DK0991651T3 - Stabiliserede carbapenemmellemprodukter og deres syntetiske anvendelse - Google Patents

Stabiliserede carbapenemmellemprodukter og deres syntetiske anvendelse

Info

Publication number
DK0991651T3
DK0991651T3 DK98931264T DK98931264T DK0991651T3 DK 0991651 T3 DK0991651 T3 DK 0991651T3 DK 98931264 T DK98931264 T DK 98931264T DK 98931264 T DK98931264 T DK 98931264T DK 0991651 T3 DK0991651 T3 DK 0991651T3
Authority
DK
Denmark
Prior art keywords
stabilized
carbapene
intermediates
synthetic use
formula
Prior art date
Application number
DK98931264T
Other languages
English (en)
Inventor
John M Williams
Karel M J Brands
Renato T Skerlj
Ulf H Dolling
Ronald B Jobson
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9719383.3A external-priority patent/GB9719383D0/en
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Application granted granted Critical
Publication of DK0991651T3 publication Critical patent/DK0991651T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DK98931264T 1997-06-16 1998-06-12 Stabiliserede carbapenemmellemprodukter og deres syntetiske anvendelse DK0991651T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US4964097P 1997-06-16 1997-06-16
GBGB9719383.3A GB9719383D0 (en) 1997-09-11 1997-09-11 Stabilized carbapenem intermediates and improved process for carbapenem synthesis
PCT/US1998/012339 WO1998057973A1 (en) 1997-06-16 1998-06-12 Stabilized carbapenem intermediates and synthetic use

Publications (1)

Publication Number Publication Date
DK0991651T3 true DK0991651T3 (da) 2004-03-08

Family

ID=26312229

Family Applications (1)

Application Number Title Priority Date Filing Date
DK98931264T DK0991651T3 (da) 1997-06-16 1998-06-12 Stabiliserede carbapenemmellemprodukter og deres syntetiske anvendelse

Country Status (20)

Country Link
EP (1) EP0991651B1 (da)
JP (1) JP3245427B2 (da)
KR (1) KR100364339B1 (da)
CN (1) CN1105719C (da)
AT (1) ATE254127T1 (da)
AU (1) AU726882B2 (da)
BR (1) BR9810135A (da)
CA (1) CA2293835C (da)
DE (1) DE69819727T2 (da)
DK (1) DK0991651T3 (da)
EA (1) EA001926B1 (da)
ES (1) ES2210773T3 (da)
HU (1) HUP0004243A3 (da)
NZ (1) NZ500955A (da)
PL (1) PL337016A1 (da)
PT (1) PT991651E (da)
SK (1) SK179799A3 (da)
UA (1) UA58469C2 (da)
WO (1) WO1998057973A1 (da)
YU (1) YU65899A (da)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001032172A1 (en) * 1999-10-29 2001-05-10 Merck & Co., Inc. Process for formulation of carbapenem antibiotic compositions
US6548492B1 (en) * 1999-10-29 2003-04-15 Merck & Co., Inc. Process for formulation of carbapenem antibiotic compositions
WO2003016312A1 (fr) * 2001-08-13 2003-02-27 Eisai Co., Ltd. Procede de preparation d'antibiotiques a base de carbapenem
EP1686129A1 (de) * 2004-08-18 2006-08-02 Sandoz AG Carbapenem-Verbindungen, ihre Herstellung und Verwendung in Synthese von Carbapenemen
CN100582106C (zh) * 2006-01-27 2010-01-20 上海医药工业研究院 一种吡咯烷硫基碳青霉烯衍生物的制备方法及其中间体
CN101328179B (zh) * 2007-06-15 2011-01-12 山东轩竹医药科技有限公司 含有氧代氮杂环的巯基吡咯烷培南衍生物
CN101367804B (zh) * 2007-06-26 2010-12-15 山东轩竹医药科技有限公司 含有金刚烷的培南衍生物
CN101362760B (zh) * 2007-08-07 2010-12-15 山东轩竹医药科技有限公司 1β-甲基碳代青霉烯化合物
EP2505190A1 (en) * 2008-06-11 2012-10-03 Ranbaxy Laboratories Limited Polymorphic forms of ertapenem monosodium salt and process for it's preparation
US20130079322A1 (en) * 2010-05-21 2013-03-28 Xuanzhu Pharama Co., Ltd. Crystalline of carbapenem derivative or its hydrate, preparation methods and uses thereof
AU2013328585A1 (en) 2012-10-12 2015-04-09 Sandoz Ag Preparation of ertapenem intermediates
WO2014085471A1 (en) * 2012-11-28 2014-06-05 Prognosdx Health, Inc. Acid-activated compositions for the treatment of cancers, methods of their use and methods of their preparation
CN103537192A (zh) * 2013-10-25 2014-01-29 上海珺领生化科技有限公司 一种提纯、浓缩厄他培南水溶液的膜集成装置

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9202298D0 (en) * 1992-02-04 1992-03-18 Ici Plc Antibiotic compounds
HRP970281B1 (en) * 1996-05-28 2002-04-30 Merck & Co Inc Carbapenem antibiotic, composition and method of preparation

Also Published As

Publication number Publication date
HUP0004243A3 (en) 2001-12-28
AU726882B2 (en) 2000-11-23
EP0991651A4 (en) 2001-06-13
DE69819727D1 (de) 2003-12-18
ES2210773T3 (es) 2004-07-01
KR20010013774A (ko) 2001-02-26
HUP0004243A2 (en) 2001-03-28
JP3245427B2 (ja) 2002-01-15
NZ500955A (en) 2001-06-29
SK179799A3 (en) 2000-09-12
EA200000030A1 (ru) 2000-06-26
CN1259949A (zh) 2000-07-12
ATE254127T1 (de) 2003-11-15
EP0991651B1 (en) 2003-11-12
PT991651E (pt) 2004-03-31
CN1105719C (zh) 2003-04-16
EP0991651A1 (en) 2000-04-12
WO1998057973A1 (en) 1998-12-23
CA2293835C (en) 2003-09-16
CA2293835A1 (en) 1998-12-23
KR100364339B1 (ko) 2002-12-18
PL337016A1 (en) 2000-07-31
YU65899A (sh) 2001-05-28
UA58469C2 (uk) 2003-08-15
EA001926B1 (ru) 2001-10-22
BR9810135A (pt) 2000-08-08
DE69819727T2 (de) 2004-09-23
AU8142998A (en) 1999-01-04
JP2000511206A (ja) 2000-08-29

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