EA200000030A1 - Стабилизированные карбапенемовые полупродукты и их синтетическое применение - Google Patents

Стабилизированные карбапенемовые полупродукты и их синтетическое применение

Info

Publication number
EA200000030A1
EA200000030A1 EA200000030A EA200000030A EA200000030A1 EA 200000030 A1 EA200000030 A1 EA 200000030A1 EA 200000030 A EA200000030 A EA 200000030A EA 200000030 A EA200000030 A EA 200000030A EA 200000030 A1 EA200000030 A1 EA 200000030A1
Authority
EA
Eurasian Patent Office
Prior art keywords
semi
products
formula
synthetic application
stabilized carbapenem
Prior art date
Application number
EA200000030A
Other languages
English (en)
Other versions
EA001926B1 (ru
Inventor
Джон М. Вилльямс
Карел М. Дж. Брандс
Ренато Т. Скерлж
Ульф Х. Доллинг
Рональд Б. Джобсон
Original Assignee
Мерк Энд Ко., Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9719383.3A external-priority patent/GB9719383D0/en
Application filed by Мерк Энд Ко., Инк. filed Critical Мерк Энд Ко., Инк.
Publication of EA200000030A1 publication Critical patent/EA200000030A1/ru
Publication of EA001926B1 publication Critical patent/EA001926B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Предложено стабилизированное карбапенемовое промежуточное соединение, представленное формулой (1), или его соль, где P - защитная группа для карбоксила, а X - группа, уравновешивающая заряд. Кроме того, предложен способ синтеза соединения, представленного формулой (2), где X- группа, уравновешивающая заряд, включающий удаление защитной группы от соединения формулы (1) для получения соединения (2).Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200000030A 1997-06-16 1998-06-12 Стабилизированные карбапенемовые полупродукты и их синтетическое применение EA001926B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US4964097P 1997-06-16 1997-06-16
GBGB9719383.3A GB9719383D0 (en) 1997-09-11 1997-09-11 Stabilized carbapenem intermediates and improved process for carbapenem synthesis
PCT/US1998/012339 WO1998057973A1 (en) 1997-06-16 1998-06-12 Stabilized carbapenem intermediates and synthetic use

Publications (2)

Publication Number Publication Date
EA200000030A1 true EA200000030A1 (ru) 2000-06-26
EA001926B1 EA001926B1 (ru) 2001-10-22

Family

ID=26312229

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200000030A EA001926B1 (ru) 1997-06-16 1998-06-12 Стабилизированные карбапенемовые полупродукты и их синтетическое применение

Country Status (20)

Country Link
EP (1) EP0991651B1 (ru)
JP (1) JP3245427B2 (ru)
KR (1) KR100364339B1 (ru)
CN (1) CN1105719C (ru)
AT (1) ATE254127T1 (ru)
AU (1) AU726882B2 (ru)
BR (1) BR9810135A (ru)
CA (1) CA2293835C (ru)
DE (1) DE69819727T2 (ru)
DK (1) DK0991651T3 (ru)
EA (1) EA001926B1 (ru)
ES (1) ES2210773T3 (ru)
HU (1) HUP0004243A3 (ru)
NZ (1) NZ500955A (ru)
PL (1) PL337016A1 (ru)
PT (1) PT991651E (ru)
SK (1) SK179799A3 (ru)
UA (1) UA58469C2 (ru)
WO (1) WO1998057973A1 (ru)
YU (1) YU65899A (ru)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU770165B2 (en) * 1999-10-29 2004-02-12 Merck Sharp & Dohme Corp. Process for formulation of carbapenem antibiotic compositions
US6548492B1 (en) * 1999-10-29 2003-04-15 Merck & Co., Inc. Process for formulation of carbapenem antibiotic compositions
WO2003016312A1 (fr) * 2001-08-13 2003-02-27 Eisai Co., Ltd. Procede de preparation d'antibiotiques a base de carbapenem
EP1686129A1 (de) * 2004-08-18 2006-08-02 Sandoz AG Carbapenem-Verbindungen, ihre Herstellung und Verwendung in Synthese von Carbapenemen
CN100582106C (zh) * 2006-01-27 2010-01-20 上海医药工业研究院 一种吡咯烷硫基碳青霉烯衍生物的制备方法及其中间体
CN101328179B (zh) * 2007-06-15 2011-01-12 山东轩竹医药科技有限公司 含有氧代氮杂环的巯基吡咯烷培南衍生物
CN101367804B (zh) * 2007-06-26 2010-12-15 山东轩竹医药科技有限公司 含有金刚烷的培南衍生物
CN101362760B (zh) * 2007-08-07 2010-12-15 山东轩竹医药科技有限公司 1β-甲基碳代青霉烯化合物
WO2009150630A2 (en) * 2008-06-11 2009-12-17 Ranbaxy Laboratories Limited Process for preparing a carbapenem antibiotic composition
WO2011143935A1 (zh) * 2010-05-21 2011-11-24 山东轩竹医药科技有限公司 碳青霉烯衍生物或其水合物的晶型及其制备方法与用途
IN2015DN02513A (ru) 2012-10-12 2015-09-11 Sandoz Ag
WO2014085471A1 (en) * 2012-11-28 2014-06-05 Prognosdx Health, Inc. Acid-activated compositions for the treatment of cancers, methods of their use and methods of their preparation
CN103537192A (zh) * 2013-10-25 2014-01-29 上海珺领生化科技有限公司 一种提纯、浓缩厄他培南水溶液的膜集成装置

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9202298D0 (en) * 1992-02-04 1992-03-18 Ici Plc Antibiotic compounds
HRP970281B1 (en) * 1996-05-28 2002-04-30 Merck & Co Inc Carbapenem antibiotic, composition and method of preparation

Also Published As

Publication number Publication date
CA2293835A1 (en) 1998-12-23
DE69819727D1 (de) 2003-12-18
CA2293835C (en) 2003-09-16
DE69819727T2 (de) 2004-09-23
JP3245427B2 (ja) 2002-01-15
DK0991651T3 (da) 2004-03-08
HUP0004243A3 (en) 2001-12-28
AU726882B2 (en) 2000-11-23
HUP0004243A2 (en) 2001-03-28
PL337016A1 (en) 2000-07-31
WO1998057973A1 (en) 1998-12-23
CN1105719C (zh) 2003-04-16
CN1259949A (zh) 2000-07-12
YU65899A (sh) 2001-05-28
BR9810135A (pt) 2000-08-08
JP2000511206A (ja) 2000-08-29
NZ500955A (en) 2001-06-29
EP0991651A4 (en) 2001-06-13
UA58469C2 (ru) 2003-08-15
SK179799A3 (en) 2000-09-12
EA001926B1 (ru) 2001-10-22
EP0991651A1 (en) 2000-04-12
AU8142998A (en) 1999-01-04
KR100364339B1 (ko) 2002-12-18
PT991651E (pt) 2004-03-31
EP0991651B1 (en) 2003-11-12
KR20010013774A (ko) 2001-02-26
ES2210773T3 (es) 2004-07-01
ATE254127T1 (de) 2003-11-15

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU