC=1)C1=CC=CC=C1 DDVIUSBRMFDHGP-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000004450 alkenylene group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 125000004419 alkynylene group Chemical group 0.000 abstract 1
- 125000004103 aminoalkyl group Chemical group 0.000 abstract 1
- 235000010290 biphenyl Nutrition 0.000 abstract 1
- 239000004305 biphenyl Substances 0.000 abstract 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/04—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms
- C07D215/06—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms having only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/20—Spiro-condensed ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/12—Ophthalmic agents for cataracts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Ophthalmology & Optometry (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Cardiology (AREA)
- Psychology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Quinoline Compounds (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Materials For Medical Uses (AREA)
- Anti-Oxidant Or Stabilizer Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9813306A FR2784988B1 (fr) | 1998-10-23 | 1998-10-23 | Nouveaux composes dihydro et tetrahydroquinoleiniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE236129T1 true ATE236129T1 (de) | 2003-04-15 |
Family
ID=9531911
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99402624T ATE236129T1 (de) | 1998-10-23 | 1999-10-22 | Dihydro- und tetrahydrochinolinderivate als medizinisches antioxydans |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US6350759B1 (de) |
| EP (1) | EP0995743B1 (de) |
| JP (1) | JP3159971B2 (de) |
| KR (1) | KR100421074B1 (de) |
| CN (1) | CN1255493A (de) |
| AT (1) | ATE236129T1 (de) |
| AU (1) | AU753044B2 (de) |
| BR (1) | BR9905587A (de) |
| CA (1) | CA2287046C (de) |
| DE (1) | DE69906445T2 (de) |
| DK (1) | DK0995743T3 (de) |
| EA (1) | EA003272B1 (de) |
| ES (1) | ES2196742T3 (de) |
| FR (1) | FR2784988B1 (de) |
| NO (1) | NO313590B1 (de) |
| NZ (1) | NZ500574A (de) |
| PL (1) | PL336139A1 (de) |
| PT (1) | PT995743E (de) |
| SI (1) | SI0995743T1 (de) |
| ZA (1) | ZA996667B (de) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6703384B2 (en) | 1998-09-23 | 2004-03-09 | Research Development Foundation | Tocopherols, tocotrienols, other chroman and side chain derivatives and uses thereof |
| CN1243000C (zh) * | 2000-02-11 | 2006-02-22 | 研究发展基金会 | 生育酚、生育三烯酚、其它苯并二氢吡喃和侧链衍生物,及其用途 |
| JP4395549B2 (ja) * | 2000-11-16 | 2010-01-13 | ザ レジェンツ オブ ザ ユニヴァースティ オブ カリフォルニア | 薬物及び発酵生成物の発見のための海洋放線菌分類群 |
| KR100488444B1 (ko) * | 2001-12-31 | 2005-05-11 | 한국과학기술연구원 | 퀴놀론 유도체 및 그 제조 방법 |
| US7176232B2 (en) | 2002-06-24 | 2007-02-13 | The Regents Of The University Of California | Salinosporamides and methods for use thereof |
| US7935704B2 (en) * | 2003-08-01 | 2011-05-03 | Nereus Pharmaceuticals, Inc. | Dehydrophenylahistins and analogs thereof and the synthesis of dehydrophenylahistins and analogs thereof |
| DE60316688T2 (de) * | 2002-08-02 | 2008-07-17 | Nereus Pharmaceuticals, Inc., San Diego | Dehydrophenylahistine und analoge davon sowie ein verfahren zur herstellung von dehydrophenylahistinen und analogen davon |
| US7919497B2 (en) | 2002-08-02 | 2011-04-05 | Nereus Pharmaceuticals, Inc. | Analogs of dehydrophenylahistins and their therapeutic use |
| US7112581B2 (en) * | 2002-09-27 | 2006-09-26 | Nereus Pharmaceuticals, Inc. | Macrocyclic lactams |
| US20070037848A1 (en) * | 2003-04-03 | 2007-02-15 | Masters Colin L | Treatment of neurological conditions |
| KR20060026052A (ko) * | 2003-06-20 | 2006-03-22 | 니리어스 파마슈티컬즈, 인코퍼레이션 | 암, 염증 및 감염성 질환의 치료를 위한 [3.2.0]헤테로사이클릭 화합물 및 그 유사체의 사용방법 |
| NZ544858A (en) * | 2003-06-20 | 2009-07-31 | Univ California | Salinosporamides and methods for use thereof |
| AU2005206560A1 (en) | 2004-01-23 | 2005-08-04 | Nereus Pharmaceuticals, Inc. | Bis-indole pyrroles useful as antimicrobials agents |
| US7579371B2 (en) | 2004-04-30 | 2009-08-25 | Nereus Pharmaceuticals, Inc. | Methods of using [3.2.0] heterocyclic compounds and analogs thereof |
| JP2007535559A (ja) | 2004-04-30 | 2007-12-06 | ネレアス ファーマシューティカルズ インコーポレイテッド | ［３．２．０］複素環式化合物及びその使用法 |
| MX2007006526A (es) * | 2004-12-03 | 2007-09-19 | Dana Farber Cancer Inst Inc | Composiciones y metodos para tratamiento de enfermedades neoplasicas. |
| US7576094B2 (en) * | 2004-12-13 | 2009-08-18 | Eli Lilly And Company | Spiro derivatives as lipoxygenase inhibitors |
| BRPI0709474A2 (pt) | 2006-04-06 | 2011-07-12 | Nerus Pharmaceuticals Inc | sìntese total de salinosporamida a e seus análogos |
| US8129527B2 (en) * | 2006-11-03 | 2012-03-06 | Nereus Pharmacuticals, Inc. | Analogs of dehydrophenylahistins and their therapeutic use |
| US7824698B2 (en) * | 2007-02-02 | 2010-11-02 | Nereus Pharmaceuticals, Inc. | Lyophilized formulations of Salinosporamide A |
| TWI366565B (en) * | 2007-06-06 | 2012-06-21 | Otsuka Pharma Co Ltd | Quinolone compound and pharmaceutical composition |
| US8394816B2 (en) * | 2007-12-07 | 2013-03-12 | Irene Ghobrial | Methods of using [3.2.0] heterocyclic compounds and analogs thereof in treating Waldenstrom's Macroglobulinemia |
| AU2009246467A1 (en) * | 2008-05-12 | 2009-11-19 | Nereus Pharmaceuticals, Inc. | Salinosporamide derivatives as proteasome inhibitors |
| JP5247667B2 (ja) * | 2008-12-05 | 2013-07-24 | 大塚製薬株式会社 | 医薬 |
| KR101053329B1 (ko) | 2009-07-09 | 2011-08-01 | 삼성전기주식회사 | 세라믹 전자부품 |
| CN102958919A (zh) * | 2010-07-02 | 2013-03-06 | 霍夫曼-拉罗奇有限公司 | 新的四氢喹啉衍生物 |
| CN103159676B (zh) * | 2011-12-16 | 2015-07-15 | 卢忠林 | 一种式i化合物的制备方法 |
| US8835643B2 (en) | 2012-02-23 | 2014-09-16 | Empire Technology Development Llc | Molecules, compositions, and methods for light absorption |
| EP4166141A1 (de) | 2014-09-14 | 2023-04-19 | Avanir Pharmaceuticals, Inc. | Kombinierungen aus deuteriertem dextromethorphan und chinidin zur behandlung von unruhe und aggressivität beim alzheimer'schen demenz |
| AU2016229295B2 (en) | 2015-03-06 | 2021-11-04 | Beyondspring Pharmaceuticals, Inc. | Method of treating a brain tumor |
| SG10202008673WA (en) | 2015-03-06 | 2020-10-29 | Beyondspring Pharmaceuticals Inc | Method of treating cancer associated with a ras mutation |
| US10155748B2 (en) | 2015-07-13 | 2018-12-18 | Beyondspring Pharmaceuticals, Inc. | Plinabulin compositions |
| JP2019511565A (ja) | 2016-02-08 | 2019-04-25 | ビヨンドスプリング ファーマシューティカルズ，インコーポレイテッド | ツカレゾールまたはそのアナログを含む組成物 |
| CN107304184A (zh) * | 2016-04-18 | 2017-10-31 | 诺华丝国际股份有限公司 | 用于从取代的1,2‑二氢喹啉除去污染物的方法 |
| AU2017278245B2 (en) | 2016-06-06 | 2022-09-15 | Beyondspring Pharmaceuticals, Inc. | Composition and method for reducing neutropenia |
| EP3565812B1 (de) | 2017-01-06 | 2023-12-27 | Beyondspring Pharmaceuticals, Inc. | Tubulin-bindende substanzen und therapeutische verwendung davon |
| KR20240110997A (ko) | 2017-02-01 | 2024-07-16 | 비욘드스프링 파마수티컬스, 인코포레이티드. | 호중구감소증의 감소 방법 |
| CN109553575B (zh) * | 2017-09-27 | 2022-06-03 | 泰兴瑞泰化工有限公司 | 一种高纯乙氧基喹啉的吸附除杂方法 |
| EP3743074A4 (de) | 2018-01-24 | 2021-12-15 | Beyondspring Pharmaceuticals Inc. | Zusammensetzung und verfahren zur reduktion von thrombozytopenie über die verabreichung von plinabulin |
| WO2022216908A1 (en) | 2021-04-09 | 2022-10-13 | Beyondspring Pharmaceuticals, Inc. | Therapeutic compositions and methods for treating tumors |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3331846A (en) | 1963-08-28 | 1967-07-18 | Lilly Co Eli | Metal catalyst process for converting alpha-amino-acetylenes to dihydroquinoline |
| IL51342A (en) * | 1977-01-27 | 1980-11-30 | Abic Ltd | Ethoxyquin derivatives,their preparation and pharmaceutical and veterinary compositions comprising them |
| GB8816269D0 (en) * | 1988-07-08 | 1988-08-10 | Int Assn Of Fish Meal Manufact | Compounds for use as anti-oxidants in fish meal/fish oil |
| US5696130A (en) | 1994-12-22 | 1997-12-09 | Ligand Pharmaceuticals Incorporated | Tricyclic steroid receptor modulator compounds and methods |
| JPH09301953A (ja) * | 1996-03-12 | 1997-11-25 | Sanwa Kagaku Kenkyusho Co Ltd | マロン酸ジアミド誘導体及びその用途 |
-
1998
- 1998-10-23 FR FR9813306A patent/FR2784988B1/fr not_active Expired - Fee Related
-
1999
- 1999-10-20 CA CA002287046A patent/CA2287046C/fr not_active Expired - Fee Related
- 1999-10-21 JP JP29930399A patent/JP3159971B2/ja not_active Expired - Fee Related
- 1999-10-21 PL PL99336139A patent/PL336139A1/xx not_active Application Discontinuation
- 1999-10-22 ZA ZA9906667A patent/ZA996667B/xx unknown
- 1999-10-22 SI SI9930251T patent/SI0995743T1/xx unknown
- 1999-10-22 AT AT99402624T patent/ATE236129T1/de not_active IP Right Cessation
- 1999-10-22 CN CN99125591A patent/CN1255493A/zh active Pending
- 1999-10-22 BR BR9905587-2A patent/BR9905587A/pt not_active IP Right Cessation
- 1999-10-22 DK DK99402624T patent/DK0995743T3/da active
- 1999-10-22 ES ES99402624T patent/ES2196742T3/es not_active Expired - Lifetime
- 1999-10-22 AU AU56009/99A patent/AU753044B2/en not_active Ceased
- 1999-10-22 EP EP99402624A patent/EP0995743B1/de not_active Expired - Lifetime
- 1999-10-22 NO NO19995175A patent/NO313590B1/no not_active IP Right Cessation
- 1999-10-22 PT PT99402624T patent/PT995743E/pt unknown
- 1999-10-22 NZ NZ500574A patent/NZ500574A/en unknown
- 1999-10-22 EA EA199900865A patent/EA003272B1/ru not_active IP Right Cessation
- 1999-10-22 DE DE69906445T patent/DE69906445T2/de not_active Expired - Fee Related
- 1999-10-22 US US09/425,267 patent/US6350759B1/en not_active Expired - Fee Related
- 1999-10-23 KR KR10-1999-0046162A patent/KR100421074B1/ko not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JP3159971B2 (ja) | 2001-04-23 |
| NO995175D0 (no) | 1999-10-22 |
| EA199900865A2 (ru) | 2000-04-24 |
| NZ500574A (en) | 2000-08-25 |
| NO995175L (no) | 2000-04-25 |
| DK0995743T3 (da) | 2003-07-21 |
| ES2196742T3 (es) | 2003-12-16 |
| FR2784988B1 (fr) | 2002-09-20 |
| JP2000128865A (ja) | 2000-05-09 |
| EA003272B1 (ru) | 2003-02-27 |
| US6350759B1 (en) | 2002-02-26 |
| KR20000029268A (ko) | 2000-05-25 |
| EP0995743A1 (de) | 2000-04-26 |
| AU5600999A (en) | 2000-05-04 |
| EP0995743B1 (de) | 2003-04-02 |
| AU753044B2 (en) | 2002-10-03 |
| KR100421074B1 (ko) | 2004-03-04 |
| CA2287046A1 (fr) | 2000-04-23 |
| PT995743E (pt) | 2003-07-31 |
| BR9905587A (pt) | 2001-12-11 |
| FR2784988A1 (fr) | 2000-04-28 |
| PL336139A1 (en) | 2000-04-25 |
| NO313590B1 (no) | 2002-10-28 |
| SI0995743T1 (en) | 2003-08-31 |
| EA199900865A3 (ru) | 2000-10-30 |
| ZA996667B (en) | 2000-05-02 |
| CN1255493A (zh) | 2000-06-07 |
| DE69906445T2 (de) | 2004-04-08 |
| CA2287046C (fr) | 2003-12-02 |
| DE69906445D1 (de) | 2003-05-08 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES2196742T3 (es) | Derivados de dihidro- y tetrahidro-quineloina como antioxidantes medicos. | |
| AU2002246728A1 (en) | Carboline derivatives | |
| ATE301653T1 (de) | Pyrazolopyridine | |
| ES2124167A1 (es) | Nuevos derivados del bencimidazol con actividad antihistaminica. | |
| DE60128003D1 (en) | Camptothecin derivate | |
| AU2002249890A1 (en) | Carboline derivatives | |
| NZ334954A (en) | Substituted heterocycles as anti-tumor agents | |
| WO2002048148A3 (en) | Pyrazolopyridine derivatives | |
| MY124078A (en) | Eletriptan hydrobromide monohydrate | |
| MY120237A (en) | Method for the synthesis of quinoline derivatives | |
| DE60201074D1 (en) | Pyrazolopyridinderivate | |
| IE863374L (en) | Indoles. | |
| MXPA04005151A (es) | Compuestos terapeuticos. | |
| AU6288700A (en) | Novel benzo[f]naphthyridine, preparation and compositions containing them | |
| AU1076802A (en) | Selective glucocorticoid receptor agonists | |
| DE69803648D1 (de) | Metalloproteaseinhibitoren, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen | |
| ATE381544T1 (de) | 1-aryl-4-cycloalk(en)ylpyrazole als antiparasitäre mittel | |
| IL109396A0 (en) | Pyrido (1,2,3-DE) quinoxaline derivatives, pharmaceutical compositions containing the same and processes for the preparation thereof | |
| GB9906328D0 (en) | 2-Substituted RNA preparation | |
| AU6149800A (en) | Pharmaceutical compositions containing 8-chloro-3(beta-diethylaminoethyl)-4-methyl-7-ethoxycarbonyl methoxy coumarin base and the salts thereof, with cholesterol-lowering activity | |
| AU1773497A (en) | Novel 2,3-benzodiazepine derivatives | |
| IL147767A0 (en) | Processes for the preparation of 2-arylvinyl alkyl ether and 1,4-diaryl-2-fluoro-2-butene compounds |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 0995743 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |